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全部话题 - 话题: signaling
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m******5
发帖数: 1383
1
来自主题: Biology版 - BGH polyA signal
5'
CTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCC
CACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGG
GTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGG 3'
I am currently designing a transgenic vector, I cloned this BGH polyA signal
from PCDNA 3.0
could anyone here familiar with it help me to check if this poly A signal is
complete enough?
j*****d
发帖数: 787
2
这个杂志将来比embo都要强
作的非常敬业的,
editorial pick 涵盖的非常广泛及时,所有顶级期刊与cell signaling相关的都会100
字提及。
缺点可能就是要求过高,稿源不足
science signaLing 是我home page 之一
b*****u
发帖数: 75
3
If the paper represents the average level of Cancer Res, don't bother Sci
Signal. Although the IF of the latter is less than 8, most of the papers
published there were initially experienced with peer-review in top journals
such as CNS, and they are really good papers.
If you story looks like the typical paper in Sci Signal, don't bother
trying the journal either. You can try others like Mol Cell, Cell Reports,
etc.
l**********1
发帖数: 5204
4
If Human
try Netpath
//www.netpath.org/
if mouse or rat
try David
//idconverter.bioinfo.cnio.es/
Protein Level
SwissProt
Taken from Ensembl Embl
Taken from Ensembl PDB id
Taken from Ensembl IPI
Taken from Ensembl
OMIM*
Taken from Ensembl
GO
Taken from Ensembl KEGG Pathways
Taken from KEGG Reactome Pathway
Taken from Reactome Reactome Reaction
Taken from Reactome
PubMed id
Taken from NCBI
or
//david.abcc.ncifcrf.gov/conversion.jsp
if crop ... 阅读全帖
b********s
发帖数: 9
5
来自主题: Biology版 - 急求一篇paper (Sci Signal)!
The Tetraspanin CD37 Orchestrates the α4β1 Integrin–Akt Signaling Axis
and Supports Long-Lived Plasma Cell Survival
Sci. Signal., 13 November 2012
link:http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/250/ra82
请发到:x*****[email protected]
谢谢。
e****s
发帖数: 1125
6
来自主题: Biology版 - Cell signaling的抗体很难work啊
我最近也有两个从Cell signaling抗体不好.
我一直蛮喜欢Cell signaling抗体的,总体非常Reliable.
不知道怎么,最近买了两个,一个Phospho抗体对Phosphorylated over un-
phosphorylated sample的选择性几乎没有。另一个,就是没有检测到我的蛋白。

sig

发帖数: 1
7
最近做了wild-type和一个mutant的RNA-seq,分析找到了一些differentially
expressed genes,尝试用GO term, 比如说DAVID,但是得出来的结果感觉不是很有提
示性,都是一些很泛泛的名词,例如morphogenesis,development等。后来我自己看了
这些基因,发现有些WNT pathway的基因被up-regulated,有些其他signaling的
components被down-regulated。请问有什么网站或者哪种分析方法可以专门分析这些
DEGs属于哪些signaling pathways吗?
同时我也发现某些mesoderm的基因有被up-regulated,另外有些endoderm的基因有被
down-regulated,请问有什么网站或者哪种分析方法可以专门分析这些DEGs属于哪个
germ layers吗?
谢谢大家!
m**********a
发帖数: 530
8
【 以下文字转载自 Immigration 讨论区 】
发信人: maojiaohuola (爪子嘛), 信区: Immigration
标 题: 求审稿机会(T cell immunology &signaling)
发信站: BBS 未名空间站 (Tue Mar 14 17:42:35 2017, 美东)
急需免疫/生物物理方向的审稿机会,感激不尽!
具体方向是:
T cell immunology
T cell signaling
Costimulatory/coinhibitory receptors
Binding kinetics
Single molecule biomechanics
FRET imaging
有合适的请站内联系!谢谢!

发帖数: 1
9
新人,在此求审稿机会,research area: stem cells, apoptosis, neural
differentiation and development, signal transduction, calcium signaling.
