j********8
发帖数: 21 | 1 讲的就是基因组印记？
要是这样岂不是将灌水发挥到了极至？
Paternally Induced Transgenerational
Environmental Reprogramming of
Metabolic Gene Expression inMammals
Epigenetic information can be inherited through the
mammalian germline and represents a plausible
transgenerational carrier of environmental information.
To test whether transgenerational inheritance
of environmental information occurs in mammals, we
carried out an expression profiling screen for genes
in mice that responded to paternal diet. Offspring
of males fed a low-protein diet exhibited elevated
hepatic expression of many genes involved in lipid
and cholesterol biosynthesis and decreased levels
of cholesterol esters, relative to the offspring of males
fed a control diet. Epigenomic profiling of offspring
livers revealed numerous modest (20%) changes
in cytosine methylation depending on paternal diet,
including reproducible changes in methylation over
a likely enhancer for the key lipid regulator Ppara.
These results, in conjunction with recent human
epidemiological data, indicate that parental diet can
affect cholesterol and lipid metabolism in offspring
and define a model system to study environmental
reprogramming of the heritable epigenome. | A******y
发帖数: 2041 | 2 Epigenetic inheritance is a very well known phenomenon. We just don't
understand as much. | u*********1
发帖数: 2518 | 3 why is this "guanshui"?
【在 j********8 的大作中提到】
: 讲的就是基因组印记？
: 要是这样岂不是将灌水发挥到了极至？
: Paternally Induced Transgenerational
: Environmental Reprogramming of
: Metabolic Gene Expression inMammals
: Epigenetic information can be inherited through the
: mammalian germline and represents a plausible
: transgenerational carrier of environmental information.
: To test whether transgenerational inheritance
: of environmental information occurs in mammals, we
|
|
