R******d
发帖数: 1436 | 1 文献上说道细胞在分化过程中基因的epigenetic state发生变化，differentiated
cell中基因
的epigenetic state和pluripotent stem cell不同。
我想问的是：
有没有可能一个时期的epigenetic state其实储层了这个基因在所有其他时期（或者细
胞）里应该具
有的epigenetic state的信息。
这些state可以不同，但是互相转换的模式在当前的epigenetic state里被记录了，而
这种记录和对
基因表达的影响是独立的。
举个直观的例子：任意找一种分化后细胞中某基因的epigenetic state pattern，就能
推断出该基
因在其他分化后细胞以及干细胞中的epigenetic state。
有人见过类似的文献报道么？
多谢了。 |
|
R******d
发帖数: 1436 | 2 有没有可能自然选择作用到epigenetics上来？
epigenetics本是可遗传的意思，那么有理由假设对这个特性可能有自然选择。
但是，epigenetics的信息在传代中会被抹去，并在zygote中重新建立。那么直接对
epigenetics的选择似乎不会存在？
有没有可能是因为mutation的差异，所以有epigenetics的差异。对epigenetics的选择
其实是对mutation的选择？
多谢了。 |
|
n***g
发帖数: 5027 | 3 这个总结不错：
申请精华帖：我了解的Epigenetics牛人一览
我是从C.D.Allis，Danny Reinberg，Tony Kouzarides，Yi Zhang， Yang Shi这几个
人发的文章看起的，这几个人基本上就是目前做表观遗传最牛的一批人了。然后你看看
他们文章citation里面出现频率比较高的人名，那往往就是大牛了，然后一点一点扩展
。个人感觉看CNS及其子刊还是王道。另外推荐一个很好的网站，http://www.epidna.com/ 可以查这个领域最top的lab，也可以查该领域最新的论文。
# ^2 P/ }, _0 h" U8 m) P6 b
; l* o$ y- |- V5 g0 I0 T然后在申请选校的过程中，我也逐渐了解到一些
epigenetics领域的big names和rising stars。所以我感觉看各个牛校的faculty也是
了解一个领域的好学校好lab的方法。我的做法是每看一个学校，就把相关领域做
epigenetics的faculty留下来，然后以后看CNS时或者Journal club上看到熟悉的名字
，就重点关注下。$ ... 阅读全帖 |
|
i**y
发帖数: 71 | 4 I really like his new paper in Cell, which really leads the epigenetics
field in the direction of addressing causality in vivo... Didn't Schier
publish a paper in Nature on the early establishment of epigenomes in embryo
? I think there is some effort in his lab to address the causative roles of
epigenetic modifications on transcription as well.
Most current neurobiologists who are interested in epigenetics are only
explaining transcriptional phenomena in the language of epigenetics. Very
few ar... 阅读全帖 |
|
B****d
发帖数: 2 | 5 We are a small but active lab that centers on translational cancer research.
On the basis of our recent findings in BET bromodomain epigenetic readers,
we decide to expand our study in this emerging field.
Position: We are seeking for independent, ambitious, and self-motivated
candidates for a postdoctoral fellow position to study the epigenetic
mechanisms in cancer. The main goal of our laboratory is to develop
innovative diagnostic and therapeutic strategies for glioma and other brain
cancers... 阅读全帖 |
|
F*D
发帖数: 361 | 6 【 以下文字转载自 Postdoc 讨论区 】
发信人: WangLab (WangLab), 信区: Postdoc
标 题: Postdoctoral Position Available to Study Epigenetic Regulation in Normal and Pathological Developme
关键字: 'Postdoctoral Position' 'Epigenetic'
发信站: BBS 未名空间站 (Mon Jul 6 15:08:10 2009, 美东)
Postdoctoral Position Available to Study Epigenetic Regulation in
Normal and Pathological Development
Epigenetics, the mechanism that defines gene expression pattern
without changing DNA sequences, provides cells with transcriptional
mem |
|
Z**********g
发帖数: 222 | 7 我也觉得现在的epigenetics研究挺乱的。感觉很多文章把chromatin dynamics与
epigenetics等同了，一概发生染色质和组蛋白修饰，就称为epigenetics。而事实上这
种chromatin state是否hereditable，尤其在establishing chromatin state的初始信
号消除之后是否仍然hereditable，很少文章提及。所以epigenetics本质上的可遗传性
以及这种遗传性不再依赖于初始细胞信号的特性，很少有人证明。 |
|
R******d
发帖数: 1436 | 8 我看了一下文献，我想问的其实是：epigenetic markers reprogramming，不是
epigenetic
memory。
epigenetic memory大概指的是复制的时候epigenetic信息传递，reprogramming或许就
是我想
问的平行的变化。
我说了我不是搞这个的，所以有什么基本概念不对烦请指出来。 |
|
m***c
发帖数: 177 | 9 Epigenetics - the fundamental phenomenon of biology
Epigenetics - research tools, models and ...
