A****A
发帖数: 16 | 1 利用ZFN等reagents做Knock in应该是一些lab目前的奋斗方向。ZFN可以产生sequence
specific DNA double strand break. DNA双链断裂可以有效的提高homologous
recombination的频率，从而达到Knock in的目的。目前，在fish里面实现高效的HR还
很困难，即使在有ZFN的帮助下。我不是做fish的，主要做DNA repair pathway. 我觉
得可以通过一些genetic或chemical的手段抑制fish的NHEJ pathway，来增加HR的频率。
model
transpare
rep
to
很多
serious的
大好 |
|
i****g
发帖数: 3896 | 2 引用200次以上的4篇：
Title: Directional guidance of neuronal migration in the olfactory system by
the protein Slit
Author(s): Wu W; Wong K; Chen JH; et al.
Source: NATURE Volume: 400 Issue: 6742 Pages: 331-336 Published: JUL
22 1999
Times Cited: 319 (from Web of Science)
Title: Vertebrate slit, a secreted ligand for the transmembrane protein
roundabout, is a repellent for olfactory bulb axons
Author(s): Li HS; Chen JH; Wu W; et al.
Source: CELL Volume: 96 Issue: 6 Pages: 807-818 DOI: 10.10... 阅读全帖 |
|
B*****e
发帖数: 1005 | 3 140后的几个也不是美国AP啊，文章比跟前几个有距离
140 黄亿华 男 1971年10月 中国科学院生物物理研究所 生命
科学 2004年02月毕业于[美国]康奈尔大学 [美国]休斯医学研究所/西南医学中
心 讲师
1: Huang Y, Smith BS, Chen LX, Baxter RH, Deisenhofer J. Insights into pilus
assembly and secretion from the structure and functional characterization of
usher PapC. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7403-7. Epub 2009
Apr
20. PubMed PMID: 19380723; PubMed Central PMCID: PMC2670885.
2: Lin SC, Huang Y, Lo YC, Lu M, Wu H. Crystal structure of the BIR1 doma... 阅读全帖 |
|
M*****n
发帖数: 16729 | 4 用fly worm研究代谢，做一些很基本的pathway, 但是怎么反映到pathogenesis上面？
用fish 也有这个问题。俺跟研究代谢的讨论过这个问题，被人家问住了。
基本的pathway，俺也没兴趣。
这些动物如果病理表型跟人差太远的话，研究的意义就打折扣了。会被人家MD狂批的。
sl
物学
，所 |
|
S**********l
发帖数: 3835 | 5 现在还有新的signaling pathway?和metablic pathway有何区别？
。举
管可
来也
象f
signa |
|
R*9
发帖数: 15 | 6 Recruiment of yfg to pathway B through xxx modification
xxx modification of yfp reveals a novel switch mechanism between pathway A
and B |
|
s******y
发帖数: 28562 | 7
这个不好，因为没有反应出我们做的功能测试。
这个标题还不错，但是我们这篇文章其实并没有强调"switching"，因为我们不想
花一大堆没有什么用的数据去证实那个蛋白被修饰后和pathway A真的没有关了
（验证阴性结果远远比验证阳性结果困难）
改成这样如何？
XXX modification renders a novel function of yfp in pathway B |
|
s******y
发帖数: 28562 | 8
这个貌似不错
zzz formation 就是pathway B的直接后果，和pathway A 是没有关系的（因为细胞内
定位差得有点远） |
|
y******8
发帖数: 1764 | 9 So far, no experimental aging research has gone beyond the frame Kenyon (
probably Ruvkun also) drew almost a decade ago. She is vigorously trying to
prove a unique aging pathway (unlike Ruvkun at this point). To summarize,
the aging regulators are Insulin/IGF pathway + reproductive system + subsets
of neurons in the CNS(other discoveries are just modulators). Unfortunately
, the longevity regulation of all these are non-separable from other more
profound effects.
