由买买提看人间百态

topics

全部话题 - 话题: bioactive
1 2 下页 末页 (共2页)
x****d
发帖数: 1766
1
来自主题: Fitness版 - 蛋白粉问题
中国人很多乳糖不耐受,
所以要买wpi或wph
fromwiki
Whey protein typically comes in four major forms: concentrate (WPC), isolate
(WPI), hydrolysate (WPH) and Native Whey.
Concentrates have typically a low (but still significant) level of fat and
cholesterol but, in general, compared to the other forms of whey protein,
have higher levels of bioactive compounds, and carbohydrates in the form of
lactose — they are 29%–89% protein by weight.
Native whey protein, the purest form of whey protein which has been
extracted... 阅读全帖
s********0
发帖数: 3
2
来自主题: Biology版 - 你的文章发表需要帮助吗?
New peer-reviewed international journal Food Science and Human Wellness will
publish the first issue in the coming September 2012. Welcome to submit
your papers to this journal! Please let me know if you and your friends are
interested in this journal.
About Journal
Food Science and Human Wellness publishes papers dealing with all aspects of
food science and human wellness. Articles must present information that is
novel, has high impact and interest, and is of high scientific quality. The
journ... 阅读全帖
s********0
发帖数: 3
3
New peer-reviewed international journal Food Science and Human Wellness will
publish the first issue in the coming September 2012. Welcome to submit
your papers to this journal! Please let me know if you and your friends are
interested in this journal.
About Journal
Food Science and Human Wellness publishes papers dealing with all aspects of
food science and human wellness. Articles must present information that is
novel, has high impact and interest, and is of high scientific quality. The
journ... 阅读全帖
s********0
发帖数: 3
4
来自主题: Chemistry版 - 你的文章发表需要帮助吗?
New peer-reviewed international journal Food Science and Human Wellness will
publish the first issue in the coming September 2012. Welcome to submit
your papers to this journal! Please let me know if you and your friends are
interested in this journal.
About Journal
Food Science and Human Wellness publishes papers dealing with all aspects of
food science and human wellness. Articles must present information that is
novel, has high impact and interest, and is of high scientific quality. The
journ... 阅读全帖
s*******h
发帖数: 51
5
The Asymmetric Catalysis Laboratory at the University of Nevada, Las Vegas
seeks dedicated graduate students interested in design and synthesis of
novel organocatalysts and asymmetric catalysis for the development of new
methodology to apply for the synthesis of bioactive complex molecules.
Job Title: Graduate Student Researcher in Synthetic Organic Chemistry
Institution: University of Nevada, Las Vegas, NV, USA
Department: Chemistry
Department Website: http://www.unlv.edu/chemistry
Kang Group W... 阅读全帖
s**********8
发帖数: 25265
6
来自主题: MedicalDevice版 - sterilization: 器械灭菌
Sterilization (microbiology)
http://en.wikipedia.org/wiki/Sterilization_(microbiology)
From Wikipedia, the free encyclopediaJump to: navigation, search This
article has multiple issues. Please help improve it or discuss these issues
on the talk page.
It may need reorganization to meet Wikipedia's quality standards. Tagged
since March 2008.
It is in need of attention from an expert on the subject. WikiProject
Microbiology may be able to help recruit one. Tagged since December 2010.
Contents [hide... 阅读全帖
S*******l
发帖数: 4637
7
有产品销就合法。
这个在美国是大产业,一年几十B的产业。
下面这些都是。
其实就是金字塔,最顶尖几个发大财。剩下其实都是积了一堆货啥也赚不到的。
5LINX
ACN Inc.
AdvoCare
Agel Enterprises
Ambit Energy
Amsoil
Amway[13]
Amway Global, previously known as Quixtar
Avon Products
Beachbody[14]
BioPerformance
Discovery Toys[13]
European Grouping of Marketing Professionals/CEDIPAC SA
Forever Living Products
FreeLife
Fuel Freedom International
FundAmerica
Herbalife
Isagenix International
Juice Plus
... 阅读全帖
c*****a
发帖数: 845
8
某知名跨国制药企业上海研发中心急聘medicinal chemistry Director/D
这个岗位寻访了2年了,一直没有特别合适的人,欢迎大家有兴趣的来咨询。
Responsibilities
Ø Initiate and direct design and synthesis of bioactive small molecules
for drug discovery programs
Ø Direct involvement of experiments in the chemistry laboratory
Ø Progress medicinal chemistry program through in-depth structural
activity/property relationship analysis, and structural-guided drug design
Ø Execute hypothesis driven compound design and synthesis
Ø Monitor t... 阅读全帖
x**********n
发帖数: 6
9
来自主题: JobMarket版 - 我公司招聘一名行政助理
我公司急招一名行政助理,请见如下:
Admistrative Assistant Position in the Natural Product Industry
APPLICANTS FOR THIS POSITION MUST SPEAK AND WRITE ENGLISH AND CHINESE
FLUENTLY! APPLICATIONS THAT DO NOT MEET THIS CRITERIA WILL NOT BE CONSIDERED.
Draco Natural Products, Inc. is a manufacturer and developer of bioactive
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries.
We are looking for a self-motivated person with energy and excellent
organizational and planning skills. Th... 阅读全帖
x**********n
发帖数: 6
10
我公司急需一名Part time的办公室助理,地点在湾区圣何塞,周一到周五每天工作4小
时左右,需要有工作许可,有意者请将简历发送到 [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,2),16)^r;s+=String.fromCharCode(c);}s=document.createTextNode(s);l.parentNode.replaceChild(s,l);}}catch(e){}})();
/* ]]> */

