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z****e
发帖数: 3400 | 2 安卓实在没法用，为了少花钱后来浪费那么多时间实在不值得。 |
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j****u
发帖数: 913 | 3 苹果就像病毒一样，所有的设备都能连在一起，用了之后感觉安卓的设备就插不上脚了 |
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b****n
发帖数: 3343 | 4 1st generation(w/o retinal display) vs 2nd generation(w/ retina display)?
[发表自未名空间手机版 - m.mitbbs.com] |
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c**i
发帖数: 6973 | 6 Ray Rivera and Al Baker, To Prevent Escapes, Police Start Scanning Irises of
Suspects; Privacy worries over a program instituted after two embarrassing
cases. New York Times, Nov. 16, 2010.
http://www.nytimes.com/2010/11/16/nyregion/16retinas.html?_r=1&scp=2&sq=iris%20scan&st=cse
Quote:
"With the new system, the authorities are using a hand-held scanning device
that can check a prisoner’s identity in seconds
"The technology uses high-resolution images to identify unique patterns in
the iris, the... 阅读全帖 |
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n***w
发帖数: 2405 | 7 我问了问老板，第一个他也说是photopic，有时候可能是mixed的情况。。。第二个他
blabla说了一堆，我没有完全听懂。。。他说除了看数量，还得看the connections
between retinal neurons.。。。。 |
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p*****m
发帖数: 7030 | 8 retinal degeneration和我说的完全不是一回事。。。
stem |
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i***0
发帖数: 160 | 9 Please check the method part of this paper, Immunoblotting of Rhodopsin."
Probing mechanisms of photoreceptor degeneration in a new mouse model of the
common form of autosomal dominant retinitis pigmentosa due to P23H opsin
mutations."Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A,
Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K.J Biol Chem. 2011 Jan 11.
[Epub ahead of print] |
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n***w
发帖数: 2405 | 10 这期的nature不是干细胞造的眼睛嘛。。。。扫了一下。。我去，太牛逼了。。。要是
真能把这个发展起来的。。。我们现在搞retinal neuroprotection的还搞毛啊。。。
。 |
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j*****d
发帖数: 787 | 11 这个NATURE ARTICLE显然是一片噱头文章
retinal neuroprotection的领域大了去了 |
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n***w
发帖数: 2405 | 12 因为喜欢AD/PD而选择了neuroscience，可是没有走成。
现在是retinal research，越研究越觉得有意思。
但是AD/PD是心中挥不去的遗憾。 |
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n*********m
发帖数: 38 | 13 Look his publication
Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights
from structural and biochemical studies on human RPE.
Liang W, Ouyang S, Shaw N, Joachimiak A, Zhang R, Liu ZJ.
FASEB J. 2011 Feb;25(2):497-504. Epub 2010 Oct 5.
PMID:
20923965
[PubMed - indexed for MEDLINE]
Related citations
2.
Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate
synthetase by N10-substituted folate analogues.
Wu D, Li Y, Song G, Cheng C, Zhang R, Joac... 阅读全帖 |
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a********k
发帖数: 2273 | 14 JCR Year and Edition: 2010 Science
Abbreviated Journal Title ISSN {2010} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2010} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 9801 94.262 70.216 8.667 18
3.8 0.04923 24.782
ACTA CRYSTALLOGR A 0108-7673 13944 54.333 24.717 0.629 70
6.2 0.04... 阅读全帖 |
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n***w
发帖数: 2405 | 15 too many diseases and I cannot describe them all.
Age-related macular degeneration
diabetic retionopathy
cataract
glaucoma
retinitis pigmentosa
Stargardt disease
Myopia
etc
And the pathophysiologies of these diseases involve so many mechanisms and
lots of studies have been done and lots of work need to be done. So if you
work on lipid research, you may link to one of these diseases, if you work
on mitochondria, you may think about this disease, if you work on
vasculature, you may be able to conn... 阅读全帖 |
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h******y
发帖数: 351 | 16 我的建议是，在和老板争论是否有deletion之前，利用其他的办法证实你的PCR所发现
的结果。PCR是很容易出错的，如果你能利用Southern证实homozygous的deletion确实
存在，相信你的老板是会接受你的结论的。
Constance L. Cepko实验室最近retract了G&D上的一篇文章，很好的说明了PCR的易错
性。有兴趣的可以看看。
http://genesdev.cshlp.org.mutex.gmu.edu/content/25/12/1344.long
“We are writing to clarify the interpretation of the results from our above
-mentioned paper. In this study, we used two methods to examine the
structure of RNA from the mouse Math5 (Atoh7) locus. Our initial
characterization was an analysis of the Math... 阅读全帖 |
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j*****d
发帖数: 787 | 17 this one may be not right.
i guess they two share the same name Zhao Chen.
