h*******o
发帖数: 4884 | 1 There are multiple ways. The most straight forward one is to directly
measure cell permeability, such as Caco2 permeability assay, with additional
in silico simulation. Also, you can use digitonin or saponin to
permeabilize cells, then measure inhibition. Or you can measure
intracellular concentration of your candidates, if there are validated
quantification methods. |
|
h*******o
发帖数: 4884 | 2 Caco2 measures both paracellular (tight junction) and transcellular (
membrane permeability) permeability. |
|
h******u
发帖数: 602 | 3 Want to use hybridization/FRET probes to detect mRNA in cells. Flow
cytometry will be used to detect signal. Will Saponine be a good
permeability agent for DNA probes?
Thanks~~~~~~~~~~~ |
|
B***v
发帖数: 113 | 4 我有一些合成的酶抑制剂，活性各不相同。
我乡检测这些不同是由于cell permeability不同导致的，还是inhibition potency导
致的。
如何设计试验？ |
|
g*****n
发帖数: 250 | 5 Caco2 permeability assay检测细胞层的通透性，而不是细胞膜的通透性。 |
|
B***v
发帖数: 113 | 6 对。我理解也是这样。假如一个化合物进入细胞非常快，但进去就出不来，Caco2给出
的结果会很低，但其实cell membrane permeability很高。
估计用质谱可以做。 |
|
d*******7
发帖数: 188 | 7 不知道发在这里合适不合适，但是还是希望有牛人来解答一下，我没有这方面的背景。
问题： 要测一种材料对液体的 permeability， 但是这种材料不是弹性的，而且很薄
，crosslink
之后比较脆，如何能够用试验方法测呢？ diffusion cell 好像对那些有弹性的薄膜有
用，但是我这
个一加紧会破坏材料本身.
还有一个问题是，这个材料本身是粘合剂 adhesion promoter, 很难把这层从基片上取
下来
有没有人做过类似材料的测试？望不吝赐教， 谢谢 |
|
t*******n
发帖数: 66 | 8 I am trying to look for a polymer that is resistant to HF and also has not
permeability for HF. Can anybody
give some advice?? Thanks a lot. |
|
d*******7
发帖数: 188 | 9 不知道发在这里合适不合适，但是还是希望有牛人来解答一下，我没有这方面的背景。
问题： 要测一种材料对液体的 permeability， 但是这种材料不是弹性的，而且很薄
，crosslink之后比较脆，如何能够用试验方法测呢？ diffusion cell 好像对那些有
弹性的薄膜
有用，但是我这个O-ring一夹紧会破坏材料本身.
还有一个问题是，这个材料本身是粘合剂 adhesion promoter, 很难把这层从基片上取
下来, 有没有一种可溶性的基片（而且表面很光滑的)??
有没有人做过类似材料的测试？望不吝赐教， 谢谢 |
|
c******7
发帖数: 2586 | 10 our reading was at 2.1 I think, basically 4.7 is right around the state
limit 4 pCi/L so you are not off too much.
If you still want this house 4.7 reading could force seller to spit out some
serious cashback, so make sure you leverage this. There are several ways to
lower your Radon readings:
A. Gas Permeable Layer
This layer is placed beneath the slab or flooring system to allow the soil
gas to move freely underneath the house. In many cases, the material used is
a 4-inch layer of clean g... 阅读全帖 |
|
f******g
发帖数: 1003 | 11 http://www.merckmanuals.com/vet/pharmacology/anti-inflammatory_
&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&
Biochemical mediators released during inflammation intensify and propagate
the inflammatory response (see Anti-Inflammatory Agents: Actions of
Inflammatory MediatorsTables). These mediators are soluble, diffusible
molecules that can act locally and systemically. Mediators derived from
plasma include complement and complement-derived peptides and kinins.
Released via the classic or alte... 阅读全帖 |
|
k****n
发帖数: 3803 | 12 ☆─────────────────────────────────────☆
GEO (CEO) 于 (Wed Aug 22 20:47:38 2007) 提到:
为个两层的公共建筑提供基础设计参数，暂时没有确定是桩基还是浅基础。
粘土层的三轴试验是应该做固结不排水（CU）还是不固结不排水（UU）。
☆─────────────────────────────────────☆
trackbed (涮羊肉) 于 (Thu Aug 23 00:52:57 2007) 提到:
CU
☆─────────────────────────────────────☆
GEO (CEO) 于 (Thu Aug 23 10:18:11 2007) 提到:
can I ask why? any details?
