l*****O 发帖数: 402 | 1 那你还是赶快去查明贫血原因吧。耽误不得。如果是成年人,underlying cause of
anemia可大可小啊,不想吓你。谢谢浦光,不过更应关心自几身体。医生只是你帮助自
几的resource,绝不可能是你的救世主。 |
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n******a 发帖数: 114 | 2 今天收到Premera的信,说老婆怀孕时做的genetic tests是invesigational的,一分钱
不给报,自己要出上千!
我们当时那个counselor说combined screening老婆做几十,我做3,4百。咋就变成这
么多了,难道年中改了什么政策吗?
一共做了12个,我列一下bloom syndrome, canavan disease, cystic fibrosis,
familial dysautonomia, fanconi anemia type c, fragile x syndrome, gaucher
disease, hb beta chain-related hemoglobinopathy, hexosaminidase a deficiency
, mucolipidosis V, niemann-pick disease, spinal muscular atrophy
有没有同样做过的兄弟姐妹,帮忙看看你们的Test report,是不是也是这么多测试和
全部是自己付啊? |
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B******1 发帖数: 9094 | 3 Urban legend:
Is Canola Oil Hazardous to Your Health?
Netlore Archive: Internet rumors claim canola oil isn't as good for you as
it's reputed to be. In fact, it's hazardous to your health!
Description: Email rumor
Circulating since: 1999/Earlier
Status: Mostly false
Analysis: See next page
Email example contributed by Andrea B., Jan. 3, 2001:
Subject: Fw: Canola Oil - A must Read
Before you buy your next bottle of cooking oil...
I think it's important that as many people as possible KNOW about t... 阅读全帖 |
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G***G 发帖数: 16778 | 4 I know a little bit about it because it is a kind of cancer.
Its symptoms include, as Mayo says, 1) high level of calciums, 2) kidney
failure, 3) anemia, and 4) bone damage.
Some factors that may increase the risk of multiple myeloma inclue:
1) age 2) sex, 3)history of MGUS, and 4) obesity.
few cases occure in people who are younger than 40.
men are more likely to develop the disease than women.
Though there is no cures for multiple myeloma, by some treatments patients
can return to nearly-norma... 阅读全帖 |
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N****O 发帖数: 4202 | 5 那就是我自己太过小心了,都没有喝水...
不过我还是不相信医生的话,在cooley's anemia foundation查了查,说:Silent
Carrier State. This condition generally causes no health problems because
the lack of alpha protein is so small that the hemoglobin functions normally
. It is called "silent carrier" because of how difficult it is to detect.
Silent carrier state is "diagnosed" by deduction when an apparently normal
individual has a child with hemoglobin H disease or alpha thalassemia trait.
就是说即使hemoglobin functions normally,我也有可能是silent c... 阅读全帖 |
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g*2 发帖数: 658 | 6 Impression: 缺铁性贫血
evidence:
1) MCV<80 but >65;
2) RDW high;
3) Mentzer index=MCV/RBC=14.7>13;
4) iron low, transferin high
另外3种可以引起小细胞贫血 (MCV<80)的有, 都不太象:
1) 地中海贫血(thalassemia)-but RDW normal,iron normal or increase, Mentzer
index<13, family history (it's X linked recessive)
2) 慢性病引起的-ferritin high in late stage, transferin normal or decrease,
有慢性病,如感染,结缔组织病, 肿瘤等
3)铁粒幼细胞贫血 (sideroblastic anemia)-iron increased, transferin normal
or decrease, 血涂片 看到basophilic stippling, 和这些情况有关:喝酒,vit B6缺
乏,ALA s... 阅读全帖 |
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s*******d 发帖数: 370 | 7 分享个最近的一个新闻
Exercise Boosts Health By Influencing Stem Cells To Become Bone, Not Fat,
McMaster Researchers Find
Main Category: Sports Medicine / Fitness
Also Included In: Obesity / Weight Loss / Fitness; Stem Cell Research
Article Date: 05 Sep 2011 - 0:00 PDT
email to a friend printer friendly opinions
Current Article Ratings:
Patient / Public: 4.25 (4 votes)
Healthcare Prof: 5 (1 votes)
McMaster researchers have found one more reason to exercise: working out
triggers influential stem ... 阅读全帖 |
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U******u 发帖数: 5829 | 8 K, 机油事小,健康和命事大,转个才看来的吧----
CAR AIR-CONDITIONING - VERY IMPORTANT!