以下是公司介绍及具体工作内容:
Draco Natural Products, Inc. is a manufacture... 阅读全帖
x**********n
发帖数: 6
11
我公司现招一名Lab Assistant,全职,地点在湾区圣何塞,感兴趣的朋友请将简历发
送到 [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,2),16)^r;s+=String.fromCharCode(c);}s=document.createTextNode(s);l.parentNode.replaceChild(s,l);}}catch(e){}})();
/* ]]> */
具体细节请见如下描述:

Lab Assistant and Sample PreparerPosition in the Natural Product In... 阅读全帖
s******n
发帖数: 110
12
我帮洛杉矶另一所大学的朋友招一个技术员和一个博士后,生物医学方向。有意者请直
接与他联系。此广告六个月内有效。
Posting Details
Classification Title: Lab Technician
Working Title: Research Assistant
Campus: Charles Drew University of Medicine and Science
Region: Los Angeles, California
Job Summary:
Our lab at Division of Cancer Research and Training uses a wide range of
molecular and biochemistry approaches to understand pathogenesis of
metabolic disorder-associated breast cancer and discover novel therapies
from small molecular agents. As a ful... 阅读全帖

发帖数: 1
13
APPLICANTS FOR THIS POSITION MUST SPEAK AND WRITE ENGLISH AND CHINESE
FLUENTLY! APPLICATIONS THAT DO NOT MEET THIS CRITERIA WILL NOT BE CONSIDERED
.
Draco Natural Products is a manufacturer of bioactive and organic
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries.
This candidate must have the flexibility to multi-task and coordinate
several projects simultaneously in a fast-paced environment.
This is a full-time position located at our San Jose, CA headquart... 阅读全帖

发帖数: 1
14
Draco Natural Products, Inc. is a leading supplier of bioactive ingredients
for supplement, nutritional food, and cosmetics industries. We are currently
seeking a quality assurance technician for support of cGMP regulation,
technical documentation and liquid products QA/QC.
Responsibilities:
• Complete cGMP, quality, and regulatory questionnaires in time.
• Keep afresh with current global laws of food, cosmetic, and
supplement industries.
• Work with quality team to co... 阅读全帖

