s****6
发帖数: 34 | 1 Thanks!! The trouble is that repressor X didn't show itself up in the
profiling data, i.e. none of the decreased mRNA seems to be such a repressor
and a direct target of that microRNA. No direct "targets" was ever found in
the profiling data...but those increased and decreased were indeed
confirmed with qPCR.
Could microRNAs alter gene expression via a mechanism that is not Waston-
Crick base-paring based?
Could microRNAs directly interact with protein factors or anything in the
transcriptional ... 阅读全帖 |
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D*a
发帖数: 6830 | 2 土摩托:你以为你真的懂进化论？（二）
2, Evolution cannot be disproved---There are all sorts of findings and
experiments that could have falsified evolution. In the century-and-a-half
since Darwin published his theory, not one has
二，不少人跟我说过，进化是发生在过去的事情，现代人无法亲眼观察这一过程，因此
进化论是无法被证伪的。错！并不是只有亲眼看见才能证伪进化论，任 何一个合格的
理论体系，都应该能够做出一些推断和预言，而这些推断或者预言都应该是能够被证伪
的。事实上，自150年前达尔文提出进化论以来，有无数考古 发现和科学实验都具有证
伪进化论的潜力，但它们都没能做到这一点。
据说现在还有人对“什么是科学”有争议。依我看，科学最核心的一条定义就是：科学
是可以被证伪的。换个更通俗的说法就是：任何科学体系都必须敞开大门，给对手提供
攻击的条件。
拿 进化论做例子。曾经有个名叫J.R.S. Ha... 阅读全帖 |
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h********n
发帖数: 4079 | 3 未必.
if gain of function can obtain a phenotype, loss of function may not
necessary get it.
rescue experiment is important.
Try to ues more than 1 approach, such as genetic approach, pharmacologic
approach or biochemical appproach.
Try to design experiments to disprove your hypothesis. |
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n********k
发帖数: 2818 | 4 Luck is definitely an important ingredient for success----In this particular
case, I would say it was more due to their "stupidity"(I solute them for
this)...I think simply many are too smart to try it and disprove it once the
idea surfaces, confronted with the sheer complexity of the numberless
possibility and extreme uncertainty, no one knows whether it would ever work
, how many factors, what conditions...Basically it was virtually a
completely dark box...another important factor I personall... 阅读全帖 |
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n********k
发帖数: 2818 | 5 她总是从一切可能的角度试图推翻她自己的实验发现，只有当她确定绝对无法推翻自
It is very good but also has limitations/preconditions: I see many (
including some established) who don't know their systems well enough to know
their limitations...For me, I require myself/anyone trained with me...stay alert and be informed, and then try
to disprove the results before accepting it...Or convince oneself before one
wants to convince others... |
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s******8
发帖数: 2131 | 6 your intuition or imagination could be hypothesis, then you collect data to
prove it or disprove it. |
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J**a
发帖数: 215 | 7 It is fair to say that more likely Ye did not cheat. But as a scientist, we
certainly need to have a much higher bar to disprove or to prove something,
because facts leave no room for even small possibilities. |
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z*t
发帖数: 863 | 8 That figure describe change of methylation level during early development. I
don't know whether that figure can be called as a "model" or a "fact"...
Then how do you think this PNAS paper?
http://www.pnas.org/content/108/9/3642.full
Also, since I'm not reading a lot... do you have evidence to prove or
disprove the active demethylation happens in zygotes? |
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b******y
发帖数: 627 | 9 Interesting. It is easy to prove or disprove whether it is actin filament or
microtubule. If neither, it should be certain kind of intermediate
filaments.
Since you are doing IF, can you pull this complex out using protein G beads
and then MS ID? |
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y****6
发帖数: 196 | 10 I heard this many times. Does any expert here help explain (or disprove)
this?
