d*******s
发帖数: 15155 | 1 女狗阉了以后对健康好
spaying female dogs
• if done before 2.5 years of age, greatly reduces the risk of mammary
tumors, the most common
malignant tumors in female dogs
• nearly eliminates the risk of pyometra, which otherwise would affect
about 23% of intact female
dogs; pyometra kills about 1% of intact female dogs
• reduces the risk of perianal fistulas
• removes the very small risk (0.5%) from uterine, cervical, and
ovarian tumors |
|
p******r
发帖数: 6213 | 2 俺家刚adopt的beagle快4岁了，没spay。网上查了，说heat两次以上，不管是否spay,
都有26%的几率得breast tumor。所以我倾向于不spay了，如果有机会找纯种beagle
mate并条件许可干脆让她have birth，这样可以降低得breast tumor的几率，而且小
beagle找人家相当容易，一般都是排着队等interview并接受home visit的那种。但LD
坚持要spay，说可以根除尿道和...感染。话也不错，但这样俺家bailey得tumor的几率
就没法降低了。似乎狗妈们对spay/neuter的热情普遍高过狗爸啊。一声叹息。
奔一张bailey的lap照，大家祝福她吧。 |
|
d*******s
发帖数: 15155 | 3 the positive, spaying female dogs
• if done before 2.5 years of age, greatly reduces the risk of mammary
tumors, the most common
malignant tumors in female dogs
• nearly eliminates the risk of pyometra, which otherwise would affect
about 23% of intact female
dogs; pyometra kills about 1% of intact female dogs
• reduces the risk of perianal fistulas
• removes the very small risk (0.5%) from uterine, cervical, and
ovarian tumors |
|
r*****a
发帖数: 27155 | 4 Breeds that have been shown to be predisposed to hair follicle tumors are
Golden Retrievers, Basset Hounds, German Shepherds, Cocker Spaniels, Irish
Setters, English Springer Spaniels, Miniature Schnauzers and Standard
Poodles. The prognosis for these hair follicle tumors is generally positive,
as the majority of the tumors are found to be benign.
interested |
|
t***g
发帖数: 557 | 5 从天堂带回主耶稣的口信
新生 译
2000年12月30日，我电邮并帖了一个贴子，是关于一位患脑瘤的年轻人死而复活的事，
他的灵魂去了天堂，身体复活，带回主耶稣不久再来的信息。这信息源于圣经老师比莱
.布丽姆(Billye Brim)的电视见证，由我的一位朋友整理而成。
从那以后，我自己调查，找到了史蒂夫.莫里因(Steve Morin)----那位年轻人的表姐朗
达(Rhonda)的丈夫，史蒂夫与年轻人的家很近，他向我讲述了事情的全过程并纠正了先
前的几个细节。以下是更准确的事实。我现在的激动之情仍然不减当初。
朗达(Rhonda)的表弟，吉米(Jamie)，20岁时生了脑瘤，1999年的1月份，作脑部的外科
手术，但医生发现无法手术治愈，而吉米也未恢复知觉，他被宣告脑死亡，处在人工维
生系统之中。
医生询问他的父母是否捐献他的器官，并告诉他们别人的一些需要。一开始，他们拒绝
了，但随后答应祷告后再作决定。医生在等待期间，为了防止器官变坏，将吉米的尸体
冷冻，但心脏仍由维生系统维持跳动，只是每分钟只有2次。
约在一周或十天后，医生再次催促吉米的父母作出决定，这次他们同意了并前去捐献器
... 阅读全帖 |
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T**********e
发帖数: 29576 | 6
wiki:
In mid-2004, Jobs announced to his employees that he had been diagnosed with
a cancerous tumor in his pancreas.[105] The prognosis for pancreatic cancer
is usually very poor;[106] Jobs, however, stated that he had a rare, far
less aggressive type known as islet cell neuroendocrine tumor.[105] Jobs
resisted his doctors' recommendations for evidence-based medical
intervention for nine months,[5] instead consuming a special alternative
medicine diet to thwart the disease, before eventually u... 阅读全帖 |
|
n*********b
发帖数: 140 | 7 The statement that 大部分脑瘤的位置是十分接近SVZ so that 脑瘤来源于成体神经
干细胞 in that paper is not
convincing or at least inaccurate. An earlier experimental result from Evan
Synder's lab (PNAS) appears
to more interesting. They found when NSCs were purified and i.v. injected
through tail vein, they were
ultimately homing to the site of brain tumors. This suggested that either
the tumor cells or the site of
the tumors can provide an microenvironment for NSCs.