The aging theory itself has evo... 阅读全帖 |
|
D*a
发帖数: 6830 | 10 你这个思想还是programmed aging的思想。
其实可以这样倒过来想。如果evolution不需要 aging，那么某个基因对aging有没有影
响，都无关紧要，没有选择压力，那么就不会被evolution 选择掉。
那么假设一个种群平均寿命是5岁，死亡原因是要么掉到沟里摔死，要么被天敌吃掉。
那么如果一个基因的结果是造成心脏在六年之后挂掉，那么这个基因有没有都无所谓。
所以这样的基因就没有选择压力，从而可能在种群中慢慢散布开来。
那么这个基因散布开之后，有另一个突变造成肝在七岁的时候挂掉，那么也没有什么关
系，同理，这个基因也会慢慢散布开来。那么长此以往，“aging”就在不需要aging的
群体中建立了。
当然最有可能的是这些基因并非炸弹定时器，而是影响其fonction从而慢慢发挥作用，
比如让心脏供血能力提升，肝代谢毒物速度加快。。。（从而引起exhausting of stem
cell pool?）
所以如果再次把这个种群放到人工环境中，我们发现他们活六年就死了，作出结论说这
个种群的平均寿命是六年。 同时，人工环境中这些基因的优势就又没有优势了。因此
我们通过基因... 阅读全帖 |
|
J********n
发帖数: 534 | 11 3 first author papers. Not bad at all.
Role of the Rho pathway in regulating valvular interstitial cell phenotype
and nodule formation.
Gu X, Masters KS.
Am J Physiol Heart Circ Physiol. 2011 Feb;300(2):H448-58. Epub 2010 Dec 3.
Regulation of valvular interstitial cell calcification by adhesive peptide
sequences.
Gu X, Masters KS.
J Biomed Mater Res A. 2010 Jun 15;93(4):1620-30.
Role of the MAPK/ERK pathway in valvular interstitial cell calcification.
Gu X, Masters KS.
Am J Physiol Heart Circ Ph... 阅读全帖 |
|
J********n
发帖数: 534 | 12 3 first author papers. Not bad at all.
Role of the Rho pathway in regulating valvular interstitial cell phenotype
and nodule formation.
Gu X, Masters KS.
Am J Physiol Heart Circ Physiol. 2011 Feb;300(2):H448-58. Epub 2010 Dec 3.
Regulation of valvular interstitial cell calcification by adhesive peptide
sequences.
Gu X, Masters KS.
J Biomed Mater Res A. 2010 Jun 15;93(4):1620-30.
Role of the MAPK/ERK pathway in valvular interstitial cell calcification.
Gu X, Masters KS.
Am J Physiol Heart Circ Ph... 阅读全帖 |
|
b********r
发帖数: 709 | 13 做Molecular biology，或genetics方面的，或是molecular diagnostics的。
其他方面也可以。我可以把resume发过去给您看一下我是否合适。
介绍一下我的背景：
以前做p53对aging的影响，以及和insulin signaling pathway, Calorie restriction
pathway，apoptosis, autophagy, sex-differentiation, heat shock genes,生理节
律等方面的联系。
目前做病毒，微生物，基因检测方面的工作。
以前还做过神经生物学小脑发育方面的工作。
非常需要review机会。多谢。 |
|
s******a
发帖数: 472 | 14 http://www.cell.com/molecular-cell/fulltext/S1097-2765(11)00331
Fifty Years after Jacob and Monod: What Are the Unanswered Questions in Molecular Biology?
=====================================================================
Tomorrow's Molecular Biology
Marc W. Kirschner
Harvard University
Today, the term molecular biology has a rather prosaic sound. After all,
there is little in contemporary biology that isn't molecular. It's hard to
remember that 50 years ago, molecular biology was distinctly ... 阅读全帖 |
|
a****d
发帖数: 1919 | 15 I guess you need more evidences to support this hypothesis. Does enhanced B
pathway photocopy the phenotype resulted from A treatment? Can you block the
phenotype resulted from A treatment through modulating other B pathway
components? |
|
f*********e
发帖数: 1144 | 16 my feeling is the other way around, the bottle-neck is lacking of
biochemistry knowledge to interpret hundreds of differential expression
metabolites into a biological sense
A more ambitious idea, we need a great biologist to reconstruct the
disconnected information between proteomics and metabolomics, correlating
alterations occured on signaling pathway and metabolomics pathway
and |
|
a**e
发帖数: 5094 | 17 做signal pathway就是这个感觉。我估计去做cancer vaccination也是这样。做什么做
久了都会吐的
signal
induction
pathway |
|
a*******a
发帖数: 4233 | 18 我觉得这个思路反了
clinical是real data，然后搞搞细胞assay体外验证一下，最后才扯一个signal
pathway圆个故事
如果临床上不能当biomarker使/mouse里面没现象，后面的就不用做了
所以大家都在screen。。。。
signal
induction
pathway |
|
l**********1
发帖数: 5204 | 19 HTTps://sysbio.med.harvard.edu/faculty/yin/
Nature 1月 2011 同期 一作同时两篇 from Pierce Lab at CalTech
理论RNA自我组织反应经路模拟内容的
Yin, P., Choi, H.M., Calvert, C.R., & Pierce, N.A. (2008). Programming
Biomolecular Self-Assembly Pathways. Nature, 451(7176), 318-22. PMID:
18202654. pdf.