WHY? Car Air-conditioning - No wonder more folks are dying from cancer than
ever before. We wonder where this stuff comes from but here is an
example that explains a lot of the cancer causing incidents.
Many people are in their cars first thing in the morning and the last thing
at night, 7 days a week.
As I read this, it makes me feel guilty and ill.
Please pass this on to as many p... 阅读全帖 |
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w***n 发帖数: 9040 | 9 The Big Book of Endurance Training and Racing
By Dr. Philip Maffetone
CHAPTER 8
THE OVERTRAINING SYNDROME
Overtraining is the most common problem that prevents endurance
athletes from reaching their potential. It’s also the most common cause of
injury and ill-health for millions of athletes. And overtraining is a
problem
that many athletes, coaches, and health-care professionals don’t recognize
until it becomes a more serious condition.
As a result, overtraining is not recognized soon enough to ... 阅读全帖 |
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a********a 发帖数: 3176 | 12 See your doctor and have your iron level in blood checked. Anemia can cause
hair loss. |
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b*s 发帖数: 82482 | 13 Pythagorean prohibition of beans is best understood as a commonsense
injunction aimed at preventing acute hemolytic anemia in individuals with a
hereditary deficiency of glucose-6-phosphate dehydrogenase in their red
blood cells.
怕吃多了不识数? |
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Z***T 发帖数: 727 | 14 研究表明,端粒的平均长度随著细胞的分裂次数的增加及年龄的增长而变短。端粒DNA
序列逐渐变短甚至消失,就会导致染色体稳定性下降,这可能是引衰老的一个重要因素
。因此,端粒似乎是一种有丝分裂钟,限制者真核生物DNA复制的能力。越来越多的证
据表明端粒的长度控制著衰老的进程。端粒缩短是触发衰老的分子钟。人的体细胞每次
有丝分裂,如果没有端粒酶的活化,就会丢失50-200bp长度的端粒,当丢失数千个核甘
酸时,细胞就会停止分裂而衰老。活化的端粒酶将会导致端粒DNA序列延长,大大延长
细胞的寿命。如果把端粒酶基因导入正常细胞,细胞寿命将大大延长。这种结果首次为
端粒的生命钟学说提供了直接证据。那么,端粒缩短为什么会导致衰老呢?有理论认为
,端粒就像一种“时间延迟”的保险丝,经过一定数目的细胞分裂以后就被用完,当端
粒变的太短时,就不能形成原来的封闭结构了。人们认为,当细胞探测到此种结构时就
会启动衰老、停止生长或凋亡,这取决于细胞的遗传背景。
1998年《Nature》上有一篇标题为“Extension of Life-Span by Introduction of
Telomerase in... 阅读全帖 |
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b*****a 发帖数: 14583 | 15 sickle cell anemia 也是几乎只有黑人会得, 但是只有统计意义,无法科学定义啊,
任何人类基
因都能在任何 race 里面找到 |
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p****n 发帖数: 9263 | 16 sickle cell anemia哪个方面无法科学定义? 请民科讲讲 |
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z***i 发帖数: 8285 | 17 跟你们说是维生素B2缺乏为什么没人信呢
看维基吧
Deficiency
Signs and symptoms
Riboflavin deficiency is also called ariboflavinosis.
It was originally known as pellagra sin pellagra (pellagra without pellagra)
,
as it exhibits certain similarities to the niacin deficiency pellagra.
In humans the classical syndrom affects the mouth (sore throat,
inflammation of the lining of mouth and tongue), angular cheilitis),
the eyes (photophobia with bloodshot, itchy, watery eyes),
the skin (moist, scaly skin particularly affectin... 阅读全帖 |
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p********f 发帖数: 5148 | 18 Jaundice is recognized by a yellow color to the animal's skin. It is often
more apparent in the whites of the eyes and in the skin at the base of the
ears. There are three primary classifications of causes of jaundice.
