g**p
发帖数: 32 | 1 official definition from textbook:
genes sharing common ancestry are called homologs.
if genes are homologs and there's no evidence of gene duplication, they're
called othologs.
if there is evidence of gene duplication, genes derived from one copy of the
duplicate are also called othologs.
Genes derived from two respective copies of the duplicate are called paralogs. |
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G********n
发帖数: 615 | 2 H^p(cohomology group) = H_p(homology group) is not true.
H^p(cohomology group) = H_p(homology group) + torsion term in some sense. |
|
H****N
发帖数: 997 | 3 It should work. Just be aware that you will have two possible recombination
events: in one event, the middle fragment is used and therefore you
insertion will not be introduced; in another, the fragment on the side is
used and you will have the desired allele with you insertion. You have
to have a genotyping strategy that can distinguish these two events. You may
also increase the length of the homologous fragment on the side to maximize
your chance of success. This is actually very similary to |
|
z**m
发帖数: 48 | 4 我们有一个蛋白， 跟一个同family 的蛋白（已经知道结构） 应该类似，但是
sequence identity 很低
有没有能 指定按照这个结构来做homology model的地方？ （ 如果自动选择肯定不会
选择这个，而是会选择一些错误的，但是sequence 类似的结构）
包子感谢 |
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m*****i
发帖数: 628 | 5 我干兴趣如下几个小鼠lncRNA 基因，如何找它们的人类 homolog 基因？谢谢！
E030003E18Rik
4930579G18Rik
4933404O12Rik
2900005J15Rik
4930526I15Rik
4921531C22Rik
9330133O14Rik
C430049B03Rik
A930005H10Rik |
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t**********1
发帖数: 16 | 6 先谢谢
我用 = 表示isomorphism, n是compact流型的维数:
H^p(cohomology group) = H_p(homology group)
而Poincare duality又说：
H^p = H^{n-p}
So: H_p = H_{n-p}。
但是我发现对好多情况不对啊，比如二维圆盘 D^2，
H_0 = Z, H_2=0
是不是哪里理解错了？难道dual spaces不是isomorphic? |
|
发帖数: 1 | 7
Download pdf published by SfN (Chapter from 'The History of Neuroscience in
Autobiography, Volume 8' edited by Larry R. Squire)
Yuh-Nung Jan's CV
Lily Jan's CV
Yuh-Nung Jan and Lily Jan
Birth
Family History and Growing Up
National Taiwan University
The Hiking Trip to Shitou in the Spring of 1967
Graduate School Application
Graduate Study at Caltech (1968锟974)
Seymour Benzer Lab (1974锟977)
Steve Kuffler锟絪 Lab at H... 阅读全帖 |
|
x****6
发帖数: 4339 | 8
The occurrence of concentrated pneumonia cases in Wuhan city, Hubei province
of China was first reported on December 30, 2019 by the Wuhan Municipal
Health Commission (WHO, 2020). The pneumonia cases were found to be linked
to a large seafood and animal market in Wuhan, and measures for sanitation
and disinfection were taken swiftly by the local government agency. The
Centers for Disease Control and Prevention (CDC) and Chinese health
authorities later determined and announced that a novel coro... 阅读全帖 |
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l**********1
发帖数: 5204 | 9 only for paralogous
please go to
//www.ncbi.nlm.nih.gov/pubmed/15865991
its page one:
What is paralogy?
Since Darwin, for most biologists (or at least, for evolutionary biologists) homology has
come to mean something like ‘similarity due to common descent’, to distinguish it from
similarity due to convergent evolution. An accurate understanding of the relationships
between living things depends upon correctly identifying homologous characteristics of
an organism from other similarity. A classic ... 阅读全帖 |
|
p*****c
发帖数: 20445 | 10 Marc R. Freeman, Ph.D.
HHMI Early Career Scientist
University of Massachusetts Medical School
Neurons hog the attention, but our brains couldn’t operate without the
unassuming neural cells called glia. Marc Freeman is working to bring these
overlooked cells—which represent about 60 percent of brain cells—their
share of credit.
