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全部话题 - 话题: replicated
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u**d
发帖数: 211
1
来自主题: SanFrancisco版 - 这次Amazon的AWS出问题没什么大不了的
我今天才看到 amazon 的报告
http://aws.amazon.com/message/65648/
看过之后,我觉得事故很难简单归咎于“容错设计”
从某种意义上,我感觉恰恰是因为设计过于强调容错了,
i.e. availability 和 consistency
上面报告里提到了,network 的一个简单错误很快就恢复了
但是在 high availability 和 strong consistency 下
在网络恢复之后,各个节点误认为当机,于是及时更新数据,导致资源耗尽
这本来就是一个两难,如果为了要避免网络和磁盘资源的拥塞
只能全局做一些 scheduling,而结果就是必然牺牲某些节点的
availability 和 consistency --- 这又和一开始的设计理念有些矛盾
如果非要对系统设计挑刺,如何 replicate, re-mirror 等等大概可以再考虑
当然,有些设计大概是可以改进的。比如报告里提到软件层 (EBS control panel)
资源耗尽,因为底层存储长时间没有响应,而 control panel 又 queue 了
非常多的 r... 阅读全帖
R******d
发帖数: 5739
2
按这个说法, 应该和穿多少也没关系。 nasal cavity的温度和你穿多少还是没关系。
quote
Abstract
Most isolates of human rhinovirus, the common cold virus, replicate more
robustly at the cool temperatures found in the nasal cavity (33–35 °C)
than at core body temperature (37 °C). To gain insight into the mechanism
of temperature-dependent growth, we compared the transcriptional response of
primary mouse airway epithelial cells infected with rhinovirus at 33 °C vs
. 37 °C. Mouse airway cells infected with mouse-adapted rhinovirus 1... 阅读全帖
D*****y
发帖数: 5788
3
【 以下文字转载自 TrustInJesus 讨论区 】
发信人: Dignity (饥不择食), 信区: TrustInJesus
标 题: [合集] 有请某文化人来说说进化论-三日为限
发信站: BBS 未名空间站 (Thu Dec 30 15:50:31 2010, 美东)
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:14:10 2010, 美东) 提到:
从哪里说起都可以
只有一条,最好代表当今进化论的权威
否则不要天天浪费大家的时间跟你一起打酱油
基督版不是给你进化论妄想打酱油的地方
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:16:08 2010, 美东) 提到:
给你三天时间放狗去找
够了吧?
☆─────────────────────────────────────☆
atep (嘚嘚) 于 (Tue Dec 7 23:28:47 2010, 美东... 阅读全帖
b*********n
发帖数: 1607
4
就用http://www.nap.edu/openbook.php?record_id=11876来说。下面的文字引用自他的
21-22页:
For life to begin, three conditions had to be met. First, groups of
molecules that could reproduce themselves had to come together. Second,
copies of these molecular assemblages had to exhibit variation, so that
some were better able to take advantage of resources and withstand
challenges in the environment. Third, the variations had to be
heritable, so that some variants would increase in number under
favorable environmental... 阅读全帖
D*****y
发帖数: 5788
5
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:14:10 2010, 美东) 提到:
从哪里说起都可以
只有一条,最好代表当今进化论的权威
否则不要天天浪费大家的时间跟你一起打酱油
基督版不是给你进化论妄想打酱油的地方
☆─────────────────────────────────────☆
jym2307 (罪魁) 于 (Tue Dec 7 19:16:08 2010, 美东) 提到:
给你三天时间放狗去找
够了吧?
