B****d
发帖数: 2 | 1 We are a small but active lab that centers on translational cancer research.
On the basis of our recent findings in BET bromodomain epigenetic readers,
we decide to expand our study in this emerging field.
Position: We are seeking for independent, ambitious, and self-motivated
candidates for a postdoctoral fellow position to study the epigenetic
mechanisms in cancer. The main goal of our laboratory is to develop
innovative diagnostic and therapeutic strategies for glioma and other brain
cancers.
Responsibility: On the basis of our prior studies, the candidate will lead
projects focused on the BET bromodomain proteins and other epigenetic
regulators in glioma. The project will apply molecular, cellular, and
bioinformatics tools as well as animal models to develop new epigenetic
therapy and design rational drug combinations. There will be ample
opportunities to collaborate with other investigators.
Qualifications: The candidate is expected to have his/her doctoral degree
awarded no more than 5 years ago in a biomedical research-related discipline
, and demonstrate a proven track record of high-quality scientific research,
as evidenced by publication record and letters of recommendation.
Experience in epigenetics, cancer genetics and data mining would be
preferred.
Application: Interested applicants should send a cover letter explaining
their research interest and career goals, an updated CV, and contact details
for 2 or more referees to j***********[email protected]. Successful
candidate will receive salary and benefits commensurate with prior
experience and qualifications. | c********e
发帖数: 598 | 2 Just looked at his cancer cell paper about LZAP, which only represent
0.3% of mutation. The mRNA level is more correlated with copy number,
a significant portion of the patients gained more copies and express
higher level of LZAP.
He claimed "protein levels were markedly decreased in 32% of primary HNSCCs
(n = 28)".
I do not know him, but I am curious why this will be the research target. | w*****r
发帖数: 2061 | 3 0.3% is a lot
HNSCCs
【在 c********e 的大作中提到】
: Just looked at his cancer cell paper about LZAP, which only represent
: 0.3% of mutation. The mRNA level is more correlated with copy number,
: a significant portion of the patients gained more copies and express
: higher level of LZAP.
: He claimed "protein levels were markedly decreased in 32% of primary HNSCCs
: (n = 28)".
: I do not know him, but I am curious why this will be the research target.
| c********e
发帖数: 598 | 4
That means 3 individual in 1000 patients.
one has deletion.
one has two copies.
one has splice problem.
Is this a lot?
【在 w*****r 的大作中提到】
: 0.3% is a lot
:
: HNSCCs
| B****d
发帖数: 2 | 5 That was my PhD work years ago. My group focuses on glioblastoma.
It is interesting that you carefully read the old paper and checked TCGA
data, which was not available back 2006. Changes at DNA levels and protein
levels are not necessarily correlate. Protein levels are obviously more
relevant to functions. | A******y
发帖数: 2041 | 6 Congratz on your R01.
【在 B****d 的大作中提到】
: That was my PhD work years ago. My group focuses on glioblastoma.
: It is interesting that you carefully read the old paper and checked TCGA
: data, which was not available back 2006. Changes at DNA levels and protein
: levels are not necessarily correlate. Protein levels are obviously more
: relevant to functions.
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