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全部话题 - 话题: autoimmune
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s****y
发帖数: 688
1
我院2001届本科毕业生余迪以第一作者在2007年的《Nature》上发表了《Roquin
represses autoimmunity by
limiting inducible T-cell co-stimulator messenger RNA》的文章。该文发现了一
条新的防止自身免疫的途径,
即限制T淋巴细胞上一种共刺激因子受体——可诱导型T细胞共刺激因子(ICOS)的表达
水平。
英国著名杂志《Nature》是世界上最早的国际性科技期刊,始终如一地报道和评论
全球科技领域里最重要的突
破。
余迪曾以第三作者的身份在05年《Nature》上发表《A Ring-type ubiquitin
ligase family member
required to repress follicular helper T cells and autoimmunity》。
这两篇论文的意义在于,通过一系列的工作,筛选到一个在自身免疫疾病中发挥重
要调节作用的新基因
Roquin。调节该基因的表达可以成为治疗自身免疫疾病的新途径。
余迪, 1997年考入武汉大学生命科学学院生物学基地班,2001
l**********n
发帖数: 240
2
来自主题: Biology版 - 一个64年出生的人
Josef Martin Penninger
Most significant scientific contributions:
Our basic approach is to genetically manipulate and change genes in mice and
to
determine the effects of these mutations in development of the whole
organism and in
diseases. From these mutations we are trying to establish basic principles
of
development and basic mechanisms of disease pathogenesis. My laboratory
focuses on
heart diseases, autoimmune diseases and cancers, and bone diseases. On all
the listed
contributions below I ... 阅读全帖
m**********t
发帖数: 19
3
来自主题: Biology版 - Posdoc fellow position available
A position is available immediately for a Posdoctoral Fellow or a Research
Associate with at least 3 years working experience and some reasonable
publications to take on a recently funded NIH project looking at the
activation of brain mast cells with respect to certain autoimmune diseases.
Animal handling, molecular biology techniques and some experience in
analyzing scientific literatures are mandatory. This is a 2 to 3 year
position with a negotiable salary and fringe benefit as defined by Tuf... 阅读全帖
b****n
发帖数: 311
4
在ips field的诸多待解决问题里,autoimmunity不见得就比未分化的细胞致癌更tough,
也不会比定向分化更难,后面这两者都不是这个field的冷水,你说autoimmunity就成拦路虎了?
a********k
发帖数: 2273
5
来自主题: Biology版 - Impact factor 2010
JCR Year and Edition: 2010 Science

Abbreviated Journal Title ISSN {2010} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2010} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 9801 94.262 70.216 8.667 18
3.8 0.04923 24.782
ACTA CRYSTALLOGR A 0108-7673 13944 54.333 24.717 0.629 70
6.2 0.04... 阅读全帖
d**b
发帖数: 1286
6
来自主题: Biology版 - 【A postdoctoral position】
A postdoctoral position is available to study the functions and molecular
mechanisms of microRNA control in lymphocyte development, immune responses,
immune tolerance, autoimmune diseases, and lymphoma. For more information,
see Cell (2007) 131:146-59, Nature Immunology (2008) 9:405-14, Cell (2009)
136:26-36.
Requirements:
Highly motivated PhD, MD, or MD/PhD with a solid background in immunology.
Working experience in the following areas is desired:
The mouse immune system
immune tolerance;
Mous... 阅读全帖
n****l
发帖数: 15
7
LONDON—U.K. drug maker GlaxoSmithKline GSK.LN +1.14% PLC said it has fired
its head of R&D in China after discovering that a paper he helped write for
the journal Nature Medicine contained data that had been "misrepresented."
Glaxo has also placed three other employees on administrative leave pending
a full review of the situation. Another employee has resigned, the company
said.
