c******r
发帖数: 3778 | 1 好像没有直接证据表明二者相关。
你上面说的间接关系是有可能的。就是说hypoxia导致肿瘤细胞migrate out of solid
tissue来获取养料，从而导致metastasis。但是这需要证据。最简单的，比如做个
migration assay，一边hypoxia，一边normaxia，然后看细胞是否向normaxia方向
migrate。当然这个实际操作上有些困难，最主要是现在的各种膜都是对oxygen自由通
透的。无法形成oxygen的梯度。
另外想办法的话，可以复杂点，直接做animal model。不是有VEGF inhibitor嘛。把肿
瘤细胞标记上luciferase之类的，然后打到老鼠里面。长到一定大小之后定期打
inhibitor，观察metastasis的差别。但是这也有技术问题。主要是现在的metastasis
没有特别好的model。皮下打的肿瘤，多数都不会自发地metastasis。所以可能需要做
些前期工作来找一个比较容易metastasis的cell line。 |
|
h*****t
发帖数: 103 | 2 谈一点点个人不成熟的看法，因为我也几乎没有做过肿瘤相关的实验，所有的观点也是
基于对文献的阅读和自己的经验，仅供参考，说的不当的地方，请大家随便拍砖。
问题一：Metastasis 和hypoxia 有明确的关系么？有人做过这方面的研究么？比方说
在时间顺序上，是先出现hypoxia，然后才出现metastasis 么？
首先从定义上来看吧，什么转移？转移就是肿瘤细胞离开原发部位，到远隔脏器形成新
的肿瘤灶。转移最容易发生在什么部位？不同的肿瘤可能尤其倾向性，一般而言，肺很
多时候是第一个受侵犯的器官（乳腺癌和前列腺癌第一个转移的远隔器官常常为骨，当
然乳腺癌第一站常为前哨淋巴结）。从肺来看，缺氧么？把鼻子和嘴巴同时都捏紧会出
现这种可能性。至于Metastasis 和hypoxia之间的关系，可能是原发部位由于肿瘤细胞
生长越来越多，造成hypoxia，而hypoxia促使肿瘤细胞发生改变，尤其是其运动、迁移
能力的改变，从而促进metastasis，metastasis之后在新的部位可能又会造成hypoxia
，然后开始下一站.....鸡和蛋好像也这样的吧？
问题二：可是如果抑制了... 阅读全帖 |
|
s**********a
发帖数: 92 | 3 对于breast cancer lung metastasis，现在发表的文章都是这样：knockdown一个基因
，lung metastasis 被抑制，但细胞生长不受影响。
我这个基因在 breast cancer cell 里面 knockout 后，lung metastasis 几乎完全被
抑制。但同时，细胞生长也受到抑制。请问这种情况下，是不是得先考虑细胞生长对
metastasis的影响？
谢谢！ |
|
n*******n
发帖数: 540 | 4 【 以下文字转载自 Faculty 讨论区 】
发信人: nnnnnnnnn (hv), 信区: Faculty
标 题: Postdoctoral Fellow position in Cancer Metastasis, Nanotechnology and Biology
关键字: postdoc,postdoctoral fellow
发信站: BBS 未名空间站 (Fri Jun 15 10:42:34 2012, 美东)
Postdoctoral Fellow in Cancer Metastasis, Nanotechnology and Biology
The Laboratory for Drug Delivery and Personalized-Medicine Technologies,
Faculty of Chemical Engineering, Technion - Israel Institute of Technology
, Haifa, Israel
Dr. Avi Schroeder, PhD
Metastasis, the sprea... 阅读全帖 |
|
n*******n
发帖数: 540 | 5 Postdoctoral Fellow in Cancer Metastasis, Nanotechnology and Biology
The Laboratory for Drug Delivery and Personalized-Medicine Technologies,
Faculty of Chemical Engineering, Technion - Israel Institute of Technology
, Haifa, Israel
Dr. Avi Schroeder, PhD
Metastasis, the spread of cancer to distant sites, is the leading cause of
cancer deaths. In this project we will construct nanotechnology tools for
detecting and treating metastatic cancer. This position requires previous
expertise with bio... 阅读全帖 |
|
a***u
发帖数: 155 | 6 上次發了一個關於tumor suppressor gene 的帖子，得到大家的熱情指教。因為本人以