☆─────────────────────────────────────☆
atep (嘚嘚) 于 (Tue Dec 7 23:28:47 2010, 美东) 提到:
请最虔诚的罪魁来说说基督教-三日为限
从哪里说都可以
该不该蒙头 该不该抹油 该不该搞基 该不该吃转基因食物
只有一条 要代表当今基督教的权威答案 好让这些问题有统一答案
给你三天时间 放狗去搜吧

☆─────────────────────────────────... 阅读全帖
O**********0
发帖数: 61
6
☆─────────────────────────────────────☆
BHistory (往者的影子) 于 (Fri Sep 9 15:00:23 2011, 美东) 提到:
本帖是热运动组装第一个蛋白质的副贴。原帖:http://www.mitbbs.com/article_t1/TrustInJesus/676133_0_1.html
因为靠热运动组装第一个蛋白质是困难的,所以有观点认为第一个蛋白质是根据某个自
然产生的遗传基因密码(DNA/RNA)组装出来的。这便是热运动组装第一个遗传密码/基因
的理论。
在俺看来,这是先有蛋还是先有鸡的问题。蛋白质好比蛋,基因好比下蛋的鸡。如果自
然界糊出一个蛋很困难,那糊出一个下那个蛋的鸡就更困难。
事实上,每三个DNA碱基对决定一个氨基酸,加上基因的头码三个,尾码三个,对应一
个100个氨基酸长链的遗传密码(306个碱基对),其自然产生的困难程度和自然排列该
特定氨基酸长链的困难程度基本一样(遗传密码更难一点)。且遗传密码翻译为第一个
蛋白质还可能需要翻译和连接氨基酸的机制(类似一些细胞器的功能)。所以自然产生
第一个... 阅读全帖
z***y
发帖数: 7151
7
可以自己测一下... 我刚刚个google过, 没有答案.
第一个:
描述一下 MSX 和 TSX 的关系. 设置MSX有什么需要注意的地方. 说出一个来即可.
第二个
Server A , B , C , AB , BC
A is publisher and B is subscriber to A using AB as distributor
B is also publisher and C is subscriber to B using BC as distributor.
On server A, there's publication called servera-pub. By design, tableA is
an article inside servera-pub.
TableA was in Server A and it is replicated to B using Transactional
replication. TableA on B also replicated to
server C using transactional
g***l
发帖数: 18555
8
计算完了把结果REPLICATION一下不就行了,为什么要去REPLICATION计算过程,搞几个
SUMMARY TABLES,REPLICATION不就解决了
i****a
发帖数: 36252
9
来自主题: Database版 - 内推力量太强大了
有接著问啊, 说他们是用SAN bit level mirroring. 应该是供应商的 storage
replication application 吧. 我们公司用的是 EMC replication manager, 他到是说
他以前用过.
同意你第一点, 他们不用 replication, 可以列出很多更好听的理由, 就一句 buggy,
有点太不专业
我是一个小棉羊式的员工, 倒不太担心合作的问题
d***e
发帖数: 793
10
来自主题: Database版 - 熟MySQL的同学请帮忙
要面个广告公司, job description如下
Mysql query performance analysis.4+ years RDBMS experience working in a high
volume production environment.
MySQL 5.x (InnoDB and MyISAM engines)
MySQL replication (Master-Master, Master-Slave ) and sharding.
Experience/familiarity with Percona toolkit for backup, restore , online
schema change.
Develop tools for db monitoring, collect and analyze performance metrics.
Expertise in Ruby, Python preferred.
Familiarity with configuration management tools like Puppet.
1. ... 阅读全帖
y*****g
发帖数: 677
11
来自主题: Database版 - 熟MySQL的同学请帮忙
1. replication,我们公司太小了,目前production db server 就一个machine,没有
replication. 我能说我用过吗?还是要实话实说
Just say there is master/slave replication setup in your company!
2. percona toolkit,没有用过,能扯用过吗?
yes, just download and play
3. develop tool for db monitoring,collect/analyze performance.什么tool啊?
谁能给点提示吗
Mysql Enterprise monitor; nagios tools etc.
4. configuration management tool like puppet,有人用过吗?
I didn't use it either. Again, download and play with it.
5. 怎么恶补performance analysis?
