e*e
发帖数: 116 | 1 A kinetic proofreading mechanism for disentanglement of DNA by
topoisomeras
es
JIE YAN, MARCELO O. MAGNASCO & JOHN F. MARKO
Cells must remove all entanglements between their replicated chromosomal DNA
s to segregate them during cell division. Entanglement removal is done by AT
P-driven enzymes that pass DNA strands through one another, called type II t
opoisomerases. In vitro, some type II topoisomerases can reduce entanglement
s much more than expected, given the assumption that they pass DNA s | s***e
发帖数: 911 | 2
It is to explain the experiment in 1997 published in Science. This experiment
shows that TOPO II/IV can drive the topology distribution far away from the
thermo-equilibrium... |
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