前不是做 cancer的，很多問題很糊塗，也找不到人討論，希望大家多多指教。
今天聽了本實驗室一個 韓國來的volunteer postdoc 的data presentation, 他的
project 是identify 某種 cancer 的metastasis driver基因。前面我說過，我們老板
是醫生，不懂research， 都是二老板指導我們做。這個韓國postdoc 是這麼做的：拿
來一個egfr mutation 的細胞株，提rna，做miroarray, 得到的結果跟public
database里另一個 egfr mutation的細胞株結果比較，他把 fold 設在1.5的時候找到
這兩個細胞株共同上調（相對於parental cell)的基因是41个，fold 設在2.0的時候是
7个，他然後用realtime pcr confirm, 找出大概五個基因，然後再用western blot最
後只剩 1－2个是real 上調的，然後他找到這個基因的相關 back... 阅读全帖 |
|
s******y
发帖数: 28562 | 7 Metastasis 和hypoxia 有明确的关系么？
有人做过这方面的研究么？比方说在时间顺序上，是先出现hypoxia，然后才出现
metastasis 么？ |
|
s******y
发帖数: 28562 | 8 我感兴趣的是，hypoxia是不是metastasis 的必要因素？
好像已经有不少证据表明是先有hypoxia，再有metastasis。 但是这两者之间有没有直
接的因果关系？ |
|
c******r
发帖数: 3778 | 9 是滴，非常正确。
即使你喀嚓了所有血管，也需要证明组织确实hypoxia了，而且还需要证明这个hypoixa
跟以后的metastasis有关，而不是因为喀嚓产生的其他物质，或者手术创伤引起的
metastasis。有很多工作要做。但是首先要尝试一下血管是否足够清楚能够喀嚓掉，然
后再说后面的事情。
2 |
|
q******g
发帖数: 3858 | 10 metastasis是很复杂的过程吧，invasion, migration离开primary site,然后在肺部附
着，生长。
我觉得你先做in vitro， 看是否影响invision, migration, proliferation, EMT,
MET, adhesion. 然后动物实验证明的确影响metastasis. |
|
l******u
发帖数: 936 | 11 whitehead 的巨牛 Bob 大叔， 现在狂做 EMT， 这个就是metastasis 领域现在最
热的方向了,还有 UCSF 的Doug，也做， 不过现在搬到瑞士洛桑的癌症研究所当所
长了， 他跟bob大叔写的review “The hallmarks of cancer” 可能是cancer 领
域引用最多的文章了, 700 times/year 。 |
|
z********i
发帖数: 610 | 12 但是马上就会成为da niu了
Massague以前也不做metastasis,应该是从kang以后才开始做的。 |
|
s*******g
发帖数: 3332 | 13 不知道有没有比较好的high throughput screening方法可以用来筛选metastasis
inhibitor? 查了查文献好像没有什么好的方法。
有了解这个的同学请帮忙解答一下，多谢。 |
|
b*****l
发帖数: 9499 | 14 正好前些日子读到去年的一篇 Gupta/Weinberg/Lander 合作的 Cell 文章，讲如何 ta
rgetting EMT 来 HT screening selective inhibitors against cancer stem cell 的
。既然是 targetting EMT 么，大约也适合你的 metastasis-specific inhibitor 的要
求。
Gupta, P. B.; Onder, T. T.; Jiang, G.; Tao, K.; Kuperwasser, C.; Weinberg, R
. A. & Lander, E. S. Identification of selective inhibitors of cancer stem c
ells by high-throughput screening. Cell, oadinstitute.org, 2009, 138, 645-65
9 |
|
O******e
发帖数: 4845 | 15 不是搞这个的，不过感觉应该是metastasis需要hypoxia来维持肿瘤的
microenvironment。
这样说，似乎应该是从H-M. |
|
j**e
发帖数: 582 | 16 My guess is, when tumor (primary or metastasis) is formed from a tiny colony
, it has enough O2. When it growth larger, it become hypoxic, inflammatory
and oxidative in property, which would promote its dissemination and
migration. |
|
s******y
发帖数: 28562 | 17 我也有类似的想法，但就是不知道这个是否已经证实。
比方说，如果故意把某个肿瘤的血管堵起来，是否会引发高度的metastasis?