http://www.petplace.com/cats/jaundice-in-cats/page1.aspx
Pale gums or mucous membranes can indicate blood loss or "shock". The
possible causes for either blood loss or shock are life-threatening and thus
should be evaluated immediately. It is often associated with anemia
http://ww |
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c*******e 发帖数: 4642 | 19 好,那个vet是说想看看steroid有效果吗,也顺便降低dose
我听他这么说的意思就是要经常去了= =
能顺便问下anemia的话,吃东西要注意什么吗?就肝脏罐头? |
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c*******e 发帖数: 4642 | 20 活泼
其实他是steroid refractory
运气真得很不好
vet措施很正确
猪头让我还是要买iron supplement
他说肝脏也有用。。。
而且他说我也有anemia。我今天眼圈黑的惊人,然后一天都没怎么吃东西,到了晚饭前
眼前发黑。。。。正好跟goldy一起补了 |
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c*****a 发帖数: 5428 | 21 昨晚给贪狗准备下面一周的口粮(自己做的碎肉拌干粮),这周的主题是内脏,去超市
看到有猪肝就想着给他做点treat吃吃。做法倒还简单,效果超级好,贪狗如此挑,都
守在烤箱前面一晚上,来回叫人,让给他拿来吃,哼叽了俩小时。。。
1. 华人超市买的猪肝,大概一磅左右一个,两刀多点。
2. 先烧一锅热水,烧开以后放肝进去,大概20分钟以后会煮熟。如果事先切成4-6块就
更快了,我懒得占切菜板和刀,就整个放进去了。
3. 煮到整个变硬,用筷子扎进最厚的地方都是硬的,并且没有血水冒出来的时候就熟
了。其实这个时候已经可以吃了,偷懒的可以直接切片吃。
4. 如果想要饼干一样硬一点的质感,可以切大概半厘米那么厚的片,然后放到预热300
度的烤箱里面,烤10分钟,把肝片儿翻面,再5分钟。
5. 凉透后放冰箱储藏。吃的时候建议掰成小块喂,要不然给多少都是半秒就不见了。
。。
6. 最后大概是一磅生猪肝能出半磅多烤肝片儿。如果
只是煮,成品更多。比较宠物店里卖的liver treat,自己做的不仅便宜而且放心。
唯一的遗憾是昨天没有拍照片,当时没想到效果这么好,所以没打算拍照发帖的。。。
[CAUTION!... 阅读全帖 |
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i*********s 发帖数: 8706 | 22 肾脏问题真的是这次才出现的。
我们有甲亢,所以要closely monitor心脏和肾脏。
一直是每六个月检查心和肾的功能,验血验尿,都算正常。。。
直到去年11月,有一丢丢不正常。
一直还有IBD。
医生现在除了肾脏问题,还怀疑肠道内壁已经有癌症。
但是这个癌症也不是一天就冒出来的啊。。。
红血球是一直都比较低。
医生说年岁大又有慢性病的猫,常见anemia。。。
所以我们经常打铁针。
一直维持还不错。。。
但是这一次也算史上最低了。。。 |
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i*********s 发帖数: 8706 | 23 肾脏问题真的是这次才出现的。
我们有甲亢,所以要closely monitor心脏和肾脏。
一直是每六个月检查心和肾的功能,验血验尿,都算正常。。。
直到去年11月,有一丢丢不正常。
一直还有IBD。
医生现在除了肾脏问题,还怀疑肠道内壁已经有癌症。
但是这个癌症也不是一天就冒出来的啊。。。
红血球是一直都比较低。
医生说年岁大又有慢性病的猫,常见anemia。。。
所以我们经常打铁针。
一直维持还不错。。。
但是这一次也算史上最低了。。。 |
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x********u 发帖数: 15396 | 24 http://www.fda.gov/Safety/Recalls/ucm313572.htm?source=govdeliv
Contact:
Brad Armistead
1-888-559-8833
FOR IMMEDIATE RELEASE - July 27, 2012 - Arthur Dogswell LLC, Los Angeles, CA
90025, is voluntarily recalling 1051 cartons packed as either 10 or 50
packages per case of Catswell Brand VitaKitty Chicken Breast with Flaxseed
and Vitamins because it has the potential to contain propylene glycol. High
levels of propylene glycol in the treats could result in serious injury to
cats. The adverse healt... 阅读全帖 |
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b******a 发帖数: 12216 | 25 第三篇——Doggone DNA – inherited health problems in pets
(这篇太长了。。。我就把两个table里的内容copy过来了。如果有感兴趣的想要看,我
可以周一去单位scan一下这篇文,然后发上来)
Inherited Health Problems in Common Breeds
Most popular dog breeds
Labrador retriever: Degenerative joint diseases; eye problems that cause
blindness; extreme muscle weakness after intense exercise or excitement.