Glaxo didn't say who was responsible for misrepresenting the data. In a
phone interview Wednesday, the fired head of ... 阅读全帖
y******8
发帖数: 1764
8
来自主题: Biology版 - IF top 500 - 2012
Abbreviated Journal Title ISSN {2012} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2012} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 13722 153.459 88.55 27.04 25
3.3 0.0517 29.478
NEW ENGL J MED 0028-4793 245605 51.658 50.807 12.667 360
8 0.65776 21.494
REV MOD PHYS 0034-6861 35720 44.982 51.882 6.478 46 10
0.13048 32.634... 阅读全帖
n***3
发帖数: 663
9
来自主题: Biology版 - James Chen又发了一篇Science
从理论上来讲,任何一条innate immune pathway都很重要,很难说哪一个更重要。很
多pathway都和autoimmunity相关。Type I IFN的相关性最常见的也就和lupus联系一下
,没有什么groundbreaking的意义. 很多的autoimmune disease和type I IFN也没有多
大的关系。
我非常赞成说James Chen很厉害,他是华人生物学家在美国典型的代表人物,很令人尊
敬和钦佩。但是他的research只是在biochem/molecular biology做的炉火纯青,从免
疫学的角度来讲还差一些,得Nobel奖更是差的太远了。华人生物科学家缺乏的是从
conceptual角度做出groundbreaking的工作的人,再形象一点儿来说,是缺乏像
Charles Janeway Jr和Ruslan Medzhitov这种能改变整个field的人物。
l********n
发帖数: 260
10
来自主题: Biology版 - 2015年影响因子新出炉
Rank full journal title Total Cites IF
1 ca-a cancer journal for clinicians 18,594 115.84
2 new england journal of medicine 268,652 55.873
4 lancet 185,361 45.217
6 nature biotechnology 45,986 41.514
7 nature 617,363 41.456
12 nature materials 64,622 36.503
13 jama-journal of the american medical association 126,479 35.289
14 nature reviews immunology 28,938 34.985
15 nature nanotechnology 34,387 34.048
16 ... 阅读全帖
s******a
发帖数: 134
11
来自主题: Biology版 - Postdoc Position in Immunology
The Avram Laboratory at University of Florida is seeking a postdoc or a
visiting Ph.D. student researcher. Our laboratory focuses on transcriptional
control of effector lymphocytes in autoimmunity. Our recent work has been
published in many high-impact journals, such as Immunity, J Clin Invest, and
J Exp Med. We are seeking candidates who are self-motivated and career-
oriented to join an exciting highly interactive research team. Interested
candidates are encouraged to contact Dr. Avram by e-m... 阅读全帖
T**7
发帖数: 264
12
来自主题: Biology版 - 求篇全文,谢谢
Autoimmunity. 2010 Apr;43(3):204-9. doi: 10.3109/08916930903510880.
Recent advances on the immunomodulatory effects of IFN-alpha: implications
for cancer immunotherapy and autoimmunity.
Rizza P1, Moretti F, Belardelli F.
EMAIL:[email protected]/* */
包子致谢
m*****e
发帖数: 129
13
来自主题: Biology版 - SCI - 2016
Rank Full Journal Title Total Cites Journal Impact Factor
1 CA-A CANCER JOURNAL FOR CLINICIANS 20,488 131.723
2 NEW ENGLAND JOURNAL OF MEDICINE 283,525 59.558
3 NATURE REVIEWS DRUG DISCOVERY 25,460 47.12
4 LANCET 195,553 44.002
5 NATURE BIOTECHNOLOGY 48,650 43.113
6 NATURE REVIEWS IMMUNOLOGY 31,545 39.416
7 NATURE MATERIALS 72,306 38.891
8 NATURE REVIEWS MOLECULAR CELL BIOLOGY 36,784 38.602
9 NATURE 627,846 ... 阅读全帖
e****0
发帖数: 678
14
来自主题: MedicalCareer版 - [我的CK笔记]外科
• Exaggerated deep tendon reflexes can be seen in lock in syndrome.
• Non bleeding varices are managed with nonselective beta-
adrenergic antagonists, such as propranolol.
• Sclerotherapy, endoscopic band ligation, and surgery are
indicated after a patient has a first episode of variceal bleeding.
• TIPS is a last resort in variceal bleeding unresponsive to
medical and endoscopic intervention.
• Ischemic colitis
 CT—thickening of eth bowel ... 阅读全帖
w*********s
发帖数: 2136
15
投诉人: Whiteclouds
投诉对象:我爱宝宝版主mitbbx及版副catdoudou
投诉标题:投诉我爱宝宝版主mitbbx及版副catdoudou大搞新闻网禁误导广大家长
投诉目标:罢免
投诉理由:
1. 事关每个人身心健康。你们凭什么封禁医药界的负面消息和非主流消息?