Freeman has been dissecting the role of glia in brain development, function,
and healing after injury, when glia hurry to the damaged area and devour
cellular debris to al... 阅读全帖 |
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g*******y
发帖数: 380 | 11 proc sql;
create table test as
select a.homolog, a.weather, avg (a.conc) as conc_st1, avg(b.conc) as
conc_st2
from st1 as a,
(select * from st2
where conc ne 0 )as b
where a.homolog=b.homolog and a.weather=b.weather and a.cas=b.cas
group by a.homolog, a.weather;
quit;
The idea is get the average conc value by weather and homolog based on the
observations which has common homolog, weather, cas# in both datasets.
However, it doesn't give me the correct averaged |
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l**********1
发帖数: 5204 | 12 Y-2-H 用多重标记 做对照和比较
比如以下的 split-luciferase+GST+HA-epitope tagged
三重标记
they found new proteins interaction paper:
//www.ncbi.nlm.nih.gov/pubmed/21530591
Protocol details:
>the wheat germ in vitro translation system for use in the splitlu
ciferase
assay and co-purifications with glutathione S transferase
(GST)- and HA-epitope tagged proteins (Fig. 2A).
>
In the split-luciferase assay, proteins of interest are fused to
N- and C-terminal fragments of luciferase. If the proteins interact,
the N... 阅读全帖 |
|
l**********1
发帖数: 5204 | 13 rna-seq
知道是啥吗
不清楚的话 维基一下吧
//en.wikipedia.org/wiki/RNA-Seq
RNA-seq, also called "Whole Transcriptome Shotgun Sequencing" [1] ("WTSS")
and dubbed "a revolutionary tool for transcriptomics",[2] refers to the use
of high-throughput sequencing technologies to sequence cDNA in order to get
information about a sample's RNA content, a technique that is quickly
becoming invaluable in the study of diseases like cancer.[3] Thanks to the
deep coverage and base level resolution provided by next-generation
s... 阅读全帖 |
|
E**********1
发帖数: 19 | 14 1. okay, first of all, I really don't know PDB actually provides predicted
3D models for every single PDB entry--maybe I am outdated. But if you could
provide everybody here with an example or a link, that would be very
helpful. I
am not sure if you are talking about homolog structures or homology
modeling. Neither is accurate information. Homology modeling is very
challenging especially when sequence homology is low. Often you cannot find
solved homolog structures to do that, am I right? ... 阅读全帖 |
|
发帖数: 1 | 15 Moderately Strong Confirmation of a Laboratory Origin of 2019-nCoV
jameslyonsweiler in Cures February 2, 2020 585 Words
Moderately Strong Confirmation of a Laboratory Origin of 2019-nCoV
On the Origins of the 2019-nCoV Virus, Wuhan, China
James Lyons-Weiler, PhD
Dr. Marc Wathelet commented that he was puzzled about my report of a spike
protein gene homologous to part of the pShuttle-SN vector, given that spike
glycoproteins are found in bat coronavirus. He urged me to analyze the
homology (seque... 阅读全帖 |
|
A********e
发帖数: 354 | 16 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
p*******g
发帖数: 2976 | 17 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
O***n
发帖数: 13127 | 18 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
a********k
发帖数: 2273 | 19 花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖 |
|
a******k
发帖数: 1190 | 20 计算机预测蛋白结构有三个level。
研究最早的是二级结构预测，就是给你一个蛋白序列，找出其中的alpha helix, beta strands
和loop区。最早的一些算法出现在上个世纪70年代。基本的idea很简单，从已有晶体结构中统计
helix, strands和loop区氨基酸的出现概率，然后根据这个进行预测。效果一般。后来出现的一些
基于贝叶斯、神经网络等等的算法考虑到了序列前后的相互影响，结果改善很多。现在二级结构预测
的准确度很高，大概80%左右的样子。说起来，二级结构预测可以算是机器学习在生物学中最早的成
功应用之一。也是bioinformatics最早热起来的方向之一。
三级结构预测就困难很多。从方法上大概可以分成三个类别：ab initio, homology modeling和
threading. ab initio预测基于力场，计算蛋白折叠构象的最小能量状态。大家都知道David
Baker是这方面的代表人物。要注意的是，Baker的ab initio预测可不是一个原子一个原子地搭
建，而是一个片断一个片断的搭建。用的力场也是low resolution的... 阅读全帖 |
|
E********8
发帖数: 22 | 21 possible publication list for people graduated since 2010
118 伊成器
1. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-
associated FTO.