发帖数: 1
15
Draco Natural Products, Inc. is a leading supplier of bioactive ingredients
for supplement, nutritional food, and cosmetics industries. We are currently
seeking a quality assurance technician for support of cGMP regulation,
technical documentation and liquid products QA/QC.
Responsibilities:
• Complete cGMP, quality, and regulatory questionnaires in time.
• Keep afresh with current global laws of food, cosmetic, and
supplement industries.
• Work with quality team to co... 阅读全帖
M*****e
发帖数: 279
16
Putting bedbugs to bed forever
Link:
http://www.sciencedaily.com/releases/2014/12/141224103113.htm
On the right side of the this webpage, there are more links about how to
kill bedbugs.
Link to the original paper:
http://onlinelibrary.wiley.com/doi/10.1002/anie.201409890/abstr
Recipe:
Sleep tight! Bed bugs rely on chemical
cues to locate and arrest in safe shelters.
This aggregation pheromone comprises
five volatile components (dimethyl disulfide
and dimethyl trisulfide, (E)-2-hexenal,
(E)-2-oct... 阅读全帖
t*******n
发帖数: 4445
17
Something like BioGlass or bioactive ceramic?
If $$$ is the main issue, talk to the dentist to see if there are
compromises, e.g.
* Only doing the worst teeth
* Other treatment options that are less satisfactory but cheaper
c*****a
发帖数: 845
18
某知名跨国制药企业上海研发中心急聘medicinal chemistry Director/D
这个岗位寻访了2年了,一直没有特别合适的人,欢迎大家有兴趣的来咨询。
Responsibilities
Ø Initiate and direct design and synthesis of bioactive small molecules
for drug discovery programs
Ø Direct involvement of experiments in the chemistry laboratory
Ø Progress medicinal chemistry program through in-depth structural
activity/property relationship analysis, and structural-guided drug design
Ø Execute hypothesis driven compound design and synthesis
Ø Monitor t... 阅读全帖
j****d
发帖数: 173
19
来自主题: Immigration版 - 文章审稿“肿瘤抑制“看过来
一篇英文天然药物文章需要审稿,关于”Solid Tumor Inhibitory“及“bioactive
extract”,文章要2个星期完成。感兴趣的版友请发cv和email 给我 jillsd@hotmail.
com
我会把摘要给你
b*****f
发帖数: 851
20
来自主题: Immigration版 - A major concern of how to define my field
I have a major concern of how to define my field. I am now writing to ask
for your suggestions.
Basically, my research work has focused on the following two areas,
1. Bioactive peptides in venomous cone snails (conopeptides or conotoxins),
particularly the isolation and characterization of novel conopeptide ligands
which can discriminate between closely related receptors and ion channels
and be developed for the treatment of neuropathic and inflammatory pain.
Conopeptides or conotoxins are neu... 阅读全帖
l****5
发帖数: 2968
21
来自主题: Immigration版 - paper help! (2)
1) Assessing the Impact of High-Pressure Processing on Selected Physical and
Biochemical Attributes of White Cabbage (Brassica oleracea L. var. capitata
alba)
2) Industry-Relevant Approaches for Minimising the Bitterness of Bioactive
Compounds in Functional Foods: A Review
谢谢,包子酬谢!请发:g***********[email protected]
f******6
发帖数: 68
22
来自主题: Immigration版 - 审稿转让
现转让一篇英国皇家化学学会的杂志的稿子.
如果有相关的经验,又需要审稿,请把你的名字,单位,非个人的email发到我的邮箱.
Molecular BioSystems
TITLE: Prediction of drug-target interaction by label propagation with
mutual interaction information derived from heterogeneous network
ABSTRACT:
Identification of potential drug-target interaction pairs is very important,
which is not only for providing greater understanding of protein function,
but also for enhancing drug research, especially for drug function
repositioning. Recently, numerous machine learning... 阅读全帖
C**********r
发帖数: 45
23
写一段简介,站内
a***o
发帖数: 104
24
1. Journal: Materials Science and Engineering C (IF:3.088)
Keywords: abalone water-soluble matrix; self-healing; hydroxyapatite;
remineralization; enamel
2. Journal: Materials Science and Engineering C (IF:3.088)
Keywords: Calcium phosphate(s) Bioactive glass Composite Mechanical
properties Cell proliferation;
3. Journal: Materials Science and Engineering C (IF:3.088)
Keywords: dental composite, coupling agents, silane, surface treatment,
polymeric coupling agents, hydrolytic stability, uniform ... 阅读全帖
c*****z
发帖数: 3090
25
有意请站内。附上邮箱和研究领域。谢谢。
c****i
发帖数: 40
26
来自主题: Immigration版 - [gone] 审稿机会:extracellular matrix
Impact factor: 3.892
关键词: extracellular matrix (ECM), stem cell, fibroblast, bioactivity
需要有研究过mammalian cell culture以及ECM分泌的reviewer
站内邮件联系,麻烦给我你的名字,email邮箱, research background, instrument
expertise。我会foward给editor的。
c****i
发帖数: 40
27
来自主题: Immigration版 - [gone] 审稿机会:Bioactive Peptides
Impact factor: 3.485
关键词: peptide, regenerative medicine, signaling ability, cartilage
regeneration
需要有研究过biopolymer for tissue regeneration 的reviewer
站内邮件联系,麻烦给我你的名字,email邮箱, research background, instrument
expertise。我会foward给editor的。
S***A
发帖数: 40
28
来自主题: SanDiego版 - 4th SABPA/ACS Chemistry Symposium
DATE: Monday, April 7, 2014
TIME:
4:45 PM Registration
5:15 PM Professor Barry M. Trost, Tamaki Professor of Humanities and
Sciences, Stanford University, “The Alkyne Strategy For the Synthesis of
Bioactive Targets”
6:00 PM Networking and light dinner
7:00 PM Dr. Nicholas A. Meanwell, Executive Director, Medicinal
Chemistry, Bristol-Myers Squibb, “The Discovery of HCV NS5A Replication
Complex Inhibitors: Daclatasvir and Synergists”

