l********z
发帖数: 810 | 1 A 42-year-old man has a temperature of 39.2°C (102.6°F) and mild jaundice
2 days after transfusion of packed red cell for the treatment of chronic
anemia. Laboratory studies show hyperbilirubinemia and a mild increase in
serum lactate dehydrogenase activity. Which of the followings will most
likely be observed on analysis of peripheral blood cells?
A) Complement protein C3bi bound to monocyte
B) Degranulated neutrophils
C) Erythrocyte ghosts
D) HLA-DR upregulation in circulating CD3+ T lymphocyt |
p****7
发帖数: 6 | 2 C, “hyperbilirubinemia and a increase in serum lactate dehydrogenase
activity”表示RBC破裂。“Ig bound to RBC”的中间状态会被检测到吗？
jaundice
【在 l********z 的大作中提到】
: A 42-year-old man has a temperature of 39.2°C (102.6°F) and mild jaundice
: 2 days after transfusion of packed red cell for the treatment of chronic
: anemia. Laboratory studies show hyperbilirubinemia and a mild increase in
: serum lactate dehydrogenase activity. Which of the followings will most
: likely be observed on analysis of peripheral blood cells?
: A) Complement protein C3bi bound to monocyte
: B) Degranulated neutrophils
: C) Erythrocyte ghosts
: D) HLA-DR upregulation in circulating CD3+ T lymphocyt
|
l********z
发帖数: 810 | 3 Thanks! There are two version of answers. I just want to confirm what should
be the best answer.
jaundice
【在 l********z 的大作中提到】
: A 42-year-old man has a temperature of 39.2°C (102.6°F) and mild jaundice
: 2 days after transfusion of packed red cell for the treatment of chronic
: anemia. Laboratory studies show hyperbilirubinemia and a mild increase in
: serum lactate dehydrogenase activity. Which of the followings will most
: likely be observed on analysis of peripheral blood cells?
: A) Complement protein C3bi bound to monocyte
: B) Degranulated neutrophils
: C) Erythrocyte ghosts
: D) HLA-DR upregulation in circulating CD3+ T lymphocyt
|
s*****r
发帖数: 69 | 4 well, I think E is a better answer. C is true for acute hemolytic
transfusion reaction. But this should be delayed reaction. Goljan's lecture
mentioned it.It's caused by the memory B cell.
Here is what I copied online.
Delayed hemolytic transfusion reaction:
Occasionally, a patient who has been sensitized to an RBC antigen has very
low antibody levels and negative pretransfusion tests. After transfusion
with RBCs bearing this antigen, a primary or anamnestic response may result
(usually in 1 to |