et
).
,
). |
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D*********t
发帖数: 370 | 8 Both are possible, depending on the tumor type and stage. For late stage
tumors, usually there are plenty of circulating tumor cells in the blood
that cannot be surgically removed or easily killed. Some of them eventually
find new homes (tissues) to grow, if not already have settled. |
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h****g
发帖数: 439 | 9 不同组织处理和固定方式的对FITC-Dextran的影响：
1，tumor tissue-OCT-section-acetone: fail
2, tumor tissue-OCT-section-PFA:fail
3, tumor tissue-PFA-sucrose-OCT-section: work!
看来FITC-dextran 和YFP一样，要用PFA固定，然后再OCT |
|
s******y
发帖数: 28562 | 10 YES YES YES!!!!!
I strongly suspect your drug inhibit the metastasis of the tumor, which is
actually the killing factor of cancer!
In such case, the tumor size would not be reduced (sometimes it can even be
bigger) but the new secondary tumors and secondary colonies in lung or bone
marrow will be significantly down.
You should contact people who is the cancer field to help you to do the
metastasis inhibition test. From the information you provided, I think you
guys already found a gold mine but |
|
p*****m
发帖数: 7030 | 11 我知道啊 所以我才说就看发奖的原则是啥了 要是发给tumor suppressor的作用 p53更
说得过去；可是要发给tumor suppressor的概念性突破 第一个说明有这么一种东西的
的人才重要 这样的话weinberg和李文华基本是同样重要的...
当然了 我之前觉得文华枪不过weinberg还有politics啦 文华混的太差 人缘也没法比
...而且weinberg在oncogene和tumor suppressor两方面都有贡献 |
|
h********n
发帖数: 4079 | 12 I am so glad to read your thought. I would like to discuss a little more.
to 1: the term of CSC is controversy, but what if I say: "In lung adenocarcinoma, there is a population of tumor cells whose potency (in vivo) is much higher than other population in the same tumor. It is important to study this population of cells. How about we call it tumor initiating cell?"
what is your opinion to my above thought?
to 4: I don't agree with you on this point. Most lung cancer model use SPC or CCSP or C... 阅读全帖 |
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w**********9
发帖数: 242 | 13 俺觉得这个polyclonal origin 很山寨. 难以置信. 等大牛或教科书改了后俺跟着就是
了.
As of heterogeneity, is this you made up or you got from somewhere ? Did
you ever read Volgestin's work about tumorigenesis in spontaneous colon
cancer ?
=======================================================
3. heterogeneity
As for the heterogeneity of primary tumor, my understanding is that tumor st
arted from one cell that got original mutation and started to divide. When c
ell expanded, some of the cells accumulated other mutations. Alth... 阅读全帖 |
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a*****g
发帖数: 543 | 14 Jumping to a deep water hole...
I would caution the widely "credited" potential of CSC(technically here refe
ring to the tumor-inititating cells identified in immune-deficient mice) ass
ociated with relapse, drug resistance and metastasis.
Can anyone point out an original research paper with some experimental data
showing these cells have any of the three major capabilities? My impression
is sadly none...But we read it everywhere...