colony |
|
s******y
发帖数: 28562 | 18 嗯，你这个例子似乎说明hypoxia 是invasion/metastasis 的上游信号。
那么现在的问题是，如果这个事情是真的话，那么单纯使用那些什么个血管生成抑制剂
岂不就会导致癌症扩散？ |
|
s******y
发帖数: 28562 | 19 嗯，我还觉得可以有另外一个比较粗暴直接的方法，就是通过手术方法把小鼠上种的肿
瘤的血管给咔嚓了，然后看看是不是就会在短时间内诱导一大群肿瘤细胞跑出来？至于
control嘛，可以在很近的地方种两个瘤，一个咔嚓，另外一个不咔嚓。
solid
metastasis |
|
c******r
发帖数: 3778 | 20 这个marker其实不难搞，就是transfect一个HIF promoter drive的东西就可以了。
不过你要真做的话要小心几个问题：
1. hypoxia在实体肿瘤里面是永远存在的。即使你不喀嚓那些血管也一样有marker的表
达。因此你的background会比较高。
2. 即使喀嚓掉血管，如果不能有效抑制VEGF等signal，血管会很快又长出来的，而且
会越来越多，越喀嚓越多，导致你无法实现有意义的hypoxia。
3. 因此，喀嚓血管可能需要和VEGF inhibitor啥的联合使用。可以看情况再考虑这个
问题。
4. 你的control tumor也需要相似的剥离，但是不结扎血管。因为显然剥离的创伤有可
能破坏tumor的包膜而导致扩散，与hypoxia无关。
5. 你的种植的tumor一定要有很高的metastasis比例才行，否则后续试验无法进行。这
种cell line可以去找找，有人有这样的cell lines。
仅供参考 |
|
c******r
发帖数: 3778 | 21 不客气，为艳mm效劳。。。
这个idea是个不错的idea：hypoxia drives metastasis。
不过技术上可能要花点时间才能搞定。如果这个系统能work就好了，虽然我看work的可
能性有点危险啊 |
|
s******y
发帖数: 28562 | 22 我也就是随便想想而已，不一定能做下去。
我其实不想去用血管生长抑制因子。因为那些因子本身会导致细胞生长的变化，
后面的结果就很难解释了。
至于血管是否能剪干净的问题，其实，剪得太干净不是一件好事，
剪的太干净的话肿瘤细胞可能在短时间内就统统坏死了，后面就没得做了。
关键是要找一个能够定量的hypoxia marker, 然后用来和metastasis 做correlation. |
|
s**********e
发帖数: 2888 | 23 计划用tail vein injection of B16F10 cells去看metastasis, 这个实验看着很容易
，想问一下这个实验容易做不？老鼠之间variation大不大？谢谢了。 |
|
s******y
发帖数: 28562 | 24 你这个题目起的。。。完全是把人家的意思搞反了吧？
这个项目今年4月份的时候我在AACR听了Dingcheng Gao讲的，他们的数据还是很清楚的
。其实在我认识的那些做病人病理的人从来都不认为EMT 和metastasis 有什么直接关
系。他们觉得这个就是一些做细胞生物的人在乱炒作概念。
不过这篇文章等了这么久才出来还是有点让我惊讶的。 |
|
c********6
发帖数: 189 | 25 1. 文章题目取的有点over与tricky，应该取作is not required for "all"
metastasis还比较恰当！
2. 文章内容把cell-based assay说的一文不值，可是EMT影响chemoresistance却是早
被很多人在cell-based system证实过！ |
|
v**********m
发帖数: 5516 | 26 楼上文章的comments
Not yet but stay tuned. But a definite fact and you can review it in the FDA
's analysis in the briefing document is that there was no SS of astrocytomas
in male rats or female rats.
Dr. Alavi had concerns about how Arena calculated the exposure margin for
Lorcaserin, that is why it appeared in the CRL. When Arena met directly with
the FDA on December 15th and 16th at the FDA, both Arena and the FDA agreed
on the CSF methodology and the number of participants that would be
acceptab... 阅读全帖 |
|
l**x
发帖数: 296 | 27 Based on AJCC gastric cancer staging:
pT2 N0 Mx
侵及肌层，无淋巴结转移, 远端转移未知
It would be nice to have PET/CT scan to evaluate distant metastasis
if there is no distant metastasis, the final stage would be Stage IB
still considered fairly early.
There are a few ongoing clinical trials. The optimal
regimen for postoperative chemoradiotherapy has not yet been established.
The common chemotherapy drugs includes:
5-FU, VBL, CTX, MeCCNU, Ara-C
FYI:
Primary tumor (T)
TX: Primary tumor cannot be assessed
T0: No... 阅读全帖 |
|
S**********e
发帖数: 1789 | 28 给你看看我们系刚进来的助理教授
Vanderbilt University School of Medicine
Fingleton, Barbara Mary , Ph.D. Assistant Professor of Cancer Biology
Publications
Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK
, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required
for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Cancer Res, 71(4), 1302-12, 2011.