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG
, He C.
Nat Chem Biol. 2011 Oct 16;7(12):885-7. doi: 10.1038/nchembio.687.
2.Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Sun F, Zhou L, Zhao BC, Deng X, Cho H, Yi C, Jian X, Song CX, Luan CH, Bae T
, Li Z, He C.
Chem Biol. 2011 Aug 26;18(8)... 阅读全帖 |
|
h******y
发帖数: 351 | 22 For the second question, the answer is Yes we can. There are several ways
to achieve this - Meganuclease such as ZFN or TALEN, or homologous rAAV
recombination.
Both ZFN and TALEN can make incisions on the chromosome DNA and then employ
non-homologous end-joining repair, which normally result in small deletion
in the endogenous loci to achieve knockout effect. But it is difficult to
knockin. For ZFN or TALEN, the biggest concern is off-target effect due to
the nature of these technologies.
rAA... 阅读全帖 |
|
b******n
发帖数: 4225 | 23 1 Science 2 Cell papers:
Devireddy LR, Teodoro JG, Richard FA, Green MR (2001) Induction of
apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-
3deprivation. Science 293: 829–834.
Devireddy LR, Gazin C, Zhu X, Green MR (2005) A cell-surface receptor for
lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123:
1293–1305.
Devireddy, L. R., D. O. Hart, D. H. Goetz & M. R. Green, (2010) A mammalian
siderophore synthesized by an enzyme with a bacterial homolog... 阅读全帖 |
|
b******n
发帖数: 4225 | 24 1 Science 2 Cell papers:
Devireddy LR, Teodoro JG, Richard FA, Green MR (2001) Induction of
apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-
3deprivation. Science 293: 829–834.
Devireddy LR, Gazin C, Zhu X, Green MR (2005) A cell-surface receptor for
lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123:
1293–1305.
Devireddy, L. R., D. O. Hart, D. H. Goetz & M. R. Green, (2010) A mammalian
siderophore synthesized by an enzyme with a bacterial homolog... 阅读全帖 |
|
p*******g
发帖数: 2976 | 25 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
y****d
发帖数: 432 | 26 【7】【Springer】GTM美国研究生数学书籍全集
LIST：
1 Introduction to Axiomatic Set Theory, Gaisi Takeuti, W. M. Zaring
2 Measure and Category, John C. Oxtoby
3 Topological Vector Spaces, H.H. Schaefer, M.P. Wolff
4 A Course in Homological Algebra, Peter Hilton, Urs Stammbach
5 Categories for the Working Mathematician, Saunders Mac Lane
6 Projective Planes, Hughes, Piper
7 A Course in Arithmetic, Jean-Pierre Serre
8 Axiomatic Set Theory, Gaisi Takeuti, Zaring
9 Introduction to Lie Algebras and Representation The... 阅读全帖 |
|
i*********5
发帖数: 19210 | 27 "I recommend you to speak with realcyclist, they will cover you the
guarantee. According to your explanation, let me tell you that we don’t
have different fits between our Whisper model, what I imagine have happen is
that your friend boutht the helmet from Europe, and then, yes the fit is
different. So if our actual size in the US doesn’t fit you, there is no
another alternative right now. We are launching our new top of the range,
Mixino helmet in March 2013 and im sure, this one, will fit you ... 阅读全帖 |
|
B********e
发帖数: 19317 | 28 http://evolution.berkeley.edu/evolibrary/article/0_0_0/evo_09
Homologies and analogies
Since a phylogenetic tree is a hypothesis about evolutionary relationships,
we want to use characters that are reliable indicators of common ancestry to
build that tree. We use homologous characters — characters in different
organisms that are similar because they were inherited from a common
ancestor that also had that character. An example of homologous characters
is the four limbs of tetrapods. Birds, bats, |
|
B********e
发帖数: 19317 | 29 http://evolution.berkeley.edu/evolibrary/article/side_0_0/recoghomols_01
Recognizing homologies
Biologists use a few criteria to help them decide whether a shared
morphological character (such as the presence of four limbs) is likely to be
a homology:
Same basic structure
The same bones (though differently shaped) support the limbs of mice and
crocodiles. In the illustration of forelimbs at left, homologous bones are
colored alike.