☆─────────────────────────────────────☆
trackbed (涮羊肉) 于 (Thu Aug 23 14:16:05 2007) 提到:
not sure what is your concern. but for... 阅读全帖 |
|
r*********t
发帖数: 4911 | 13 Earlier, demonstrators gathered near 79th and State streets. Some hoisted
signs that read “NO MORE DRUG WAR” and “NO GUNS,” with an illustration
of a handgun crossed out. Another sign read “They Don't Care About Us,”
ban手枪开始了。
然而华盛顿dc自己就ban过手枪。对此左逼教授的解释和sweetsister完全一致
"It's not a scientific study. It's an anecdote," said Philip Cook, a
professor of public policy studies at Duke University. "They might have
pointed to Washington, D.C., back in the days when D.C. banned handguns and
yet had high ... 阅读全帖 |
|
J**S
发帖数: 25790 | 14 刚看了，我们COUNTY要换成植物，才有REBATE。
Can I receive a rebate for installing a concrete patio, a walkway or an
extension to my driveway?
No. The program does not allow non-permeable hardscape. However, permeable
hardscape, such as gravel, brick, brick pavers or flagstone with permeable,
mortar-less material for grout lines (such as sand and gravel) are allowed.
Keep in mind that the conversion area must still meet the fifty percent (
50%) living plant coverage requirement. |
|
c******r
发帖数: 3778 | 15 OVERNIGHT CORNEAL RESHAPING (OCR) — Overnight corneal reshaping (OCR) is
the process of wearing a specially designed, rigid gas-permeable (RGP)
contact lens while asleep to temporarily effect a change in the corneal
curvature resulting in clear vision during waking hours without correction.
This technique is also referred to as:
●Corneal refractive therapy (CRT)
●Overnight corneal reshaping (OCR)
●Vision shaping treatment (VST)
●Orthokeratology (Ortho-K)
The process — After wearing OCR lenses, t... 阅读全帖 |
|
S*****s
发帖数: 287 | 16 I think it is project dependent, and probably investigator dependent, so it
is my personal opinion here. In mammalian cells, GFP shows up as soon as it
is translated, so it can be hard to tell membrane expression from
cytoplasmic expression. In my study, the wild type protein had efficient
membrane trafficking, and mutant protein decreased trafficking efficiency.
GFP fusion protein was not able to show the weak membrane expression of the
mutant protein. When I used HA-tagged protein, I detected ... 阅读全帖 |
|
C*********h
发帖数: 83 | 17 大致读了文章的摘要，应该是cell death领域的同行，做的方向主要还是apoptosis的
下游，呼吸链如何影响apoptosis的，以及cancer specific apoptosis以及ER-
mitochondria contact。
从Grimm的文章来看，他即便不是杰出的科学家，也是一个decent scientist。希望他
Rest in Peace.
如这篇review，citation 139.
The permeability transition pore in cell death.
Apoptosis. 2007 May;12(5):841-55. Review
这篇2011的EMBO J的citation是 81
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform
for apoptosis induction
Apoptosis重要的东西基本都做的差不多了，确实没什么可以做的。大lab都在做
physiology,做各种小鼠模型。Grimm凭一己之力做... 阅读全帖 |
|
l*******G
发帖数: 1191 | 18 http://www.ldolphin.org/gspeed.html
Faster than the Speed of Light?
Lambert Dolphin, Physicist
Superman was able to leap tall buildings in a single bound, he was more
powerful than a locomotive, and was said to be able to travel faster than a
speeding bullet.