Epigenetics - influence on future biological and medical research, drug
industry and opportunities
Epigenetics - speak out whatever you know |
|
c********r
发帖数: 1125 | 10 外行瞎说几句。
传统的生化路子做epigenetics貌似已经很饱和了，想再出大文章并不容易，竞争很厉
害，就是那几个大牛实验室（reinberg,allis,shi yang,anj Rao..)瓜分资源和文章，
当然你要是能进那几个实验室发了cns出路自然不愁。
现在貌似更多的是结合epigenetics与其他领域解决epigenetics在发育／干细胞中的问
题，比如zhang yi现在基本已经完全转去做这个，另外与genomics结合，或者与stem
cell,免疫甚至neuroscience结合都是挺不错的方向。
国内回去的做epigenetics好相当不少了，xu guoliang, gong zhizhong, cao
xiaofeng，zhu bing,还
有近几年回国的shen xiaohua, tang fuchou，li guohong，guan jisong等等，我个人
觉得还远算不上过时的领域，可挖的东西还比较多。 |
|
F*D
发帖数: 361 | 11 【 以下文字转载自 Postdoc 讨论区 】
发信人: WangLab (WangLab), 信区: Postdoc
标 题: Postdoctoral Position Available to Study Epigenetic Regulation in Normal and Pathological Developmen
发信站: BBS 未名空间站 (Sun Jul 12 15:33:21 2009, 美东)
Postdoctoral Position Available to Study Epigenetic Regulation in
Normal and Pathological Development
Epigenetics, the mechanism that defines gene expression pattern
without changing DNA sequences, provides cells with transcriptional memory
to allow the transmission of gene expr |
|
W*****b
发帖数: 85 | 12 Postdoctoral Position Available to Study Epigenetic Regulation in
Normal and Pathological Development
Epigenetics, the mechanism that defines gene expression pattern
without changing DNA sequences, provides cells with transcriptional
memory to allow the transmission of gene expression patterns during cell
division, and with developmental flexibility to permit reprogramming of
gene expression patterns during embryogenesis. The far-reaching
consequences of epigenetics on normal development |
|
W*****b
发帖数: 85 | 13 Postdoctoral Position Available to Study Epigenetic Regulation in
Normal and Pathological Development
Epigenetics, the mechanism that defines gene expression pattern
without changing DNA sequences, provides cells with transcriptional
memory to allow the transmission of gene expression patterns during cell
division, and with developmental flexibility to permit reprogramming of
gene expression patterns during embryogenesis. The far-reaching
consequences of epigenetics on normal development and pat |
|
p********y
发帖数: 557 | 14 One Postdoctoral fellow in Epigenetic Modulation of Pain Signaling (
available immediately)
Senior faculty member in the Department of Medicine/Gastroenterology is
seeking a highly motivated post-doctoral fellow who is interested in
investigating the role of epigenetic pathways in regulating pain pathways.