Second, CSCs are defined vaguely. The standards mentioned by ht... 阅读全帖 |
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a*****g
发帖数: 543 | 15 Just my two cents:
1. 我不反对也不支持CSC的model.但是光从mutation的普遍性来说并不能否定CSC. 我
们现在还没法确定这些genetic heterogeneity是driver 还是passager.大多数只是ca
ncer的result而不是cause。Moreover, it is possible that CSC and Non-CSCs all
have genetic changes;remember the so-called CSCs don't have to follow the
biology of typical stem cells.
If cancer strictly follows evolution model, should one imagine certain gene
tic lesions gain dominance?
As for the genomic stability, why should we believe it is promoting tumor?
As far as I know,... 阅读全帖 |
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a*****y
发帖数: 269 | 16 【 以下文字转载自 SanDiego 讨论区 】
发信人: alvinpy (生命就是一场歪打正着), 信区: SanDiego
标 题: Post-Doc Positions at Pfizer
发信站: BBS 未名空间站 (Tue Nov 16 20:10:46 2010, 美东)
Please send in cover letter and CV to Nathan Lee: n**********[email protected]
Postdoctoral Positions in Pfizer Oncology, La Jolla CA
The post doctoral positions will be responsible for elucidating the
mechanism of action of existing Pfizer
portfolio compounds, ensuring that we have the appropriate patient selection
strategies for such
mechanisms, aligning ... 阅读全帖 |
|
b******n
发帖数: 82 | 17 http://www.cell.com/abstract/S0092-8674%2810%2901180-3
The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect,
and Proliferation in the PTEN Pathway
Min Fang, Zhirong Shen, Song Huang, Liping Zhao, She Chen, Tak W. Mak,
Xiaodong Wang
* Highlights
* The ER UDPase ENTPD5 is upregulated by AKT in PTEN mutant cells
* ENTPD5 hydrolyzes UDP to UMP to promote protein N-glycosylation
* ENTPD5, along with CMPK1 and AK-1, hydrolyze ATP to AMP, increasing
aerobic glycolys... 阅读全帖 |
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l**********n
发帖数: 240 | 18 Josef Martin Penninger
Most significant scientific contributions:
Our basic approach is to genetically manipulate and change genes in mice and
to
determine the effects of these mutations in development of the whole
organism and in
diseases. From these mutations we are trying to establish basic principles
of
development and basic mechanisms of disease pathogenesis. My laboratory
focuses on
heart diseases, autoimmune diseases and cancers, and bone diseases. On all
the listed
contributions below I ... 阅读全帖 |
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S*****s
发帖数: 242 | 19 You are fine unless you are severely immune deficient
科普一下：
The cancer cells you injected carry allogeneic antigens, and these antigens
could be recognized by immune cells and will be quickly rejected, just like
the rejection of kidney in the transplantation. The number is not an issue
because the rejection for allogeneic antigens is very strong, even entire
kidney, liver etc.
If you injected your own tumor cells, that will be different issue (but it
is obviously you were not doing that). These ... 阅读全帖 |
|
l***o
发帖数: 7937 | 20 Is Cancer transmissible? The answer may be 99.99% no, but exceptions are:
(1) identical twins. You body would likely not be able to identify the tumor
as "foreign" tissue.
(2) Some tumors have a viral background. There might be a tiny chance that
you could catch something.
(3) As already mentioned, there are tumors that can be transmitted in the
animal kingdom like an infectious disease. |
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s*********n
发帖数: 2283 | 21 Is it safe to say ...
1) If Cell phone radiation is beyond a certain/unknown threshold, it
will
hurt users or cause cancer in a long-term usage model.
2) Mostly the current cell phone radiation may not be strong enough to
reach that threshold.
If this is the case, I guess it is about defining the threshold.
BTW, is epidemiology the only area we should look at?
PS. The Newman Case. http://www.foxnews.com/story/0,2933,64790,00.html
In 2000, a Maryland neurologist named Christopher Newman filed an... 阅读全帖 |
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y****6
发帖数: 196 | 22 I read this paper a year ago. I do think this is something interesting. It
looks like some tumor cell transporting systems are specific to these
fluorescent dyes. PET imaging depends on tumor-specific characterirstics
such as higher metabolic rate (FDG probe), or tumor markers. This paper is
different in that the fluorescent dyes are supposed to be non-selective.