Read my p... 阅读全帖
c**t
发帖数: 2744
12
来自主题: Database版 - 大虾帮忙看看MySQL的设置
[OK] Currently running supported MySQL version 5.6.30
[OK] Operating on 64-bit architecture
-------- Storage Engine Statistics -----------------------------------------
------------------------
[--] Status: +ARCHIVE +BLACKHOLE +CSV -FEDERATED +InnoDB +MEMORY +MRG_MYISAM
+MyISAM +PERFORMANCE_SCHEMA
[--] Data in MyISAM tables: 170K (Tables: 17)
[--] Data in InnoDB tables: 28M (Tables: 107)
[!!] Total fragmented tables: 5
-------- Security Recommendations ------------------------------------------
... 阅读全帖
s*****r
发帖数: 43070
13
来自主题: Programming版 - 如果要做一个铁路售票网站
中国铁路客票发售与预订系统由中央级、地区级和车站级三层结构组成,包括全国票务
中心管理系统、地区票务中心管理系统和车站电子售票系统。
系统采取集中与分布相结合的方案,在全路票务中心内安装中央数据库,Sybase数据库
产品Adaptive Server Enterprise、Replication Server、Sybase IQ,中间件产品
Open Client、Open Server以及开发工具PowerBuilder和PowerDesigner在其中都有着
非常重要的应用;这一系统主要用于计划与调度全系统的数据,并接收下一系统的统计
数据和财务结算数据。
在地区票务中心设有地区数据库,Sybase的Adaptive Server Enterprise、
Replication Server、Open Client、Open Server、PowerBuilder、PowerDesigner将
全面支持这一数据库,它主要用于计划与调度本地区数据,并可响应异地购票请求。
系统的基础部分是由Sybase的Adaptive Server Enterprise、Replication S... 阅读全帖
z***e
发帖数: 5393
14
来自主题: Programming版 - 被mongodb坑了,求指点!
我那个游戏用的mongodb,简单嘛,反正json一存就完事,然后又自动支持sharding/
replication,有朋友的建议说连redis/memcache都可以不用了,简直尼玛就是一本万
利。。。
然后。。。没有免费午餐。。。我的两个shard(每个40G,然后每个是3个replication
)第一周在人数达到1800左右的时候硬盘空间占满,升级到每个80G。。。现在接近4k
用户,马上又要满了。。。
上网搜,似乎是个wellknown issue,mongodb是所谓的preallocation,就是尼玛管它
三七二十一先给你占一大坨空间
http://stackoverflow.com/questions/22307172/mongodb-is-taking-t
http://www.itexto.com.br/devkico/en/?p=44
现在我这状况,每1000用户要占40G的话,而每个replication要求至少是3个server(
mongodb的要求),那这样下去很快就费用受不了了。。。但是的确mongo用起还是很方
便(我也懒得换db了,要改的太多)
... 阅读全帖
w**z
发帖数: 8232
15
https://aws.amazon.com/message/5467D2/?utm_content=buffere5a1e&utm_medium=
social&utm_source=linkedin.com&utm_campaign=bufferSummary of the Amazon
DynamoDB Service Disruption and Related Impacts in the US-East Region
Early Sunday morning, September 20, we had a DynamoDB service event in the
US-East Region that impacted DynamoDB customers in US-East, as well as some
other services in the region. The following are some additional details on
the root cause, subsequent impact to other AWS services t... 阅读全帖
w**z
发帖数: 8232
16
Cassandra可以设定每个dc的replicate number 它会帮你replicate.你也可以设
consistency level. 如果你设成 all, 那就是strong consistency, 那CAP 里的 P
就被不能保证了。你要保证throughout,加Node 就行了Cassandra scale 非常容易。但
是跨DC replicate,latency一定会变大的。

consistency,
r****o
发帖数: 105
17
本文献给YL
(七)古怪的CDC6
 这里再给大家讲一个在大肠杆菌中表达蛋白质的例子,一个很夸张的例子,但是很有启发性。
Bruce Stillman 是冷泉港的现任主管,是一个绝对的牛人。不但科学做得很好,而且还很爱
国。他是澳洲人,在美国待了N年,却从没有加入美国国籍,所以他只是外籍院士。我们的晚间报
告有一个是他作的。他主要研究真核生物的DNA复制。这是一个到现在为止都没有完全弄明白的领
域。在报告里面,他特别提到了表达纯化CDC6蛋白的经历,我觉得十分有意思。这个蛋白, 用他
的话说,是"a pain in the ass"。
 CDC6是干什么的呢?这要从ORC说起。真核生物的DNA有多个复制起始位点(replication
origin),ORC(Origin Replication Complex)是一个很大的蛋白复合体,可以识别这些复制起始位
点。ORC在整个细胞周期里面都是与DNA结合的。在G1期里面,CDC6这个蛋白会与ORC结合,同
时让MCM(DNA解旋酶)也装载到ORC上,形成一个pre-replication protein complex。这个co
q*****n
发帖数: 331
18
来自主题: Biology版 - 弱问 瞬时转染原理
Plasmid DNA does not replicate in mammalian cells.
