发帖数: 1 | 1 难道没有人知道做实验的embryos都是健康的吗？一个健康的人有必要做艾滋病免疫基
因编辑？ |
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t******g
发帖数: 183 | 2 Jiankui He says there is a second, potential, pregnancy underway of #CRISPR-
edited embryos. #GeneEditSummit |
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发帖数: 1 | 3 China a leading player
China spent a record 1.76 trillion yuan ($254 billion) on
research and development, and the country is catching up with the US's
investment in the same area, spurring a genetic arms race that has been
labeled "Sputnik 2.0" by Dr. Carl June, an immunotherapy specialist at the
University of Pennsylvania.
China has invested heavily in gene-editing technology, bankrolling research
into a number of world "firsts," including the first use of the gene-editing
tool CRISPR-Cas9 in ... 阅读全帖 |
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M*****8
发帖数: 17722 | 4
错，鸟的细胞和器官组织全面超越哺乳动物。
鸟的体温比人类高，选于水的最高密度温度附近。
可以说鸟的有限体积和质量是对功能精益求精的杰作。
鸟类在地球的历史远超哺乳动物的人类，是温血动物之最。
人类目前试图用猪或羊的细胞和组织，但用鸟的可能效果更佳。
Three Human Chimeras That Already Exist
Some people—--such as fetuses that absorb a dead twin--—have two sets of
DNA
The news that researchers want to create human-animal chimeras has generated
controversy recently, and may conjure up ideas about Frankenstein-ish
experiments. But chimeras aren't always man-made—and there are a number of
examples of human chimeras that alr... 阅读全帖 |
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发帖数: 1 | 5 贺建奎已经甩开老美单独干了，
美国人现在急眼了 怕发现CCR5突变对大脑发育这个重要发现没有自己的位置 纷纷表示
自己在小鼠上已经做出了结果，贺建奎是他们的follower,
还要点儿碧莲吗，
The Chinese team, led by He Jiankui of the Southern University of Science
and Technology in Shenzhen, claimed it used CRISPR to delete CCR5 from human
embryos, some of which were later used to create pregnancies. HIV requires
the CCR5 gene to enter human blood cells.
The experiment has been widely condemned as irresponsible, and He is under
investigation in China. News of the first gene-edited babies... 阅读全帖 |
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g********d
发帖数: 4174 | 8 France sees first 'saviour sibling'
PARIS (AFP) – Doctors in France on Monday announced the country's first
birth of a "saviour sibling," selected at the embryonic stage to be a close
genetic match to save a brother or sister suffering from a fatal inherited
disorder.
The baby was born at the Antoine Beclere Hospital in Clamart, in the suburbs
of Paris, said doctors Rene Frydman and Arnold Munnich.
The child, born to parents of Turkish origin and named Umut-Talha (Turkish
for "our ho... 阅读全帖 |
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m******1
发帖数: 19713 | 9 Researchers Discover Sex-Change Gene
By Diane Anderson-Minshall
Dmrt1 XX XY CHROMOSOMES X390 (FAIR UNCREDITED) | ADVOCATE.COM
Researchers at the University of Minnesota Medical School and College of
Biological Sciences have discovered a gene that is required to maintain male
sex throughout life.
The research team, led by David Zarkower and Vivian Bardwell of the
University of Minnesota’s department of genetics, cell biology, and
development, found that removing an important male development gene... 阅读全帖 |
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g********d
发帖数: 4174 | 10 http://www.cnn.com/2012/02/19/politics/virginia-personhood-bill
Richmond, Virginia (CNN) -- In the Virginia House of Delegates, Republican
Robert Marshall is a longtime abortion opponent who has tried repeatedly to
pass legislation in his state that would give rights to the unborn.
This year, on his third try, Marshall just might get his wish, and that has
advocates for women's reproductive rights concerned.