Koon, HB, Fingleton, B, Lee, JY, Geyer, JT, Cesarman, E, Parise, RA, Egorin,
MJ, Dezube, BJ... 阅读全帖 |
|
M********s
发帖数: 104 | 29 以前网上淘到的一个,
College of _____
Department of __________
XXX ____ Avenue, 7th Floor
(city), (State) (zip) (推荐人地址)
August 12, 2007
U.S. Citizenship & Immigration Services
Nebraska Service Center
850 “S” Street Lincoln, NE 68508
Re: Dr. ____ ___ (your full name)
Dear Sir/Madam,
I strongly support the National Interest Waiver application for ______ ___,
M.D, Ph.D.. Dr. ___ is an extraordinary young scientist who is making
significant contributions to our understanding of ... 阅读全帖 |
|
l*h
发帖数: 4124 | 30 1. i would have been completely honest with the pt from the beginning, to
explain the options at hand. quite few patients pursue painful treatment
without known benefits.
2. i would have ordered FDG-PET before surgery to look for metastasis.
regional met should be easily seen on CT or ultrasound before surgery. when
there is regional metastasis, there is almost certain also remote metastasis
. there is just some time lag. you cannot assume there is no. i truly don't
trust the so-called "spleen s... 阅读全帖 |
|
v*******n
发帖数: 8995 | 31 好像非常合适我的背景，请考虑一下我， 谢谢
ying wang
[email protected]
/* */
背景是molecular biology，cancer(ovarian cancer, tumor metastasis)/stem cell
biology
文章有molecular cell 和cancer research
1. Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, and Sen GL.DDX6
Orchestrates Mammalian Progenitor Functionthrough the mRNA Degradation and
Translation Pathways. Mol Cell. doi:10.1016/j.molcel.2015.08.014
2. Mistry DS, Chen Y, Wang Y, Sen GL. Transcriptional profiling of SNAI2
regulated genes in primary human kerat... 阅读全帖 |
|
y*****l
发帖数: 5997 | 32 1月有个会议，这个最近有什么炒点吗？
Exelixis reports encouraging data from Phase II MBC trial
4 days 2 hours 36 minutes ago - Datamonitor via Comtex
Exelixis, Inc., a biotechnology company, has reported positive preliminary
data from a cohort of 45 patients with metastatic breast cancer, or MBC,
participating in the ongoing cabozantinib Phase II randomized
discontinuation trial, or RDT.
As of the October 15, 2011 data cut-off, 45 patients with previously treated
estrogen receptor-positive, triple negative, or in... 阅读全帖 |
|
m****s
发帖数: 18160 | 33 【 以下文字转载自 Biology 讨论区 】
发信人: valine (valine), 信区: Biology
标 题: Postdoctoral position available
发信站: BBS 未名空间站 (Mon Jul 1 15:38:12 2013, 美东)
Postdoctoral Fellow Position
A postdoctoral fellow position is available to study ERK3 kinase signaling
in cancer progression and metastasis. ERK3 is a member of the atypical MAP
kinase subfamily. In contrast to the well-studied classic MAPKs, such as
ERK1/2, little is known concerning the molecular regulation of ERK3
signaling and its function in cancer... 阅读全帖 |
|
T**********e
发帖数: 29576 | 34 下面这篇文章对Jobs的胰腺内分泌癌治疗总结的不错，看来死的有点冤。
1. 10-2003 确诊，07-2004终于手术切除，期间Jobs一直在试自己选的diet疗法。扫描发现癌变在扩大才动了手术，这段时间癌转移的多少不可知，但肯定越拖转移的越多。
2.手术后没化疗和放疗。Jobs 2005年演讲说这表明病情乐观，不知是哪个庸医给他灌输的。2004年手术是大面积切除，部分胰腺和胃和小肠，胆和胆管都切除，目的是要消除扩散，但不系统化疗和放疗怎么能最大程度减少扩散威胁？哪个外科大夫这么信自己的手艺？
3.2009年换肝，这在扩散性癌治疗是有争议的，因为换肝后压制免疫反应有可能促进别处癌的生长。也有可能当时肝已经不行了没办法。
这种癌正常治疗大多数可活10年以上，Jobs真该到东岸Hopkins或Harvard找个靠谱的大夫。
Jobs’s Unorthodox Treatment
Some of Apple trailblazer Steve Jobs’s cancer treatment choices, from
alternative therapies to a liver tra... 阅读全帖 |
|
i****e
发帖数: 156 | 35 In my understanding, EMT & metastasis must be related with CSCs, CAFs, and
cancer cell microenviroment. I donot believe any cancer cell can regenerate
a tumor after spreading to other tissues. Only CSCs can. I also believe the
cross-talking between cancer cells and CAFs, and the microenviroment of
cancer cells have important regulation to metastasis. So before discovering
an effective metastasis-inhibitor, we need to clear the metastasis mechanism
first. |
|
v****e
发帖数: 131 | 36 I am an Assistant Professor in the Dept. of Molecular and Cellular Biology
at Baylor College of Medicine, Houston, Texas. A postdoctoral fellow
position is currently available in my lab. My research interests/projects
include:
1. ERK3 signaling in cancer progression and metastasis, with a particular
interest in inflammation-associated cancer progression and metastasis.