The speed of a bullet (300-900 m/sec) is no big deal in these days of
supersonic aircraft and spacecraft. Yet our fastest space vehicles do no
better than one one-hundred thousandth (1:10-5) of the current speed of
light. Overcoming gravity... 阅读全帖 |
|
f**d
发帖数: 768 | 19 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
|
h**g
发帖数: 94 | 20 【 以下文字转载自 Stock 讨论区 】
发信人: Cibora (City of Gold), 信区: Stock
标 题: 平安夜里话石油
发信站: BBS 未名空间站 (Wed Dec 24 15:31:34 2014, 美东)
前些日子，看到板上好多大侠讨论了石油和油价的问题。今天事情少，俺也随便说两句
自己的理解。
很多人讨论石油，都是从美国vs俄罗斯、沙特vs美国、传统油气产业vs页岩油气产业这
样的大视角来说。我本人见识狭小，这些大局的东西俺都看不懂，俺就从俺懂的石油公
司的角度随便说说。
之前网上一个常见的观点是，这一把油价雪崩，美国各大石油公司都会受伤惨重。我对
此比较保留。在美国财阀政治的大背景下，石油公司都有强大的政治力量，如果不取得
石油财团的谅解，油价能那么莫名其妙在没有任何big event的情况下，突然就从100+
的高位崩到60以下，并且做出长期走低的姿态？我认为，大石油公司在这场油价雪崩中
必然是有收益的，因此他们才愿意支持并维持低油价一段较长的时间。问题在于大石油
公司在这场油价雪崩中，到底会有什么样的收益。
有这么一个故事，说两个人在山里走，突... 阅读全帖 |
|
发帖数: 1 | 21 Yarmouth Port, Massachusetts
From Wikipedia, the free encyclopedia
Yarmouth Port, Massachusetts
Census-designated place
Boardwalk at Bass Hole
Location in Barnstable County and the state ofMassachusetts.
Coordinates: 41°42′17″N 70°13′15″WCoordinates: 41°42′17″N 70°13′
15″W
Country United States
State Massachusetts
County Barnstable
Town Yarmouth
Area
• Total 6.47 sq mi (16.76 km2)
• Land 6.04 sq mi (15.65 km2)
• Water 0.43 sq mi (1.11 km2)
Elevation 52 f... 阅读全帖 |
|
发帖数: 1 | 22 在网上发现了一个圣诞节商店，商店的建筑很有特色，而且遍布全美国，大概有70多个
店铺，以后大家买圣诞节用品可以去那里，似乎各州都有。我们这里和麻州的地址是：
CHRISTMAS TREE SHOP AUGUSTA, GA, 239 ROBERT C. DANIEL JR. PARKWAY,
AUGUSTA EXCHANGE, AUGUSTA, GA 30909, 706.738.0570, CHRISTMAS TREE SHOP
, MAGNOLIA PARK, 1117 WOODRUFF ROAD, GREENVILLE, SC 29607. 864. 297.
3667
CHRISTMAS TREE SHOPS NATICK, 1298 WORCESTER ST. ROUTE 9, SHERWOOD
PLAZA, NATICK, MA 01760, 508.655.9800
CHRISTMAS TREE SHOPS SOMERVILLE, 177 MIDDLESEX AVENUE, ASSEMBLY SQUARE
... 阅读全帖 |
|
发帖数: 1 | 23 【Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH D005368
[edit on Wikidata]
Filariasis is a parasitic disease caused by an infection with roundworms of
the Filarioidea type.[1] These are spread by blood-feeding black flies and
mosquitoes. This disease belongs to the group of d... 阅读全帖 |
|
发帖数: 1 | 24 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
|
发帖数: 1 | 25 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
|
发帖数: 1 | 26 12月28日 仔细阅读以下文章
或许这些文章可以告诉你们孩子被伤害病毒的答案。
Astellas Pharma 应该和这些人体实验有莫大的关系！
Founded 2005; 11 years ago
Headquarters 2-5-1, Nihonbashi-Honcho, Chūō-ku, Tokyo 103-8411, Japan
Key people Yoshihiko Katakana
(President and CEO)
Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH ... 阅读全帖 |
|
h********o
发帖数: 3320 | 27 只要是permeable的就能拿钱，permeable的paver，path都可以。 |
|
z*********n
发帖数: 94654 | 28 你咋看的啊，呵呵，仔细读读
permeable
permeable,
allowed. |
|
h********o
发帖数: 3320 | 29 我不管这些了。有些地方我肯定用nonpermeable paver，能种植物的稍微种点，能拿多