The only thing they do is to provide a template for RNA transcription
because they all contain strong promoter such as CMV.
Becaue they don't replicate, their level will decrease and dispear after a
few days, that's why they are called "transient expression".
At low frequency, they may intergrate into genome, then they can replicate
along with the genome. You can use antibobitic to select this low frequent
clones, that is called "stable clone se
a****o
发帖数: 1786
19
来自主题: Biology版 - Realtime PCR 郁闷中
Do you mean technical replicates or biological replicates?
Technical replicates should be very similar. It is more likely that your
biological samples are not very similar. rtPCR itself should be very robust
unless you are dancing on the edge of its detection limit (>30 or >35 cycles
).
a****d
发帖数: 1919
20
帮着贴一个过来,呵呵,前几天lab里面还在讨论这个呢。
First Self-Replicating Synthetic Bacterial Cell
First Self-Replicating, Synthetic Bacterial Cell Constructed by J. Craig
Venter Institute Researchers
ROCKVILLE, MD and San Diego, CA (May 20, 2010)— Researchers at the J. Craig
Venter Institute (JCVI), a not-for-profit genomic research organization,
published results today describing the successful construction of the first
self-replicating, synthetic bacterial cell. The team synthesized the 1.08
million base pair chrom
d*****r
发帖数: 2583
21
来自主题: Biology版 - IBM Unveils Cognitive Computing Chips
http://www.youtube.com/watch?v=cia3XfQT2fk
他们的computing hardware还是基于Carver Mead的neuromorphic silicon neuron和
synchronous spiking neuron network, IBM Research在这个方面投了很多钱,甚至把
Kwabena Bohen的实验室以前的PhD学生(John Arthur/Paul Merolla in the video)都
挖到IBM去。现在这个方向还没有看到有大的突破的迹象。
Scientific American 2005, Neuromorphic Architecture:
http://www.stanford.edu/group/brainsinsilicon/pdf/05_journ_SciA
phChips.pdf
IBM Press Release:
http://www-03.ibm.com/press/us/en/pressrelease/35251.wss
ARMONK, N.Y., - 18 Aug 2011:... 阅读全帖
m********m
发帖数: 263
22
An new study from nine labs leads to Partial Retraction of a 2009 Science paper, or even more papers will be retracted:
Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue
Syndrome: A Multi-Laboratory Study
Published Online September 22 2011 Science 11 November 2011:
Vol. 334 no. 6057 pp. 814-817 DOI: 10.1126/science.1213841
Abstract
Murine leukemia viruses (MLVs), including xenotropic-MLV–related virus (
XMRV), have been controversially linked to chronic fatigue syndrome... 阅读全帖
T**********t
发帖数: 25
23
如果是几个individual在一组,那么它们就是biological replicates
生物之间存在biological variation(个体差异)
如果你pool了,就看不到这样的差异
这个问题你应该弄明白
设计的实验的时候 应该有biological replicates和technique replicates
m******5
发帖数: 1383
24
Did anyone here used plasmid or cDNA clones from OriGene?
is their product reliable?