和DNA发夹模式用于DNA自我组织反应经路模拟内容的
Yin, P., Choi, H.M., Colby, R.C., & Niles, A.P. (2008). The abstraction of a
DNA hairpin motif is used to program diverse self-assembly (and disassembly
) pathways. Nature, 451, 318-22. pdf.
他那会的老板是牛津的... 阅读全帖 |
|
X******n
发帖数: 914 | 20 现在很多lab都是从低等到高等都做，比如在酵母里map一个pathway，然后在高等模式
里面去验证。比如Susan Linquist
老板总是想做network evolution，针对某个pathway从酵母，线虫，果蝇，老鼠到人全
做。可我总是觉得在扯。现在的方法连一个network都map不全，还谈啥进化呢？ |
|
l*****1
发帖数: 8 | 21 http://www.ncbi.nlm.nih.gov/pubmed?term=20551945
Nature Reviews Clinical Oncology 7, 401-414 (July 2010) | doi:10.1038/
nrclinonc.2010.64
Targeted therapy in non-small-cell lung cancer—is it becoming a reality?
Filip Janku, David J. Stewart & Razelle Kurzrock
Abstract
Treatment outcomes in advanced or metastatic non-small-cell lung cancer (
NSCLC) remain unsatisfactory, with low long-term survival rates. Palliative
chemotherapy offers a median survival not exceeding 1 year. To date, various
comb... 阅读全帖 |
|
M**a
发帖数: 4816 | 22 26 January, 2012 Volume 1, Issue 1EditorialMore than the Sum of Its Parts p1
Boyana Konforti
Full Text | PDF (62 kb)
More than the Sum of Its Parts
Boyana Konforti
Editor, Cell Reports
Welcome to the first issue of Cell Reports, a new open-access journal that
covers all of biology with a focus on high-quality short papers. There are,
of course, other open-access journals—in fact, quite a number have launched
just in recent years (and there will almost certainly be more to follow)—
though few hav... 阅读全帖 |
|
M**a
发帖数: 4816 | 23 26 January, 2012 Volume 1, Issue 1EditorialMore than the Sum of Its Parts p1
Boyana Konforti
Full Text | PDF (62 kb)
More than the Sum of Its Parts
Boyana Konforti
Editor, Cell Reports
Welcome to the first issue of Cell Reports, a new open-access journal that
covers all of biology with a focus on high-quality short papers. There are,
of course, other open-access journals—in fact, quite a number have launched
just in recent years (and there will almost certainly be more to follow)—
though few hav... 阅读全帖 |
|
k*****d
发帖数: 12 | 24 参观回来汇报一下。
公司不大，一起去的同事数了一下椅子，有30把左右，还有空着的办公桌和椅子。
没有wet lab，一间大办公室加几个小会议室。
可以把你的DNA sample给他们，他们给你找测序公司去测序，我的印象是送到Illumina
还有BGI或者类似的地方。
Alignment和call variants这些步骤就是用open source的软件，比如BWA和GATK。他们
的主要工作是用他们的数据库帮你annotate你的sample的variants，比如是不是已知的
somatic mutation或某个GWAS study里发现的相关SNP，这部分叫knome variant。这个
数据库包括已经报道的variants, 比如cosmic，还有一些文献报道的数据，但他们没有
力量跟踪所有的pubmed的文章。这个数据库和它的客户端的程序都可以卖给你，数据库
是SQLite，就放在local hard disk上，你也可以自己写SQL statement。还有一部分叫
knome pathway，帮助分析你的那些variants有没有集中在某些pathway里。 |
|
j*p
发帖数: 411 | 25 Try DAVID (there is KEGG pathway) or ingenuity pathway analysis and get your
genelist ranked in someway. Instead of trying them one by one blindly, you
need to kind of having an idea to try which ones first. |
|
a***y
发帖数: 19743 | 26 I see. Thanks. I think the bioinformatician already tried to look at it from
pathway perspective and only found one pathway that seem to correlate, and
we are little puzzled by why that is the only one.