Extracellular signal-regulated kinase 3 (ERK3) is a member of the atypical
MAP kinase subfamily. Unlike ERK1 and ERK2 that have ... 阅读全帖 |
|
l********n
发帖数: 260 | 37 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M,
Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC,
Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage
response and radioresistance through CHK1. Nat Cell Biol. In Press.
2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-
Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces
epithelial-mesenchymal transition but suppresses tumorigenesis, migration
a... 阅读全帖 |
|
l*h
发帖数: 4124 | 38 i knew both TACE and sorafenib were approved for HCC. however i question the
indications upon which they were used.
why was TACE used as a primary treatment when multi-site metastasis already
occurred and local sites and regional metastasis were resected?
i don't think anyone has shown sorafenib is effective when remote metastasis
is obvious.
i truly don't think it's ethical to use every patient as a lab rat. in
addition, there is no proper study design, there will be no improvement for
future t... 阅读全帖 |
|
l*h
发帖数: 4124 | 39 regarding Tc-99m bone scan: it reflects bone-building activities. dark spots
are most commonly seen 1. after fracture, before healing is complete; 2.
primary bone tumors; 3. bone metastasis. other causes include chronic bone
infection and late stage of aseptic necrosis. certain arthritis can also
cause increased update at those sites.
all those diseases have some scintillation signatures on the scans. so a
careful reading can give a likely cause of the increased uptake. i am not an
expert in rea... 阅读全帖 |
|
l*h
发帖数: 4124 | 40 regarding Tc-99m bone scan: it reflects bone-building activities. dark spots
are most commonly seen 1. after fracture, before healing is complete; 2.
primary bone tumors; 3. bone metastasis. other causes include chronic bone
infection and late stage of aseptic necrosis. certain arthritis can also
cause increased update at those sites.
all those diseases have some scintillation signatures on the scans. so a
careful reading can give a likely cause of the increased uptake. i am not an
expert in rea... 阅读全帖 |
|
G***G
发帖数: 16778 | 41 现在有如下这些胃癌数据参数。老板让挖掘。我不知道挖掘什么。
有经验的请指点一下，这些临床数据中可以挖掘些什么？
how to do clinical analysis based on clinical data?
maybe this is a big question.
let's give an example. suppose we have the 200 gastric patients' data like
the following. What kind of analysis should be done? what parameters should
be focused
and what parameters should be ignored?
Classification by age
hospital days
Postoperation hospital day
Family history
Biopsy before surgery
Operation duration(min)
Surgeon
Anesthesia
Volume of blood tr... 阅读全帖 |
|
s******r
发帖数: 2876 | 42 搭车问一声，这个tumor suppressor 和 metastasis suppressor怎么区别？
如果已经抑制tumor growth了，甚至导致tumor shrink了，tumor cell数目已经减少了
，那可转移的tumor cell也少了，不是也会导致metastasis减少了吗？
我做的这个基因是tumor suppressor and/or metastasis suppressor, 这个才是我做
的方向, 有好多老鼠的活要做.
embryonic lethal这种事有点难, 主要是我没啥development的经验. 先干着吧. 我本
来跟老板说我不想lead这个project, 现在估计只有我能lead, 除非老板再招一个人干
活, 我就可以把这个脱手了.