2. 关于疫苗利弊的讨论早已进入主流媒体了。你凭什么不让大家看到?
3. 药品(包括疫苗)近年屡有recall. 你凭什么禁止有关信息来误导家里有小宝宝的父母去盲目迷信药品质量?
4. 美加庸医遍地都是,医疗事故屡见不鲜。你凭什么制造版面气氛让家长对处方和诊断不过脑子的去盲信?
5. 凡事要听多方面意见,有点科学精神,你们动辄删贴封人缺乏领导版面的基本素质
6. 为人父母要首先自己要学会尊重不同意见,不然以后怎么教育好孩子?
7. 综上所述,建议罢免!
【 以下文字转载自 Parenting 讨论区 】
发信人: whiteclouds (/ 参考消息 /), 信区: Parenting
标 题: CDC to Study Vaccines and Autism
发信站: BBS 未名空间站 (Tue M... 阅读全帖
w*********s
发帖数: 2136
16
CDC to Study Vaccines and Autism
HuffingtonPost.com
David Kirby
Author/Journalist
Posted: March 18, 2011 05:46 PM
The Centers for Disease Control and Prevention wants to study autism as a
possible clinical outcome of immunization, as part of its newly adopted 5-
year research agenda for vaccine safety, the agency said on its website.
The CDC will also study mitochondrial dysfunction and the potential risk for
post-vaccine "neurological deterioration," and convene an expert panel on
the feasibili... 阅读全帖
m****s
发帖数: 18160
17
☆─────────────────────────────────────☆
whiteclouds (/ 参考消息 /) 于 (Tue Mar 22 18:47:29 2011, 美东) 提到:
投诉人: Whiteclouds
投诉对象:我爱宝宝版主mitbbx及版副catdoudou
投诉标题:投诉我爱宝宝版主mitbbx及版副catdoudou大搞新闻网禁误导广大家长
投诉目标:罢免
投诉理由:
1. 事关每个人身心健康。你们凭什么封禁医药界的负面消息和非主流消息?
2. 关于疫苗利弊的讨论早已进入主流媒体了。你凭什么不让大家看到?
3. 药品(包括疫苗)近年屡有recall. 你凭什么禁止有关信息来误导家里有小宝宝的父母去盲目迷信药品质量?
4. 美加庸医遍地都是,医疗事故屡见不鲜。你凭什么制造版面气氛让家长对处方和诊断不过脑子的去盲信?
5. 凡事要听多方面意见,有点科学精神,你们动辄删贴封人缺乏领导版面的基本素质
6. 为人父母要首先自己要学会尊重不同意见,不然以后怎么教育好孩子?
7. 综上所述,建议罢免!
发信人: whiteclouds (/ 参考消息... 阅读全帖
w*********s
发帖数: 2136
18
事关每个人身心健康。你们凭什么封禁医药界的负面消息和非主流消息?
【 以下文字转载自 Parenting 讨论区 】
发信人: whiteclouds (/ 参考消息 /), 信区: Parenting
标 题: CDC to Study Vaccines and Autism
发信站: BBS 未名空间站 (Tue Mar 22 18:44:33 2011, 美东)
CDC to Study Vaccines and Autism
HuffingtonPost.com
David Kirby
Author/Journalist
Posted: March 18, 2011 05:46 PM
The Centers for Disease Control and Prevention wants to study autism as a
possible clinical outcome of immunization, as part of its newly adopted 5-
year research agenda for vaccine safety, the agenc... 阅读全帖
n****a
发帖数: 2525
19
来自主题: Medicalpractice版 - Recurrent abdominal pain
Young patient, 28 yrs old. Had Hx of Hashimoto, thyroid removed around 2001.
On Synthroid tx, but on 2002 had her first episode of pancreatitis, with
lipase in 3000s. Subsequently had repeated episodes of abdominal pain, many
thought it as pancreatitis, but lipase has always been normal, with CT ab
not showing any calcifications in the abdomen.
Patient here this time again, GI feels it is pancreatitis again. She takes
Synthroid regularly according to herself but TSH always elevated.