Same relationship to other features
The limb bones |
|
n*********m
发帖数: 38 | 30 Look his publication
Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights
from structural and biochemical studies on human RPE.
Liang W, Ouyang S, Shaw N, Joachimiak A, Zhang R, Liu ZJ.
FASEB J. 2011 Feb;25(2):497-504. Epub 2010 Oct 5.
PMID:
20923965
[PubMed - indexed for MEDLINE]
Related citations
2.
Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate
synthetase by N10-substituted folate analogues.
Wu D, Li Y, Song G, Cheng C, Zhang R, Joac... 阅读全帖 |
|
g*****n
发帖数: 241 | 31 我的文章大体上是证明一个蛋白（A）down regulate另一个比较热门的tumor
suppressor (B)（之前没有报道过），先在线虫里面做，然后延伸到cancer cell line
里面也是一致。工作量不大，不是海量的数据。
总的来说就是线虫里面A的mutant里面见到B增加（western和immunostaining），然后B
的mutant可以suppress A的phenotype。还有过表达B也可以suppress由于过表达A造成
的相反的phenotype。在cancer cell line里面，过表达A的homolog，发现B的homolog
减少，siRNA knockdown A发现B增多。如果增加A上游的ligand，发现B显著减少，如果
knockdown A之后再增加同样的ligand就没有那么显著的效果。另外证明了A和B可以结
合，也narrow down了binding region （通过GST pull down，但不是co-IP）。还证明
了A可以磷酸化B （这里用的是人的homolog，因为线虫的A没有活性）。
基本结果就是这些了，A和... 阅读全帖 |
|
m*****z
发帖数: 1451 | 32 什么跟什么？homology arm is for homology directed repair.
HEJ? NHEJ non-homologous end joining?
你说的是哪个？ |
|
n******7
发帖数: 12463 | 33 不是
这是说，本来女性有两个Ｘ，男性有一个Ｘ，所以女性里面有个Ｘ是没有活性的，来保
证男女都只有一个Ｘ激活
但是这个区域在Ｘ Ｙ染色体上都有，所以不管男女都有两个copy
所以既不需要，实际上也没有失活
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435358/
THE X AND Y CHROMOSOMES
The human sex chromosomes (X and Y) originate from an ancestral homologous
chromosome pair, which during mammalian evolution lost homology due to
progressive degradation of the Y chromosome [1]. The X-chromosome in
placental mammals represents approximately 5% of the haploid genome and the
gene content is almost complet... 阅读全帖 |
|
m*********D
发帖数: 1727 | 34 （CRISPR的背景资料请参阅Feng Zhang的“Genome engineering using the CRISPR-
Cas9 system”，Nature Protocols 8, 2281–2308 (2013)）
背景
我们是作一个与激素相关的肿瘤的。这个肿瘤的治疗方法已经相当完善，就是让身体里