The House of Delegates passed a so-called "personhood" bill Tuesday
sponsored by Marshal... 阅读全帖 |
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x********e
发帖数: 35261 | 11 这个是真杂交，mosaic embryos。这根本搞不出纯粹的人器官嘛，只能说是拿来做实验
继续捞钱。 |
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t******g
发帖数: 1667 | 12 这种赤裸裸的种族歧视行为该不该收到谴责甚至起诉？？？
http://www.mitbbs.com/news_wenzhang/Headline/31857429.html
近日，美国一对白人夫妇Aaron和Rachel Halbert产下一对黑人三胞胎。这是基因变异
还是喜当爹？然而夫妻二人却还很开心，原来两人是通过供精者的剩余胚胎体外受精的
，也就是三胞胎是试管婴儿，跟这对父母没多大关系，因为两人并没有生育能力。
Mitbbs.com
令人惊讶的是，这对夫妇目前已经收养了5个黑人孩子，其中包括刚产下的这对三胞胎
。Mitbbs.com
Aaron和Rachel Halbert两人是基督教长老会会员，从两人相认开始，他们就决定领养
非裔美国人（即美国黑人），而不是跟他们肤色一样的白种人。因为他们知道，白人孩
子在很多方面都比黑人孩子受到优待，他们觉得，黑人孩子更需要得到关心和平等对待
，每年都有太多的黑人孩子被无辜抛弃，甚至没人领养。Mitbbs.com
在这对福音派信徒夫妇领养了两个黑人孩子后，他们觉得这两个孩子的生活有了翻天覆
地的变化，能给他们带来全新的生活是一件多么美好的事情。... 阅读全帖 |
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p******e
发帖数: 897 | 13 Arizona Rep. Trent Franks allegedly made unwanted advances toward female
staffers in his office and retaliated against one who rebuffed him,
according to House GOP sources with knowledge of a complaint against him.
The allegations, which reached Speaker Paul Ryan and top GOP leaders in
recent days, led to Franks' sudden resignation this week. Franks originally
announced that he would resign on Jan. 31, 2018. But just hours after
POLITICO inquired about the allegations, he sped up his resignation... 阅读全帖 |
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发帖数: 1 | 14 靠，能正常点吗？早就说过，这个在法学没有明确规定，现在只有部分州承认unborn。
如果unborn定义被认可，还争议个P呀。
而且unborn child有权利，只能baby lives。embryo 和死婴不是
: 肚子里的当然不是，可是堕了胎之后就可以称为儿童了啊（堕胎了就不是unborn
,
: clear?)。你脑子秀逗了？
: 还好意思说我嘴巴不干净。你骂大陆人多少次，哪次干净了？
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发帖数: 1 | 15 8州之内是embryo，流出来，怎么说。你知道这么多，解释一下。这是生命不，是
unborn还是born
: 你这人也能问别人正不正常？这么基础的常识，你到现在都搞不清楚，俺心善，
给你一个
: 不需要智商也能理解的结论。
: 堕了胎之后，生下来的那个人，也可以称作 fetus, 懂???
: 只要生下来来了，就可以称作儿童，懂？
: unborn
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m****s
发帖数: 18160 | 16 【 以下文字转载自 Biology 讨论区 】
发信人: Suave911 (911), 信区: Biology
标 题: Post-doc Position Available in Cancer/Signal Transduction
发信站: BBS 未名空间站 (Fri Jun 21 10:21:47 2013, 美东)
Post-doc Position Available in Cancer/Signal Transduction
Molecular Cell Biology, Leiden University Medical Center, The Netherlands
A Post-Doctoral position is available in a dynamic, international and
interdisciplinary research team to study the molecular basis of subverted
TGF-β signal transduction in cancer.
Focus of the res... 阅读全帖 |
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p*l
发帖数: 1359 | 17 embryos基本透明的，用optical coherence tomography contrast 不好。intrinsic contrast还是临床或者大动物模型这些probe delivery比较难的情况合适。
有兴趣你可以看看这片文章： Nature medicine, 15(10), 1219. 这个第一作者是我的
偶像。standford 做光学出身，从基本成像技术，一直做到了发nature medicine。里面有个拍了几天几夜的电影，里面的老鼠真可怜。 |
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h*w
发帖数: 134 | 18 一个好的技术最重要的是发现好的应用，而不是完全来源于技术本身。
Ben的文章在于它有很好的合作者。当时我们也shock一下，但是回过头一项，实际可以
做。 不过的有一个fulltime的做半年的imaigng processing。 实际上应用有限。
optical imaging 从临床上来说，设备便宜而且实时。 由于深度问题，内窥视一个重
要解决办法。
至于contrast optical imaigng， animal study 可能应用。 临床不太行。 OCT 的优
点就是 不要contrast ， images look like histology. OCT是目前所有
opticalimaigng 中最有临床价值的。不是忽悠
Embryo imaging with OCT is its imaging speed (3D in real time).