I know that ... 阅读全帖
w***0
发帖数: 222
20
来自主题: Medicalpractice版 - Recurrent abdominal pain
I see your point and the thinking process. It is legitimate to have the
autoimmune related as one of your differentials.
are you going to tell us the labs/studies? you mentioned MRCP NL and
previous recurrent abdominal pain and past diagnosed diseases including
pancreatitis.
I am following your thinking and thought you might show us some more
results
suggesting the patient has autoimmune cholangitis or "something like
that"
Personally, I still believe this is a recurrent pancreatitis (common
thi... 阅读全帖
I****a
发帖数: 407
21
来自主题: Medicalpractice版 - 好诡异的一个临床案例啊
From story, there is not enough information to say there is APS. As A++
pointed out, the antibody testing are very frequently falsely positive
especially in infection and renal failure setting and if the antibody titers
are low positive. He has a stroke like symptoms but CNS vasculitis could
also cause this. Overall my impression is that this guys has an autoimmune
process with antibody messing around the kidneys and perhaps CNS, bone
marrow. The PCP infection is secondary.
If all his serology t... 阅读全帖
A*******s
发帖数: 9638
22
来自主题: Medicalpractice版 - 【有奖竞猜】什么病让他这么看我?
Why so interesting? only 1% Bell's palsy presented with bilateral signs.
What does it tell you?
PCPs, ER Doc and some specialists are still using antiviral treatment for
bell's palsy. Studies showed it is not effective. What is effective?
Steroids if you start it early enough.
It makes sense in this case. Apparently his symptoms started after a unilateral HSV-1 infection. The HSV-1 infection associated autoimmune process explains why the infection was unilateral, but the bell's palsy was bilate... 阅读全帖
A*******s
发帖数: 9638
23
来自主题: Medicalpractice版 - 【有奖竞猜】什么病让他这么看我?
Bell‘s palsy应该是很容易诊断的, wrinkle可以weak也可以消失, 取决于病情程度
。但单侧时很容易区分, 因为有对侧对照。
这个例子让我觉得bell’s palsy跟病毒感染的关系是间接的, autoimmune是病因。
就是感染在先, 反应在后。 否则一侧的感染不会引起双侧病变。 这个病人的症状在
左侧, 但他的palsy右侧显得更重。
为什么autoimmune只损害面神经?为什么只有1%是双侧? 有待版上牛人解答。

central
.
all
the
...
I****a
发帖数: 407
24
Good job! That is the most likely diagnosis. Blow is the direct copy of
blood paper, How I treat hemophagocytic lymphohistiocytosis
1. Michael B. Jordan1,2,*,
2. Carl E. Allen3,*,
3. Sheila Weitzman4,
4. Alexandra H. Filipovich2, and
5. Kenneth L. McClain3
The diagnosis of HLH† may be established:
A. Molecular diagnosis consistent with HLH: pathologic mutations of PRF1,
UNC13D, Munc18-2, Rab27a, STX11, SH2D1A, or BIRC4
or
B. Five of the 8 criteria listed below are fulfilled:... 阅读全帖
y******a
发帖数: 590
25
Good question! HUVS and HUV are different entities. HUVS can be caused by
lupus. 我那个病人,所有的血清学检查都是阴性的(所有你能想到的, commercially
available的抗体),除了关节炎没有lupus的11条表现,没办法给lupus的诊断。他还
做了好多次淋巴结和骨髓的穿刺活检,血液系统肿瘤也排除了。
Sometimes we do give patients a diagnosis of "evolving autoimmune process",
if it smells like autoimmune process. 但是这个病人,我感觉不是adaptive
immune system的问题。
不好意思,主要是考虑到HIPPA,不能再讨论了。
b******a
发帖数: 704
26
Most likely, this baby has been diagnosed with primary autoimmune
neutropenia, which usually linked with a good prognosis.
Here is what I could copy and paste from internet as a first grade in
Medicine, lol.
Autoimmune neutropenia (AIN) is caused by granulocyte-specific antibodies.
In most cases, AIN is not associated with any other illness or underlying
disease, and therefore is called primary AIN if anti-Granulocyte specific
antibodies are detected, or chronic benign neutropenia (CBN) if ther... 阅读全帖
A*******s
发帖数: 9638
27
If it is an autoimmune disease which is most likely the cause, I believe
early steroids will do a good thing to the patient. What else could be?
amyloidosis? I don't think steroids would do any harm. You can always
discontinue it if biopsy result shows you a surprise.
