m********8 发帖数: 314 | 1 RNAi治疗现在发展到什么程度了?难道体内药物递送不再是问题了吗?看这篇文献,这
个药物载体的构建都不在正文里提了。 Supplementary Methods里面的图1(S-Figure
1 Schematic diagrams illustrating the preparation of (DSS)6-liposome-siRNA
and the evaluation in vitro)显示SiRNA和带骨靶向多肽的脂质体混一下就能得到有
效装载SiRNA的靶向性药物了。这个是成熟可靠的方法的话,那么RNAi治疗前景应该非
常好?
A delivery system targeting bone formation surfaces to facilitate RNAi-based
anabolic therapy. Nature Medicine 18, 307–314 (2012) doi:10.1038/nm.2617
http://www.nature.com/nm/journal/v18/n2/extref/nm.2617-S1.pdf |
N****n 发帖数: 294 | 2 看着Alnylam的股票猛长,你会觉得那根本不是个问题。 |
w***a 发帖数: 4361 | 3 看着整个biotech sector 2013年的表现,你会觉得生物wsn的春天已经来了。
【在 N****n 的大作中提到】 : 看着Alnylam的股票猛长,你会觉得那根本不是个问题。
|
A******y 发帖数: 2041 | 4 Biotech is just fine. The problem is the supply side. We have too many Ph.
D.s and most of them are useless. I blame the system that most of them are
poorly trained, and a lot of American Ph.D.s are exceptional..exceptionally
lazy.
Btw, Biotech is the only industry still currently enjoy above 25% margin of
return some of them are even above 50%.
【在 w***a 的大作中提到】 : 看着整个biotech sector 2013年的表现,你会觉得生物wsn的春天已经来了。
|
b****r 发帖数: 17995 | 5 印象中大部分biotech公司三年内都完蛋了?
Ph.
are
exceptionally
of
【在 A******y 的大作中提到】 : Biotech is just fine. The problem is the supply side. We have too many Ph. : D.s and most of them are useless. I blame the system that most of them are : poorly trained, and a lot of American Ph.D.s are exceptional..exceptionally : lazy. : Btw, Biotech is the only industry still currently enjoy above 25% margin of : return some of them are even above 50%.
|
g*****n 发帖数: 250 | 6 基因治疗的垮台早已表明RNAi没有前景,但是人们仍然要忽悠。
干细胞治疗还可以苟延残喘几年。
至于Biotech industry,某些方向会消声灭迹,但是,总体上还是会很强。忽悠的东西
总会不断出现。 |
z*t 发帖数: 863 | 7 记得对肝脏效果比较好,ambion的创始人在Austin开了公司,去年的cprit有show mir-
34对肝癌的效果
Figure
based
【在 m********8 的大作中提到】 : RNAi治疗现在发展到什么程度了?难道体内药物递送不再是问题了吗?看这篇文献,这 : 个药物载体的构建都不在正文里提了。 Supplementary Methods里面的图1(S-Figure : 1 Schematic diagrams illustrating the preparation of (DSS)6-liposome-siRNA : and the evaluation in vitro)显示SiRNA和带骨靶向多肽的脂质体混一下就能得到有 : 效装载SiRNA的靶向性药物了。这个是成熟可靠的方法的话,那么RNAi治疗前景应该非 : 常好? : A delivery system targeting bone formation surfaces to facilitate RNAi-based : anabolic therapy. Nature Medicine 18, 307–314 (2012) doi:10.1038/nm.2617 : http://www.nature.com/nm/journal/v18/n2/extref/nm.2617-S1.pdf
|
A******y 发帖数: 2041 | 8 I know many companies growing just fine. The richest scientist in the US
has found over 20+ companies and they are all still exist or brought by big
pharmas.
【在 b****r 的大作中提到】 : 印象中大部分biotech公司三年内都完蛋了? : : Ph. : are : exceptionally : of
|
b****r 发帖数: 17995 | 9 谁是The richest scientist?
big
【在 A******y 的大作中提到】 : I know many companies growing just fine. The richest scientist in the US : has found over 20+ companies and they are all still exist or brought by big : pharmas.
|