不能生产激素或用一个小分子化合物抢占激素受体上激素的结合部位。但多年治疗后，
会有相当比例的病人产生抗药性。这个抗药性机理相当复杂。我们实验室一直致力于筛
选和现有药物不同的机理的小分子化合物，包括受体和DNA的结合或其他与受体相关的
pathway的inhibitors。前几年成功地筛选出了几个不同机理的化合物，个别在细胞水
平达到了nM的级别，动物测试也在10 mg/kg的水平。
最近在这个领域对抗药性肿瘤的研究发现，部分病人的抗药性是因为受体激素结合部位
发生了突变。一个或几个氨基酸的突变就能导致肿瘤细胞的生长不能被现有药物抑制。
所以，我们很想知道我们筛选出来的化合物对这些突变受体是不是也起作用。理论上来
说，我们的化合物不和激素竞争，突变不会影响我们化合物的效果。但只... 阅读全帖 |
|
N**G
发帖数: 392 | 35 前几年，我老板发展出一套基于derived functor 的algebraic K theory,把高阶K定义
成K_0的在很一般意义下的 derived functor(实际上是所谓satellites, 卫星），然后
发展出的这一整套K theory 满足Quillen K theory的所有性质，比如localization
sequence啊，reduction by resolution啊，divessage 啊之类的，并且在一些标准代
数结构的计算上，这两个K theory给出的结果都是一样的，所以我老板就有个自然的问
题，到底他自己的K theory和Quillen的K theory是不是同构的，也就是说Quillen的代
数K 理论是不是universal的。
他把这个问题给我当时的一个师弟Eric Bunch做，基本上在课上已经把怎么怎么做都讲
出来了，其实就是去算一下这两个K theory在一个category上的某种injectives（用
simplicial tower构造出来的）上是不是一样的，他自己懒得去算，就叫我们去算，而
当时Eric正好有兴趣，就去... 阅读全帖 |
|
f**d
发帖数: 768 | 36 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
|
f****g
发帖数: 2073 | 37 看看专家写的。。。
标 题: 除掉拉登也是个生物学课题
关键字: fpqn
发信站: BBS 未名空间站 (Wed May 4 11:33:46 2011, 美东)
写论文写到无聊，下班又太早，翻看下了腾讯本拉登专题，索性把除掉拉登和生物学比
较下。
PI来了又走了，从克林顿，布什到奥巴马，3代PI，十几年过去了，定位拉登基因一直
是个难题。用尽了各种高科技手段，牺牲了众多大兵phd的青春或者生命，还是巴马的
团队几乎在最后时刻撞了大运，靠跟踪partner信使搞定了拉登的位置，然后把拉登彻
底地knock out了。
于是乎，奥巴马的CNS发表了，他也可以光荣的宣布: 我是第一个knock out本拉登的，
意义重大，二次诺奖。。嘿嘿
运气，绝对的运气，生物学里头，如果没有运气，绝对的灰头土脸。
拉登基因被knockout好几天了，世界表型似乎没有什么变化，除了拉登homolog们要扬
言复仇。只见transcript增加，没见到蛋白变化。没意义。
一个拉登没了，旁路途径的拉登活性可能就要增加了。如此解释，这分明就是在
discussion里面耍赖么。
耍赖没关系，这也是idea... 阅读全帖 |
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w********2
发帖数: 632 | 39 Phylogenetic analysis
Phylogenetic analysis of gene or protein sequences for the presence of an
incongruent phylogenetic signal is considered to represent the most rigorous
method for de- tecting past HGT events (Koonin et al., 2001; Syvanen, 1994)
. Smith et al. (1992) established the basic require- ments for application
of the phylogenetic congruency test to identify and support cases of HGT.