支修益提醒，有的上班族习惯带饭，但午饭最好当日早上做，不要带隔夜的菜，这是因
为青菜是提前炒好的，由于已放入盐，隔夜的菜会产生不少亚硝酸盐，长期食用会增加
患胃癌等消化道肿瘤的风险。
同时，随着冰箱的普及，人们吃隔夜菜和回锅菜的概率也相应增加，不健康的饮食习惯
又成了胃癌促发的一个原因，“冰箱并非保险箱，很多细菌繁殖的速度甚至更快，放在
冰箱里的隔夜菜不仅没有得到保鲜反而被污染，而且很多菜经过回锅也易产生致癌物质
，”支修益说。 |
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F*Q
发帖数: 3259 | 11 No, I did not want to disprove it. But I realized the self-conflicting
issues in the prevailing hypothesis and pointed them out when talking to
people in that field. Some people acknowledged them immediately and agreed
with me. |
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l**********1
发帖数: 5204 | 12 LZ just prepare Move on to lower rank journal
from your MS met aggressive one reviewer at least one and s/he prefer
gave her/his even negative reply which can be delayed one working day that
is better.
pls refer below english forum they talked about this topic
>>
59. physicsprof - June 16, 2010 at 10:55 am
Where does this notion that "the work of Einstein may at one time have been
dismissed"? Please check your facts. It was 1905 when Einstein made his
groundbreaking discoveries. Two of the subj... 阅读全帖 |
|
l**********t
发帖数: 5754 | 13 "进化理论可能不过是盲人摸象，冰山一角，我们却奉为圣旨一般，不能提
出质疑，否则就是反对科学，显然是更不科学的。"
Good point. Unfortunately, "evolution theory" the science has been hijacked
by the atheists to serve an idealogical purpose -- as the "scientific"
foundation of their atheism belief, while "evolution theory" the science
itself has nothing to do with proving or disproving creation by God. |
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O******s
发帖数: 59 | 14 either prove or disprove, this reproducibility study will provide nothing
new other than the ashes of burning money
foundation
reproducibility.
getting
to |
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B******1
发帖数: 9094 | 15 I think the Moon is coming closer to the Earth when LZ was measuring the
sample. Thus the gravity field felt by the sample was changing by the
seconds. Another reason could be there was a huge, invisible giant walking
acound the lab and caused the disturbance. LZ should design an accurate
experiment to prove or disprove the above hypotheses and ask his or her
child to carry out said experiment for a chance to win the Intel Award . . . |
|
g*****j
发帖数: 1211 | 16 1.生附子的毒性的趣事
This is a story. Modern medicine is built upon reproducible evidence.
And a story is far from that. This is why there is publication and
literature, so that all the details are presented to establish
reproducibility, and author's claim will be held responsible and be
examined rigorously. To believe stories like that are very dangerous,
because this is exactly how FLG became rampant, and people like 刘太医，张
吾本 could be famous, and they sure want you to "保持一种“存而不议”的科学态度"
2.是不是已知chemi... 阅读全帖 |
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k*********g
发帖数: 791 | 17 this "tetrahedron model of proton" is supposed to be provable or disprovable
by standard classcical electrodynamics, perturbation technique in specific.
in case some complexibility is involved, we may invoke some powerful
numerical computation to give an answer. |
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c**********r
发帖数: 891 | 18 Probably not. But you really should ask a real attorney about this.
Federal Rule of Evidence:
RULE 408. COMPROMISE OFFERS AND NEGOTIATIONS
(a) Prohibited Uses. Evidence of the following is not admissible — on
behalf of any party — either to prove or disprove the validity or amount of
a disputed claim or to impeach by a prior inconsistent statement or a
contradiction:
(1) furnishing, promising, or offering — or accepting, promising to accept,
or offering to accept — a valuable consideration in co... 阅读全帖 |
|
j******d
发帖数: 70 | 19 I have a guess but can neither prove it nor find an example to disprove it.
Can anyone help?
Let $x$ be real number and $a>0$, $b>1$ be integers, then
[([x]+a)/b]=[(x+a)/b]
where [.] is smallest integer greater than . |
|
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g******a
发帖数: 69 | 21 look at his email address.
usually these kind of papers are not believable. |
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c*******h
发帖数: 1096 | 22 I don't know if this Tribikram Pati is the elderly Indian mathematician
who excels at analysis,
but how can you judge a paper by only looking at the author's address.. |
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g******a
发帖数: 69 | 23 by numerous examples.
well, there could be exceptions. |
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f*******t
发帖数: 84 | 24 en, not bad, this guy can use tex. |
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k*r
发帖数: 19 | 25 Prove or disprove:
If E(Z|X)=0, then E[E(Z|Y)|X]=0.