However no mechanism was studied in this paper. Can anyone think of any
mechanism?
这个不新鲜。也不一定要有和没有的区分，多和少的区分就可以了。肿瘤细胞和正常细
胞物质代谢有... 阅读全帖 |
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Z**********g
发帖数: 222 | 23 不太熟悉 T cell immunotherapy,想问几个问题:
1. 这个成功的案例关键在于CLL中存在CD19这个tumor associated antigen吧.而在其
他很多癌尤其是实体瘤中,tumor antigen/tumor associated antigen不甚明了吧.
2. 该治疗存在副作用,就是把正常的B cell也给灭了吧.
3. T cell immunotherapy治疗leukemia的优势是engineered T cells在血道中可以和
leukemic cells充分作用,但对于实体瘤来说,这种充分的正面交锋却有限.
4. 对于一个晚期癌症病人来说,靠T cell攻击癌细胞,想必疗效会很有限,因为太温和了
,远不及放化疗手术凶猛直接.
不知是否有理? |
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j*p
发帖数: 411 | 24 本人在wet lab里面做纯数据分析，for NGS data analysis, 简单介绍一些自己接触过
，并且觉得挺有用的工具，说的有点杂，权作抛砖引玉，还请不吝赐教。
Next-Gen sequencing(NGS)和现在正在发展的3rd-gen sequencing将会在生物学研究中
被越来越广泛应用。不管你信不信，反正我信了。一是基于实验成本的降低（$1k
whole-genome sequencing is coming），越来越多的实验室可以操作；二是可以提供
相对low throughput experiment多的多的数据和信息，可以看到很多从前看不到的东
西；三是sequencer本身对测序的准确性正在逐渐提高，所以实验固有错误率降低；四
是各种算法的成熟应用，这使得很多由于实验产生的误差在出数据后通过对数据的分析
得以过滤。按照library preparation来分，NGS主要有DNA-seq和RNA-seq
DNA-seq is usually used as ChIP-seq to study transcription factor(TF)-DNA
bi... 阅读全帖 |
|
j*p
发帖数: 411 | 25 本人在wet lab里面做纯数据分析，for NGS data analysis, 简单介绍一些自己接触过
，并且觉得挺有用的工具，说的有点杂，权作抛砖引玉，还请不吝赐教。
Next-Gen sequencing(NGS)和现在正在发展的3rd-gen sequencing将会在生物学研究中
被越来越广泛应用。不管你信不信，反正我信了。一是基于实验成本的降低（$1k
whole-genome sequencing is coming），越来越多的实验室可以操作；二是可以提供
相对low throughput experiment多的多的数据和信息，可以看到很多从前看不到的东
西；三是sequencer本身对测序的准确性正在逐渐提高，所以实验固有错误率降低；四
是各种算法的成熟应用，这使得很多由于实验产生的误差在出数据后通过对数据的分析
得以过滤。按照library preparation来分，NGS主要有DNA-seq和RNA-seq
DNA-seq is usually used as ChIP-seq to study transcription factor(TF)-DNA
bi... 阅读全帖 |
|
c******r
发帖数: 3778 | 26 这个marker其实不难搞，就是transfect一个HIF promoter drive的东西就可以了。
不过你要真做的话要小心几个问题：
1. hypoxia在实体肿瘤里面是永远存在的。即使你不喀嚓那些血管也一样有marker的表
达。因此你的background会比较高。
2. 即使喀嚓掉血管，如果不能有效抑制VEGF等signal，血管会很快又长出来的，而且
会越来越多，越喀嚓越多，导致你无法实现有意义的hypoxia。
3. 因此，喀嚓血管可能需要和VEGF inhibitor啥的联合使用。可以看情况再考虑这个
问题。
4. 你的control tumor也需要相似的剥离，但是不结扎血管。因为显然剥离的创伤有可
能破坏tumor的包膜而导致扩散，与hypoxia无关。
5. 你的种植的tumor一定要有很高的metastasis比例才行，否则后续试验无法进行。这
种cell line可以去找找，有人有这样的cell lines。
仅供参考 |
|
s****9
发帖数: 932 | 27 谢谢你的包子，看在包子的面子上，多说几句。