The test com- pares the phylogenetic tree constructed from a specific
protein or gene sequence with th... 阅读全帖 |
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发帖数: 1 | 40 Argonaute (Ago) proteins are complexed with small DNA or RNA guides and
cleave nucleic 24
acid targets whose sequences are complementary with the guides1. Agos in
eukaryotes bind 25
to small interfering RNAs (siRNAs) or microRNAs (miRNAs) to suppress gene
expression by 26
degrading mRNAs in a targeted manner, a regulatory process known as RNA
interference 27
(RNAi). Agos in eubacteria and archaea are complexed with DNA or RNA guides
and function 28
as defense systems against foreign mobile genet... 阅读全帖 |
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C*I
发帖数: 4736 | 41 一直在误导，现在还在误导。 说说明corona virus 不可以从蝙蝠直接传染给人，必须
经过一个中间宿体性的其它动物才能传染给人。所以，病毒发生后，就故意误导全国人
民去海鲜市场找证据，找其它野生动物的麻烦。 而且还是病毒所去找的，找完了还装
模做样化验呀，分离呀什么的。最后把责任全部推给了海鲜市场的动物。可是那种动物
，一直不敢说，说了其它相关已经在人就会去早那种动物监测。 所以压根不说，打马
虎眼。
事实上，早在2013 年，就是这个武汉病毒研究所，已经从来自云南的蝙蝠身上所携带
的corona virus中分离出第一株蝙蝠SARS类似样的冠状病毒的活病毒，其中就包含了类
似于S类型的基因。从而证实这株病毒能够使其接受和SARS病毒相同的受体，并能够感
染人的细胞。对此新发现，武汉病毒所还把它以武汉病毒研究所的英文简称命名“WIV1
”，以彰显这一发现的重要价值和属于自己第一个发现的巨大研究成果。这个成果刊载
于2013年11月的《自然》杂志。
就是说，从云南弄回来的这种蝙蝠所携带的类似于sars的 corona virus， 可以不经过
其它受体/宿体，而直接传染给人。 他们... 阅读全帖 |
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C*I
发帖数: 4736 | 42 一直在误导，现在还在误导。 说说明corona virus 不可以从蝙蝠直接传染给人，必须
经过一个中间宿体性的其它动物才能传染给人。所以，病毒发生后，就故意误导全国人
民去海鲜市场找证据，找其它野生动物的麻烦。 而且还是病毒所去找的，找完了还装
模做样化验呀，分离呀什么的。最后把责任全部推给了海鲜市场的动物。可是那种动物
，一直不敢说，说了其它相关已经在人就会去早那种动物监测。 所以压根不说，打马
虎眼。
事实上，早在2013 年，就是这个武汉病毒研究所，已经从来自云南的蝙蝠身上所携带
的corona virus中分离出第一株蝙蝠SARS类似样的冠状病毒的活病毒，其中就包含了类
似于S类型的基因。从而证实这株病毒能够使其接受和SARS病毒相同的受体，并能够感
染人的细胞。对此新发现，武汉病毒所还把它以武汉病毒研究所的英文简称命名“WIV1
”，以彰显这一发现的重要价值和属于自己第一个发现的巨大研究成果。这个成果刊载
于2013年11月的《自然》杂志。
就是说，从云南弄回来的这种蝙蝠所携带的类似于sars的 corona virus， 可以不经过
其它受体/宿体，而直接传染给人。 他们... 阅读全帖 |
|
C*I
发帖数: 4736 | 43 Published: 30 October 2013
Isolation and characterization of a bat SARS-like coronavirus that uses the
ACE2 receptor
Xing-Yi Ge, Jia-Lu Li, Xing-Lou Yang, Aleksei A. Chmura, Guangjian Zhu,
Jonathan H. Epstein, Jonna K. Mazet, Ben Hu, Wei Zhang, Cheng Peng, Yu-Ji
Zhang, Chu-Ming Luo, Bing Tan, Ning Wang, Yan Zhu, Gary Crameri, Shu-Yi
Zhang, Lin-Fa Wang, Peter Daszak & Zheng-Li Shi
Nature volume 503, pages535–538(2013)Cite this article
Abstract
The 2002–3 pandemic caused by severe acute respirator... 阅读全帖 |
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G****e
发帖数: 1912 | 44 https://www.theepochtimes.com/scientific-puzzles-surrounding-the-wuhan-novel
-coronavirus_3225405.html
Scientific Puzzles Surrounding the Wuhan Novel Coronavirus
BY YUHONG DONG February 3, 2020 Updated: February 6, 2020FONT BFONT SText
size Print
Analysis
The sudden outbreak of the Wuhan Novel Coronavirus (2019-nCoV) has resulted