Moreover, in many of their plasmid they denote the plasmid are not
replicable by regular DNA purification method, is this possible? Looks to me
they are just trying to get customers to buy the plasmid from them instead
of purifying the plasmid indefinitely in their own bench
I attached their 'explanation below'
;Due to the inherent nature of this plasmid, standard methods to replicate
additional amounts of DNA ... 阅读全帖
H*******i
发帖数: 196
25
来自主题: Biology版 - 进化论的两大致命伤!
DNA可以“self replication”,不过是双链的self-replication,单链都存在于体系
中(本版著名人物lulu qian的方向相关)
不过体系中的双链都是精心设计过的,自催化是没问题的,“replication”算也行不
算也行。。
w***i
发帖数: 175
26
来自主题: Biology版 - 诺奖得主原来是个接盘侠
更加狗血的是,还真有人把前女朋友介绍给同事去接盘。广大的接盘男们信心大振。
大侠牛B, 大学未毕业就发了三篇paper,其中包括science
UCLA alumnus Randy Schekman, a professor of molecular and cell biology at UC
Berkeley, has won the 2013 Nobel Prize in physiology or medicine for his
role in figuring out how proteins are secreted and transported in human
cells.

He shares the prize with James E. Rothman of Yale University and Thomas C. S
üdhof of Stanford University for solving the mystery of how the cell
organizes its transport system.
Schekman became the... 阅读全帖
G**s
发帖数: 21
27
Co-Author of Stem-Cell Paper Asks for Retraction
Teruhiko Wakayama Says Stem-Cell Research Had ‘Crucial Mistakes’
TOKYO—The co-author of two breakthrough papers on making stem cells said
Monday he had asked for the papers to be retracted, citing “crucial
mistakes” in the research.
The decision is the latest and perhaps heaviest blow against the research,
which was published in Nature in January and has been under intense scrutiny
in recent weeks.
A spokeswoman for Nature said the journal was sti... 阅读全帖
o******n
发帖数: 511
28
谢谢你的回复。
那如果不是balanced design请问怎么处理好?
比如实际中,有的样品测序没有出来,所以不是每个genotype都有3个replicates。
gwas里面每个genotype应该也会测几个replicate的吧,而且也不一定是balanced
design,他们是怎么把不一样大的trait data matrix和kinship matrix联系起来的呀?
也许做gwas的人不会遇到我这个问题吧,他们的每个replicates也都genotype过,有
SNP data,所以trait data和kinship的矩阵大小一致。可是我们没有每株植物的SNP
data。
我这个问题看来真的不好办…… :-(
l********e
发帖数: 415
29
首先,第一种用的是biological replicate, 比较好。
其次,结果不一样的原因是两种算法的n值不一样,第一种是3,第二种是9. 因为实际
上只有3个biological replicate, 所以第二种算法其实是错的。
最后,任何biological replicate小于5的实验,基本上都是耍流氓。
f****b
发帖数: 2410
30
当年和Dr. Howard Green有着同样的志向,奔向医学研究。
Howard Green, Who Found a Way to Grow Skin and Saved Lives, Dies at 90
By SAM ROBERTSNOV. 5, 2015
Dr. Howard Green, at Harvard around 1984, discovered how to regenerate skin
that could be grafted onto burn victims.
On July 1, 1983, two young brothers and a friend were exploring a derelict
house in their Casper, Wyo., neighborhood when they stumbled on several
seductive cans of paint in a cupboard. Mischievously, they splashed the
paint on the walls and, inevita... 阅读全帖

发帖数: 1
31
来自主题: Biology版 - 韩文到底有没有被重复?
This is a good point: Replicable vs. Not replicable.
To claim the replication of another research, one should get the same or at
least similar results
As the original paper using the experimental materials and protocols used by
the authors of
The original paper.

HeLa
c********n
发帖数: 225
32
Date:2016年08月22日
(NBT paper 上线三个多月以后)
(韩春雨Addgene 更新protocol 两个星期以后)
Title:NgAgo你做出来了吗?
