z***b
发帖数: 29 | 1 先说说我的家族史.我母亲有一姐一妹,都在四.五十岁时得了乳腺癌,但发现时都是比较
早期的,经治疗后现在都还在.我母亲本人五十四岁时患卵巢癌,七年后六十二岁时去世.
我今年三十八岁,去年四月初我的ob建议我去做了一个mammo,一个礼拜后radiologist联
系我说右侧乳房有些部位需要进一步检查,于是又对右侧乳房做了一次mammo.当时
radiologist就看了结果,对我说我的右侧乳房有calcification,这很大可能是良性的,
但是他当时不能100%确认,所以必须六个月后再做一次mammo来确定.于是去年十月份我
又做了一次mammo,这次两侧乳房都做了.结果出来后radiologist说当时我右侧乳房的
calcification看来不是恶性的,但为了保险起见六个月后要我再做一次mammo.于是我又
约了4月中旬再做.如果到时去做的话,那我从去年4月到今年4月就足足做了四次mammo!
这两天我上网看看,发现原来mammo由于辐射高本身也是诱发癌症的,现在觉得很犹豫了,
究竟要不要再做这个mammo呢?
能不能请对mammo screening有研究的人士帮我看看,说说你们的意见呢?多谢啦! | l**x
发帖数: 296 | 2 It sounds like your family carry the BRCA mutation.
In this scenario, especially with calcifications, the benefit of having
mammogram outweighs the risk.
If you want to confirm, you could have your gene tested for the BRCA1 or 2
mutations. | y*****g
发帖数: 193 | 3 You need not only mammogram, also BCRA1+BCRA2 gene type test with strong
family history. | z***b
发帖数: 29 | 4 非常感谢楼上两位的意见.其实我8年前在UCLA见过一位gene specialist,她根据我的家
族史计算出我在80岁之前的乳腺癌的概率是18%.她也提到过BRCA1 and 2的问题,还告诉
我说做这个测试要>$3000,必须有保险公司的pre-approval.我当时嫌麻烦,而且觉得自
己还年轻,就不了了之了.而且我总有一个疑问:如果我去做了,结果出来非常不好,那么
我的下一步是什么?天天惶惶不可终日?频繁做mammo?还是干脆割除乳房?
我的姥姥和太姥姥一生都非常健康,都是八九十岁时自然衰老而去,到了我母亲这一辈就
成了个"癌窝窝",真不知道这当中发生了什么基因变异? | g*****j
发帖数: 1211 | 5 I think it is early to say you have BRCA mutation. After all, it is not
very common in patients with breast cancer. It is not a bad idea to have
genetic testing though, if there is family history of early breast or ovary
cancer. If god forbid, you do carry BRCA mutation, breast and ovary removal
with breast reconstruction is an option to end the worry, especially if you
do not expect to be pregnant. | l**x
发帖数: 296 | 6 The information from your genetic test will give you opportunity to make a
decision whether to intervene or not.
For example, I know there are women choose to have their breasts and ovaries
removed once they find out they carry the mutation. | j**f
发帖数: 7403 | 7 俺不是学医的，就是问问： 那个良性还是恶性，可以做局部组织TEST么？
就是活体测试(biopsy)？ 不懂，打酱油路过。。。
世.
了,
【在 z***b 的大作中提到】
: 先说说我的家族史.我母亲有一姐一妹,都在四.五十岁时得了乳腺癌,但发现时都是比较
: 早期的,经治疗后现在都还在.我母亲本人五十四岁时患卵巢癌,七年后六十二岁时去世.
: 我今年三十八岁,去年四月初我的ob建议我去做了一个mammo,一个礼拜后radiologist联
: 系我说右侧乳房有些部位需要进一步检查,于是又对右侧乳房做了一次mammo.当时
: radiologist就看了结果,对我说我的右侧乳房有calcification,这很大可能是良性的,
: 但是他当时不能100%确认,所以必须六个月后再做一次mammo来确定.于是去年十月份我
: 又做了一次mammo,这次两侧乳房都做了.结果出来后radiologist说当时我右侧乳房的
: calcification看来不是恶性的,但为了保险起见六个月后要我再做一次mammo.于是我又
: 约了4月中旬再做.如果到时去做的话,那我从去年4月到今年4月就足足做了四次mammo!
: 这两天我上网看看,发现原来mammo由于辐射高本身也是诱发癌症的,现在觉得很犹豫了,
| y*****g
发帖数: 193 | 8 10% of breast cancers were caused by BRCA mutation. If you carries the
mutated gene, it doesn't necessarily mean that you will develop the cancer.
With your strong family history, many insurance will cover the gene test
result.
Some MDs will refer pts to genetic couseling if they suspect gene mutation
before and after genetic test, so you know what kind of options you have.
Sometimes, people fears more about the unknown to the fact than knowing the
bad news.
Removal of breast or ovaries after childbearing age is not the only
prophylaxis choice for high risk women, you could choose to close monitoring
, or take Tamoxifen etc.. It is more about your decision how to manage your
health. |
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