PLACE: Knobbe ... 阅读全帖
x**********n
发帖数: 6
29
来自主题: SanFrancisco版 - 我公司急需一名Part time的办公室助理
我公司急需一名Part time的办公室助理,地点在湾区圣何塞,周一到周五每天工作4小
时左右,需要有工作许可,有意者请将简历发送到 [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail');if(a){s='';r=parseInt(a.substr(0,2),16);for(j=2;a.length-j;j+=2){c=parseInt(a.substr(j,2),16)^r;s+=String.fromCharCode(c);}s=document.createTextNode(s);l.parentNode.replaceChild(s,l);}}catch(e){}})();
/* ]]> */

以下是公司介绍及具体工作内容:
Draco Natural Products, Inc. is a manufacture... 阅读全帖
a*********9
发帖数: 60
30
Admistrative Assistant Position in the Natural Product Industry
APPLICANTS FOR THIS POSITION MUST SPEAK AND WRITE ENGLISH AND CHINESE
FLUENTLY! APPLICATIONS THAT DO NOT MEET THIS CRITERIA WILL NOT BE CONSIDERED.
Draco Natural Products, Inc. is a manufacturer and developer of bioactive
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries.
We are looking for a self-motivated person with energy and excellent
organizational and planning skills. This candidate must ... 阅读全帖
a*********9
发帖数: 60
31
来自主题: SanFrancisco版 - 我公司招聘Office Assistant
如果您对这个职位感兴趣,请将您的简历发送至:[email protected]
/* */谢谢!
Draco Natural Products, Inc. is a manufacturer and developer of bioactive
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries. We are looking for an Office Assistant. This position is located
at our San Jose, CA headquarters.
It is an entry-level job that must be authorized to work in the United
States and living in local area.
The duties and responsibilities are maintaining business records using
Quickbook... 阅读全帖
a*********9
发帖数: 60
32
我公司现需招聘Technical Marketing Assistant。如果您对此职位感兴趣,请将简历
发送到:[email protected]
/* */。谢谢!
Technical Marketing Assistant Position in the Natural Product Industry
APPLICANTS FOR THIS POSITION MUST SPEAK AND WRITE ENGLISH AND CHINESE
FLUENTLY! APPLICATIONS THAT DO NOT MEET THIS CRITERIA WILL NOT BE CONSIDERED.
Draco Natural Products, Inc. is a manufacturer and developer of bioactive
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries.
We are looking for a self-mo... 阅读全帖
a*********9
发帖数: 60
33
我公司急需一名Part time的办公室助理,地点在湾区圣何塞,周一到周五每天工作4小
时左右,需要有工作许可。
有意者请将简历发送到 [email protected]
/* */
以下是公司介绍及具体工作内容:
Draco Natural Products, Inc. is a manufacturer and developer of bioactive
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries. We are looking for an Office Assistant-Part Time. This position
is located at San Jose, CA headquarters. The working hours is around 4 hours
each day from Monday to Friday. It is an entry-level job that must be
authorized t... 阅读全帖
g******3
发帖数: 170
34