I can try the tools you mentioned. Ingenuity is kind of expensive, at lab
lunch they were talking about buying one license but I don't know what would
happen.
your
you |
|
r*****u
发帖数: 56 | 27 A postdoctoral position is immediately available in the newly established
Cheng Lab, Department of Human Nutrition, Food and Exercise, Virginia Tech.
Motivated professionals, who are interested in research on type 2 diabetes,
obesity and cancer [1-7], are welcome to apply. Strong background/expertise
in biochemistry, molecular biology and/or cell biology is required. Previous
experience in signal transduction pathway analysis [1-3,5-7], mitochondrial
function [2,6,7], or redox (oxidation/reducti... 阅读全帖 |
|
D*a
发帖数: 6830 | 28 connection，我感觉是pathway A is connected to cancer B
a link between pathway A and B
tether从来没见过啊，也可能是我看不认识就跳过去了。。。
tie好像太口语了？
； |
|
l***y
发帖数: 4671 | 29 multi-hypothesis 的最关键的环节是 critical experiments：如何用尽量少的实验，
来尽可能多地检验一系列互斥的 hypotheses 之中哪些是错的，哪些可能是对的。只能
证伪一个 hypothesis 的实验要尽量避免，因为效率低。
这样子，实验结果在大多数情况下总是能继续推进 research，而不是 negative 的结
果导致 project 挂掉。
microarray 的筛选也谈不上有多中性。比如说，GSEA 和 IPA pathway enrichment
analysis 都有很强的 bias，原因就是用到的 hypothesis 有问题：使用不带权重的
Fisher exact test，并且不考虑各 gene set 或者各 pathway 的 overlap。
再结合前一段时间版上热闹过的 plos one 上的攻击 disease signature 的那篇文章
看 microarray assay，所谓中性可想而知了。
而基于 high-throughput screening 和 bioinformatics 来做 mec... 阅读全帖 |
|
l**********1
发帖数: 5204 | 30 Johns Hopkins too 连tenure都过不了
不是看已有领域的挖掘 还要看新领域的digged out data and results.
please refer:
for example:
Lee Martin, Ph.D.
Professor of Pathology, Neuroscience
//pathology.jhu.edu/department/divisions/neuropathology/faculty-staff.cfm
his group recent paper:
线粒体上的控制 NO 的通道控制着细胞老化和自然死亡的过程
"The mitochondrial permeability transition pore regulates nitric oxide-
mediated apoptosis of neurons induced by target deprivation.” (2011)
J Neurosci. 31: 359-370.
PubMed link:
//www.ncbi.nlm.nih.gov/pubmed/2... 阅读全帖 |
|
G***G
发帖数: 16778 | 31 我做了一个pathway analysis的网站。用户输入一组基因，就可以知道哪些pathway
是enriched的。
这片文章刚刚也录用了。
现在的问题是，老板跟学校的一个校长介绍了这个网站。周五校长要和我们讨论
这个网站商业化的问题。
关键问题：1）可不可能商业化？2）我愿不愿意商业化。
请问我该如何回答呢？
我的网站目前是纯学术目的的。用到了很多免费的公用的数据库（这些不是我创建的）
比如KEGG，biocarta， reactome等。
所以是不是不能商业化？要是商业化的话，我需要买他们的license？
另外一个问题，商业化对我有什么好处？学校会给我投资吗？ |
|
l**********1
发帖数: 5204 | 32 LZ pls go to
//idconverter.bioinfo.cnio.es/
then bottom
Functional Level
click it or those icons
then go go go
KEGG Pathways
Reactome Pathway
original post:
http://www.mitbbs.com/article_t/Biology/31649343.html
9th floor
ps: BAO ZI two= W-E-I B-I 20 please? |
|
|
b****r
发帖数: 17995 | 34 我这个预测的最根本前提就是NGS和未来的计算能力能让我们相当有把握地找到致癌突
变。接下来的模型只是验证一下，失败的风险理论上要远低于现在的技术水平下找到的
那些致癌突变
另外2W！显然并不符合人体内的状况。现在的主流观点是double hits，了不起就是
multiple hits。正常人体一个细胞内的突变率没有那么高，很少哪个正常细胞有机会
积累什么几十个突变，应该最多积累个几个突变也就发生质变成为癌细胞了。而且我觉
得很多癌症应该是殊途同归的，就好比现在已经发现很多时候都会和P53，PTEN， AKT
，MAPK，RAS等一些主要的pathway接上，将来药物的选择也可以拿这些已有的pathway
作为线索
下。 |
|
m**b
发帖数: 617 | 35 NGS assisted personalized medicine in cancer therapy has already underway.