如果让提问题，可以提很多，
首先，做单抗的抗原是不是N Terminal，或者细胞外的部分。如果不是，抗体识别的
epitope很可能不是细胞外的部分。如果我做这个实验，首先就是把单抗结合上颜色（
eg. Alex488），用FACS染一下，看看能不能特异结合细胞外的抗原。
如果这个抗体识别的是细胞内的抗原。经典的免疫学认为，抗体不能够neutralize细胞
内的东西（当然，前年有篇PNAS说可以）。
如果可以识别胞外抗原，而且抗原是肿瘤特异的，那么很有意思。首先，应该看一下，
这个抗体对于抗原的结合能不能影响蛋白的功能。比如，overexpress 这个抗原之后，
加抗体，in vitro culture对肿瘤细胞的生长有没有影响。如果有，可以猜想它是一个
受体，抗体甚至有可能是个agonist。这样的话，这个project会变的很有意思。如果是
negative result，说明也推翻不了太多问题。
接下来，你当然可以直接打tumor（最好是overexpression的tumor把window放大）到
BALB/c上，然后打抗体看有... 阅读全帖 |
|
t**l
发帖数: 109 | 28 如果你真的想做Treg这个圈子，foxp3 reporter mouse必须有，许多做cancer的人也开
始做免疫，而且发了一些paper说tumor cell express foxp3 too. 如果你不能在foxp3
reporter mouse的环境下做你的tumor model,你是不是用bead或者FACS surface
staining分离出来你tumor sample里面的Treg, 然后再做Foxp3 Intracellular stain
测纯度。
关键是不清楚你下部要做什么。 |
|
n*********m
发帖数: 38 | 29 Immunology Retraction Exposes Misconduct
07/10/2013 Andrew S. Wiecek
Nature retracts a 1994 paper after the first author was found to have "most
likely" committed research misconduct. Learn more...
Last week, Nature retracted a highly-cited paper published in 1994 because
the authors were unable to reproduce the results, according to the
retraction notice (1). But the real reason behind the retraction might have
more to do with the first author’s scientific misconduct.
Nature has retracted a 19... 阅读全帖 |
|
n*********m
发帖数: 38 | 30 mmunology Retraction Exposes Misconduct
07/10/2013
Andrew S. Wiecek
Nature retracts a 1994 paper after the first author was found to have "most
likely" committed research misconduct. Learn more...
Last week, Nature retracted a highly-cited paper published in 1994 because
the authors were unable to reproduce the results, according to the
retraction notice (1). But the real reason behind the retraction might have
more to do with the first author’s scientific misconduct.
Nature has retracted a 199... 阅读全帖 |
|
m******g
发帖数: 467 | 31 自己吐槽一下，虽然对于看过文献的研究系统／漂亮的图什么的记得比较清楚
但是作者什么的老是不太记得
有时候看到有的人可以一堆一堆地数出来，感觉好厉害啊！
觉得这期science比较有趣，虽然没有那种看得超感动的文章，但是还是有不少很值得
一看的paper的。
Science 13.11.22
推荐：
1. Organization of the Mitotic Chromosome
用5C和Hi-C, 发现分裂中期结构是与位点无关的均质，并用polymer模拟
“A simple, robust model explains higher-order organization of mammalian
chromosomes.”