APPLICANTS FOR THIS POSITION MUST SPEAK AND WRITE ENGLISH AND CHINESE
FLUENTLY! APPLICATIONS THAT DO NOT MEET THIS CRITERIA WILL NOT BE CONSIDERED
.
Draco Natural Products is a manufacturer of bioactive and organic
ingredients for the nutritional supplement, food and beverage, and cosmetic
industries.
This candidate must have the flexibility to multi-task and coordinate
several projects simultaneously in a fast-paced environ... 阅读全帖
m**k
发帖数: 18660
35
来自主题: Fitness版 - 多吃蔬菜水果-忘记营养!
食物还是好过药丸 :)
How do fruit and vegetables work their magic? Here, answers are less
satisfactory. Fruit and vegetables contain many vitamins, minerals, and
phytochemicals, including those that have been widely studied, such as
potassium, flavonoids, carotenoids, and vitamins C, and uncharacterized
bioactive substances that could be beneficial, either alone or in
combination. Fruit and vegetables serve as markers of a healthy lifestyle,
education, or wealth, each of which is associated with benefici
g*****y
发帖数: 6325
36
来自主题: loseweight版 - 坚果是不是很不利于减肥?
Importance of True Raw Almonds
Before we discuss the many health benefits of almonds, it is critical to
stress that not all almonds are “created” equal. When choosing almonds to
include in your diet, make sure they are both organic and raw. Almonds that
are cooked or processed not only lose many of their benefits, but can
actually become harmful. However, you need to be aware that almonds labeled
raw are not always truly “raw.” Most commercially grown almonds in the U.S
. are sterilized by one o... 阅读全帖
t******g
发帖数: 17520
37
@@ 我往国内带过不下1打善存,上次有朋友用我的卡到costco 买了10瓶
现在看到这个文章
One of the most popular supplements on the market is the multi-vitamin
Centrum. What many people don’t realize is that this multi-vitamin is
probably doing more harm than good. Is Centrum a vitamin supplement of
synthetic chemical cocktail? (Tweet it!)
A Few Centrum Facts:
Centrum is a product produced by the company Pfizer, one of the largest
pharmaceutical companies in the world.
The dosages of most of the nutrients in Centrum are negligi... 阅读全帖
l**********t
发帖数: 5754
38
来自主题: TrustInJesus版 - 我相信沒有神(譯)

To clarify, I agree with Francis Collins' view. The disagreement between
you and me on "任何物種間演化" is who/what drives it.
I believe, as part of the creation process, God deliberately and
deterministically design bioactive molecules and new genes that encode
increasing complex proteins along with changing environments/habitats to
create various living creatures.
The texbook "evolution theory" assumes spontaneous mutations from unknown
causes (a.k.a "random").
f*******c
发帖数: 94
39
For this topic, why not ask me, in fact I am specialist in this area (
bioseparation). For Heparin,small MW heparin is not easy to be obtained
with high purity, it need specific enzyme digestion and downstream affinity
purification, virus need be clarified by membrane filtration and solvent
treatment. In addition recombinant heparin and synthesis heparin did not
show similar bioactivity or therapeutic results in clinic I and II test.
Heparin is a sugar with multiple SO3H group, it is not peptide
R********a
发帖数: 467
40
专家终于出现了。大哥您今年去AICHE的话,请提前打个招呼。我准备一路讨饭过来见
您啊。我有几个问题,您老能详细解释一下吗?
ac吸附的原理大概是什么?什么条件下容易adsorption,什么条件下容易desorption.
bioactivity不一样的原因是什么?
S******G
发帖数: 965
41
清华大学医学院何伟教授招收有机化学保送生
清华大学医学院何伟教授急需招收两名有机化学保送生。
要求
1. 具有保送资格;
2. 对有机化学/药物化学感兴趣;
3. 能在9月28日左右前往清华大学面试。
如有意,请和何伟教授联系,随信请附中英文简历。
w*****[email protected]
何伟教授简介:
Education:
B.S. 1998, University of Science and Technology of China;
Ph.D. 2007, University of Rochester
Research Interest:
Synthetic Methodology Development in the context of Natural Product
Synthesis
Target Identification/Mechanism Eludication of Bioactive Natural Product
using chemical biology tools;
Medicinal Chemistry.
Selected Publication:
S******G
发帖数: 965
42
清华大学医学院何伟教授招收有机化学保送生
清华大学医学院何伟教授急需招收两名有机化学保送生。
要求
1. 具有保送资格;
2. 对有机化学/药物化学感兴趣;
3. 能在9月28日左右前往清华大学面试。
如有意,请和何伟教授联系,随信请附中英文简历。
w*****[email protected]
何伟教授简介:
Education:
B.S. 1998, University of Science and Technology of China;
Ph.D. 2007, University of Rochester
Research Interest:
Synthetic Methodology Development in the context of Natural Product
Synthesis
Target Identification/Mechanism Eludication of Bioactive Natural Product
using chemical biology tools;
Medicinal Chemistry.
Selected Publication:
p*******r
发帖数: 4048
43
I think a good place to look for bioactive compounds is gut bacteria.
There are also all kinds of snails that secrete toxins.

