m*******r 发帖数: 202 | 1 Thanks, Epigenetics. Please enjoy double-yellow baozi. |
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s**********9 发帖数: 290 | 2 谢谢epigenetics.
姐妹们有吃fenugreek的吗?效果明显吗?已经坚持吃一周了,效果不明显,不知道要
吃多久呢? |
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w*****y 发帖数: 1201 | 3 连续两年生老大和老二的话,好像老二是Autism的概率比较高。
这个只是个统计结果了,还没有很solid的scientific证据。
据最近几年来epigenetics的研究,有可能有些相关。
http://www.healthrelatedinfos.com/autism-risk-higher-in-close-s
Autism Risk Higher In Close Second-born Child Birth
A recent study suggests that there could be a higher risk of autism for
second children born soon (less than two years) after the first one.
Women who have children close together are at risk for an increased
likelihood of autism, at least that is what the research is showing.
The findi... 阅读全帖 |
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w*********s 发帖数: 2136 | 4 CDC to Study Vaccines and Autism
HuffingtonPost.com
David Kirby
Author/Journalist
Posted: March 18, 2011 05:46 PM
The Centers for Disease Control and Prevention wants to study autism as a
possible clinical outcome of immunization, as part of its newly adopted 5-
year research agenda for vaccine safety, the agency said on its website.
The CDC will also study mitochondrial dysfunction and the potential risk for
post-vaccine "neurological deterioration," and convene an expert panel on
the feasibili... 阅读全帖 |
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g*****o 发帖数: 1564 | 5 最好还是不要吧,triple negative的治疗现在来说不是很好,而且你老婆现在还是
grade 3,希望还是配合医生积极治疗,不要错过治疗最佳时间,后悔莫及。
激素促排卵肯定要take很大的risk,万一你老婆因为这个原因耽误了治疗,将来你会后
悔吗,将来怎么跟小孩子说。而且你老婆现在这个情况下的卵泡会不会有些genetic或
epigenetic的变化,会导致将来小孩子的一些问题。你们有没有跟医生讨论过。想要小
孩子可以领养,或者用别人的卵子啊。
不管怎样,祝福你们。 |
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R*******d 发帖数: 13640 | 6 http://en.wikipedia.org/wiki/Dutch_famine_of_1944
Dutch famine of 1944 Legacy[edit]
This famine was close to unique as it took place in a modern, developed and
literate country, albeit suffering under the privations of occupation and
war (other example: the famine during the siege of Leningrad). The well-
documented experience has allowed scientists to measure the effects of
famine on human health.
The Dutch Famine Birth Cohort Study, carried out by the departments of
Clinical Epidemiology and B... 阅读全帖 |
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s******e 发帖数: 370 | 7 以前PBS有个片子里也说到过类似的例子,说的是可能是epigenetics的因素 |
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w*********s 发帖数: 2136 | 8 CDC to Study Vaccines and Autism
HuffingtonPost.com
David Kirby
Author/Journalist
Posted: March 18, 2011 05:46 PM
The Centers for Disease Control and Prevention wants to study autism as a
possible clinical outcome of immunization, as part of its newly adopted 5-
year research agenda for vaccine safety, the agency said on its website.
The CDC will also study mitochondrial dysfunction and the potential risk for
post-vaccine "neurological deterioration," and convene an expert panel on
the feasibili... 阅读全帖 |
|
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t*******r 发帖数: 22634 | 10 哈哈,难道是传说中的 "一哭二闹三上吊"?
学究的说法是不是 epigenetics? |
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g*****o 发帖数: 1564 | 11 这不可能吧
婴幼儿时期应该有生长的爆发,青春期可能更重要?
应该是青春期时期营养+锻炼+父母身高吧
难道是2岁的时候,某些epigenetics的东东被激发了,诱导高基因? |
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t*******r 发帖数: 22634 | 12 由于 epigenetic 理论的存在,后天可以 turn on/off 基因表达,俺深深地怀疑 "都
是先天造成" 这种说法。。。
但这个可能跟娃小时候的早期教育有关。。。比如目前流行的那种,娃学前全面铺开搞
才艺,娃上学后 180 度转向搞 academic 的搞法,从基因表达的角度看,有点折腾的
说。。。当然,两栖动物两面开花的牛蛙,那另说。。。 |
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w***s 发帖数: 114 | 13 对的,是不严谨。。。我给改了。
70%。 你的“经常”是30%。一个原因是epigenetic difference
。。。不过这个还是gene表达level的问题,我不知道是?%。应该说比起心脏病二型
糖尿病来讲,genetic components的影响非常有压倒力。 |
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t*******r 发帖数: 22634 | 14 identical twins 才 70% 同时都有?