Work will involve animal models and cultured cells, both neurons and
epithelial cells. Research efforts include performing small animal surgery,
developing molecular probes, and conducting im... 阅读全帖 |
|
j*********o
发帖数: 237 | 15 【 以下文字转载自 Biology 讨论区 】
发信人: justdengtao (老男孩), 信区: Biology
标 题: 求推荐epigenetic或stem cell方面的review
发信站: BBS 未名空间站 (Fri Aug 7 11:40:00 2015, 美东)
先多谢了！！
Tao Deng,Ph.D
Email: [email protected]
/* */
Research Fellow
National Cancer Institute
National Institutes of Health
Summary of Research Experience:
Deep understanding of epigenetic regulations, including DNA methylation,
histone modifications and chromatin dynamics
Rich experience on mouse embryonic stem cell manipulation
Full hands-on exp... 阅读全帖 |
|
j*********o
发帖数: 237 | 16 【 以下文字转载自 Biology 讨论区 】
发信人: justdengtao (老男孩), 信区: Biology
标 题: 求推荐epigenetic或stem cell方面的review
发信站: BBS 未名空间站 (Fri Aug 7 11:40:00 2015, 美东)
先多谢了！！
Tao Deng,Ph.D
Email: [email protected]
/* */
Research Fellow
National Cancer Institute
National Institutes of Health
Summary of Research Experience:
Deep understanding of epigenetic regulations, including DNA methylation,
histone modifications and chromatin dynamics
Rich experience on mouse embryonic stem cell manipulation
Full hands-on exp... 阅读全帖 |
|
D*a
发帖数: 6830 | 17 最近模模糊糊的一个想法。
看了几篇文章关于老鼠爸爸或者老鼠妈妈吃东西可以影响后代的gene expression的文
章，想那这个是不是可以算做获得性遗传？这一代由于需要adapt环境，而引起了下一
代的变化。至于下一代是更适应环境还是更不适应？好像这些文章没有做到那里去。
也许拉马克他老人家不是这个意思，那么我就重新问一下问题：
由环境引起的亲代的适应性调整能不能通过epigenetics的途径引起后代的适应性增加
？或者说，这些有证据的epigenetics的变化是不是增加了后代的适应性？或者说，
epigenetics的影响是不是可以最终转化成蛋白的表达量这样的东西从而固定下来，从
而引起后代适应性的变化？
一篇cell的，虽然我觉得他们做得太少了，http://www.cell.com/retrieve/pii/S0092867410014261
记得还有一篇，什么metabolic的change可以一直影响到F2。文章忘了，明天去实验室
翻翻。
有没有人有证据支持或者反驳我这个想法呀？或者随便想到的什么讨论讨论。 |
|
j*****d
发帖数: 787 | 18 我想拉马克的遗传进化学说是个针对de novo的新性状 的遗传
epigenetics其实还是相当稳定的，至少我们目前所讨论的epigenetics都有内在“机制
保障+感应”， 也就是说epigenetics是相对传统DNA genetics来讲遗传规律。 不要神
化这个概念，它其实 只是 regulation of gene expression 反式调控(trans?)的一个
深化。 |
|
n********k
发帖数: 2818 | 19 I c, I agree both are very good scientifically and have vision too...u also
said, Schier actually is not in anyway in epigenetic field; Jerry runs hard
core epigenetic lab and has done beautiful and systematic work on the field
but he is really not a neural guy, nor Jaenisch..., as well, Jerry's later
work is more hot than systematic i would say...
mechanistic
epigenetics
good |
|
j*****1
发帖数: 3 | 20 A newly established laboratory within the Department of Biology at New York
University is seeking a motivated postdoctoral fellow. The research focuses
on the molecular mechanisms of epigenetic regulation, particularly the role
of non-coding RNAs and epigenetic marks in chromatin organization in fission
yeast.
The applicants for the post-doc position must have a Ph.D. in Biochemistry,
Cell Biology, Genetics, Molecular Biology, or related fields, and should
have experience in some of the followin |
|
j*****1
发帖数: 3 | 21 A newly established laboratory within the Department of Biology at New York
University is seeking a motivated postdoctoral fellow. The research focuses
on the molecular mechanisms of epigenetic regulation, particularly the role
of non-coding RNAs and epigenetic marks in chromatin organization in fission
yeast.