（最近这类文章真多，好像周周都有？感觉个人不是那么感兴趣了～～～）
2. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction
in the Mouse
testis determinant factor Sry
spermatogonial proliferatio... 阅读全帖 |
|
m******g
发帖数: 467 | 32 自己吐槽一下，虽然对于看过文献的研究系统／漂亮的图什么的记得比较清楚
但是作者什么的老是不太记得
有时候看到有的人可以一堆一堆地数出来，感觉好厉害啊！
觉得这期science比较有趣，虽然没有那种看得超感动的文章，但是还是有不少很值得
一看的paper的。
Science 13.11.22
推荐：
1. Organization of the Mitotic Chromosome
用5C和Hi-C, 发现分裂中期结构是与位点无关的均质，并用polymer模拟
“A simple, robust model explains higher-order organization of mammalian
chromosomes.”
（最近这类文章真多，好像周周都有？感觉个人不是那么感兴趣了～～～）
2. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction
in the Mouse
testis determinant factor Sry
spermatogonial proliferatio... 阅读全帖 |
|
n********t
发帖数: 1079 | 33 40个老鼠在哪呢？另外您还得把这个SD母鼠自发肿瘤发生率就是80%甚至更高的地洗了
。。。
http://www.ncbi.nlm.nih.gov/pubmed/11381627
Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats
throughout their lifespan starting at 5 weeks. Their mean survival times
were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and
87 to 95.8% in males and females, respectively. The common neoplasmas were
pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular
Leydig cell tumor in males and mamma... 阅读全帖 |
|
s****9
发帖数: 932 | 34 我也来说说check－piont blockade。
首先效果并没有楼上说的好。Ipilimumab（anti－CTLA－4） objective response
rate在10%左右（各个地方PhaseIIItrial的效果不一），最好的在MSKCC，也在15%左右
。真正有survival benefit的人群在10%不到，提高的average surivival只有3个月。
考虑到toxicity，这个药目前只在PhaseIII和VI的melanoma上用，就是因为那些病人存
活率不超过5%，等于死马当活马医来治疗。希望能有那么10%不到的人能够中奖且收益
。你说的50%的response，包括了CR，PR，和SD，意义不大。在其他的恶性度比较高的
肿瘤包括NSCLC（肺癌）和prostate cancer Ipilimumab效果不好。其实CTLA－4在老鼠
上效果就只对high immunogenic的肿瘤有效。
anti－PD－1看起来效果比Ipilimumab好，但也只能说稍好，副作用稍小，适用的肿瘤
更多（在NSCLC也有效，renal cell cancer tri... 阅读全帖 |
|
S*****s
发帖数: 242 | 35 最早发现Ctla-4的是James Allison？这是谁告诉你的？Pierre Goldstein！连ctla-4
对免疫的抑制功能都是Jeffery Bluestone发现的，这才是关键的发现。这个Jim
Allison是开发抗体的，这个credit要给他。不过这离Lasker也太远了吧？ James
Allison现在是拉上他在MD Anderson的情妇拼命的抢credit，故意误导舆论。这不就有
像你这样被误导成了义务宣传员的？ 建议好好阅读这篇新的Science Letter, 搞清楚
才发言。
https://www.sciencemag.org/content/344/6180/149.1.full
Science 11 April 2014:
Vol. 344 no. 6180 p. 149
DOI: 10.1126/science.344.6180.149-a
LETTERS
Immunotherapy: It Takes a Village
We in the cancer immunology and immunotherapy community are th... 阅读全帖 |
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j******i
发帖数: 939 | 36 我不是做这个的，只是对immunotherapy感兴趣。参考文献：
Rituximab resistance
Rituximab has become a ubiquitous component of treatment regimens for
follicular non-Hodgkin lymphoma. Despite widespread clinical use, the
mechanisms by which tumor cells resist rituximab-mediated destruction remain
unclear. Rituximab relies in part on immune effector mechanisms for its
antitumor effect, and thus resistance may be mediated not only by intrinsic
tumor-cell alterations but also by the host immunological environment. In
this a... 阅读全帖 |
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w***r
发帖数: 709 | 37 Ventura et al. (2007) and Xue et al. (2007) suggest that restoring p53
function alone is sufficient to cause regression of several different tumor
types in mice and thus might represent a potent therapeutic strategy to
treat certain human cancers.