我觉得 identical twins 小时候生活在同一个家庭环境的统计比例,应该不会低于 70
% 吧。
也就是说。。。genetics 相似度 100%。。。epigenetic 所在的环境相似度,> 70%?
这么说来 mutations 的因子更大? |
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t*******r 发帖数: 22634 | 15 另外这个跟 identical twins 的中老年心脏病/二型糖尿病 不一定有可比性。。。因
为统计上大部分 identical twins 在 14 岁以前,是在同样的家庭学校环境。。。但
长大后,铁定不会跟同一个老婆上床,基本不会向同一个老板汇报演出。。。也就是说
,epigenetic 所在的环境相似度不同。。。 |
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t*******r 发帖数: 22634 | 16 我非专业的路人甲,跑过来说一句。体力好和是不是精神分裂倒是关系不大。体力好多
半主要是闲的。
是抑郁还是精神分裂,我估计对方不太可能告诉你,但抑郁也是要小心的。
为了下一代而言,跟你老公沟通一下。。。我个人觉得,说句不中听的,长期而言,能
把有精神问题的婆婆送回去,还是送回去吧。。。这不是无情,而是为下一代考虑。。
。环境因子对娃的大脑精神系统发育的影响,不可小觑。。。环境因子甚至都还有一代
代传下去的可能。gene turn on/off 的 epigenetic 理论。。。美帝这边第一代移民
,跟国内不一样,本来适应新环境就不容易,朋友圈子也不如国内。。。跟你老公说,
很多时候做这种两难决定,不是一件让人愉快的事,但有些决定人生也逃不过。。。给
他点时间想想,也看一些可靠渠道的遗传/环境因子的研究和讨论。。。在做完决定之
前,先别停药。反正药也不差这两天。。。 |
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t*******r 发帖数: 22634 | 17 这个也不一定靠谱,否则人类现在还是猴子。。。epigenetics 理论认为后天可能
enhance 基因的某些 feature 并且还能一代代传递下去,即使不出现选择因子。。。 |
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y****i 发帖数: 455 | 18 J Cell Mol Med. 2009 Jul 7. [Epub ahead of print]
Oxidative stress induced lung cancer and COPD: opportunities for epigenetic
therapy.
Thank you very much.
Please email me: y****[email protected] |
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b********n 发帖数: 22 | 19 Postdoctoral Fellowship – Restriction Enzyme Division – Job Code 1042HZ
The Restriction Enzyme Division invites applications for the position of
postdoctoral fellow. Projects will be part of a basic research program
focusing on restriction enzymes specific to 5-hydroxymethylcytosine. The
project will involve cloning, overexpression, purification, assay-
development, and engineering of such enzymes, and their application to
questions of epigenetics. Research will be undertaken in a highly
coll... 阅读全帖 |
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i*******D 发帖数: 993 | 20 【 以下文字转载自 Faculty 讨论区 】
发信人: invalidID (因为你的ID), 信区: Faculty
标 题: 大家都用什么画图软件啊?
发信站: BBS 未名空间站 (Thu Oct 20 22:13:12 2011, 美东)
感觉很多老美的ppt或者poster里面的示意图,3d效果图等等颜色非常鲜艳,质感又好
。尤其是生物,物理方面的学科。比如这个widi上的。
http://en.wikipedia.org/wiki/Epigenetics
那些花真的不知道他们是用神马画出来的。似乎中国人的poster之类的就做得不是很漂
亮。我平时也就用一些简单的画图软件,不知道是否有什么简单快捷的工具软件可以用
。 |
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n********k 发帖数: 2818 | 21 决定归来:同济。关于本人可以biologybioard考古或问问。。。自我评价:对科研要
求比较高,
执着,科研思路开阔,视野宽广,大局好,有点小野心,小理想化,想实实在在做点东
西,对人严而不MEAN,正直不自私,热心,very open/fair-minded and mentoring...