One is working in Tianjin, another one working in Nanjin.
Correct me if I am not right. and I will delet this post.
4: Zhao C, Bellur DL, Lu S, Zhao F, Grassi MA, Bowne SJ, Sullivan LS, Daiger
SP,
Chen LJ, Pang CP, Zhao K, Staley JP, Larsson C. Autosomal-dominant retinitis
pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding
of
U4/U6 snRNAs. Am J Hum Genet. 2009 Nov;85(5):617-27. Epub 2009 Oct 29.
P... 阅读全帖 |
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a********k
发帖数: 2273 | 18 I am not sure these are all correct. But zhao chen earned his PhD in Tianjin
Medical.
Daiger
retinitis |
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n***w
发帖数: 2405 | 19 如果说是眼睛， retinal prosthetics开发得有阵子了。 |
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g*********5
发帖数: 2533 | 20 What are lentiviral vectors?
Lentiviral vectors are a type of retrovirus that can infect both
dividing and nondividing cells because their preintegration complex (virus
“shell”) can get through the intact membrane of the nucleus of the target
cell. Lentiviruses can be used to provide highly effective gene therapy as
lentiviruses can change the expression of their target cell's gene for up to
six months. They can be used for nondividing or terminally differentiated
cells such as neurons, ma... 阅读全帖 |
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a****l
发帖数: 125 | 21 大鸟 mentioned that lentivirus cannot get access to G0 cells. But what are
the stages of those non-dividing cells such as neurons, macrophages,
hematopoietic stem cells, retinal photoreceptors, and muscle and liver cells?
有人用lentivirus 做 tail vein injection 去infect liver 吗？ |
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n***w
发帖数: 2405 | 22 没有zhaohu之前发的图片那么有娱乐性，
老鼠用DiI perfuse，然后flatmount。
retina has three vascular layer, one is the most superficial layer where
lies the veins and arteries，the second is the superficial capillary bed and
the deepest is called the deep capillary bed.
Enjoy.
When I see all X'max lighting trees, I always image them as vascular trees
with mural cells on them. lol |
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s******y
发帖数: 28562 | 23 也很漂亮啊，那么的富于哲理学的曲线和树枝
and |
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p****n
发帖数: 9263 | 24 Adverse ReactionsBased upon normal doses for either indication or route. (
Adverse effects such as flushing, diarrhea, myalgia, and visual disturbances
may be increased with doses >100 mg/24 hours.)
>10%:
Central nervous system: Headache (16% to 46%)
Gastrointestinal: Dyspepsia (7% to 17%; dose related)
2% to 10%:
Cardiovascular: Flushing (10%)
Central nervous system: Insomnia (≤7%), pyrexia (6%), dizziness (2%)
Dermatologic: Erythema (6%), rash (2%)
Gastrointestinal: Diarrhea (3% to 9%), gastri... 阅读全帖 |
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l**********1
发帖数: 5204 | 25 can only got below:
please go to
//www.iovs.org/content/27/11/1587.full.pdf
//www.iovs.org/content/29/9/1380.full.pdf
//www.sciencedirect.com/science/article/pii/0739626086900079
from
//scholar.google.co.uk/scholar?
hl=en&q=Scanning+electron+microscopy+in+retinal+research+279++1985+borwein&btnG=Search&as_sdt
=0%2C5&as_ylo=&as_vis=0
NB: if you still need that
Scan Electron Microsc. 1985;(Pt 1):279-301.
might should ask Harvard or Yale etc Ivy league one library copy service to your facility libra... 阅读全帖 |
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L*****o
发帖数: 48 | 26 多谢啊。我也看过这个video，可还是有些不明白。
这个video说的是分离retinal pigment epithelium，而一般paper上的retina whole
mount staining应该只是neural retina，而不包括后面的eye cup吧？如何才能把那层
网状的neural retina展平贴片呢？ |
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n***w
发帖数: 2405 | 28 can you culture primary RGCs? |
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g*********5
发帖数: 2533 | 29 thanks for your advice, andy.