不胜感激!!!!
j**********e
发帖数: 442
10
Downloadable at: http://userwww.service.emory.edu/~hmialon/Ecstasy.pdf
Economics of Ecstacy
In this paper, lovemaking is modeled as a signaling game. In the act of love
-making,
a man and a woman send each other possibly deceptive signals about their
true state
of ecstasy. Each has a prior belief about the other’s state of ecstasy.
These prior beliefs
are associated with the other’s sexual response capacity, which varies in
different ways
for men and women over the life-cycle. The model predicts
m*****t
发帖数: 3477
11
来自主题: EE版 - 问一下,RF还是Mixed signal
甭想了,mixed-signal ms出来可以找到工作,但是并不容易,离精通差的太远了。
ic design上课就是一个感性认识,什么都没有tap out过硬。
前面的几个老id,你问哪个,哪个都会告诉你,phd出来再工作个3-5年,人家也才敢说
:我
入门了。
mixed-signal (不是就光做个adc pll)比rf范围还广,需要的东西还多。
mbright是做ams的,可能有点bias?
z********2
发帖数: 170
12
control方向好找工作吗?communication或者signal processing呢?
小弟现在有个ut dallas的offer 是做存储器的方向,感觉那里和TI关系紧可能进TI还
是有希望的。
还有UCSB的communication,signal processing和control的ad,估计是没有钱了。现
在正在犹豫去哪里。
UCSB的排名是不错,但是感觉ut dallas好像工作会好找点。自己本是做器件工艺的。
希望大家给点意见啊
x***d
发帖数: 227
13
My new GPS doesn't have any signal, no one satellite, it says poor reception.
How do you think? How to get the signal? what is the problem?
I am travelling for my work, 600 miles, and this shit city, based on my
memory,
this GPS doesn't work. How can I get it work?
Thanks a million!
j***u
发帖数: 26
14
电路用small signal analysis分析完,然后我给出simulation results,但是input是
square wave,不是sin wave。老板说不合适,要改成sin wave,small signal
analysis指的是sin wave信号,不是square wave信号。理论上好像是这么回事,不过
这年头好像sinwave信号很少见呀。我分别跑了电路对sinwave和square wave的
frequency response,是有一点不同,但是大体上是一致的。大家什么看法
I******y
发帖数: 815
15
我又 第二板。 现在需要用第三板。 太贵了。 如你有 电子的, 可以分享吗? 谢
谢。 HAPPY
Discrete-Time Signal Processing (3rd Edition) (Prentice Hall Signal
Processing) by Alan V. Oppenheim and Ronald W. Schafer (Hardcover - Aug 28,
2009)
s*****2
发帖数: 117
16
比如在信号检测中,
接收信号为Y,发送的replica signal为HS,
可用MLD算法来计算所有S下的|Y-HS|^2
这里面的replica signal该如何翻译比较好?
thanks
ET
发帖数: 10701
17
我们的目标就是让后辈少误入歧途,或者让道中人早日迷路知返。
lol...
其实我觉得根本原因是,analog /mixed-signal design的要求越来越高了。 而市面上
能做相对知识面不需要那么宽的designers,可能已经日趋饱和。可以类比为,当初能网
络编程做网页做网站就能称之为程序员,找份工作,到现在当个程序员也需要这算法,
那算法。
还在琢磨中,不知正确与否。
就看ucb的ee140 course project的变化趋势,早些年设计个opamp就是个project, 无
论是telescopic, folded, two-stages,很少有gain-boosting的吧。 现在的projects就
是个whole sensor,这个sensor要有voltage reference, current reference, ADC, M
UX (VGA), 还有啥switched-cap amplifier. 虽然是个team project.
市面上要求的analog/mixed signal的designers, 基本都是要做high speed adc &
ET
发帖数: 10701
18
我们的目标就是让后辈少误入歧途,或者让道中人早日迷路知返。
lol...
其实我觉得根本原因是,analog /mixed-signal design的要求越来越高了。 而市面上
能做相对知识面不需要那么宽的designers,可能已经日趋饱和。可以类比为,当初能网
络编程做网页做网站就能称之为程序员,找份工作,到现在当个程序员也需要这算法,
那算法。
还在琢磨中,不知正确与否。
就看ucb的ee140 course project的变化趋势,早些年设计个opamp就是个project, 无
论是telescopic, folded, two-stages,很少有gain-boosting的吧。 现在的projects就
是个whole sensor,这个sensor要有voltage reference, current reference, ADC, M
UX (VGA), 还有啥switched-cap amplifier. 虽然是个team project.