不报太多希望,我想合适的人选的大多会选择暂时留在美国,但是如果有对科研仍存幻
想,对中国还没有完全放弃,想回国发展的,那么也许就是我要找的寻找的“合作者”
,背景训练不是最重要因素,关键是对科研和人生的态度和取向,当然科研习惯也很重
要。看了这些梦语版的话,如果有一点共鸣,那么请来汗,也许我们可以一起做点什么。
Key words:(Neural) stem cell biology, adult neurogenesis,cancer,
epigenetics/Transcriptional regulation, splicing, non-coding RNA (long and
short), bioinformatics/systems biology, mouse genetic... 阅读全帖 |
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s****g 发帖数: 9 | 22 Multiple postdoctoral fellow/visiting scholar positions are available in the
Biodesign Institute at Arizona State University in the group of
Computational Genomics and Evolutionary Medicine (CGEM).
We are:
A young dynamic group studies the nascent and fancy field of genomics and
evolutionary medicine. The research of CGEM group focuses on three areas: (
1) Integrative Network Biology. We integrate multi-scale (phenotypic,
genetic and epigenetic) data from large cohort studies to reconstruct th... 阅读全帖 |
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s**u 发帖数: 9035 | 23 发信人: shmu (shmu), 信区: Returnee
标 题: 复旦大学上海医学院生物医学研究院招聘,待遇惊人
发信站: BBS 未名空间站 (Sat Jun 2 10:00:30 2012, 美东)
注意待遇,PI 8000/月,
junior faculty 5000/月
就是那样低,连上海户口不给,
正式职工也不是,因为复旦大学有的是人
有个学院每年80-90人申报副教授,只有6-7 名额,而且2008年以后的新职工是合同制
,没有户口,没有正式职工待遇。
2008年以后的新职工,讲师6年无法升副教授就要开除。决大多数人根本无法达标,
因为每年80-90人申报副教授,只有6-7 名额.
年轻人最讨厌海龟
一个学院一年6-7个副教授的名额,常常有2-3个名额被引进人才拿走。
海龟真惹人恨。
所以海龟要求越来越高,待遇越来月底。
The Institutes of Biomedical Sciences (IBS) of Shanghai Medical School,
Fudan University, is a scientific platform establis... 阅读全帖 |
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h****t 发帖数: 65 | 24 We are inviting applications for a postdoctoral position in Dr. Jiang’s
laboratory at University of Wisconsin-Madison School of Pharmacy Drug
Discovery Division. Our research focuses on the discovery of new chemical
probes for elucidating the roles of protein glycosylation in transcriptional
regulation. The successful candidate will join a highly motivated team of
researchers with access to multidisciplinary collaborations. Further
information can be found at the page: http://pharmacy.wisc.edu/j... 阅读全帖 |
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f**********g 发帖数: 48 | 25 申请绿卡用,目前只有几篇。
方向:Cell Biology, Stem Cells, Regenerative Medicine, Epigenetics,
Pancreatic/hematopoietic/neural development/differentiation。
可以提供本人CV和详细信息。
万分感谢! |
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w*****7 发帖数: 9 | 26 Dalian Medical University is seeking 2-3 innovative scientists to join the
faculty at the level of Assistant or Associate Professor at Institute of
Cancer Stem Cells (ICSC).
Dalian Medical University is located at the beautiful city of Dalian, China.
It has 1.5 Million square meters, over 20 thousands students, 14 affiliated
hospitals, and over 60 medical teaching bases. Recently, Dalian Medical
University is expanding rapidly by recruiting talented scientists all over
the world. More than 14 ... 阅读全帖 |
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y****z 发帖数: 92 | 27 A Chemical Biology postdoctoral position is available in the Cen lab in the
Department of Pharmaceutical Sciences at Albany College of Pharmacy and
Health Sciences-Vermont Campus. Our research program focuses on the design
and synthesis of molecular probes and therapeutic agents targeting
epigenetic modifying enzymes. The ultimate goal is to translate these
findings into novel treatments for cancers and age-related diseases.