海量数据不是问题。 |
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S***J
发帖数: 1210 | 19 云老师发了个贴说清华目前的找人标准，很多人不相信。特地调研了一下清华生命学院
最近回去的人的情况，如云老师所说，绝大多数都有2cns，如果只有一篇cns，那基本
上还有>2的子刊。这个不仅仅局限于胖老师经常说的结构生物学，而是所有方向都基本
如此。
当然这些新回去的绝大部分都是千青（有些不是的是因为回去那一年千青还没开始）。
网页上的Title有的是教授，有的是研究员，估计当时还没有统一。但校内一律都是副
教授，也就是相当于这边的AP。我还特地打听了一下，国内的TT制度好像没有Tenured
Associate这一档，清华5年考核通过了就是正经的full professor。
有些老师看不上国内的科研，我就仅列出两位回国后的publication，咱就不说颜宁等
这种Early T的个例了。说两个没太有名气的，还没有评上T的，各位老师可以参考一下
，看看自己有没有别人这么productive。
一. Guangshuo Ou （11年回国，千青）
Select item 25342559
1.CYLD mediates ciliogenesis in multiple organs b... 阅读全帖 |
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w****6
发帖数: 116 | 20 if your wife doesn't mind, you two can use a donor egg to do ivf to filter
embryos to have a boy. technology is very advanced to do that. so your son
will have genes from you and your donor, but your wife will get pregnant and
give birth. |
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D*******d
发帖数: 5 | 21 According to my boyfriend who is PHD in cellular and molecular biology ,the
facial structure of kids have lots to do with genetics. when the embryo is
formed the genes of two parents get's exchanged and some gene which were not
expressed in parents will be expressed. You shouldn't ruin your marriage
because someone's kids look like your husband. It is quite possible that
the kid might be look alike with grandfather or grandmother or other
relatives in their family who might have same facial fe... 阅读全帖 |
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s********5
发帖数: 5 | 22 Biomechanics of tissue morphogenesis：
One of the major efforts will be to measure and apply forces to cells and
tissues isolated from developing frog embryos to understand how cell motility
and tissue architecture are integrated. There is a strong bioengineering
aspect to this work in constructing and applying novel technologies at
cellular and tissue scales and working with computer simulations of the
mechanics. Other aspects of this work involve high resolution timelapse
confocal imaging and m |
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m****s
发帖数: 18160 | 23 【 以下文字转载自 Biology 讨论区 】
发信人: Suave911 (911), 信区: Biology
标 题: Post-doc Position Available in Cancer/Signal Transduction
发信站: BBS 未名空间站 (Fri Jun 21 10:21:47 2013, 美东)
Post-doc Position Available in Cancer/Signal Transduction
Molecular Cell Biology, Leiden University Medical Center, The Netherlands
A Post-Doctoral position is available in a dynamic, international and
interdisciplinary research team to study the molecular basis of subverted
TGF-β signal transduction in cancer.
Focus of the res... 阅读全帖 |
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b****b
发帖数: 199 | 24 sorry, this is also important.
What is hCG?
hCG is a hormone produced by your placenta when you are pregnant. It appears
shortly after the embryo attaches to the wall of the uterus. If you are
pregnant, this hormone increases very rapidly. If you have a 28 day menstrual
cycle, you can detect hCG in your urine 12-15 days after ovulation.
and
may
result.
detect
had
waited |
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g*****j
发帖数: 1211 | 25 It takes about 2 day for your husbands sperm to swim to the right place
to meet the egg. It takes another 3-4 days for the fused egg & sperm to
travel to your uterine for implantation. In other words, conception
does not occur until about 1 week later after the special "aa". During
that week, the embryo travels in your body, but still not connected to
your blood circulation, which means even systemic infection will not
touch it.