Martins et al. (2006) also demonstrate that restoration of p53 activity
results in tumor regression but add the sobering caveat that tumors may be
able to quickly generate resistance by finding other ways to disrupt the p53
pathway.
比如加上inducible p53在必... 阅读全帖 |
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g***o
发帖数: 92 | 38 Our lab is part of the Brain Tumor Center at Duke University. We are seeking
a postdoctoral fellow immediately to work on a collaborative project
dedicated to understanding and treating brain tumors, employing genetically
engineered mouse models. Ideal candidates will be self-driven individual
with strong motivation, aspiring to undertake necessary tasks in order to
advance brain tumor treatment. Individuals with training in the fields of
cancer mouse models and neurobiology/developmental biolog... 阅读全帖 |
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v********a
发帖数: 646 | 39 点击fulltext，只有这么多内容：
http://cancerdiscovery.aacrjournals.org/content/5/7/OF20.abstra
Chimeric antigen receptors (CAR) link antigen-binding domains with T-cell
signaling domains and represent potential anticancer agents. However, only
CARs targeting CD19 in hematologic malignancies have demonstrated
significant clinical efficacy. To identify the mechanisms underlying the
poor efficacy of CARs targeting other tumor antigens, Long and colleagues
compared the in vivo antitumor activity of CD19 CAR T ... 阅读全帖 |
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l********n
发帖数: 260 | 40 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M,
Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC,
Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage
response and radioresistance through CHK1. Nat Cell Biol. In Press.
2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-
Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces
epithelial-mesenchymal transition but suppresses tumorigenesis, migration
a... 阅读全帖 |
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m**i
发帖数: 355 | 41 替朋友发的，请回信我站内。
Description:
The Engineering Immunity Lab in the Department of Microbiology, Immunology
and Molecular Genetics and the Broad Stem Cell Research Center at UCLA is
currently seeking highly skilled and motivated postdoctoral researchers in
tumor immunology and cancer immunotherapy. Our laboratory focuses on
dissecting the cellular and molecular mechanisms regulating tumor immunology
and utilizing the knowledge to engineer immune cells against cancer. Being
part of the UCLA/Caltech/USC... 阅读全帖 |
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l********9
发帖数: 28 | 42 With liquid biopsy, you can check many things, like circulating tumor DNA,
circulating tumor cells and lymphocytes, assuming you are also getting tumor
biopsies. |
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g******1
发帖数: 295 | 43 email resume to arthurbuffet At hotmail dot com if interested
https://boards.greenhouse.io/guardanthealth/jobs/525188#.WEjjvrIrLIU
About the Role
We are looking for a Research Associate team member who will partner with
the successful delivery of world-class in vitro diagnostic (IVD) quality
products for Guardant Health as we undergo an explosive growth phase. You
will work closely with the R&D teams to perform laboratory experiments
including sample preparation, nucleic acid extraction, PCR... 阅读全帖 |
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g******1
发帖数: 295 | 44 【 以下文字转载自 JobMarket 讨论区 】
发信人: gofor011 (gofor011), 信区: JobMarket
标 题: [内推］Clinical Laboratory Scientist
发信站: BBS 未名空间站 (Mon Dec 12 23:28:05 2016, 美东)
If interested, please email your resume to arthurbuffet At hotmail.com
ABOUT THE ROLE
The Clinical Laboratory Scientist is responsible for performing high