市面上要求的analog/mixed signal的designers, 基本都是要做high speed adc & ... 阅读全帖
f**h
发帖数: 1149
19
来自主题: EE版 - 怎么放大弱的digital signal
假设有个几十毫伏的digital signal (0 1 0 0 1 ... ),可以用什么电路模块把它转
换成几百毫伏的digital signal呢? 这个data rate大概是Gigabit级别
Y*P
发帖数: 519
20
【 以下文字转载自 JobHunting 讨论区 】
发信人: YeP (也不), 信区: JobHunting
标 题: Signal Integrity Intern Opportunity
发信站: BBS 未名空间站 (Wed Apr 3 12:20:07 2013, 美东)
My team has a Signal Integrity Intern opportunity in bay area. The intern
will work with senior team member on SI of server development. Please
message me if you are interested. Thank you.
s********5
发帖数: 2
21
大家好,小弟在一水校读phd,今天是第二年,目前在找暑期
实习,但是对工业界的岗位分类不太明白,有点疑惑。
现在自己在做的是on-chip RF/MM-WAVE IC 的passive circuits modeling,比如
transmission line, interconnects,spiral inductor,filter之类的。课程背景主
要是一些IC的课,比如analog circuit, RF/microwave IC等active circuit之类的。
虽然课程上的还行,无奈研究都没涉及active 方面的,流的片也只有passive circuit
,投IC的position也没啥底气。想做本行但是发现职位基本没有单独招passive
circuit的。目前看来只有做signal integrity的比较靠边了,比如大家都会用到VNA,
TDR,还有常用的EM solver,像ADS, HFSS, Maxwell,Q3D之类的。
所以想请教一些在公司工作的前辈,我这种情况是不是主要投signal integrity的
position比较靠谱呢?
Thanks... 阅读全帖
d********3
发帖数: 899
22
This individual will be a key member of the design team. The candidate will
participate in the product definition process with marketing and customers
and be involved in all aspects of the IC design cycle from the architectural
concept phase through back-end release to production. He/she will also have
the opportunity to routinely interface with the MEMS designers to
contribute at a system level (MEMS + ASIC). The candidate should be self-
motivated and an excellent team player with superior co... 阅读全帖
L********r
发帖数: 758
23
If you are interested, please text me your email address. Thanks
The job focuses on the development of image and signal processing
algorithms. The position requires solid fundamental knowledge in the related
fields of algorithm development, including image segmentation, statistical
data analysis, signal processing, filter theory texture analysis,
classification, feature extraction.
Software skills required include C++, OOD/OOP, MATLAB and/or Python.
Minimum Qualifications
Bachelor with at l... 阅读全帖
c******l
发帖数: 3
24
来自主题: Engineering版 - help!!!! Signal processing
I have to determine a topic for my thesis now. All what I can choose are from
radar, 
I do not have strong background of radar or signal processing, but I am
interesting with the field. Would somebody give me some suggestion about radar
or radar signal processing? What directions should I consider ? Sorry for the
poor English, cannot input Chinese at school. It’s really a headache problem
for me …..
z*******3
发帖数: 20
25
本人UCSD博士后,最近在准备绿卡申请,希望增加自己的审稿次数,如果有哪位前辈有
合适的审稿机会愿意转让,不胜感激!
关键词:Intracellular Trafficking, Signaling Transduction, TLR signaling
pathway
本人有过多次独立审稿经历,可以提供专业而及时的审稿意见。如果需要CV,站内联系
,或者发email至[email protected]
/* */
再次感谢。
k*******d
发帖数: 1340
26
Mathworks ?
The best match are hedge funds, but very hard to get into... For sell side,
algo trading may use signal proc but for derivatives pricing, signal proc
is not very useful. The job market is bad and the future of quant is not as
good as u imagine. Take a look at posts on this boArd.