The applicants for the position must have a Ph.D. in Biochemistry, Cell
Biology, Genetics, Molecular Biology, or related fields, and should have
experience in some of the following experim |
|
u*********1
发帖数: 2518 | 22 想问下，epigenetics&psychiatry（比如autism）这个方向如何呢？好像现在对autism
的扶持很大。感觉这个方向进入industry是不是比较容易呢？在学术界又如何呢？但是
刚才又看到版面上有人发表帖子"is neuroscience dying out in industry".麻烦请内
行讲讲这个方向的现状和前景吧。
另外epigenetics&stem cell这个方向呢？感觉是大热门吧。做的人会不会很多了？如
果对于研究生新生，进入这个领域，会不会有点太晚了？而且是不是有点赶时髦的嫌疑。
谢谢。 |
|
z****g
发帖数: 3340 | 23 这个是"epigenetic memory"的extension, 但目前没有任何实验结果支持你的假说。光
epigenetic memory目前就没法搞
定。 |
|
b****r
发帖数: 17995 | 24 据我所知现在对epigenetics的理解还远远没到这个程度
甚至还没有任何一个疾病在epigenetics的水平真正被完整地characterize过，更别说
对每个位置的含义进行分析了
目前还处在对正常组织的epigenome的characterize过程中
而且我老很不看好几年之内这个领域会有什么大进展，人类目前的科技水平处理这个数
据代价还实在太高。入行需谨慎！ |
|
R******d
发帖数: 1436 | 25 可以提供更详细一点关于“epigenetic memory”的资料么？我看了以下这篇文章的
abstract，好像说的就是这个。
http://www.ncbi.nlm.nih.gov/pubmed/20644535
我可以理解epigenetic state可以通过细胞复制的时候从上一代传到下一代。有没有从
不同细胞之间平行转换的报道？
我觉得可能有文献里隐约有这个意识，比如ips就是一个特例。不过我不是搞这个的,
有的文献我注意不到 |
|
z****g
发帖数: 3340 | 26 “有没有从不同细胞之间平行转换的报道”这个基本不靠谱。为什么“ips就是一个特
例”？ what you mean or imply?
另外epigenetic memory是俺N年前刚入门epigenetics时自己提出的一个说法，不一定
是正式的名词。 |
|
R******d
发帖数: 1436 | 27 希望你指出其中一点，我也好有个头绪。我做计算机预测的，没有epigenetics的背景
。希望能尽快学点，不然也不这样对于不对的地方追问了。
good
far.
epigenetic |
|
z*t
发帖数: 863 | 28 The guy is actually the first to demostrate environment affected mestable
epiallele existed in mammals, the postdoc who work with him is at Baylor now
, he told me about he's not quite in favor of transgenerational epigenetic
inheretance in epidemiological study, he's going to study the early time(
pregnacy/neonatal) will affect the risk of disease by affact the epiallele.
For transgenerational epigenetic inheretance, Yang Shi seems conduct project
with worms,and the recent paper by Oliver Rando... 阅读全帖 |
|
z*t
发帖数: 863 | 29 效果咋样？花销大不？
我觉得现在急于bisulfite的甲基化测定虽是最solid的办法，但总归是针对群体的，而
即使被普遍认为homogenous的系统如cell line也会存在一定程度的heterogenety，（
比如细胞周期，细胞对特定药物的敏感度）,即使epigenetics研究的就是population
heterogenety但现有手段几乎不可能得到pure homogenous sample，可能最终还是要看
single cell level的epigenetic state
methylation |
|
Z**********g
发帖数: 222 | 30 很有意思的一个话题.我也有些疑问:
1. 环境对亲代所造成的影响是否真的会传递给其生殖细胞?比如公鼠吃高脂肪的食物可
能导致其肝脏代谢功能的改变,但这种改变如何发生在生殖细胞上,从而遗传给下一代?