complexity laboratory testing (Next generation DNA sequencing) on patient
specimens, performing quality control and quality assurance procedures,
interpreting and reporting patient results, and... 阅读全帖 |
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发帖数: 1 | 45 澎湃新闻：《肿瘤生物学》被 SCI 除名，曾撤稿 107 篇中国医学论文
曾撤回 107 篇中国医学论文的《肿瘤生物学（Tumor Biology）》期刊，如今被科学引
文索引（Science Citation Index，SCI）除名。
7 月 18 日，Web of Science 引文数据库所有者科睿唯安 (Clarivate Analytics) 表
示，科睿唯安期刊评审专家团队经过仔细评估，最终决定：《肿瘤生物学》（Tumor
Biology）由于不再满足 Web of Science 期刊收录的一贯而严格的标准，该刊自 2017
年 7 月起不再被 Web of Science 数据库旗下的 SCI 收录。
科睿唯安旗下的权威引文数据库 Web of Science 包括三个旗舰引文索引 SCI、SSCI（
Social Sciences Citation Index）和 A &HCI（Arts & Humanities Citation Index
）。自 1973 年以来，科睿唯安每年会发布前一年引文索引数据库的引用数据。据悉，
新近出炉的引用数据涵盖 81 个国家、2... 阅读全帖 |
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T*****u
发帖数: 3257 | 46 FYI。
Cancer stem cells (CSCs) are cancer cells (found within tumors or
hematological cancers) that possess characteristics associated with normal
stem cells, specifically the ability to give rise to all cell types found
in a particular cancer sample. CSCs are therefore tumorigenic (tumor-
forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs
may generate tumors through the stem cell processes of self-renewal and
differentiation into multiple cell types. Such cells are propose |
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s*********n
发帖数: 2283 | 47 How do you think about it?
http://www.foxnews.com/story/0,2933,64790,00.html
In 2000, a Maryland neurologist named Christopher Newman filed an $800
million lawsuit against Motorola and Verizon. His claim was that using
his cellular phone caused the brain cancer that he had been diagnosed
with in 1998.
Newman used a cell phone for an estimated 343 hours from October 1992
until his March 1998 diagnosis of a brain tumor. That adds up to about
1.2 hours of talk-time per week. Newman said he held his... 阅读全帖 |
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w********h
发帖数: 12367 | 48 Polymer Gel Can Block Toxic Leakage Problem in Gene Therapy
Duke engineers identify technique to confine most cell-killing gene products
to targeted tumor
Friday, November 18, 2005
Durham, N.C. -- Duke University biomedical engineers have devised a
potentially patentable method to arrest toxic leakages of genetically
engineered viruses that have plagued attempts to use gene therapy against
cancerous tumors. The problem has been that viruses carrying anti-tumor
genes have tended to leak from tumo |
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A*G
发帖数: 256 | 49 （左上肺叶肿块，左下肺叶肿块) (Mass at left superior lung lobe, and left
lower lung lobe)
高分化腺癌，以细支气管肺泡癌为主，肿块大小分别为1.5*1.0*0.8cm和1.0*0.6*0.8cm
，局部累犯脏层胸膜。Well differentiated adenocarcinoma, mainly bronchioloalveolar (
BAC), tumor size:1.5*1.0*0.8cm & 1.0*0.6*0.8cm，locally invaded to visceral
pleural.
未见明确脉管内癌拴及神经侵犯。There is no tumor emboli and no perineural invasion.
（左上肺叶后段肿块）可见部分肺泡扩张，符合肺气肿改变。另见部分区肺泡上皮不典
型增生伴癌变，病灶大小φ 0.5cm。
(mass at left superior lobe posterior lung segment) There are some alveolar inflation, ... 阅读全帖 |
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h*******y
发帖数: 1220 | 50 A glucagonoma is a rare tumor of the alpha cells of the pancreas that
results in up to a 1000-fold overproduction of the hormone glucagon. Alpha
cell tumors are commonly associated with glucagonoma syndrome, though
similar symptoms are present in cases of pseudoglucagonoma syndrome in the
absence of a glucagon-secreting tumor.
he primary physiological effect of glucagonoma is an overproduction of the
peptide hormone glucagon, which enhances blood glucose levels through the
activation of anabolic... 阅读全帖 |
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