A common cold is a localized infection occurring in your upper
r |
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t*******n
发帖数: 4445 | 26 From the Merck manual:
"Before the 20th day after fertilization: Drugs given at this time may have
an all-or-nothing effect, killing the embryo or not affecting it at all.
Teratogenesis is not likely during this stage." |
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t*******n
发帖数: 4445 | 27 Generally, prior to 20th day after fertilization, drugs would either cause
embryo death or nothing.
Of 速效感冒冲剂:
Tylenol - safe for pregnancy
Chlorpheniramine - safe for pregnancy
Small amounts of caffeine is not a problem (you can still drink coffee or
tea)
Not that familiar with Chinese medicine, but I don't think 人工牛黄 is a
problem.
If you are still worried then check with the doctor - need to see he/she
soon anyway. |
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w**********9
发帖数: 242 | 28 For a functional liver to form, you will need 1), mitosis on hepatocyte,
epithelial cells, smooth muscle cell and more 2),the cells must form a 3D structure
that accompany tons of sinus, boold vessels and bile ducts. That means all
cells must coordinate precisely knowing where, when to grow and to stop. In
the embryonic stage, embryos have many factors to guid the organogenesis,
but in adult stage, those factors are not conveniently available any more.
Anyway, I am very skeptical that a functio... 阅读全帖 |
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c***m
发帖数: 902 | 29 “试管婴儿” 是国内外对“体外受精和胚胎移植”（In vitro fertilization and
embryo transfer, IVF-ET）的俗称. 体外受精是一种特殊的技术，是把卵子和精子都
拿到体外来，让它们在体外人工控制的环境中完成受精过程，然后把早期胚胎移植到女
性的子宫中，在子宫中孕育成为孩子。利用体外受精技术产生的婴儿称为试管婴儿. 最
初在实施这项技术时, 卵子和精子在体外受精, 早期胚胎体外发育的确是在试管里进行
的. 现在只有少数实验室仍然用试管做体外受精, “试管婴儿”这个名称缺因其形象有
趣沿用至今.
胚胎移植是试管婴儿技术得到广泛应的基础.胚胎移植又称受精卵移植，是指将雌性个
体的早期胚胎(通过体外受精或手术采集的方式获得)的，移植到性周期同步的、生理状
态相同的其他雌性个体或自身体内，使之继续发育为新个体的技术。
胚胎移植生理学基础
（1）同种个体的供，受体的生殖器官的生理变化是相同的，为供体胚胎移入受体提供
相同的生理环境。
（2）早期胚胎在一定时间内处于游离状态，为胚胎的收集提供了可能。
（3）受体对移入子宫的外来胚胎基本上不发生免疫排斥反应，为... 阅读全帖 |
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c***m
发帖数: 902 | 30 “试管婴儿” 是国内外对“体外受精和胚胎移植”（In vitro fertilization and
embryo transfer, IVF-ET）的俗称. 体外受精是一种特殊的技术，是把卵子和精子都
拿到体外来，让它们在体外人工控制的环境中完成受精过程，然后把早期胚胎移植到女
性的子宫中，在子宫中孕育成为孩子。利用体外受精技术产生的婴儿称为试管婴儿. 最
初在实施这项技术时, 卵子和精子在体外受精, 早期胚胎体外发育的确是在试管里进行
的. 现在只有少数实验室仍然用试管做体外受精, “试管婴儿”这个名称缺因其形象有
趣沿用至今.
胚胎移植是试管婴儿技术得到广泛应的基础.胚胎移植又称受精卵移植，是指将雌性个
体的早期胚胎(通过体外受精或手术采集的方式获得)的，移植到性周期同步的、生理状
态相同的其他雌性个体或自身体内，使之继续发育为新个体的技术。
胚胎移植生理学基础
（1）同种个体的供，受体的生殖器官的生理变化是相同的，为供体胚胎移入受体提供
相同的生理环境。
（2）早期胚胎在一定时间内处于游离状态，为胚胎的收集提供了可能。
（3）受体对移入子宫的外来胚胎基本上不发生免疫排斥反应，为... 阅读全帖 |
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c*******e
发帖数: 9475 | 32 Fetal development stopped, empty sac with no embryo |
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o**********e
发帖数: 18403 | 33 Don't worry too much. The endocrinologist above is right. Embryo's week 3-
8 is organ development and more likely to suffer nonlethal birth defect. I
think you squeaked through this one. But ask the doctor to review your
medical record and each drugs you had, is also a good idea. Also, any idea
what pregnancy test did they run for you on 4/20? What surgery was it for
?