German shepherd: Degenerative joint diseases; temperament issues; eye
problems; heart conditions; a thyroid condition that can cause skin and
behavioral chages; dege... 阅读全帖 |
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N*****y 发帖数: 2959 | 26 很不愿意相信,不过这艰难的时刻还是没有征兆的忽然降临了。
纽约今年的冬天注定无比漫长。。。。
昨天,我们把C少送去朋友家代为照顾了。这甜蜜的一对第一次被分开了,猫爹猫娘很
难受。不过为了更好的照顾年糕,也为了防止C少被感染,就只能先这样了。好再C少在
朋友家作威作福,叫饭,捣乱,撒娇,耍无赖一样没差,估计暂时不劳我们操心了。
年糕食量减少了很多,确认出现贫血的症状,身体其他器官目前都还算正常。她精神不
错,还和往常一样时刻跟随在我们的左右,跳上跳下的各种求爱抚。
我们还在积极的研究各种治疗方案,任何机会都不会放过,只希望她呆在我们身边幸福
快乐的久那么一点点。
现在求她吃饭变成了每天最大的难题,一天的喜怒哀乐都和她吃了多少紧密相关。可惜
医生嘱咐不能增加任何stress,所以也不能抢灌。她现在只有看见猫草才会扑上来,难
道是该吃素了吗?
就暂时说这些吧,请不要问太多,会适时更新一些情况的。
需要很多很多的正能量和对年糕最大的祝福,猫娘囊中羞涩木有很多包子了。先衷心谢
谢所有的小伙伴们了。
-------------------------------------------------... 阅读全帖 |
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i***R 发帖数: 663 | 27 什么都完美了,要人做什么呢。对基因和蛋白的研究还远远没有达到通透的水平,怎么
通过测序就知道某种变化是好是坏呢。
除非特殊严重的基因缺陷需要避免比如downs syndrome,其实很多基因的变化是为了适
应不同的环境。比如sickle cell anemia 病人对疟疾有抗性。人群中基因背景差异越
大,抵御大规模瘟疫的能力就越强。非洲是人类的发源地,也是基因变异最多的地方,
部落和部落之间的差异都相当大,而美洲是变异最少的地方,因为从白令海峡移民过去
的人种十分单一。结果如何,非洲丛林孕育那么多种类的疾病,HIV,埃博拉,疟疾,欧
洲殖民者带去的流感,鼠疫,天花,但非洲种族从来没有被wipeout 过。但美洲几千万
的Aztec 人仅仅经历2次瘟疫就全部消失了。
基因不一定完全决定性状,小RNA,甚至蛋白质也可以影响胎儿的发育。Dr. Mellon 甚
至认为人类有可能感知环境的变化,继而通过小RNA调节基因表达水平和下一代的性状
,也就是说不仅可以被动的物竞天择,物种甚至可能主动适应环境,这在几代以内就可
能产生变化。
所谓灵魂应该也有基因基础,但这个问题太深奥,任何前沿研究说来都 |
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P******a 发帖数: 478 | 28 B12 and Be a Vegetarian
Vitamin B12 is one of the B vitamins and is critical for the metabolism of
every cell in our bodies, especially the bone marrow, GI tract, and nervous
tissue. B12 is created in our intestinal systems but also must be supplied
in the diet.
If we don't receive enough, we can eventually use up our body's supplies,
which leads to health problems that can include headaches, bruising,
depression, fatigue, anemia, and irritability. We can go several years
without ingesting any B |
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D****g 发帖数: 275 | 29 The plasma should be around 55-60% if you spin down at 10,000g for 5-10 min,
if you get more than that, your mice may have anemia, if you get less than
that, your mice may have polycythemia. |
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h******y 发帖数: 1374 | 30 Scientists turn human skin into blood
Scientists at McMaster University have discovered how to make human blood
from adult human skin.
The discovery could mean that people needing blood for surgery, cancer
treatment or treatment of blood conditions like anemia will be able to have
blood created from a patch of their own skin to provide transfusions.
Clinical trials could begin as soon as 2012.