Link:
http://blog.sciencenet.cn/blog-851798-997067.html
Key Points:
-在follow NBT原始protocol 无法重复验证NgAgo基因编辑功能之后,作者追加实验,
用Addgene更新的protocol,再次无法重复验证NgAgo基因编辑功能。对照组CRISPR/
Cas9,2/2 成功率。
Date:2016年08月24日(NBT paper 上线三个多月以后)
Title:Go forth and replicate!
Link:
http://www.nature.com/news/go-forth-and-replicate-1.20473
Key Points:
编者注:业界大规模重复验证NgAgo基因编辑功能,而不得其果的经历,
可能会带来对于“重复” (replication)实验数据发表方式的革新。
T**E
发帖数: 1892
33
Neutrino experiment affirms faster-than-light claim - November 18, 2011
An updated version of this story is now available (see 'Neutrino experiment
replicates faster-than-light finding').
It is a remarkable confirmation of a stunning result; but most physicists
remain skeptical. That seems the most probable outcome of a release of new
data expected on 17 November from researchers with the Italian OPERA
collaboration, who say they have confirmed their controversial finding that
flighty subatomic ... 阅读全帖
z****i
发帖数: 406
34
1. 是可以直接算,答案是e^{-rT1}. 他不满意,说有没有别的办法,我想了半天,他
说怎么样replicate. 就是在T1的时候买1/S(T1)个股票就好了。 这就是为什么结果跟
T2无关。
2. 假设expiration date 是T, 现在是t, 现在的股价是S. 如果现在exercise手上的
option, 到T时的收益为(S-K)e^{r(T-t)}. 如果instead我short一个股票,到T时的收
益更多。 (分情况讨论下就看出来了)
3. 大牛,我不是很明白你的意思。。。能不能详细讲一下,或者写个小code啊? 多谢
啦~~
4. 对, 原因是lognormal distribution的性质。
5. B>S时做replication就行。 B 面试官说,用Black Schole做吧。于是就解那个ODE(BS equation 里面的time
derivative项去掉,因为是perpentual的), 解完了找两个boundary condition 把常
数定出来, 结果是 (B/S)^{-
l*********t
发帖数: 89
35
你这是static replicate,但是如果dynamic replicate岂不是就没有arb了么? Black
-Sholes不就是建立在dynamic replicate的基础上么?
并且John Hull的课后题,和有的面试书让price payoff 为 max(S^2-K, 0) 的option
岂不是没有现实意义了么?
还不是完全理解,希望进一步说明,多谢!
k*****x
发帖数: 713
36
来自主题: Quant版 - 关于risk neutral prob一问
option price 都是从 no arbitrage replication 来的。讲究的就是replication, 和什么真的假的probability 一点关系也没有。risk neutral probability 根本就是一个计算的捷径,和 probability 一点关系也没有,这里的本质只有一个就是replication.
n******m
发帖数: 169
37
来自主题: Quant版 - 问道题目
先回答 ghlian:
概率是不一样,但是payoff的分布也不一样。当然,说“对称”是不妥的。
不过这两种情况确实是抵消的。
假设在某个时间 t1, barrier hit了,此时 S(t1)=H, 考虑后续发展,可能最后 S(T)
高于 H,(senario2) 也可能低于 H (senario3)
现在你对所有后续路径积分,integrand = payoff = (S(T)-H) (in both case), 积分
的结果就是
forward(S(t1))-H = S(t1)-H = 0
正解见 xuzhikai19 和 rrua,的 replication.
不过我现在被这种有决策参与的replication搞晕了,
你能用一个exercise price=100的forward replicate出这个barier option的payoff,
好像只能说明这个forward比这个option值钱阿??就像你可以选择永远不early
exercise, 那么american option的payoff也完全跟european的一样,但这不说明两者
同价。
是我哪个地方没弄... 阅读全帖
s*****n
发帖数: 2174
38
你问的问题, 本质上是logitic regression model 的
model diagnostics. 这个问题本身就是一个困难的问题.
你要考虑的, 不是给Y分组, 而是给X分组.
分两种情况
(1) Logistic model with replication
同样的X下, 有多个Y(0/1)的观测. 这种情况比较容易.