L***n
发帖数: 25
27
来自主题: MedicalDevice版 - Mixed Signal Electrical Design Engineer needed
Location: Medical device company in NYC
The Mixed Signal Electrical Design Engineer designs analog and digital
circuitry for new medical imaging products as well as improves circuitry in
existing products. Tasks include analyzing, designing, prototyping, and
testing analog, digital and support circuitry used in medical imaging
products. Responsibilities include documenting designs, working with other
engineering disciplines, and transitioning prototype designs to
manufacturing. Major responsibi... 阅读全帖
w*******y
发帖数: 60932
28
Cellock-brand time-proven build quality and reliability
- Creates enough interference to block all cell phone signals around you (
GSM 930Mhz~960Mhz/CDMA 870Mhz~880Mhz/DCS 1805Mhz~1920Mhz)
- Fully metal construction - creates a solid and techie feel
- Creates a 0.5M ~ 15M (about 2 to 40 feet) radius of cell phone signal
black out area
- Built-in 1500mAh battery lasts 3 to 4 hours, also works and charges on AC
and Car 12V power with including adaptors
- Light (6oz) weight, fits-in-a-pocket size
.
w*******y
发帖数: 60932
29
mwave has POWERLINK PL-150N Wireless 802.11b/g/n USB 2.0 22.5dBm High-Power
Adapter Built-in Antenna and Heatsink Improving 2X Signal Reception and
Speed:
http://www.mwave.com/mwave/SKUSearch_v3.asp?px=DS&scriteria=AA9 PL-150N Wireless 802.11b/g/n USB 2.0 22.5dBm High-Power Adapter Built-in Antenna and Heatsink Improving 2X Signal Reception and Speed
for $8.99 + FS for mclub members (Free to join)
w*******y
发帖数: 60932
30
Link:
http://www.mwave.com/mwave/SKUSearch.asp?px=DS&scriteria=AA9895 PL-150N Wireless 802.11b/g/n USB 2.0 22.5dBm High-Power Adapter Built-in Antenna and Heatsink Improving 2X Signal Reception and Speed
Description:
POWERLINK PL-150N N150 Wireless 802.11b/g/n USB 2.0 22.5dBm High-Power
Adapter Comply with 802.11N, 802.11g and 802.11b Standards Built-in Antenna
and Heatsink Improving 2X Signal Reception and Speed
Features:
Double Performance
Double Distance
Supports WMM function
Supports NDS and... 阅读全帖
p***e
发帖数: 3852
31
翻出这个旧帖子。如果1065附近真的是顶的话,那么跟着可能就是一个15%的大回调。
。。
Dow Theory shows buy signal but pullback due
Mon Aug 10, 2009 11:58am EDT
NEW YORK (Reuters) - Dow Theory, one of the oldest stock market
forecasting methods, has shown a new buy signal: the Dow Jones
Transportation Average joined the Dow Jones Industrial Average to close
above January highs, according to Bank of America Merrill Lynch.
However, the bank's analysts said on Monday that a momentum indicator known
as breadth thrust, which focuses on the
t******2
发帖数: 2265
32
来自主题: _Stockcafeteria版 - today222: your signal
I will write a summary in a new thread to tell you all and how my model
interpret market in past 10 days.
in short, that MAYBE isn't a wrong signal at all. It's still need time to
prove it's correct. BUT, IT IS too early to say it is a wrong signal now.
today's surge open DOES mean alot.
z******n
发帖数: 2595
33
【 以下文字转载自 Automobile 讨论区 】
发信人: zhangjun (zhangjun), 信区: Automobile
标 题: 请问4个turn signal bulb 都不亮,是该换common flasher or fl
发信站: BBS 未名空间站 (Sun Feb 26 17:05:12 2012, 美东)
是该换common flasher or flasher relay.