少拿多少，大不了少拿点钱。就是不拿钱我也要把草都去掉。
permeable
permeable,
allowed. |
|
J**2
发帖数: 30 | 30 他的论文还是很牛的，不过回国时间好像有问题。下面连接可以看到他的简历，
http://www.nimte.ac.cn/jgsz/glbm/rlzy/pyrygs/201106/t20110601_3
三、候选人代表性论文（著）：
1. Jian Zhang, Xi Liu, Raoul Blume, Aihua Zhang, Robert Schlögl,
Dang Sheng Su, Surface-modified carbon nanotubes catalyze oxidative
dehydrogenation of n-butane, Science 322 (2008) 73. 影响因子：29.75
2. Jian Zhang, Dang Sheng Su, Raoul Blume, Robert Schlögl, Rui Wang,
Xiangguang Yang, Andreja Gajović, Surface chemistry and catalytic
reactivity of nanodiamond for the... 阅读全帖 |
|
发帖数: 1 | 31 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
|
C****a
发帖数: 6593 | 32 前些日子，看到板上好多大侠讨论了石油和油价的问题。今天事情少，俺也随便说两句
自己的理解。
很多人讨论石油，都是从美国vs俄罗斯、沙特vs美国、传统油气产业vs页岩油气产业这
样的大视角来说。我本人见识狭小，这些大局的东西俺都看不懂，俺就从俺懂的石油公
司的角度随便说说。
之前网上一个常见的观点是，这一把油价雪崩，美国各大石油公司都会受伤惨重。我对
此比较保留。在美国财阀政治的大背景下，石油公司都有强大的政治力量，如果不取得
石油财团的谅解，油价能那么莫名其妙在没有任何big event的情况下，突然就从100+
的高位崩到60以下，并且做出长期走低的姿态？我认为，大石油公司在这场油价雪崩中
必然是有收益的，因此他们才愿意支持并维持低油价一段较长的时间。问题在于大石油
公司在这场油价雪崩中，到底会有什么样的收益。
有这么一个故事，说两个人在山里走，突然蹦出个老虎。一个人扭头便跑，另一个低下
头系鞋带。跑的那个人说：你系鞋带也跑不过老虎啊。系鞋带的人说：我不需要比老虎
跑得快，我只要比你跑得快。如果这两个人是亲朋友好友，这个故事自然就很残忍。但
是倘若这两个人不是亲朋好友，而是仇家冤家，... 阅读全帖 |
|
b***i
发帖数: 3043 | 33 【 以下文字转载自 Stock 讨论区 】
发信人: Cibora (City of Gold), 信区: Stock
标 题: 平安夜里话石油
发信站: BBS 未名空间站 (Wed Dec 24 15:31:34 2014, 美东)
前些日子，看到板上好多大侠讨论了石油和油价的问题。今天事情少，俺也随便说两句
自己的理解。
很多人讨论石油，都是从美国vs俄罗斯、沙特vs美国、传统油气产业vs页岩油气产业这
样的大视角来说。我本人见识狭小，这些大局的东西俺都看不懂，俺就从俺懂的石油公
司的角度随便说说。
之前网上一个常见的观点是，这一把油价雪崩，美国各大石油公司都会受伤惨重。我对
此比较保留。在美国财阀政治的大背景下，石油公司都有强大的政治力量，如果不取得
石油财团的谅解，油价能那么莫名其妙在没有任何big event的情况下，突然就从100+
的高位崩到60以下，并且做出长期走低的姿态？我认为，大石油公司在这场油价雪崩中
必然是有收益的，因此他们才愿意支持并维持低油价一段较长的时间。问题在于大石油
公司在这场油价雪崩中，到底会有什么样的收益。
有这么一个故事，说两个人在山里走，突... 阅读全帖 |
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a***c
发帖数: 578 | 34 最近发表的一篇文章，发现运动前服用ibuprofen可能会造成一定肠道损伤
Med Sci Sports Exerc. 2012 Dec;44(12):2257-62.
Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes.
Abstract
INTRODUCTION:
Nonsteroidal anti-inflammatory drugs are commonly used by athletes to
prevent anticipated exercise-induced pain, thereby putatively improving
physical performance. However, these drugs may have potentially hazardous
effects on the gastrointestinal (GI) mucosa during strenuous physical
exercise. The aim of the curre... 阅读全帖 |
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g*2
发帖数: 658 | 35 ACUTE DIARRHEA — Diarrhea and the urge to defecate in long distance runners
(colloquially referred to as "runner's trots") are common, and frequently
interrupt exercise and impact performance. Exercise-associated diarrhea
ranged from 14 to 38 percent in long distance runners and marathoners, while
urgency to defecate during exercise ranged from 24 to 54 percent. Fecal
incontinence is relatively uncommon (4 percent).