If you can find a counterexample where Z,Y are continuous r.v.,
that'll be better. |
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A*******r
发帖数: 768 | 26 you can disprove but not prove it |
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s*******7
发帖数: 743 | 27 外行感觉：In 1987, he proved that an elliptic curve over the rational
numbers is supersingular at infinitely many primes. In 1988, he disproved
Euler's sum of powers conjecture for fourth powers.[5]
这两个成果还蛮牛吧，而且是核心热点项目。呵呵。 |
|
c*********0
发帖数: 757 | 28 1) Prove or disprove: if two events are mutually exclusive, then the two
events are independent.
2)a coin is tossed a sequence of times, what is he probability that the
first head will occur after the fifth toss, given that it has not occurred
in the first two tosses
3) prove that for any three events ,A,B,C, each having positive probability
and with the property that P(A n B) > 0, THEN : P(A n B n C)=P(A)P(B I A)P(C
l A n B) |
|
d**e
发帖数: 2420 | 29 Given two 2x2 matrices
A=diag(a1,a2), B=[a1+b1+p1,-p2;-p1,a2+b2+p2]
Let BI=the inverse of B, that is, B^(-1)
and C=A*BI
Assume all parameters are positive,i.e., a1,a2,b1,b2,p1,p2>0.
If a2,b1,b2,p1,p2 are fixed, then the principal eigenvalue of C is a
function of a1, denoted by, f(a1).
Prove or disprove that function f is monotone with respect to a1.
Any comment or suggestion is welcome. Thanks a lot. |
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a***n
发帖数: 3633 | 30 Thanks! I also made a counter example to disprove the argument soon I post
it. But my example is way too tedious than yours. |
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w*********s
发帖数: 2136 | 31 Why Almost Everything You Hear About Medicine Is Wrong
http://www.newsweek.com/2011/01/23/why-almost-everything-you-he
If you follow the news about health research, you risk whiplash. First
garlic lowers bad cholesterol, then—after more study—it doesn’t. Hormone
replacement reduces the risk of heart disease in postmenopausal women, until
a huge study finds that it doesn’t (and that it raises the risk of breast
cancer to boot). Eating a big breakfast cuts your total daily calories, or
not—as a st... 阅读全帖 |
|
S***p
发帖数: 19902 | 32 Prove of disprove the following claim
suppose Sum_{n=0,1...}f_n converges pointwisely to a function f on a set E
and {f_n} converges uniformly on E
then Sum_{n=0,1...}f_n uniformly on E |
|
c**a
发帖数: 316 | 33 I think we can disprove it.
E(Wt+Wt/2 | Ws +Ws/2) = E(Wt|Ws+Ws/2) + E(Wt/2|Ws+Ws/2)
=E(B1 + Ws|Ws+Ws/2) + E(B2+Ws/2|Ws+Ws/2)
=E(B1+ B2|Ws+Ws/2) + E(Ws+Ws/2|Ws+Ws/2)
Hence, Wt+Wt/2 is a martingale iff the first term is zero.
B1 =W(t)-W(s) and its conditional expectation is zero.
B2 = W(t/2)-W(s/2) and its conditional expectation is generally not zero.
If we take the derivative we have
0.5dw(t/2) +dw(t)
since we have dw(t/2), we dont know if it is a martingale. |
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o******6
发帖数: 538 | 34 ☆─────────────────────────────────────☆
WaterIsMe (PrincessM) 于 (Wed Jul 1 16:23:39 2009, 美东) 提到:
Q1
An enchanted hat
At a particular school, an enchanted hat assigns each incoming student to
one of four residential houses. School lore says that the hat sorts students
into houses entirely on the basis of personality and moral character. But
this year, a rumor is circulating that the hat actually assigns each student
completely randomly.
The Headmaster hopes to disprove the rumor and reason |
|
m****e
发帖数: 255 | 35 Sorry no Chinese input
you need additional variables to prove/disprove the data is faked.
For example, if you have the time stamp of each event, you can do time
series analysis. PACF and ACF graphs will also help.