The researchers have also shown that the conversion is direct. Making blood
from skin does not require ... 阅读全帖 |
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m*****n 发帖数: 5245 | 31 http://www.ncbi.nlm.nih.gov/pubmed/12735210
Rev Clin Exp Hematol. 2002;Suppl 1:7-11.
Immunogenicity of erythropoietin and other growth factors.
Indiveri F, Murdaca G.
Department of Internal Medicine, Division of Internal Medicine and Clinical
Immunology, University of Genoa, Italy.
Abstract
Erythropoietin (EPO) is a 165 amino-acid sequence glycoprotein which plays
an important role in maintaining regular generation of erythrocytes, Jacobs
et al. describe the cloning of the human EPO and recombin... 阅读全帖 |
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p****n 发帖数: 9263 | 32 Adverse ReactionsBased upon normal doses for either indication or route. (
Adverse effects such as flushing, diarrhea, myalgia, and visual disturbances
may be increased with doses >100 mg/24 hours.)
>10%:
Central nervous system: Headache (16% to 46%)
Gastrointestinal: Dyspepsia (7% to 17%; dose related)
2% to 10%:
Cardiovascular: Flushing (10%)
Central nervous system: Insomnia (≤7%), pyrexia (6%), dizziness (2%)
Dermatologic: Erythema (6%), rash (2%)
Gastrointestinal: Diarrhea (3% to 9%), gastri... 阅读全帖 |
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g****1 发帖数: 261 | 33 http://worldtruth.tv/monsanto-found-guilty-of-chemical-poisonin
A French farmer who can no longer perform his routine farming duties because
of permanent pesticide injuries has had his day in court, literally, and
the perpetrator of his injuries found guilty of chemical poisoning. The
French court in Lyon ruled that Monsanto’s Lasso weedkiller formula, which
contains the active ingredient alachlor, caused Paul Francois to develop
lifelong neurological damage that manifests as persistent memory l... 阅读全帖 |
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p*****c 发帖数: 20445 | 34 Michael Rape, Ph.D.
University of California, Berkeley
Michael Rape’s love of science began in the basement of his parent’s house
, where he used to conduct rudimentary biochemistry experiments. Today, he
uses far more sophisticated methods to understand a complex process critical
to nearly all organisms: ubiquitylation. The term describes the attachment
of a regulatory protein called ubiquitin—named for its ubiquity—onto other
proteins. Ubiquitin tags communicate a wealth of information to the ... 阅读全帖 |
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g********s 发帖数: 67 | 35 国内朋友小孩得再生障碍性贫血,想来美国治疗,请问大家有谁知道美国哪个美国医院
或医生是这方面的权威?谢谢! |
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h*****u 发帖数: 97 | 36 根据严重程度,采取不同治疗方法。程度较重的小孩最好做移植。如果需要做移植,我
可以提供一些信息。 |
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d******1 发帖数: 709 | 37 去boston children's hospital (BCH).
全世界也没几个地方比BCH做得好了,在红细胞方面。 |
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g********s 发帖数: 67 | 38 谢谢。可以把信息发到我站内信箱吗?
他们的国内药物治疗不是很理想,估计得试移植。 |
|
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b*******1 发帖数: 16 | 40 岗位一:吴虹课题组博士后工作人员 (2名)
主要职责:
1)独立开展科研工作,动手进行体内外实验;
2)协助PI负责实验室研究课题的设计和开展;
3)参与科研基金撰写;
4)协助培养研究生。
招聘条件:
1)品学兼优,身体健康,年龄在40岁以下;
2)近年来在国内外获得分子生物学、细胞生物学、肿瘤遗传学、药理学等相关专业博
士学位;
3)至少具备一项以下领域内的工作经验和文献发表:
a. 独立运用细胞和动物模型进行肿瘤药物的机理研究
b. 在分子生物学和细胞生物学领域有深厚的知识背景;
c. 在蛋白质分析、核酸分析和细胞生长分析等相关技术方面有丰富的经验;
d. 对治疗癌症的药物疗效和安全性评价方面有强烈的兴趣和研究背景 ;
4)有较强的团队合作精神,沟通协调能力强,动手能力强,工作细心,积极主动,能
持之以恒;
聘用待遇:
本职位将为你提供在生物学领域极具竞争力和创造性的工作机会。博士后工作人员薪酬
标准按照北京大学生命科学院和北大-清华生命科学中心相应规定及个人工作经验及能
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l*****7 发帖数: 8463 | 41 The Nobel Prize was given in 1934 to George Whipple, George Minot and
William Murphy of the U.S.A. "for their discoveries concerning liver therapy
in cases of anaemia," and the first to be divided between three people.