2. 生殖细胞的遗传重组是genetics变异的一个重要来源,也是进化的来源.对于
epigenetics而言,生殖细胞在减数分裂时其epigenetic pattern是否也进行了重组?
3. 从进化上来说,获得一个新的性状,需要长时间的外界环境的选择.而个体对环境的适
应性如果能够很容易的直接遗传给下一代,那理论上进化应该是神速的. |
|
z*t
发帖数: 863 | 31 那篇cell相当坑爹，我在jc上讲过，看上去很花，信息量很少，而且一篇paper内的结
论并不能相互印证，是大家critisize paper的好选择。。。至于metastable
epiallele遗传,现在的看法一是会产生后代phentype variance，是不是de novo gain
of phentype就是见仁见智的问题了，二是epigenetic inheretance可以传递10-50代。
瑞士FMI的 Antonie Peter有个学生Urszula Brykczynska写了个thesis放在网上，对
epigenetic inheretance做了相当详细的review，推荐一读 |
|
l******o
发帖数: 3764 | 32 1.if high blood cholesterol/glucose level can change the epigenetic pattern
of somatic cells--i.e. up/down regulates methylation or histone modification
, I think it is also possible to change that of germ cells to some extent.
2.not quite understand what you mean...
3.as joyhead said, I tend to view epigenetics as a part of gene expression
regulation, and also epigentic chances as quantitative rather than
qualitative traits. In another word, changes are subtle. So I don't see why
it would viola... 阅读全帖 |
|
m*******y
发帖数: 16 | 33 是的，进化一直都是一个单向的行为，基因组自己变，变完了交给环境去筛选。
如果有个机制能从环境影响到基因组，那就完美了（获得性遗传或者epigenetic）
我觉得要是有人能证明epigenetic的这些修饰，会影响被修饰区域的变异概率（点突变
或者重组），那这个循环就完美了 |
|
i**y
发帖数: 71 | 34 No particular reasons... I feel their works are relatively more mechanistic
than most other "neuro-epigenetists". Schier doesn't even study epigenetics
in the nervous system. He just happens to study both Rudolf Jaenisch is good
too, although he doesn't seem to work as much on epigenetics as before.
these |
|
t*d
发帖数: 1290 | 35 Wen Yuan et al.
Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3
Lysine 27 Methylation
Science 24 August 2012; Vol. 337, No. 6097
同期评论中提到，H3K27 上的修饰比其他 histone 为点的修饰更 epigenetics，因为
这个为点的修饰可以在母细胞分裂时被复制到两个子细胞中。
难道不是所有的 histone 修饰都可以被复制吗？否则怎么能叫 epigenetics 呢？了解
的请讲讲，多谢了！ |
|
t**l
发帖数: 109 | 36 现在发现foxp3 treg th17领域的人也开始跳epigenetic的坑了。是不是以后的趋势就
是epigenetic?
还有到底是发现了foxp3+ treg？ 是Sakaguchi还是Rudensky? |
|
j*********o
发帖数: 237 | 37 先多谢了！！
Tao Deng,Ph.D
Email: [email protected]
/* */
Research Fellow
National Cancer Institute
National Institutes of Health
Summary of Research Experience:
Deep understanding of epigenetic regulations, including DNA methylation,
histone modifications and chromatin dynamics
Rich experience on mouse embryonic stem cell manipulation
Full hands-on experience on Next-generation sequencing
Selected Publication:
1. Deng T*, Zhu ZI*, Zhang S, Postnikov Y, Huang D, Horrsch M, Furusawa T,
Beckers J,... 阅读全帖 |
|
c*********t
发帖数: 340 | 38 以前city of hope的chair, 很有名，人又超级好的
帮他打个广告
https://goo.gl/zMPrC5
Van Andel Research Institute’s Laboratory of Dr. Gerd P. Pfeifer has a
position available for one Postdoctoral Fellow. The Pfeifer lab studies DNA
methylation with the intent of elucidating the mechanisms and significance
of DNA methylation changes in cancer and other diseases. Specifically, we
are interested in candidates with a background in molecular biology.