Here is one of the first clinical example published in 2010:
http://genomebiology.com/content/11/8/R82
Key points:
1) Rare cancer with no standard chemo therapy
2) Initial treatment with radiation therapy and EGFR inhibitor (patient had
high EGFR expression) failed to stabilize disease progression
3) DNA sequencing + RNA expression + pathway analysis identified genes in
known cancer pathways with CNV and expression chang... 阅读全帖 |
|
j*******g
发帖数: 10 | 36 please email to j*****[email protected], thanks a lot!
Growth Factors. 2004 Sep;22(3):151-5.
Thrombopoietin signalling in physiology and disease.
Fishley B, Alexander WS.
Source
The Walter and Eliza Hall Institute for Medical Research, IG Royal Parade,
Parkville, VIC. 3050, Australia.
Abstract
Thrombopoietin (TPO) is a key physiological regulator of steady-state
megakaryocytopoiesis, the process of megakaryocyte production and maturation
that ultimately results in the formation of platelets. Ten years ha... 阅读全帖 |
|
g*****n
发帖数: 241 | 37 谢谢aardlbx。那请问到底哪种情况算是在同一个signaling pathway呢？
我所知道的是两个hypomorph的组合如果导致synergistic的话，应该是同一个pathway
，好像最理想化的是penetrance和其中一个的null allele的相同。
我对经典遗传只是初窥门径，谢谢各位同行指教 |
|
l**********1
发帖数: 5204 | 38 楼主 还有一个 antagonistic 的组合 也可能是同一个sgnalling pathway 哦
one book ite Chapter 11
by Barry Sinervo
title:
"Genetic Cooperation and Conflicts in Mating and Social System"
its web link:
//bio.research.ucsc.edu/~barrylab/classes/CHAPTER_PDFS/Chap_11_Conflict.pdf
推论: Stochastic Monte_carlo or Hiden Markov Modeling might be needed.
details pls refer:
Washington University in St. Louis the School of Medicine online lecture:
title:
Computational Molecular Biology, aka Algorithms for Computational
Biol... 阅读全帖 |
|
s******s
发帖数: 13035 | 39 这个同意。
如果是学发育生物的，就知道只分上下前后，而没有啥左右发育的pathway的。
那个第三个dimension其实是远近。一般动物左右没有理由不对称，根本就没有
那条pathway. 倒是random的左右区别有可能，比如那种大钳子的螃蟹。 |
|
l**********1
发帖数: 5204 | 40 LZ 可以参考下上周的 Science one report:
Yi W. et al. and Hsieh-Wilson LC (2012)
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
Science 337: 975-980
Abs:
Cancer cells must satisfy the metabolic demands of rapid cell growth
within a continually changing microenvironment. We demonstrated that the
dynamic posttranslational modification of proteins by O-linked β-N-
acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose
metabolism. O-GlcNAcylation was induced ... 阅读全帖 |
|
b******k
发帖数: 2321 | 41 hygiene hypothesis
看过gray's anatomy没？里面有一集有个病人，自己是个生物学家，吃了一肚子的钩虫
还是蛔虫啥的要研究治疗过敏的方法。因为寄生虫多了激活Th1 pathway,Th2相应的会
被抑制，因此过敏反应也会被抑制
话说回来了，在找到特异性的无害induce Th1 pathway治过敏之前，估计大多数人宁愿
过敏也不会愿意一肚子寄生虫之类的吧。。 |
|
u**********d
发帖数: 573 | 42 可能这里还是要看看上游的pathway到底怎么影响这个TF的。影响nuclear
localization？stability？specificity？
IgG当然是要的，但最好还有一个pathway变化前后的相互对照。 |
|
s******9
发帖数: 283 | 43 其实楼主的问题我以前问过，当时没有什么讨论。再跟进一点想法：
高通量蛋白分析可以分in vivo（proteins in natural environment）和in vitro方法
。in vitro主要是protein array和Y2H，in vivo当然是MS。不用多说，各有明显优缺
点。
NGS的优点在于它是separation independent & single-molecule based。其他的
single-molecule技术都不能做high-throughput，原因是受限于limited fluorophores