in all of China’s Hubei Province and three major cities in Zhejiang
Province being subjected to quarantine. Other nations are anxiously trying
to get their people out o... 阅读全帖 |
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c******9
发帖数: 8 | 45 安特诺生物医药（厦门）有限公司是厦门市第三批“双百”创业、创新领军人才、
外籍归国博士于2012年12月成立的中外合资公司，落户于厦门火炬创业园。公司主要从
事肿瘤监测和免疫治疗相关的实验和临床研究，提供从美国引进的专用于评价肿瘤治疗
效果与转移程度的“循环肿瘤细胞检测”服务，是一家集科研与检测服务于一体的生物
高科技公司。公司核心研发科学家和管理人员均为生物医药领域具有几十年工作经验且
具行业权威性人物。
2013年底，因公司发展需要，整体搬迁至厦门火炬（翔安）产业区，并投资新建了
国家级标准化的GMP实验室。
目前，公司与厦门大学药学院转化中心建立了项目合作关系，成立了厦门大学药学
院安特诺细胞医药研发中心，并与多家三甲医院开展临床科研与应用研究。
公司正处于全力发展阶段，诚邀从事肿瘤免疫学、免疫学方面的有志之士具有博士
及以上学历者加盟，负责实验室研发及管理。我们的科研、管理团队将为您提供良好的
专业发展机会。对于入聘人选，公司将提供良好工作环境与丰厚的福利和薪酬待遇。
工作地点： 厦门市翔安区厦大药学院
薪酬范围：US$ 30,000-40,00... 阅读全帖 |
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z**l
发帖数: 113 | 46 https://dow.taleo.net/careersection/10060/jobdetail.ftl
首先声明，我不是计算化学那个组的，但是如果有背景符合我可以帮你们递简历。另外
有什么情况要问我可以尽量回答。
Computational Chemist- Discovery Chemistry R&D-1303723
Description
Dow AgroSciences, based in Indianapolis, Indiana, USA, develops leading-edge
crop protection and plant biotechnology solutions to meet the challenges of
the growing world. Dow AgroSciences is a wholly owned subsidiary of The Dow
Chemical Company and had annual global sales of $6.4 billion in 2012.
The Discovery Chemistry... 阅读全帖 |
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w******e
发帖数: 953 | 47 How safe does transgenic food need to be?
Laura DeFrancesco1
Journal name:
Nature Biotechnology
Volume:
31,
Pages:
794–802
Year published:
(2013)
DOI:
doi:10.1038/nbt.2686
Published online 10 September 2013 Corrected online 26 September 2013
Article tools
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How safe does transgenic food need to be?
Download as PDF (812 KB) View interactive PDF in ReadCube
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Disputes over how to assess a foodstuff's safety continue to play into
public fears a... 阅读全帖 |
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p*********g
发帖数: 9527 | 48 【 以下文字转载自 Biology 讨论区 】
发信人: cheerfly (fly), 信区: Biology
标 题: 除掉拉登也是个生物学课题
关键字: fpqn
发信站: BBS 未名空间站 (Wed May 4 11:33:46 2011, 美东)
写论文写到无聊，下班又太早，翻看下了腾讯本拉登专题，索性把除掉拉登和生物学比
较下。
PI来了又走了，从克林顿，布什到奥巴马，3代PI，十几年过去了，定位拉登基因一直
是个难题。用尽了各种高科技手段，牺牲了众多大兵phd的青春或者生命，还是巴马的
团队几乎在最后时刻撞了大运，靠跟踪partner信使搞定了拉登的位置，然后把拉登彻
底地knock out了。
于是乎，奥巴马的CNS发表了，他也可以光荣的宣布: 我是第一个knock out本拉登的，
意义重大，二次诺奖。。嘿嘿
运气，绝对的运气，生物学里头，如果没有运气，绝对的灰头土脸。
拉登基因被knockout好几天了，世界表型似乎没有什么变化，除了拉登homolog们要扬
言复仇。只见transcript增加，没见到蛋白变化。没意义。
一个拉登没了，旁路途径的拉登活性可能就... 阅读全帖 |
|
l**********t
发帖数: 5754 | 49 good point. the static (gene / phenotype) homology itself is not sufficient to prove or
disprove the root causes that lead to the homology in a unique dynamic process occurred in the past. |
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