Previously, pernicious anemia had been an incurable condition, but these
workers had found that sufferers could survive if they would eat large
quantities of raw liver each day, with the hope that this could soon be
replaced by more potent liver extracts. There was no mention at t... 阅读全帖 |
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h******y 发帖数: 351 | 42 Metformin improves defective hematopoiesis and delays tumor formation in
Fanconi anemia mice
Qing-Shuo Zhang, Weiliang Tang, Matthew Deater, Ngoc Phan, Andrea N.
Marcogliese, Hui Li, Muhsen Al-Dhalimy, Angela Major, Susan Olson, Raymond J
. Monnat Jr. and Markus Grompe
Blood 2016 :blood-2015-11-683490; doi:10.1182/blood-2015-11-683490
http://www.bloodjournal.org/content/early/2016/10/18/blood-2015-11-683490?sso-checked=true
Thank you very much! |
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h******y 发帖数: 351 | 43 Metformin improves defective hematopoiesis and delays tumor formation in
Fanconi anemia mice
Qing-Shuo Zhang, Weiliang Tang, Matthew Deater, Ngoc Phan, Andrea N.
Marcogliese, Hui Li, Muhsen Al-Dhalimy, Angela Major, Susan Olson, Raymond J
. Monnat Jr. and Markus Grompe
Blood 2016 :blood-2015-11-683490; doi:10.1182/blood-2015-11-683490
http://www.bloodjournal.org/content/early/2016/10/18/blood-2015-11-683490?sso-checked=true
Thank you very much! |
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m***d 发帖数: 441 | 44 http://www.markjshen.net/2008/01/usmle-dr-goljan.html
USMLE - Dr. Goljan
首先說,這名字不念gol-dgen,正確念法是gol-'yang,重音在後面,Dr. Goljan 偏好
這樣的純正polish發音。
準備USMLE之前,看到一位前輩分享的心得,Dr. Goljan的上課錄音值得一聽,於是因
緣際會之下也找到了這位神祕名師的錄音檔與講義,本來想說只是試聽看看,沒想到,
一試成主顧!往後最重要的病理複習計畫,竟完全以Goljan的37堂課為主軸規畫!
我還記得第一次聽是快退伍前一次周末值班,在陰暗的值班室裡聽的,挫折感不小,
Goljan上課速度挺快的,從口氣感覺得出來他是挺臭屁的人,很多笑話我也都聽不太懂
,更糟糕的是,Goljan頗喜歡問台下學生問題,我卻因為最基本的發音問題,一直搞不
懂他到底在問甚麼,一直倒帶repeat數次才終於搞懂,不過也因為如此印象特別深刻。
好比說Goljan問台下學生在AIDS病人身上看到anemia要想到甚麼?他停了一會就公布答
案,因為Pneumocystis carin |
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l********z 发帖数: 810 | 45 A 42-year-old man has a temperature of 39.2°C (102.6°F) and mild jaundice
2 days after transfusion of packed red cell for the treatment of chronic
anemia. Laboratory studies show hyperbilirubinemia and a mild increase in
serum lactate dehydrogenase activity. Which of the followings will most
likely be observed on analysis of peripheral blood cells?
A) Complement protein C3bi bound to monocyte
B) Degranulated neutrophils
C) Erythrocyte ghosts
D) HLA-DR upregulation in circulating CD3+ T lymphocyt |
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a*****o 发帖数: 174 | 46 for fatigue cases, i will also consider preg. and anemia.
the new female teen. cases, some will present with fatigue. we will need to
spend time on getting her talk about her sx.hx. |
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l*******8 发帖数: 1745 | 47 来自主题: MedicalCareer版 - 流感来袭 这么严重啊?我们这里还为不用强制打H1N1而高兴呢。昨天24h on call , 没有收到呼
吸系统疾病的,2 DVT, 1 stroke, 1 neutropenia and severe anemia with HIV, and
one hemoptosis with sarcoidosis. |
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m****8 发帖数: 419 | 48 interesting, but i am sure PO2 is normal in co poisoning and anemia. the PO2
is arterial Po2, not tissue po2. |
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