I don't know if you know Bell's palsy which is also thought to be autoimmune
. Steroids will only work if started within 72 hrs. This is evidence based.

GN
f**d
发帖数: 768
28
来自主题: Neuroscience版 - eBook: From computer to brain
这是一本计算神经科学的优秀著作,全文拷贝这里(图和公式缺),有兴趣的同学可以
阅读
如需要,我可以分享PDF文件(--仅供个人学习,无商业用途)
From Computer to Brain
William W. Lytton
From Computer to Brain
Foundations of Computational Neuroscience
Springer
William W. Lytton, M.D.
Associate Professor, State University of New York, Downstato, Brooklyn, NY
Visiting Associate Professor, University of Wisconsin, Madison
Visiting Associate Professor, Polytechnic University, Brooklyn, NY
Staff Neurologist., Kings County Hospital, Brooklyn, NY
In From Computer to Brain: ... 阅读全帖
f**********g
发帖数: 2252
29
来自主题: _pennystock版 - Anyone following IMMU?
Ask Biofish?
Immunomedics Reports Progress on Development of Antibody-SN-38 Conjugates at
Cancer Meeting
4 hours 6 minutes ago - PMZ via Comtex
GlobeNewswireImmunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company
primarily focused on the development of monoclonal antibody-based products
for the targeted treatment of cancer, autoimmune and other serious diseases,
today announced at the 102nd Annual Meeting of the American Association for
Cancer Research results from 2 studies on the develop... 阅读全帖
n**e
发帖数: 2026
30
在《诊断骗局之鱼目混珠》一文中,尼罗河揭示贝志城在中央电视台文献记录片中展示
的“远程诊断”不过是他自己从教科书上摘录的内容。人们不禁要问,既然贝志城声称
手里有上千份电邮回复,其中30%作出了铊中毒的正确诊断。一个绝对数字是48份邮件
作出了铊中毒的正确诊断。拿出一份邮件来给大家见识一下这个“正确诊断”应该是没
有问题的。贝志城之所以不能出示“正确诊断”并不是因为他手里没有这样的东西,而
是他遇到一道绕不过去的坎:时间限制性。注意下面这段对话(中央电视台文献记录片
《朱令的12年》):
贝志城:十号发了那是个周一,周三我就给朱令他爸爸打电话说,我看到提问里还有说
是铊中毒。
贝志城:很多医生很激烈地发表意见,说一定要作这个化验,因为她的症状太像铊中毒
了。
朱令父亲:贝志城给我打了个电话,说有人觉得是不是就是铊中毒。
朱令母亲:他(贝志城)说,阿姨你是怎么了,这么多人都说是铊中毒,你为什么就不
去化验。
一个无法改变的事实是,贝志城在48小时之内(1995年4月10日到12日)就锁定了铊中
毒诊断。而他手里根本就没有在48小时之内回复的“正确诊断”。这就是为什么他不敢
当众展示“正确... 阅读全帖
n**e
发帖数: 2026
31
【 以下文字转载自 WaterWorld 讨论区 】
发信人: nile (nile), 信区: WaterWorld
标 题: 清华投毒案——诊断骗局之神话先知
发信站: BBS 未名空间站 (Sat Feb 27 11:11:40 2016, 美东)
核心提要:贝志城通过远程诊断帮助协和医生挽救了朱令的生命,他自己却在第二年被
北大“劝退”。这里面的全部秘密就在于一个关键问题:时间限制性。尼罗河对证据的
分析表明,所谓“远程诊断“不过是一个明修栈道的先知神话。
在《诊断骗局之鱼目混珠》一文中,尼罗河揭示贝志城在中央电视台文献记录片中展示
的“远程诊断”不过是他自己从教科书上摘录的内容。人们不禁要问,既然贝志城声称
手里有上千份电邮回复,其中30%作出了铊中毒的正确诊断。一个绝对数字是84份邮件
作出了铊中毒的正确诊断。拿出一份邮件来给大家见识一下这个“正确诊断”应该是没