08 camry. 万分感谢。
t**********0
发帖数: 9359
34
【 以下文字转载自 shopping 讨论区 】
发信人: tiantian2010 (甜甜), 信区: shopping
标 题: 新买desktop在monitor上无法显示 signal
发信站: BBS 未名空间站 (Thu Nov 29 18:28:24 2012, 美东)
HP的desktop h8-1234的, 只有hdmi和dvi port
monitor没问题,放别的laptop上都显示
用dvi to dvi cable 链接了,monitor都没反应

发帖数: 1
35
http://www.economist.com/news/china/21712159-tough-times-loom-america-south-china-sea-china-seizes-underwater-drone-and-sends
Warning shot
China seizes an underwater drone and sends a signal to Donald Trump
Tough times loom for America in the South China Sea
IT WAS an operation carried out with remarkable cool. On December 15th, less
than 500 metres away from an American navy ship, a Chinese one deployed a
smaller boat to grab an underwater American drone. The object was then taken
to the Chines... 阅读全帖
l****z
发帖数: 29846
36
你讲的完全没有道理阿.
===========
但要真正实施起来,估计得去中国取
经,建立派出所,居委会,各地再多建一些打死孙志刚的收容所
===========
我的那些措施其实没有针对非法移民,针对的是接受非法移民的公司和人. 同时给非法
移民一个signal. 所以什么孙志刚的类别完全不成立. 非法移民现在能存活下来主要是
当地人的宽容.如果这个宽容没有了,非法移民就没戏了.
这个和当初日本鬼子在东北坚壁清野的做法差不多.
D*******o
发帖数: 3229
37
同意。现在能做的就是把这个问题无限搁置,不赶人,不给出路。经济好的时候雇佣廉
价劳动力,经济不好的时候找不到工作自己就回去了。有人犯法逮住了驱逐出去。
发信人: wuwd (woodhead), 信区: USANews
标 题: Re: 关于非法移民,其实就是看美国政府给什么signal
发信站: BBS 未名空间站 (Mon Sep 10 19:00:10 2012, 美东)
那我们接着讨论,你最后提到这个和日本鬼子在东北坚壁清野的做法差不多, 我理解
你是说中国东北的老百姓坚壁清野赶走日本鬼子的做法, 而不是日本鬼子坚壁清野消
灭抗联队伍的做法。
我举另外一个例子,还是抗战日本鬼子的时候,中共对付日本鬼子的扫荡就采取坚壁清
野的做法,但最后鬼子是被打走的而不是被赶走的。当然日本鬼子能在中国占了那么多
年,一个主要原因是一些当地人的宽容(所谓的汉奸)。你所说的没错,现在的非法移
民能存活下来主要是当地人的宽容,特别的是接受非法移民的公司和人。问题就来了,
这些接受非法移民的公司和人就是共和党天天宣传要保护的private sector small
business, 你把这些 sm... 阅读全帖
D*******o
发帖数: 3229
38
我的建议是尽量不抓不关非法移民,已经过来的并且有雇主支持的可以发给工作签证。
所有人通过EB或亲属移民,不给非法移民额外佩额,立法杜绝非法移民大赦。
发信人: huangshiren (平安 & 金池 & 梁博), 信区: USANews
标 题: Re: 关于非法移民,其实就是看美国政府给什么signal
发信站: BBS 未名空间站 (Mon Sep 10 19:12:24 2012, 美东)
问题是你说的办法,政府收不到税,同时还要花钱抓非法移民,关非法移民,审理非法
移民,遣送非法移民。实际就是政府花钱给私人公司老板养廉价劳工。这样政府开销太
大,没法支撑。
c******n
发帖数: 16666
39
土地还真有这个 规矩
还正好就是10年

如果政府有这么一个规定: 偷来的车开了10年后就不算偷了.那么是不是偷车的人会更
多? 其实就是一个signal的问题.
D*******o
发帖数: 3229
40
F1来美国,H1B工作都是走正常的合法的道路。要block这一途径,可以,法律能通过国
会批准就行。既然这个法律没有出台,我们一切遵照合法途径,理应比非法的有更高的
优先级。现在的问题,30以下的F1毕业找工作反倒不如非法移民EAD自由,所以说这个
现象很操蛋。
发信人: ttgl (无所), 信区: USANews
标 题: Re: 关于非法移民,其实就是看美国政府给什么signal
发信站: BBS 未名空间站 (Mon Sep 10 23:13:33 2012, 美东)
前几年刚衰退的时候,NBC有关H1争论得很厉害。
有建议和楼主类似,大致记得些内容:
留学生都承诺过学成回国的,所以:
雇佣留学生的公司应该缴纳高额惩罚税
逾期居留或者课时不够的留学生按felony起诉
私自打工的留学生剥夺财产后驱逐出境
禁止留学生生小孩,违反者驱逐出境,小孩不自动获得美国国籍。
不记得其他了,有映像的人补充吧
a******e
发帖数: 5411
41
来自主题: Automobile版 - 3-way signal?
this intersection should have left turn signal installed.
the guy behind you probably knew about the fact that it was red light on the
other side.