。同理，蛋白分析能够也做到SM sensitivity和separation independent，将是true
breakthrough。
MS的优势很明显，但是sensitivity， throughput和cost-effectiveness都有瓶颈的。
所以in vivo基本无法做到single-molecule proteomics。但是对于in vitro，如果
protein被DNA barcoded（比如ribosome di... 阅读全帖 |
|
N******n
发帖数: 3003 | 44 A total of 90 KEGG pathways were broken down into over 130 million extensive
linear subpathways that considered all multiple gene assignments. Among
these subpathways, 4,644 well-defined subpathways were identified and their
significance evaluated via permutation tests. Subsequently, text-mining
association analysis was performed for the selected significant well-defined
subpathways
From;Pathway-Based Evaluation in Early Onset Colorectal Cancer Suggests
Focal Adhesion and Immunosuppression along... 阅读全帖 |
|
s******a
发帖数: 252 | 45 The current metabolic pathways are good but far from complete. Try your luck
to see if there's a genetic factor in related pathways. |
|
p***i
发帖数: 96 | 46 我是博士后，打算申请一笔小的fellowship, 一年三万，共两年。这个fellowship我已
经试过两次了，都没有拿到，并且不告诉你理由。我的课题目前发现了细胞水平A--B--
C--D一个pathway, 我打算在B的knockout老鼠上证实一下。 老板让我showA--B， C--D
的data，propose 在细胞水平上证明这个pathway, that is all. 基本上是propose已
经做出来的东西。我很不情愿这样做，因为我的课题另外一个方向刚刚被scoop了。 我
担心这一个方向也会遭此同样的命运，因为毕竟还没有发表出来。我发信给老板解释我
的concern，并且提出3个更有趣的proposal的方向,（听说这个grant fund novel
ideas that are too early to be funded by R01) 他还是坚持原来的意见，并且说把
另外3个proposal放到其他的grant application 里面。
请问版内各位高人，
1.我的concern有道理吗？
2.我应该再与老板据理力争吗？
3.以前课题没有什么进展的时... 阅读全帖 |
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l**********1
发帖数: 5204 | 47 Sure
plus one Plos Bio 2012 paper from that Tom Maniatis lab too:
Zhao M. xxx mmm nnn and Tom Maniatis (2012)
Stochastic Expression of the Interferon-β Gene
PLoS Biol. 10: e1001249.
HTTP : //www.ncbi.nlm.nih.gov/pubmed/22617958
plus
2012 one Nature sister:
Multi-layered stochasticity and paracrine signal propagation shape the type-
I interferon response.
HTTP: //www.ncbi.nlm.nih.gov/pubmed/22291574
ps: for how to Stochastic Hidden Markov chain simulating MAVS KEGG pathway
pls just try one R&Pyt... 阅读全帖 |
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f*******d
发帖数: 92 | 48 我们想证明在某种treatment 条件下，NfkB pathway turned on by proteosome
degradation of IkBalpha. 老板说一定要S 35 labeling＋MG132，然后再IP，看
IkBalpha 的ubiquitination 才能证明它是走的那个pathway. 有什么办法可以绕过这
个实验，还是得到同样的结论呢？ 最近想生宝宝，实在不想做这种放射性的实验阿。 |
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z*****n
发帖数: 444 | 49 I think what we want to do is targeting the thermogenesis pathway
specifically to reach a status in which you generate modest heat but do not
disturb other physiological functions, such as enzyme activity. The heat
could be from brown fat, beige fat or white fat, which may all involve the
sympathetic nerve activity through beta 3 adrenergic receptor, cAMP pathway.
Sympathetic activity independent activation of adipose tissue is possible,
such as an significant increase of UCP1, which may be able... 阅读全帖 |
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