有问题的。贝志城之所以不能出示“正确诊断”并不是因为他手里没有这样的东西,而
是他遇到一道绕不过去的坎:时间限制性。注意下面这段对话(中央电视台文献记录片
《朱令的12年》):
贝志城:十号发了那是个周一,周三我... 阅读全帖
n**e
发帖数: 2026
32
【 以下文字转载自 WaterWorld 讨论区 】
发信人: nile (nile), 信区: WaterWorld
标 题: 清华投毒案——诊断骗局之神话先知
发信站: BBS 未名空间站 (Sat Feb 27 11:11:40 2016, 美东)
核心提要:贝志城通过远程诊断帮助协和医生挽救了朱令的生命,他自己却在第二年被
北大“劝退”。这里面的全部秘密就在于一个关键问题:时间限制性。尼罗河对证据的
分析表明,所谓“远程诊断“不过是一个明修栈道的先知神话。
在《诊断骗局之鱼目混珠》一文中,尼罗河揭示贝志城在中央电视台文献记录片中展示
的“远程诊断”不过是他自己从教科书上摘录的内容。人们不禁要问,既然贝志城声称
手里有上千份电邮回复,其中30%作出了铊中毒的正确诊断。一个绝对数字是84份邮件
作出了铊中毒的正确诊断。拿出一份邮件来给大家见识一下这个“正确诊断”应该是没
有问题的。贝志城之所以不能出示“正确诊断”并不是因为他手里没有这样的东西,而
是他遇到一道绕不过去的坎:时间限制性。注意下面这段对话(中央电视台文献记录片
《朱令的12年》):
贝志城:十号发了那是个周一,周三我... 阅读全帖
s******n
发帖数: 518
33
既然你关心农药,那就推荐一个孟山都的roundup的危害的文章:
https://www.ecowatch.com/15-health-problems-linked-to-monsantos-roundup-
1882002128.html
Food
Guest Contributor
Jan. 23, 2015 11:44AM EST
15 Health Problems Linked to Monsanto's Roundup
Monsanto invented the herbicide glyphosate and brought it to market under
the trade name Roundup in 1974, after DDT was banned. But it wasn’t until
the late 1990s that the use of Roundup surged, thanks to Monsanto's
ingenious marketing strategy. The strategy? Genetically engineer ... 阅读全帖
e*******r
发帖数: 1433
34
来自主题: Military版 - 擅服碘片中毒 美國57起
http://www.msnbc.msn.com/id/42135438/ns/health-health_care/
As demand spikes for potassium iodide in the wake of Japan’s nuclear
crisis, U.S. poison control centers are starting to receive reports of
illness in people who’ve ingested the drug aimed at protecting against
radiation sickness.
At least seven people have reported reactions to the drug, often called by
its chemical name, KI, including two who said they were suffering from
serious symptoms including vomiting, racing heart and dizziness... 阅读全帖
e*******r
发帖数: 1433
35
来自主题: Military版 - 擅服碘片中毒 美國57起
摘要
He warned that the drug could cause serious reactions in some people and
even backfire in the case of an actual emergency, putting people past a two-
week window of safe dosage. After that period of time, the drug can induce
severe hypothyroidism, a condition that essentially shuts down thyroid
function
“It is inappropriate, foolhardy and dangerous to be taking iodine
supplements at this time,” Wartofsky said. “It’s very important to hold
off until it’s absolutely necessary.”