M****q
发帖数: 21
42
本人的车车上,low tire pressure signal 一直亮,找到mechanic向里面冲了气,还
是一直亮,怎样自助修理,多谢各位!
f****l
发帖数: 5514
43
备胎上有sensor吗?
[在 MrLaoq () 的大作中提到:]
:本人的车车上,low tire pressure signal 一直亮,找到mechanic向里面冲了气,还
:是一直亮,怎样自助修理,多谢各位!
:...........
g*******u
发帖数: 3948
44
右转有“right turn signal” 但是没有 "no turn on red" 这个情况红灯能转吗?
c*i
发帖数: 348
45
出售S.M.Kay的Fundamentals of Statistical Signal Processing
Estimation Theory $60
Detection Theory $60
hardcover 英文原版 99成新
m****s
发帖数: 18160
46
【 以下文字转载自 EE 讨论区 】
发信人: mbta (mbta), 信区: EE
标 题: 湾区serdes I/O team招junior analog & mixed signal IC designer
发信站: BBS 未名空间站 (Wed Aug 28 16:56:26 2013, 美东)
湾区知名公司的serdes team招junior analog IC designer。待遇中上。做的东西是
cutting edge的,个人觉得比较有意思。绿卡政策友好。
请PM。最好有一段简单的介绍,gpa,学校,course focus,project经历,research。
。。这种。我的感觉,老板对人的要求比较高。
PS:如果有工作经历更好,老板会根据背景给title,不仅仅限于junior。
m****s
发帖数: 18160
47
【 以下文字转载自 EE 讨论区 】
发信人: mbta (mbta), 信区: EE
标 题: 湾区serdes I/O team招junior analog & mixed signal IC designer
发信站: BBS 未名空间站 (Wed Aug 28 16:56:26 2013, 美东)
湾区知名公司的serdes team招junior analog IC designer。待遇中上。做的东西是
cutting edge的,个人觉得比较有意思。绿卡政策友好。
请PM。最好有一段简单的介绍,gpa,学校,course focus,project经历,research。
。。这种。我的感觉,老板对人的要求比较高。
PS:如果有工作经历更好,老板会根据背景给title,不仅仅限于junior。
m*******e
发帖数: 115
48
来自主题: Classified版 - A signal processing R&D position
I work in a semiconductor company. My group is looking for a candidate to
fill a R&D position in Denver area in Colorado.
The candidate is expected to be knowledgeable in theory of one or more of
following areas: signal processing, communication, feed back control, or
pattern recognition.
The candidate is expected to have PhD. Fresh PhD or a few years working
experience are both welcome.
The candidate is expected to be able to research problems independently,
develop novel solutions, and test al... 阅读全帖
h******e
发帖数: 908
49
现在中部一牛校,PhD念的太不爽准备这个学期quit拿MASTER找工作,整整瞎捣鼓了三
年多的电子设备系统(设计制造调试),高深的理论没多少倒是动手能力得到了很大
的锻炼。
现在想做ANALOG/MIXED SIGNAL IC Design,原来国内有个硕士,在联发科实习过一年多
就做模拟集成电路的,半导体,模拟电路设计是强项,求各位内推,有资源的请投条站
内信。
跪谢!
n*********h
发帖数: 98
50
代友转发,请勿回信箱,直接发联系人的email。谢谢!
================================================
We are a fast-growing medium-size company located in Silicon Valley,
and currently have a few job openings in analog/mixed-signal design
for high-speed SerDes.
Ideal candidates should have previous circuit-design experiences in at
least one of the following: CDR, PLL/DLL, (wireline) transmitter, data
converter; all levels of experiences are welcome.
The company offers a friendly work environment and opportunities to
wor... 阅读全帖
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