The problem is very hard if there is no protocol for analyzing the data. |
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s**********8
发帖数: 25265 | 36 Informed consent
From Wikipedia, the free encyclopedi
"Informed Consent" redirects here. For the House episode, see Informed
Consent (House). For the website, see Informed Consent (website).
Scales of justice
Tort law
Part of the common law series
Intentional torts
Assault · Battery
False imprisonment
Intentional infliction of
emotional distress (IIED)
Transferred intent
Property torts
Trespass (land · chattels)
Conversion · Detinue
Replevin · Trover
Defenses
Assumption of risk
Comparative negli... 阅读全帖 |
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d**o
发帖数: 618 | 37 It is very easy to disprove. Since you ask it I will do it.
Aplusplus said: "I did a couple of years research on opioids and cocaine. I
felt all
substances which could bring joy to human beings are potentially abusive,
just a matter of degree."
Note that he was 武断 too, by using "all substances"
There are many substances that bring joy and are physiologically needed, but
cannot possibly be abusive. Water for example, if you have no water to
drink for a day and feel thirsty, does a bottle of wate... 阅读全帖 |
|
d**o
发帖数: 618 | 38 It is very easy to disprove. Since you ask it I will do it.
Aplusplus said: "I did a couple of years research on opioids and cocaine. I
felt all
substances which could bring joy to human beings are potentially abusive,
just a matter of degree."
Note that he was 武断 too, by using "all substances"
There are many substances that bring joy and are physiologically needed, but
cannot possibly be abusive. Water for example, if you have no water to
drink for a day and feel thirsty, does a bottle of wate... 阅读全帖 |
|
f**d
发帖数: 768 | 39 这是一本计算神经科学的优秀著作，全文拷贝这里（图和公式缺），有兴趣的同学可以
阅读
如需要，我可以分享PDF文件（－－仅供个人学习，无商业用途）
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖 |
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z*z
发帖数: 1309 | 40 这只能说明那网站不准, 至少一个DATA POINT DISPROVE |
|
t********r
发帖数: 4908 | 41 ☆─────────────────────────────────────☆
blackbone (能不能少灌点儿。) 于 (Fri Apr 2 14:32:48 2010, 美东) 提到:
就是象我LD这样的。带着俩娃去植物园玩了一大圈，准备
回家了，下起了雨来。结果人家植物园有RAINY DAY
GUARANTEE的POLICY，就又给了她一整套票，3个月以内
可以免费再回来玩一次哈。。
☆─────────────────────────────────────☆
zzz (睡眠不足) 于 (Fri Apr 2 14:33:44 2010, 美东) 提到:
zan your LD
☆─────────────────────────────────────☆
FridayFriday (不抛弃，不放弃) 于 (Fri Apr 2 14:34:24 2010, 美东) 提到:
太牛了！！
☆─────────────────────────────────────☆
zzz (睡眠不足) 于 (Fri Apr 2 14:36:31 ... 阅读全帖 |
|
K*******n
发帖数: 4307 | 42 An enchanted hat
At a particular school, an enchanted hat assigns each incoming student to on
e of four residential houses. School lore says that the hat sorts students i
nto houses entirely on the basis of personality and moral character. But thi
s year, a rumor is circulating that the hat actually assigns each student co
mpletely randomly.
The Headmaster hopes to disprove the rumor and reasons that if she can show
the hat's assignments to be somewhat predictable, it cannot be assigning ran
dom |
|
D*****y
发帖数: 5788 | 43 The meaningfulness of any given proposition or any linguistic construct is
now seen to depend upon whether there are any specific conditions that would
disprove what the proposition or construct is asserting. If such conditions
cannot at least be imagined, then nothing meaningful is being said, no
knowledge is being communicated, and there is therefore no way to arrive at
a certain interpretation of the language under consideration. |
|
e***e
发帖数: 3872 | 44 Mrs. Browning: To George Sand
A RECOGNITION
True genius, but true woman! dost deny
The woman's nature with a manly scorn,
And break away the gauds and armlets worn
By weaker women in captivity?
Ah, vain denial! that revolted cry
Is sobbed in by a woman's voice forlorn, --
Thy woman's hair, my sister, all unshorn
Floats back dishevelled strength in agony,
Disproving thy man's name: and while before
The world thou burnest in a poet-fire,
We see thy wom |
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