But even if radi... 阅读全帖
s********n
发帖数: 26222
36
方舟子在此文中说“虫子不吃的, 人能吃吗”是中国人的质疑, 而美国人是不会问这
样的问题的, 这显然是骗人的。见下文和其中引用的文献, 其中不少是美国人的科研

"Comments on the human health impact of Bacillus thuringiensis toxin gene
product in genetically modified crops"
EPA Review Docket Number OPP-00678B
Professor Joe Cummins
Professor Emeritus of Genetics
University of Western Ontario
I have studied the Environment Protection Agency (EPA) document "Bt Plant-
Pesticides Biopesticides Registration Action Document B. HUMAN HEALTH
ASSESSMENT" and comment in the following ... 阅读全帖
b*******y
发帖数: 4304
37
中药的科学研究丰碑(修改版)
饶毅1 黎润红2 张大庆2
中国 北京 100871北京大学 1生命科学学院 2医学部
摘要
1970年代早期,多数中国科学家,在文化大革命中努力生存而无机会开展研究。两位年
轻的研究者屠呦呦和张亭栋,分别在发现抗疟新药青蒿素和揭示砒霜化学成分三氧化二
砷对白血病的治疗作用的过程中起了关键作用。回顾四十年前开始的历程,不乏曲折和
反讽。青蒿素工作源于中国帮助越南抵抗美国,三氧化二砷源于观察、验证和改进乡村
中医的实践。虽然他们的药物挽救了世界上很多生命,两位研究者迄今未获国内外充分
肯定,屠呦呦有争议、张亭栋基本默默无闻。相关的文献埋没于冷僻的杂志和一般不易
看到的内部会议资料。基于原始中文论文、文件和采访,我们在此呈现这些发现的历史
概貌。没有逃脱我们的注意,在古代和近现代中文文献及医疗实践中,可能还有尚待重
新发现的珍宝。
引言
在中国使用了上千年的传统药物,能否改善现代人类的健康?在中国,有些人不认为这
是问题,而在中国以外的世界,中药并非现代人类普遍使用药物的主要来源。
对中药有两种截然相反的看法:在现代医学进展到今天后中药意义很小,甚至毫... 阅读全帖

发帖数: 1
38
11 月13日 终于找到另一股在我家害我的势力
昨天,这些人折腾了一天,白天,晚上皮啦啦,也不知道谁把谁杀了,谁把谁带走了。
反正我先生和孩子被绑架了,就不知道是不是已经遇害了。我本来是打算睡觉的,但他
们头上,地下装电磁波攻击器,让我几乎窒息。虽然我没倒下,但其实他们在我身上扎
的毒针已经蔓延,我能感觉到我的呼吸有窒息的感觉。我想我对他们已经非常仁慈了,
但他们不依不饶地攻击我,欲置我于死地,让我非常生气,特别是肆意伤害我家里的人
,绑架我先生和孩子,而且有许许多多无辜的生命毁于他们之手,有必要把他们曝光。
当然我还没分析这里边是那几个人具体攻击我,伤害我的,但他们显然都是一伙的。鉴
于他们伤害我的头部,胸部 和胃部,我就把这几部分的医生都曝光,受害者慢慢去调
查,追查他们吧。
Cleveland Clinic, Website: my.clevelandclinic.org
Call 855. REFER. 123 or 855.733.3712
Lung Cancer
Results: 57 Doctors
PREV123NEXT
Results per page:
Dav... 阅读全帖
m***n
发帖数: 12188
39
治死鲁迅的那个医生,后来回日本又干了許多年。
不过那时的医学水平就那个样子。而且那个医生只是非常不负责任,心不在焉,不一定
是他有意害人。
鲁迅早死可能有一下几个因素:
1)因为父亲考试作弊,小时候非常仇恨社会,心理扭曲。心身互动,带来了后来抑郁
和免疫系统紊乱的种子。
2)长期大量抽烟。
3)熬夜,学洋人喝咖啡,生活无规律。
4)甲状腺功能可能有问题,不过那时的医学不懂。hypothyroidal,易疲劳,抑郁,于
是大量喝咖啡抽烟提神。
4)很早就补牙。并且因此大骂中医,不会拔牙,连个牙齿都不会补。当时补牙用的是
amalgam,一年毒性等于吸500年的雾霾。
其实中医说他“肾亏”,意思就是免疫系统问题大,是没错的。牙周炎除了口腔卫生,
和免疫系统也有联系,他的autoimmune system有大问题。鲁迅有偏头痛,migraine,

发帖数: 1
40
来自主题: Military版 - 12 月28日 答案2 (2011)
12月28日,答案 2 (2011)
Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH D005368
[edit on Wikidata]
Filariasis is a parasitic disease caused by an infection with roundworms of
the Filarioidea type.[1] These are spread by blood-feeding black flies and
mosquitoes. This disease belongs... 阅读全帖
m********d
发帖数: 502
41
自体免疫疾病/攻击就一定不能治疗?你对基因了解多少?你知道基因可以被表达也可
以被沉默?更何况从基因到疾病表现有多少步需要被转录和表达?任何一部错误都会导
致疾病。就是正确被表达到蛋白质这一步,蛋白质本身折叠错误也会产生prion。
西医对整个蛋白质组和基因组的全面认知还早的很。会个Autoimmune就以为知道全世界
。真是太幼稚了。
中医治病不管这些分子层面,因为不需要!!就像你饿了就要吃饭,吃了就充饥。你不
需要知道为什么米可以充饥的生化过程。你为什么认为中医的药物不包含可以治疗牛皮
藓的成分?谦虚使人进步。

genetic
m***n
发帖数: 12188
42
很明显,是偏头痛,migraine。
一种 autoimmune 疾病
m********5
发帖数: 17667
43
What .. ?! Migraine is an autoimmune disease? Can you give me a link?