This postdoctoral position is available immediately for a motivated PhD
g... 阅读全帖 |
|
发帖数: 1 | 39 Epigenetic可能是导致中国人怕冷 爱喝热水的原因。也是基因遗传，可能是trauma基
因遗传。 |
|
发帖数: 1 | 40 Postdoctoral positions are available immediately in Dr. Zhonghua Gao's lab
at the Penn State University College of Medicine. The newly renovated lab is
located in the Biochemistry and Molecular Biology Department with jointly
support from the Cancer Institute. The lab has a broad interest in
understanding how chromatin modifications by epigenetic regulators affect
mammalian development as well as diseased states, such as autism and cancer
(Mol Cell. 2012 Feb 10;45(3):344-56; Nature. 2014 Dec 18;... 阅读全帖 |
|
b**********g
发帖数: 141 | 41 在准备Eb1a，找Editor发了邮件，也有五六个Journal同意把我放到list里，可是过了
半年才拿到一篇，希望大家帮忙推荐一下哈！Genetics, gene regulation,
epigenetics, stem cells, cancers, non-coding RNAs, etc. |
|
f*********o
发帖数: 38 | 42 The successful candidates will lead or work with multi-disciplinary teams
and have responsibility for Ph.D. scientists and scientific associates
optimizing molecules toward oncology drug candidates. We are seeking highly
motivated and accomplished Group Leaders, Senior investigators and
Investigators with true passion for innovative drug discovery with the
following backgrounds:
• Epigenetics and cancer biology with expertise in all aspects of
Molecular and Cellular Biology.
• ... 阅读全帖 |
|
f*********o
发帖数: 38 | 43 The successful candidates will lead or work with multi-disciplinary teams
and have responsibility for Ph.D. scientists and scientific associates
optimizing molecules toward oncology drug candidates. We are seeking highly
motivated and accomplished Group Leaders, Senior investigators and
Investigators with true passion for innovative drug discovery with the
following backgrounds:
• Epigenetics and cancer biology with expertise in all aspects of
Molecular and Cellular Biology.
• ... 阅读全帖 |
|
f*********o
发帖数: 38 | 44 The successful candidates will lead or work with multi-disciplinary teams
and have responsibility for Ph.D. scientists and scientific associates
optimizing molecules toward oncology drug candidates. We are seeking highly
motivated and accomplished Group Leaders, Senior investigators and
Investigators with true passion for innovative drug discovery with the
following backgrounds:
• Epigenetics and cancer biology with expertise in all aspects of
Molecular and Cellular Biology.
• ... 阅读全帖 |
|
发帖数: 1 | 45 Postdoctoral positions are available immediately in Dr. Zhonghua Gao's lab
at the Penn State University College of Medicine. The newly renovated lab is
located in the Biochemistry and Molecular Biology Department with jointly
support from the Cancer Institute. The lab has a broad interest in
understanding how chromatin modifications by epigenetic regulators affect
mammalian development as well as diseased states, such as autism and cancer
(Mol Cell. 2012 Feb 10;45(3):344-56; Nature. 2014 Dec 18;... 阅读全帖 |
|
b**********g
发帖数: 141 | 46 在准备Eb1a，找Editor发了邮件，也有五六个Journal同意把我放到list里，可是过了
半年才拿到一篇，希望大家帮忙推荐一下哈！Genetics, gene regulation,
epigenetics, stem cells, cancers, non-coding RNAs, etc. |
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k**h
发帖数: 35 | 47 准备申请绿卡，
Mainly focus on Epigenetic modifications and gene expression regulation.
Email: p*****[email protected]
谢谢。 |
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M******4
发帖数: 36 | 49 真诚求审稿机会，生物信息，系统生物学，epigenetics，cancer biology方面的文章
。多谢了。 |
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发帖数: 1 | 50 急需审稿机会， 我能审的方向为 molecular biology, molecular genetics,
genetics and genomes, epigenetics 等。我会尽我所能及时的，客观的，认真的，具
体的审稿。 欢迎来信要我简历。 谢谢！ |
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