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发帖数: 233 | 1 Here is some literature I found....
I'm interested in this gene
Thanks!
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded
by the OAS1 gene.[1][2]
This gene encodes a member of the 2-5A synthetase family, essential
proteins involved in the innate immune response to viral infection. The
encoded protein is induced by interferons and uses adenosine triphosphate
in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-
oligoadenylates (2-5As). These molecules activate latent RNase L, which
results in viral RNA degradation and the inhibition of viral replication.
The three known members of this gene family are located in a cluster on
chromosome 12. Mutations in this gene have been associated with host
susceptibility to viral infection. Alternatively spliced transcript
variants encoding different isoforms have been described.[3]
寡聚腺苷酸合成酶基因-1(OAS-1)
位点rs2660的单核苷酸多态性(SNP)与慢性乙型肝炎病毒(HBV)感染者自发性HBeAg血清
转换的关系 |
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