The ideal candidate should have a Ph.D. in Organic Chemistry, Chemical
... 阅读全帖 |
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J********7 发帖数: 43 | 28 Genomics, epigenetics, bioinformatics,miRNA
[email protected]
/* */
谢谢 |
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b*y 发帖数: 94 | 29 有4-5篇10几分的一作二作,帮老板审过PNAS,STEM CELLS,Differentiation
可以提供CV,站内联系,谢谢。 |
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m*****1 发帖数: 5879 | 31 审稿,方向:
植物领域:
PLANT miRNA, DNA methylation,DNA Demethylaytion,epigenetics, RNA related
work, molecular biology, CRISPR/cas9.
可以提供CV, 站内或 Email [email protected]
/* */
谢谢 |
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y****z 发帖数: 92 | 32 A Chemical Biology postdoctoral fellow position is available in Dr. Yana Cen
’s lab in the Department of Medicinal Chemistry at Virginia Commonwealth
University (VCU)-MCV Campus. Our research aims to understand the roles of
mammalian enzymes play in physiological and pathological processes and to
use this knowledge to identify novel therapeutic targets for the treatment
of human diseases. In particular, we are interested in a class of epigenetic
modification enzymes called sirtuins, which are in... 阅读全帖 |
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d********a 发帖数: 1852 | 33 【 以下文字转载自 Biology 讨论区 】
发信人: p53 (吃饱了撑得要长肉), 信区: Biology
标 题: 近期上海面试简略情况供参考
发信站: BBS 未名空间站 (Tue May 24 22:44:35 2011, 美东)
投了5个院所,几个印象供参考:
1. 在国内的一些院所,CNS已经不是golden tickets, 而是注重研究方向。个人印象,
目前国内生物/医药研究的重点方向
是干细胞/epigenetics,重大疾病相关,生物制药相关。大多数院所在建转化医学研
究院/研究项目。
2. 所面试的几个地方都很专业。Offer一般是当场拍板。
3. 具体待遇各处不同,大约是15-30万。房补在40-100万之间。上海房价比较可怕。
4. 和各处新进PI交谈感觉国内研究经费比较充足。 |
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v**r 发帖数: 20 | 34 Send CV to d********[email protected]. 代转.
Position Title: Informatics Specialist
Division: Novartis Institutes for BioMedical Research (NIBR)
Business Unit: CFO
Country: China
Work Location: Shanghai
Company/Legal Entity: China Novartis Institutes for BioMedical Research Co.,
Ltd
Functional Area Information Technology
Job Type: Full Time
Employment Type: Permanent
Job Description: Novartis Institute for Biomedical Research (NIBR) is a
world leader in pharmaceutical research with a widely recognized c... 阅读全帖 |
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p*******g 发帖数: 2976 | 35 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
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w*****7 发帖数: 9 | 36 Dalian Medical University is seeking 2-3 innovative scientists to join the
faculty at the level of Assistant or Associate Professor at Institute of
Cancer Stem Cells (ICSC).
Dalian Medical University is located at the beautiful city of Dalian, China.
It has 1.5 Million square meters, over 20 thousands students, 14 affiliated
hospitals, and over 60 medical teaching bases. Recently, Dalian Medical
University is expanding rapidly by recruiting talented scientists all over
the world. More than 14 ... 阅读全帖 |
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h*******8 发帖数: 11 | 37 做植物或者微生物的可以看一下这个广告。华中农大生科院的实力是很强的,有作物遗
传改良国家重点实验室和农业微生物国家重点实验室。
http://my.aspb.org/networking/apply_now.aspx?view=2&id=214571
Multiple Faculty Positions in Plant Biology and Microbial Biology
Description & Details
The College of Life Science and Technology, HuazhongAgricultural University
