s*r
发帖数: 2757 | 1 http://madhadron.com/a-farewell-to-bioinformatics
...
Bioinformatics is an attempt to make molecular biology relevant to reality.
All the molecular biologists, devoid of skills beyond those of a laboratory
technician, cried out for the mathematicians and programmers to magically
extract science from their mountain of shitty results.
And so the programmers descended and built giant databases where huge
numbers of shitty results could be searched quickly. They wrote algorithms
to organize shitty results into trees and make pretty graphs of them, and
the molecular biologists carefully avoided telling the programmers the
actual quality of the results. When it became obvious to everyone involved
that a class of results was worthless, such as microarray data, there was a
rush of handwaving about “not really quantitative, but we can draw
qualitative conclusions” followed by a hasty switch to a new technique that
had not yet been proved worthless.
And the databases grew, and everyone annotated their data by searching
the databases, then submitted in turn. No one seems to have pointed out that
this makes your database a reflection of your database, not a reflection of
reality. Pull out an annotation in GenBank today and it’s not very long
odds that it’s completely wrong.
... | w***a
发帖数: 4361 | 2 shitty results, hahaha
.
laboratory
【在 s*r 的大作中提到】
: http://madhadron.com/a-farewell-to-bioinformatics
: ...
: Bioinformatics is an attempt to make molecular biology relevant to reality.
: All the molecular biologists, devoid of skills beyond those of a laboratory
: technician, cried out for the mathematicians and programmers to magically
: extract science from their mountain of shitty results.
: And so the programmers descended and built giant databases where huge
: numbers of shitty results could be searched quickly. They wrote algorithms
: to organize shitty results into trees and make pretty graphs of them, and
: the molecular biologists carefully avoided telling the programmers the
| I*****y
发帖数: 6402 | 3 it's the difference between good shit and bad shit.
Good shit is still better, and therefore bears better chance of appearing on
CNS.
.
laboratory
【在 s*r 的大作中提到】
: http://madhadron.com/a-farewell-to-bioinformatics
: ...
: Bioinformatics is an attempt to make molecular biology relevant to reality.
: All the molecular biologists, devoid of skills beyond those of a laboratory
: technician, cried out for the mathematicians and programmers to magically
: extract science from their mountain of shitty results.
: And so the programmers descended and built giant databases where huge
: numbers of shitty results could be searched quickly. They wrote algorithms
: to organize shitty results into trees and make pretty graphs of them, and
: the molecular biologists carefully avoided telling the programmers the
| c**********e
发帖数: 70 | 4 当我每次发现实验数据有问题的时候，做实验的人都很气愤，他们即使不相信我的结论
，也没办法自己去验证，唉。 | n*********4
发帖数: 99 | | s*****j
发帖数: 6435 | 6 想起来前些年去开个会, 有个分会场专门讲 bioinformatics. 上去讲的都是大都是各
个大学里 bioinformatics center 的头头. 都是将我们做了多少数据, 多少人在用,
blah blah blah. 现在前景大好.
我就问, 说如果我要改行搞这个, 需要学多少统计? 是要到学校里去学几年, 还是啃
一本 "statistics for biologist" 就够了. 结果大家都笑了, 我说你们笑什么. 坐
主席台上的分会主席说, 我什么统计都没学过.
.
laboratory
【在 s*r 的大作中提到】
: http://madhadron.com/a-farewell-to-bioinformatics
: ...
: Bioinformatics is an attempt to make molecular biology relevant to reality.
: All the molecular biologists, devoid of skills beyond those of a laboratory
: technician, cried out for the mathematicians and programmers to magically
: extract science from their mountain of shitty results.
: And so the programmers descended and built giant databases where huge
: numbers of shitty results could be searched quickly. They wrote algorithms
: to organize shitty results into trees and make pretty graphs of them, and
: the molecular biologists carefully avoided telling the programmers the
| b******n
发帖数: 4225 | 7 哈哈，好玩
【在 s*****j 的大作中提到】
: 想起来前些年去开个会, 有个分会场专门讲 bioinformatics. 上去讲的都是大都是各
: 个大学里 bioinformatics center 的头头. 都是将我们做了多少数据, 多少人在用,
: blah blah blah. 现在前景大好.
: 我就问, 说如果我要改行搞这个, 需要学多少统计? 是要到学校里去学几年, 还是啃
: 一本 "statistics for biologist" 就够了. 结果大家都笑了, 我说你们笑什么. 坐
: 主席台上的分会主席说, 我什么统计都没学过.
:
: .
: laboratory
| n*********4
发帖数: 99 | 8 官越大，知道的越少。
结果大家都笑了, 我说你们笑什么. 坐主席台上的分会主席说, 我什么统计都没学过.
【在 s*****j 的大作中提到】
: 想起来前些年去开个会, 有个分会场专门讲 bioinformatics. 上去讲的都是大都是各
: 个大学里 bioinformatics center 的头头. 都是将我们做了多少数据, 多少人在用,
: blah blah blah. 现在前景大好.
: 我就问, 说如果我要改行搞这个, 需要学多少统计? 是要到学校里去学几年, 还是啃
: 一本 "statistics for biologist" 就够了. 结果大家都笑了, 我说你们笑什么. 坐
: 主席台上的分会主席说, 我什么统计都没学过.
:
: .
: laboratory
| t*d
发帖数: 1290 | 9 愤青一枚。
.
laboratory
【在 s*r 的大作中提到】
: http://madhadron.com/a-farewell-to-bioinformatics
: ...
: Bioinformatics is an attempt to make molecular biology relevant to reality.
: All the molecular biologists, devoid of skills beyond those of a laboratory
: technician, cried out for the mathematicians and programmers to magically
: extract science from their mountain of shitty results.
: And so the programmers descended and built giant databases where huge
: numbers of shitty results could be searched quickly. They wrote algorithms
: to organize shitty results into trees and make pretty graphs of them, and
: the molecular biologists carefully avoided telling the programmers the
| g*******g
发帖数: 15 | 10 statistics本来就不是bioinformatics里面最重要的部分吧...
【在 s*****j 的大作中提到】
: 想起来前些年去开个会, 有个分会场专门讲 bioinformatics. 上去讲的都是大都是各
: 个大学里 bioinformatics center 的头头. 都是将我们做了多少数据, 多少人在用,
: blah blah blah. 现在前景大好.
: 我就问, 说如果我要改行搞这个, 需要学多少统计? 是要到学校里去学几年, 还是啃
: 一本 "statistics for biologist" 就够了. 结果大家都笑了, 我说你们笑什么. 坐
: 主席台上的分会主席说, 我什么统计都没学过.
:
: .
: laboratory
|
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