你可以比较
Y hat = Model(X)
Y empirical = #1/(#1+#0) under X
然后算一下correlation什么的.
(2) Logistic model without replication
同样的X下, 只有一次Y的观察, 或者是0或者是1. 这种
情况下, 必须借助额外的assumption. 常用的就是model
的连续性, 即相似的X意味着相似的P(Y=1)
这时, 需要把所有的observation根据X进行clustering.
然后在每个cluster内, 看成是replication. 进行第一
种情况那样的算empirical rate和predicted rate.
可是如果X的维度较高, 高
o****o
发帖数: 8077
39
来自主题: Statistics版 - R的循环语句该怎么用。
for this particular question, SAS actually is pretty handy:
*******************************;
data test;
do id=1 to 20000;
x=rannor(0);
output;
end;
run;
ods select none;
proc surveyselect data=test out=samp method=srs
seed=93759437 sampsize=1000 rep=100 ;
run;
ods select all;
proc univariate data=samp noprint;
by replicate;
histogram x/outhistogram=hist outkernel=kernel noplot;
run;
proc sgplot data=hist;
series x=_MIDPT_ y=_OBSPCT_ /group=replica... 阅读全帖
b******a
发帖数: 704
40
ZZ: What is hepatitis B? — Hepatitis B is a serious disease that harms the
liver. The liver is a big organ in the upper right side of the belly. A
virus causes this disease. The virus spreads from person to person when
their bodily fluids touch. This can happen in a few ways, like having sex or
sharing needles.
It is estimated that there are more than 300 million carriers of the
hepatitis B virus in the world, with over 500,000 dying annually from
hepatitis B-related liver disease. In China, HB... 阅读全帖
f*******y
发帖数: 421
41
来自主题: Neuroscience版 - ibm cognitive computing
Today, IBM researchers unveiled a new generation of experimental computer
chips designed to emulate the brain’s abilities for perception, action and
cognition. The technology could yield many orders of magnitude less power
consumption and space than used in today’s computers.

In a sharp departure from traditional concepts in designing and building
computers, IBM’s first neurosynaptic computing chips recreate the phenomena
between spiking neurons and synapses in biolog... 阅读全帖
f*******y
发帖数: 421
42
来自主题: Neuroscience版 - ibm cognitive computing
Today, IBM researchers unveiled a new generation of experimental computer
chips designed to emulate the brain’s abilities for perception, action and
cognition. The technology could yield many orders of magnitude less power
consumption and space than used in today’s computers.

In a sharp departure from traditional concepts in designing and building
computers, IBM’s first neurosynaptic computing chips recreate the phenomena
between spiking neurons and synapses in biolog... 阅读全帖
c******o
发帖数: 1184
43
高新技术?
MakerBot Replicator 2 Desktop 3D Printer
$2,199.00 & FREE Shipping.
