g********0
发帖数: 6201 | 1 Cancer Postdoc on Probation for Falsifying Data
06/05/2012 Jesse Jenkins
A former postdoc at Brigham and Women’s Hospital and Harvard Medical School
who confessed to splicing together Western blots has been put on probation
by the federal government.
A former postdoc at Brigham and Women’s Hospital (BWH) and Harvard Medical
School who deliberately fabricated data in federally funded lung cancer
research has been put on probation by the government.
The postdoc, Jian Ma, fabricated images in a manuscript submitted in 2008
for publication in the Journal of Clinical Investigation, according to a U.S
. Office of Research Integrity (ORI) official notice of research misconduct
that was published last week in the Federal Registry. The manuscript was
originally titled “TSC1 loss synergizes with KRAS activation in lung cancer
development and confers rapamycin sensitivity.”
A former postdoc at Brigham and Women’s Hospital and Harvard Medical School
who deliberately fabricated data in federally funded lung cancer research
has been put on probation by the government. Source: Brigham and Women’s
Hospital
Prior to its scheduled publication date of January 2009, one of Ma’s co-
authors reportedly became suspicious of the data and withdrew the paper.
Following the withdrawal, BWH and Harvard Medical School conducted a joint
internal investigation into Ma’s research. In the end, the institutes found
that Ma was guilty of research misconduct and reported their findings to
the ORI.
As a result, the ORI placed Ma on probation for a period of three years
effective May 31, 2012. During this period, Ma must be supervised when
involved in any federally funded research project and is prohibited from
acting in an advisory capacity to the U.S. Public Health Services-supported
research.
“We did find research misconduct and reported our findings to the ORI. We
concur with the findings and administrative actions put forward by the ORI,
” said BWH director of public affairs Dinah Vaprin in a statement released
by the institute.
The manuscript’s lead author Kwok-Kin Wong, a researcher at the Dana-Farber
Cancer Institute, released a statement that explained that Ma’s colleagues
noticed irregularities with one of the Western blots in the submitted
manuscript. “When we asked the postdoctoral fellow to show us the original
film for this piece of data, he confessed to splicing the figure together
from several blots,” Wong said in the statement.
John Dahlberg, director of the ORI’s division of investigative oversight,
explained that ORI initially attempted to contact Ma to reach a voluntary
agreement, but Ma did not respond. A formal charge letter was issued to Ma’
s last known address in April 2012. After 30 days without a response from Ma
, the ORI’s determinations were made final.
“It was a relatively straightforward process to complete the investigation,
” said Dahlberg. “He admitted to it and just wanted to get it behind him.
The problem is that he then disappeared. We don’t know where he went.”
Since the discovery of Ma’s fabrication, his colleagues redid and carefully
reanalyzed the experiments conducted for the unpublished manuscript,
according to Wong. In 2010, the study was published in Oncogene under a
revised title and with Ma listed as the second author (1).
References
Liang, M.-C. C., J. Ma, L. Chen, P. Kozlowski, W. Qin, D. Li, J. Goto, T.
Shimamura, D. N. Hayes, M. Meyerson, D. J. Kwiatkowski, and K.-K. K. Wong.
2010. TSC1 loss synergizes with KRAS activation in lung cancer development
in the mouse and confers rapamycin sensitivity. Oncogene 29(11):1588-1597 | n*********b
发帖数: 140 | 2 Mistreating a postdoc who has made a mistake under supervision is also a
misconduct. | l***i
发帖数: 108 | 3 揭发问题的是oncogene的第一作者liang？
School
probation
Medical
.S
【在 g********0 的大作中提到】
: Cancer Postdoc on Probation for Falsifying Data
: 06/05/2012 Jesse Jenkins
: A former postdoc at Brigham and Women’s Hospital and Harvard Medical School
: who confessed to splicing together Western blots has been put on probation
: by the federal government.
: A former postdoc at Brigham and Women’s Hospital (BWH) and Harvard Medical
: School who deliberately fabricated data in federally funded lung cancer
: research has been put on probation by the government.
: The postdoc, Jian Ma, fabricated images in a manuscript submitted in 2008
: for publication in the Journal of Clinical Investigation, according to a U.S
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