http://lst.hzau.edu.cn/ ), invites applications for multiple faculty positions in Plant Biologyor Microbial Biology at the Full or Associate Professor levels. Candidates pursuing innovative research in areas ... 阅读全帖 |
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E*********r 发帖数: 4984 | 39 简单看了一下那个公司,湾区这边类似的公司很多,都号称可以诊断癌症。在公司的介
绍中,注意一句句子...often expands treatment options by matching each
patient with targeted therapies that are relevant to the molecular changes
in their tumor. 尤其特别注意Molecular这个词。肿瘤的形成原因很多,至今还无法
搞清,DNA上的变化当然是比较基本的,包括突变、重组、增加或减少某个片段等。这
些可以通过测序发现,但是这些变化并不一定会形成肿瘤,同样的变化,有些人得了肿
瘤,有些人没有,这当中包括一些抑癌基因的表达增强,或者免疫系统杀死肿瘤细胞等
等。还有不少肿瘤是属于Epigenetics范畴,譬如甲基化和乙酰化等,还有在蛋白水平
的变化,和病毒引起的肿瘤等等,总之,测序仅仅提供了基因的序列,至于这些基因如
何表达,基因和基因之间的相关性和调控而引发肿瘤,测序是无法提供信息的。目前测
序还是停留在学术领域,进入临床有一些,还未普及,停留在初期阶段,应该... 阅读全帖 |
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E*********r 发帖数: 4984 | 40 测序绝大多数是预测,所以给出的大部分是Probability。 我们都知道疾病的发展除了
在DNA和RNA层面的,更多的是Protein以及Post-translational Modification。 当然
Epigenetics也是有相当的份量。 测序解决的是突变问题,而在蛋白层面一点用都没有
。 所谓的高发病人,或者有基因缺陷的病人,最终得病的情况很难找到一个理想的
Cohort来进行分析,因为之前或许已经接受Medical Intervention了。 人体是个神奇
的东西,如果有些基因有缺陷,其它的会进行弥补,所谓的Gene Redundancy。这个你
测序根本无法看出来。 你举的这些例子我听过很多,我有不少朋友在Illumina,PACB,
Ariosa Dx,Counsyl,23andme, Natera,Verinata等工作,我们经常谈论这些话题。测序
的东西用来唬唬局外人一定会显得很神奇,但是实际上我觉得目前而言用处不大。
Tethys当年在搞糖尿病的概率分析,去年倒闭了。 Davis好几年前那家号称一次测序把
所有可能患的疾病都找出来,公司名字我忘记了,但是三... 阅读全帖 |
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t*m 发帖数: 4414 | 41 站内联系。
Job Title: Research Tech – Lead, Molecular Sequencing
Job ID:
Location: LMA, Boston, MA
Full/Part Time: Full-Time
Regular/Temporary: Regular
Job Summary
The Belfer Institute for Applied Cancer Science at Dana-Farber Cancer
Institute is dedicated to the discovery of cancer genes essential for tumor
maintenance, and translating basic discoveries into new effective therapies
for cancer. This highly integrated goal-oriented organization represents a
new academic construct that provides an un... 阅读全帖 |
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n*******u 发帖数: 3 | 42 谢谢,
Please contact me at e******[email protected] for more detail. Thanks. |
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c***c 发帖数: 113 | 43 准备申请绿卡,单位不支持博后办EB1B,准备办EB1A。想多攒点审稿经历。请好心人帮
忙推荐一些相关的审稿机会。
Research Areas:
currently focus on osteoarthritis and chondrocyte biology, including the
role of NFAT1, RunX2 and BSP joint disorders and chondrocyte function,
epigenetic regulation of gene expression.
Previously studies include genetic dissection of rheumatoid diseases in MRL/
lpr mice and T cell differentiation.
I graduated from medical college in China so I can review clinically related
manuscripts.
I've reviewed some manuscripts for me... 阅读全帖 |
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w*******i 发帖数: 477 | 44 同求 Cancer biology, epigenetics, molecular biology, long non-coding RNA,
chimeric RNA |
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a******l 发帖数: 37 | 46 同求! [email protected]
/* */ |
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w*******i 发帖数: 477 | 48 妻子10月底J2五年到期过期,现在在工作, 因为俩小孩在上Daycare, 我是生物博后,
为了能养家户口,需要尽快得到I-140 申请EAD,真诚求审稿机会。 现在审稿只有个位
数,希望各位帮忙尽快攒到20+审稿!再次先谢过了。
本人: 主要从事 RNA splicing and fusion genes in Prostate cancer research,
同时做 Histone modification, Epigenetics 方面, RNA seq, Bioinformatics.
癌症生物学,分子生物学,细胞生物学,生物化学,免疫学等方面的都熟悉。
我的EMAIL: [email protected]
/* */
or [email protected]
/* */
万分感激!
Fujun |
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