t**x
发帖数: 20965
44
看来没有几个人全看我家的故事
第一,除了重症监护室,病理和病历,我不觉得别的地方联合
第二,我整个过程并没有怪医生太多。第一页和最后总结怪的是美国政府唯利是图,不
管病人死活。政府是最大的黑社会。没有明确说,但是目标根本不是医院医生,是反政
府。
第三,更多资料目前没有放上去。如果你看了相信我家孩子的事情。更多的资料绝对让
你对整个体制寒心,因为医生为了不承担责任不给我家孩子的急性肝衰竭诊断病因,可
医生们发表的资料显示49%没有给病因,另一篇文章里说没有给的很多都是代谢病。这
个数据都是公开的,很多没有的死了或移植了。
这个根本不是一个病人的事情,是至少几十个孩子故意给美国医院害死。

First 348 acute liver failure... 最重要的三篇文章。
这种事情可不是偶然一起。。。医院杀害或不救助采取移植是美国医院很普遍的现象。
不是所有都这么干,但却绝不是小范围这么干。
The etiology of ALF in 348 children included acute acetaminophen toxicity (
14%), metabolic disea... 阅读全帖
t**x
发帖数: 20965
45
来自主题: Military版 - 没有律师愿意接这个案子
我时间的确是损失, 的确是亏。
问题是医疗系统因为大家都不说话, 就不改进, 就是草菅人命。
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662127/
这是篇医生们自己的文章。
这篇文章这么说
The etiology of ALF in 348 children included acute acetaminophen toxicity (
14%), metabolic disease (10%), autoimmune liver disease (6%), non-APAP drug-
related hepatotoxicity (5%), infections (6%), other diagnosed conditions (10
%); 49% were indeterminate. Outcome varied between patient sub-groups; 20%
with non-acetaminophen ALF died or underwent liver transplantation and ne... 阅读全帖
s*****r
发帖数: 11545
46
来自主题: Military版 - 屠呦呦团队的2018新年期望
变态反应性疾病 are autoimmune diseases too, so why use the word also?
z*****1
发帖数: 133
47
看看这个是神马:
PANDAS
Pediatric Autoimmune Neuropsychiatric Disorders Associated with
Streptococcal Infections
这不是熊猫么?
百度翻译:大熊猫(小儿自身免疫性神经精神障碍与压力)
g******t
发帖数: 11249
48
PANDAS
Pediatric Autoimmune Neuropsychiatric Disorders Associated with
Streptococcal Infections
百度翻译:(小儿自身免疫性神经精神障碍与压力)
汉语的优越性在哪里?
m*****n
发帖数: 3575
49
外F fuck傻了?
全称要和全称对比
简称要和简称对比
你拿简称和全称比大小,是不是外F智力下降了?
PANDAS 英文简称
Pediatric Autoimmune Neuropsychiatric Disorders Associated with
Streptococcal Infections 英文全称
小儿自身免疫性神经精神障碍与压力 中文全称
中文简称还没有
可以命名啊——
小儿免疫精神病
这个比起英文是多了两个字符,四个音节
但是听得懂什么意思啊
英文一缩写就缩写成黑话,不在那个语境里谁知道熊猫是什么意思?
c******n
发帖数: 5697
50
Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has
recently been reported as a potential broad-spectrum antiviral drug.8,9
Chloroquine is known to block virus infection by increasing endosomal pH
required for virus/cell fusion, as well as interfering with the
glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition
assay demonstrated that chloroquine functioned at both entry, and at post-
entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d).... 阅读全帖
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