I don't know how to culture the primary cells.
and I want establish some rho-zero cells (delete the mtDNA)
and I need long time incubation the cell with EB.
so how many passages usual the primary RGC survive?
thanks. |
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n***w
发帖数: 2405 | 30 Although I work on retinas, I do not focus on ganglion cells even though my
research involves a bit of glaucoma.
So I cannot provide more information rather than a suggestion.
You may look up some people in this field and see how it works.
Good luck. |
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f*******o
发帖数: 150 | 31 Rank, Abbreviated Journal Title, ISSN, Total Cites, 2011 Impact Factor, 5-
Year Impact
Factor, Immediacy Index, Articles Cited Half-life, Eigenfactor® Score,
Article Influence® Score
1 CA-CANCER J CLIN 0007-9235 10976 101.780 67.410 21.263
19 3.8 0.04502 24.502
2 NEW ENGL J MED 0028-4793 232068 53.298 50.075 11.484
349 7.8 0.66466 21.293
3 ANNU REV IMMUNOL 0732-0582 15990 52.761 42.901 9.174
23 ... 阅读全帖 |
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n***w
发帖数: 2405 | 32 Photonic crystal light collectors in fish retina improve vision in turbid
water
文章链接：http://www.sciencemag.org/content/336/6089/1700.full?sid=0f2184cc-e5e3-4f26-a94f-bbabf6ae257a
视网膜里的感光细胞有两种，一种是视杆细胞（rod），一种是视锥细胞 (cone)。Rod
可以感受一个到几个的光子，所以灵敏度很高，一般用于dim vision，而cone则需要比
较高强度的光来刺激，一般用于白天等比较亮的情况下，决定visual acuity。
在大部分的生物里，rod和cone是平行分布的，但是这篇文章研究了彼式象鼻鱼(
Gnathonemus petersii)，一种生活在浑浊环境里的鱼。很早之前就有人发现了他们的
视网膜结构是比较另类的，既不是dim下用rod，bright下用cone，他们视网膜结构属于
grouped retina。这是种什么结构呢？就是cone在上，rod在下，呈杯状，具体的看文
章的图... 阅读全帖 |
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u**********d
发帖数: 573 | 33 我知道这位兄台是他的那篇zfp521的nature，号称找到了pax6、sox1之前的神经命运决
定因子，后来看到他在一个会议上讲3d retinal cup，这个体系看起来确实挺简单的，
大部分的活细胞自己干了，人就看着，不是想象的那样要不断地加各种诱导因子。不知
道养小脑又是怎么个思路？ |
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n***w
发帖数: 2405 | 34 100ug/g浓度高吗？我就是看了文献里用了这个浓度，所以就上了，反正也work。。。
我就是看retinal cell proliferation... |
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V**F
发帖数: 164 | 35 方向: neurodegenerative diseases, synaptogenesis, fly genetics, iPS cell
disease modeling, macular degeneration, retinal development.
I can review general genetics, cell biology, neuroscience, stem cell papers
as well.
保证速度和质量，多谢！ |
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c********n
发帖数: 67 | 37 Ultrastructure of rabbit retinal nerve fibre layer--neuro-glial
relationships, myelination, and nerve fibre spectrum
Circadian rhythmicity in neutrophil chemotaxis.
Thanks very much for you kindly help
h***[email protected] |
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r**b
发帖数: 143 | 38 Defective trafficking of rhodopsin and its role in retinal degenerations.
Hollingsworth TJ, Gross AK.
Int Rev Cell Mol Biol. 2012;293:1-44.
l****[email protected]
包子答谢... 呵呵 |
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n***w
发帖数: 2405 | 40 视网膜色素变性的英文是retinitis pigmentosa ..... |
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y******8
发帖数: 1764 | 41 Abbreviated Journal Title ISSN {2012} Total Cites Impact Factor
5-Year Impact Factor Immediacy Index {2012} Articles Cited Half-
Life Eigenfactor Score Article Influence Score
CA-CANCER J CLIN 0007-9235 13722 153.459 88.55 27.04 25
3.3 0.0517 29.478
NEW ENGL J MED 0028-4793 245605 51.658 50.807 12.667 360
8 0.65776 21.494
REV MOD PHYS 0034-6861 35720 44.982 51.882 6.478 46 10
0.13048 32.634... 阅读全帖 |
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