上个月刚刚写了一个新的关于cancer的animal protocol(实验室以前没有独立的animal
protocol), 还好以前phd的时候写过不少类似的. 现在又写一个development的
protocol, 这两个月都在写东西. 老板坚决不肯在animal protocol上出现他老 |
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h********n
发帖数: 4079 | 43 要有单独的实验证明. 比如在细胞上做knockdown or overexpress, 但后打到老鼠尾
巴静脉看哥哥器官的cancer.
不过总体来说, metastasis suppressor 比较难确认, 因为in vivo的实验是必须的,
而且实验方法不太多. 所以你看看文献里面metastasis suppressor确认的数目不多.
有几篇review讲了这个问题, 我现在找不到, 你自己查查吧.
如果是rumor suppressor and metastasis suppressor, 实验会有些难度, 我也不太有
经验.
animal |
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i****e
发帖数: 156 | 44 Acturally I do not think anyone can give you an exact answer. First,no one
can guarantee a surgery is able to remove all the cancer cells in a patient,
Second, no one knows if the metastasis has happened before a surgery. So
metastasis could be happening either before or after a surgery. Of cos, the
earlier to do surgery, the less chance of metastasis, and the longer life
for the patient to survive. |
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G***G
发帖数: 16778 | 45 how to do clinical analysis based on clinical data?
maybe this is a big question.
let's give an example. suppose we have the 200 gastric patients' data like
the following. What kind of analysis should be done? what parameters should
be focused
and what parameters should be ignored?
Classification by age
hospital days
Postoperation hospital day
Family history
Biopsy before surgery
Operation duration(min)
Surgeon
Anesthesia
Volume of blood transfusion
Ascites
Peritoneal metastasis
Hepatic metastas... 阅读全帖 |
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s******y
发帖数: 28562 | 46
看到是可以看到的，做病理的那些人也不完全否定EMT 的存在，他们最反感的是传统理
论里把EMT 作为癌症转移的前提。我上面说的有点不太清楚，我那个同事生气的背景是
这样的：我和他讨论一个癌症转移有关的合作项目，然后我说我要检测一下这个东西是
否引起EMT, 用这个来作为项目的理论背景，然后他就怒了说EMT 和metastasis 在病
理上从来没有人确认过关系，都是一些做细胞生物的人炒出来的搞得这个好像是定论一
样，事实上根本就是一个没啥证据的假说。但是因为这个假说影响力太大，他发有关
metastasis 的病理文章的时候经常碰到审稿人要求他去检测这个东西，每次都被他骂
回去。
我另外一个做前列腺癌的同事也说了类似的事情。还说最近她一篇文章被审稿人死缠着
去测她的东西是如何影响EMT, 然后她实在拗不过就去测了，但是发现说她做的那个会
促进metastasis 的东西其实是会增加e cadherin 以及其他epithelial marker 的表达
的，也就是说和EMT 正好相反。但是这个又不能叫MET, 因为那些癌细胞本来就不是
messenchymal cell. 然后审稿... 阅读全帖 |
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g*****j
发帖数: 1211 | 47 Single lesion < 5 cm without metastasis, the best treatment is liver
transplant, with a 5yr survival > 70%. If metastasis already occurred,
complete recovery is difficult. A new drug Sorafenib can extend median
survival by 12 wk. |
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t*******n
发帖数: 4445 | 48 Yes. The surgeon can do their best to look for metastasis. But that does
not guarantee against recurrence.
The reason is the tumor constantly sheds cells into the body's circulation (
If I remember correctly, up to 100,000 cells for a 1cm x 1cm tumor). Most
of them are killed by the body's immune system, but a single one spared can
lead to metastasis. |
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g*****j
发帖数: 1211 | 49 想请问大家的问题包括以下：
1.这种情况预后会很差么？在网上搜了一下淋巴转移还是很影响预后的，但是不知道具
体到父亲这种情况，就是术后几年以后出现转移，发现得早，这样子的预后具体会有多
乐观还是悲观。
- I am not familiar enough with esophageal cancer. But overall,
metastasis to the lymph node is always bad news. In terms of prognosis,
whether or not metastasis is present matters more than the size of
metastatic tumor.
2.本来想让父母今年到美国来玩的。机票也都买好了，父亲现在还是很想来的。我们也
支持，到这边玩玩心情好一些，也许病情会有转机。（他们以前来过几次，每次也都还
玩得挺开心的）。但是不知道这二个月以后的复查要怎么样。医生说要做个CT看一下。
可是旅游保险好像都不保pre-existing conditions，所以想问问各位知不知道没有保
险做CT大约... 阅读全帖 |
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