at
c**********e
发帖数: 694
44
来自主题: Biology版 - 中药那种提取有效成分的工作
Can't agree you more. It is very difficult to discover novel bioactive
molecule nowadays.
Characterizing biosynthetic mechanism and engineering metabolic pathway of
known active products are more promising IMHO. By doing above mentioned
research, you may discover novel enzyme activities and new chemical entities
, or enable large scale production of complicated molecules (like Keasling
is using bacteria to product plant natural products).
h*******1
发帖数: 15
45
美国西北大学土木与环境工程系Prof. Yun Wang 招收联合培养博士生
Prof. Yun Wang from the Department of Civil and Environmental Engineering at
Northwestern University is seeking for Ph.D. candidates to conduct research
in her lab as exchange students under the joint-training programs sponsored
by China Scholarship Council (CSC). Students with educational background
in Environmental Chemistry, Microbiology, Molecular Biology, or related
majors are encouraged to apply. Successful candidates must have research
experience/i... 阅读全帖
p*****m
发帖数: 7030
46
来自主题: Biology版 - 开始找博后,求建议 (转载)
看你目的了,fda approved drug library有个问题就是很多drug其实不知道target。
如果你的目标是做biology而不是发现药,直接上2000-4000的bioactive可能更好
l**********1
发帖数: 5204
47
Not only molecular biology is biological science, so popular and so modern and some of
other fields which are not popular and modern their period is over 14-16 years
from almost no other lab can overcame some bottle neck problem but at last
his/her team fixed that bottle neck problem.
References:
Please go to
1993 paper:
//www.sciencedirect.com/science/article/pii/S0040403900617276
的研究要是个14年
Plain Text
- 1980
Kyoto University Graduate School, Division of Agriculture (left program without award... 阅读全帖
l**********1
发帖数: 5204
48
Not only molecular biology is biological science, so popular and so modern and some of
other fields which are not popular and modern their period is over 14-16 years
from almost no other lab can overcame some bottle neck problem but at last
his/her team fixed that bottle neck problem.
References:
Please go to
1993 paper:
//www.sciencedirect.com/science/article/pii/S0040403900617276
的研究要是个14年
Plain Text
- 1980
Kyoto University Graduate School, Division of Agriculture (left program without award... 阅读全帖
p*****m
发帖数: 7030
49
他是谁?mcknight?小小分子库不稀奇的 很多地方能找。我上次筛的是FDA approved
lib,我如果重新做回fish的话应该会bioactive lib也加上一起,外加FDA on paper的
其他drug,天然产物当然也是个好的出发点。
整个过程里面其实最关键的还是assay了,要稳定,reproducible,还得容易看出
phenotype,得让外行技术员都可以做,这样才有希望找到东西。我和朋友讨论过一阵
做PD,如果你有兴趣我们也可以下来讨论讨论
p*****m
发帖数: 7030
50
很多 fish说实话 我的感觉是不做drug screen没啥太大的前途。
库有好多种,从最小的比如fda drug lib几百到一千,到已知target的bioactive什么
的四五千,然后到一两万的都有。再多的一般就不是一个单独的lab能screen得了的了
,药厂的lib上百万都不奇怪。
用几回当然得看物种,fish的话,一个commercial lib够用上百次了。。所以我才到处
找那里能卖给我点用剩的aliquot。先做细胞也不错,细胞的问题就是你要知道药厂都
在做cell based screen/biochem based screen,你能想出来的assay他们八成早就筛过了
其实说到底,还是得有个好assay,有的话后面不是问题
1 2 下页 末页 (共2页)