GL! |
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o**********e
发帖数: 18403 | 34 Don't worry too much. The endocrinologist above is right. Embryo's week 3-
8 is organ development and more likely to suffer nonlethal birth defect. I
think you squeaked through this one. But ask the doctor to review your
medical record and each drugs you had, is also a good idea. Also, any idea
what pregnancy test did they run for you on 4/20? What surgery was it for
?
GL! |
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f*****c
发帖数: 231 | 35 B chao is ultrasound imaging. Long time exposure to ultrasound wave may case
problems in your tissue or embryo brain. The common result is heating and
damage to neuro system. Use it as a tool, but avoid long term exposure. |
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d*********t
发帖数: 27 | 36 Blessing. if bleeding occurs right around your period, it is likely to be
implantation bleeding. Implantation bleeding occurs when embryo tries to
embed into your uterus wall - it happens lot. don't worry. |
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i****a
发帖数: 608 | 39 昨天见医生终于还是确定会流产了。其实前天下班之后就发现有一点点粉红色的
discharge，昨天早上discharge多了一些，颜色也变成了深褐色，肚子开始有点隐隐的
痛，腰部很酸很酸。昨天下午又做了一次B超，看到了gestational sac & yolk sac，
没看到embryo。HCG637，没有什么变化，OB说肯定不会是正常的怀孕了，而且我的身体
已经开始反应，想要自己把sac排出来，如果不行的话，周一再做手术。
虽然早知道这样的结果不可避免，回到家还是哭了一场。然后就等着希望能够自然流产
，肚子一直在疼，也一直看到有出血，上厕所的时候还能看到鲜红的血，量不大，我都
不知道算不算bleeding。
这样等着真的是种折磨。不知道什么时候发生，会不会发生，一切都是未知。 |
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M********8
发帖数: 3837 | 40 你这牙医也太急着抢钱了，不道德。我怀孕的时候去洗牙，看到有蛀牙，牙医主动说不
动拍X光（防护服也不好），特别是first trimester, 不上麻药补，让我扛到生了以后
做。
http://www.americanpregnancy.org/pregnancyhealth/dentalwork.htm
What about x-rays used in dental work during pregnancy?
Routine x-rays, usually taken during annual exams, can usually be postponed
until after the birth. X-rays are necessary to perform many dental
procedures, especially emergencies. According to the American College of
Radiology, no single diagnostic x-ray has a radiation dose significant
eno... 阅读全帖 |
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z*****9
发帖数: 256 | 42 其实在孕期就发现胚胎弄错了已经很幸运了,如果对孩子日夜呵护了若干年以后才发现,
那时的感情才是最难了断的. |
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J**2
发帖数: 165 | 44 Huge bless! You will have a healthy and samrt baby soon!
Your OB should check the thickness of your uterus endometrium around the
time of egg releasing. If the line is too thin, it won't support the embryo
grow well, that might be another reason for miscarriage. In this situation,
HCG might help maintaining good uterus line thickness. Good luck! |
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a****9
发帖数: 773 | 45 学习了一下：
Subchorionic hemorrhage (subchorionic hematoma) is the most common
sonographic abnormality in the presence of a live embryo. Vaginal bleeding
affects 25% of all women during the first half of pregnancy and is a common
reason for first-trimester ultrasonography. Sonographic visualization of a
subchorionic hematoma is important in a symptomatic woman because pregnant
women with a demonstrable hematoma have a prognosis worse than women without
a hematoma (see example images below). However, ... 阅读全帖 |
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i***o
发帖数: 1509 | 50 Bless，推迟也很可能的。HcG测了没?
请问mM有没有吃叶酸?有些人会推迟例 |
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