Athletes have described an association with the intensity of exercise, pre-
race... 阅读全帖 |
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s******y
发帖数: 28562 | 36 http://www.sciencemag.org/cgi/content/abstract/science.1195298
Published Online October 28, 2010
Science DOI: 10.1126/science.1195298
Science Express Index
Reports
Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure
Roger L. Clem and Richard L. Huganir*
Traumatic fear memories can be inhibited by behavioral therapy or extinction
training in rodent models, but are prone to relapse. Under some conditions,
however, these treatments generate a permanent effect on behavior
sugges... 阅读全帖 |
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s*****g
发帖数: 7857 | 37 On your histogram:
PI+only (%#) --necrosis (dots on the Left side top)(died)
PI+/Annexin-V+ (%#)--later apoptosis (dots on the Right side top)(died)
PI-/Annexin-V+(%#) --early apoptosis (dots on the Right side bottom)(Not died)
PI-/Annexin-V- (%#)--alive & No apoptosis cells (health cells)(dots on the Left side bottom)
I use The sum of "PI+/Annexin-V+ (later apoptosis)" and "PI-/Annexin-V+(
early apoptosis)" to count Total Apoptosis (%)
You do not need do permeablize. If you permeablize, all ce... 阅读全帖 |
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y*********u
发帖数: 183 | 38 请问有哪些commercial available的质粒好用的？
有人用过如下这个质粒么？
Generation of a double-fluorescent double-selectable Cre/loxP indicator
vector for monitoring of intracellular recombination events.
Pfannkuche K, Wunderlich FT, Doss MX, Spitkovsky D, Reppel M, Sachinidis A,
Hescheler J.
Source
Institute for Neurophysiology, Robert Koch Str. 39, 50931 Cologne, Germany.
Abstract
Here we describe the generation of a double-fluorescent Cre/loxP indicator
system. This protocol involves (i) all cloning steps to generate ... 阅读全帖 |
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n**********7
发帖数: 29 | 39 大家好。
我最近在用flow检测一种膜蛋白的表达。对于这种蛋白，现有的用于flow的抗体都是
recognize c－terminal的，所以只能做intracellular flow。我的基本步骤是分离细
胞后，加Fc block，fix，permeablize，0.5% BSA block buffer,然后分别染一抗和二
抗，只有single color。
现在遇到的问题是，这种蛋白在treatment之前，不仅在细胞表面有表达，也存在于
intracellular vesicles里，所以不知道permeablize之后会不会检测到的量不仅仅是
表面的表达量。具体应该怎么做才能够保证我仅仅检测到cell surface的量呢？或者除
了flow之外还有其他的方法更适合解决这个问题？
多谢了！
做这个实验有两个多月了，反复试结果都不好，真着急！！ |
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b*******r
发帖数: 62 | 40 what is special about permeability? you guys cannot figure out way to
accurately
measure and scale up perm and then come here to scare we cheme engineers
using permeability. is not dimensionless permeabiity a special form of
transfer coefficient? we cheme engineer alreay know how to correctlate
mass and heat transfer coefficients in various fluid process, including
heterogeneous heat transfer media
can you upstream guys talk about something insight so that we could learn
anything useful from |
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y*****a
发帖数: 580 | 41 I will put some words that petroleum engineers will alert (and thus these
terms represents big traps for geologists and engineers) here: fracture(DFN)
, relative permeability, permeability, saline (salt, evaporite), aquifer,
fault, inconfirmity/disconfirmity/misconfirmity, thief zone, shale, basement
rock, CBM, viscous oil/heavy oil/tar/butamin, blow-out, workover ...
Petroleum 101.
If you were CEO of an oil company, what you are looking for? How much money
you will be earning? This requires: |
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d****i
发帖数: 360 | 42 Two papers please! Thanks a lot! E-mail: x**********[email protected]
The first one is the Addition/Correction for the second one! Thanks!