http://www.amazon.com/MakerBot-Replicator-Desktop-3D-Printer/dp
T*******x
发帖数: 8565
44
来自主题: History版 - 韩春雨论文正式撤稿 (转载)
【 以下文字转载自 Biology 讨论区 】
发信人: cancercell (cancercell), 信区: Biology
标 题: 韩春雨论文正式撤稿
发信站: BBS 未名空间站 (Wed Aug 2 17:02:39 2017, 美东)
We are retracting our study because of the continued inability of the
research community to replicate the key results in Figure 4, using the
protocols provided in our paper. In this figure we report that the
Natronobacterium gregoryi Argonaute can efficiently create double-strand
breaks and edit the genome of human cells using 5ʹ phosphorylated
single-stranded DNA ... 阅读全帖
T*******x
发帖数: 8565
45
来自主题: History版 - 韩春雨论文正式撤稿 (转载)
《自然-生物技术》社论与韩春雨及同事的撤稿声明
原文以Time for the data to speak为标题
发布在2017年8月2日的《自然-生物技术》社论上
标题:是该数据说话的时候了
doi:10.1038/nbt.3938
一项宣称通过Argonaute酶实现基因编辑的研究被撤回,这显示了论文发表后的同行评
议在全天候媒体时代的重要性。
本期,韩春雨及同事撤回了发表于去年5月的一篇论文。该论文称,短5′磷酸化单链
DNA可引导格氏嗜盐碱杆菌核酸内切酶(NgAgo)产生双链断裂,实现对人类基因组的编
辑。论文一发表,便引起科研人员的极大兴趣和媒体的竞相报道。但是很快,在推特
、 博客和其它社交媒体的助燃之下,有关该研究可重复性的质疑开始迅速增多。去年
11月 ,本刊发表了“编辑部关注”(Editorial Expression of Concern),提醒科研
界留 意这些可重复性方面的担忧。为了最终解决这个争议,多个研究小组在数月里生
成了更 多的实验数据。如今尘埃落定,这也是世界各地的许多实验室为澄清NgAgo的功
能而付 出的大量时间、精力和资金的证明。
韩春雨的这篇论... 阅读全帖
y***u
发帖数: 7039
46
来自主题: Military版 - 罗伯特揭露方二剽窃的公开信
An Open Letter to Shi-Min Fang
from Robert Root-Bernstein, Ph. D., Professor of Physiology,
Michigan State University, East Lansing, MI 48824 USA;
r******[email protected].
Dated 3 August 2011.
A number of people, including myself, have accused you of plagiarizing my
work. You and your followers have denied it. Let’s use this difference of
opinion to educate ourselves about what constitutes plagiarism in and see if
we can reach an accord.
Let me begin by stating that I am basing my arguments on The Univ... 阅读全帖
l*****7
发帖数: 8463
47
来自主题: Military版 - 科研造假,低素质是个大问题
科研造假,低素质是个大问题
1.
http://www.reuters.com/article/2012/03/28/us-science-cancer-idU
In cancer science, many "discoveries" don't hold up
2.
http://www.mitbbs.com/article_t/Biology/31915105.html
eLife将检验50篇高引用率文章
发信人: Addgene (基因加加加), 信区: Biology
标 题: eLife将检验50篇高引用率文章
发信站: BBS 未名空间站 (Mon Sep 22 16:30:07 2014, 美东)
ELife 编辑Randy Schekman 在访谈中说:“We've been approached by an
organization called the Reproducibility Project, where a private foundation
has agreed to provide funds for experiments in the fif... 阅读全帖
w*********g
发帖数: 30882
48
美国人工智能程序ALPHA在模拟空战中战胜资深战斗机飞行员,或将开启无人自主智能
空优战斗机之门】
来源: replicator 于 2016-06-29 05:00:10 [档案] [旧帖] [给我悄悄话] 本文已被
阅读:553 次 (3890 bytes)
字体:调大/重置/调小 | 加入书签 | 打印 | 所有跟帖 | 加跟贴 | 当前最热讨论主题
本文内容已被 [ replicator ] 在 2016-06-29 05:03:00 编辑过。如有问题,请报告
版主或论坛管理删除.
一个人工智能战斗机驾驶系统在模拟空战中击败了两架进攻的喷气战斗机。据英国广播
公司(BBC)6月28日报道,被称为阿尔法的人工智能系统使用了4个模拟喷气战机对抗两
个攻击战机,在没有损失的情况下,成功地防守一个海岸线。
据报道,由美国研究人员开发的阿尔法系统还在模拟空战中对抗两名退役的战斗机驾驶
员,结果人工智能系统取得了胜利。
在这次模拟空战中,由两架攻击喷气战斗机组成的蓝队具有更强的武器系统。但是阿尔
法的红队通过躲避动作击败了敌机。一名军事航空专家说,这个结果具有深远的意义。
来自辛辛那提大学... 阅读全帖
c****3
发帖数: 10787
49
来自主题: Military版 - 诺贝尔化学奖的应用
stargate里有个东西叫replicator,就是直接在原子层面的分子机器人,吃进去的金属
,不管是什么,自动组装成新的replicator。这个已经远远超出我们现在技术能力的想
象了。

possibility
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