Biomacromolecules
Quaternary Ammonium β-Cyclodextrin Nanoparticles for Enhancing Doxorubicin
Permeability across the In Vitro Blood−Brain Barrier
Eun Seok Gil, Jianshu Li, Huining Xiao and Tao Lu Lowe
2009, 10 (4), p 1020
Biomacromolecules
Quaternary Ammonium β-Cyclodextrin Nanoparticles for Enhancing Doxorubicin
Permeability across the In Vitro Blood− |
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M********r
发帖数: 179 | 43 这道题我可以选出正确答案，但是有些地方还是有点含糊。比如pleural fluid正常的
cell number 是多少，正常
protein 含量是多少？为何此患者胸腔积液细胞含量如此高？
A 70 year old man comes to the emergency department because of shortness of
breath for 2 hours. He had
a myocardial infarction 2 years ago. A chest X-ray shows bilateral Kerley B
lines and bilateral pleural
effusions that are great on the right. If a thoracentesis were done,
laboratory studies would show
serum total protein 7g/dl
pleural fluid
specific gravity 1.008
total protein 1g/dl
leukocyte count... 阅读全帖 |
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h*******y
发帖数: 1220 | 44 did some search:
myocardial troponin can also be released in the setting of increased
membrane permeability (4). With increased membrane permeability, smaller
troponin fragments could be released into the systemic circulation. In this
setting, myocyte damage may not be permanent and necrosis does not occur. |
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R*j
发帖数: 248 | 45 I assume you are talking about a oral sustained dosage form.
What is the point to make "sustained release formulation" for class III drug
(high solubility, low permeability)?
Most available excipients or formulations are very unlikely to enhance drug'
s permeability. (But I do know a company called Emishpere has developed a
novel carrier to facilitate drug permeation across GI tract membrane. Who
knows whether FDA will approve it or not).
Although "Sustained release" won't increase apparent drug |
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q****n
发帖数: 5 | 46 J Crit Care. 2010 Aug 3. [Epub ahead of print]
Alveolar fluid clearance is faster in women with acute lung injury compared
to men.
Bastarache JA, Ong T, Matthay MA, Ware LB.
Source
Division of Allergy, Pulmonary and Critical Care Medicine, Department of
Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650
, USA.
Abstract
PURPOSE:
Studies suggest that there is a sex difference in the development and
outcomes of acute lung injury (ALI). Few studies have directly addressed t... 阅读全帖 |
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s********n
发帖数: 26222 | 47 方舟子在此文中说“虫子不吃的， 人能吃吗”是中国人的质疑， 而美国人是不会问这
样的问题的， 这显然是骗人的。见下文和其中引用的文献， 其中不少是美国人的科研
。
"Comments on the human health impact of Bacillus thuringiensis toxin gene
product in genetically modified crops"
EPA Review Docket Number OPP-00678B
Professor Joe Cummins
Professor Emeritus of Genetics
University of Western Ontario
I have studied the Environment Protection Agency (EPA) document "Bt Plant-
Pesticides Biopesticides Registration Action Document B. HUMAN HEALTH
ASSESSMENT" and comment in the following ... 阅读全帖 |
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c**i
发帖数: 6973 | 48 You say, "你跟本不用查找专业文献，反渗透膜是porous 的高分子材料，有点高分子
物理知识的人都知道温度降低，高分子链的热物理性能和构型会发生改变，这样膜的孔
径就会收缩，透水率就会明显降低."
In the primary school, we learn that if we heat a metal with a hole, the
hole will be bigger. Search the Web, with the terms (metal hole heat).
What is used in reverse osmosis (RO) is not metal but polymer. Thus there is
nothing intuitive about how pore will behaves. Indeed emperically there are
two types of pores in a RO membrane.
(1) That temperature affects membrane permeability is a fact. ... 阅读全帖 |
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c****g
发帖数: 37081 | 49 shale不好搞，
permeability比钢还低，擦；
shale层忒薄，要横着打洞；
非得刺激，要不然不出液体；
出液时间忒短；
还tnnd不稳定； |
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b********n
发帖数: 38600 | 50 http://www.nytimes.com/2015/02/15/opinion/sunday/frank-bruni-re
Jefferson would weep to see how permeable the wall between church and state
has become, but he would spin in his grave if he witnessed how we have lost
respect for scientific understanding and literacy. To be proud of one's
ignorance is an unpardonable sin. |
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