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全部话题 - 话题: prolific
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t******n
发帖数: 2939
1
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burst (FakeMask的马甲) 于 (Fri Mar 15 23:53:05 2013, 美东) 提到:
如果这是真的,那班上很多人还呼吁买保险,我看保险不用买了,哪怕还有房贷,只要
房子不太贵,也勉强够了!求懂行的验证,如果真的,我将来也不买保险了,只要多生
几个即可。我是认真的,哈哈
☆─────────────────────────────────────☆
luowei (天堂<>地狱) 于 (Sat Mar 16 00:00:30 2013, 美东) 提到:
是的,你要有孩子,也要有足够高的收入,而且只能领到孩子18岁
如果你做薄厚10年,现在死了,老婆孩子大概每个月1400/月,吃饭够了

☆─────────────────────────────────────☆
burst (FakeMask的马甲) 于 (Sat Mar 16 00:18:54 2013, 美东) 提到:
那你的算法有点问题啊。lilykang的先生10年前15万的可能性不大,估计... 阅读全帖
h***a
发帖数: 312
2
来自主题: WaterWorld版 - 大家吃GMO的东西么?
http://www.aaemonline.org/gmopost.html
https://www.youtube.com/watch?v=eeW5yUSqdhY
American academy of enviromental medicine
Genetically Modified Foods
According to the World Health Organization, Genetically Modified Organisms(
GMOs) are "organisms in which the genetic material (DNA) has been altered in
such a way that does not occur naturally."1 This technology is also
referred to as "genetic engineering", "biotechnology" or "recombinant DNA
technology" and consists of randomly inserting geneti... 阅读全帖
S*********g
发帖数: 24893
3
【 以下文字转载自 StephenKing 俱乐部 】
发信人: StephenKing (金博士), 信区: StephenKing
标 题: 不系安全带,John Nash今天车祸死了
发信站: BBS 未名空间站 (Sun May 24 11:17:59 2015, 美东)
John Forbes Nash, Jr.
Born June 13, 1928
Bluefield, West Virginia, U.S.
Died May 23, 2015 (aged 86) [1]
Residence United States
Nationality American
Fields
Mathematics
Economics
Institutions
Massachusetts Institute of Technology
Princeton University
Alma mater
Princeton University
Carnegie Institute of Te... 阅读全帖
b*s
发帖数: 82482
4
来自主题: WebRadio版 - 关于读写速度
看见了这个page:
http://what-if.xkcd.com/76/
In the preface to Opus 200, the prolific writer Isaac Asimov estimated that
he had published about 15,000,000 words between age 30 and 50. His average
over his writing career might have been around 1 word per minute, and at
times he was averaging writing several thousand words per day. (Over his
entire life, his average dips as low as 0.5 words per minute.) Some pulp
writers have even higher averages.
不知道中文作家的写作速度如何?看起来好像都不太高。
Asimov好像写了大约五百本:
Some books, o... 阅读全帖
a*******l
发帖数: 15032
5
来自主题: EnglishChat版 - Celtic 是什么意思?
I do not think so.
The biography doesn't mention it.
http://movies.yahoo.com/movie/contributor/1800354375/bio
Blond, blue-eyed Josh Lucas (who early in his career was billed as Joshua
Lucas) has carved a niche portraying cynics, cads and ne'er-do-wells. While
he yet may not have had the breakthrough role that would make him a
household name. he has emerged as a fine and prolific character actor,
capable of earning the audience's sympathies or condemnation.
Born in Arkansas to parents in the medi
l******e
发帖数: 956
6
以前龙虾主要是埋在地里作肥料,然后是给奴隶和仆人吃的。麻州仆人吃太多导致造反
,最后在和约上规定一周不能被强迫吃三次龙虾。
Homarus Americanus, alternatively known as the New England, Maine, or
Atlantic lobster, was once so prolific on Cape Cod that the colonists
actually used them primarily as fertilizer for their crops or as bait for
their fish hooks. As sustenance, lobster was little more than "poverty food,
" fit only for feeding indentured servants, slaves, children or cows. In
Massachusetts, the servants finally rebelled and won an amendment to their... 阅读全帖
y***n
发帖数: 2318
7
信源:《赫芬顿邮报》|编辑:2015-06-13
科学家们仍然在为加州遭遇历史性干旱寻找原因,但一名州议会众议员觉得原因显而易
见,这就是上帝对堕胎深感恚怒。
点击图片看原样大小图片 点






上星期,加州州议会众议员香侬・格罗夫(Shannon Grove,共和党人)在加州
保卫生命立法宴会(California ProLife Legislative Banquet)上发言时提出了一个
假设,这就是加州在1200年间所遭遇的最严重干旱可能是来自神的报应,因为加州允许
女性自由堕胎。
格罗夫对听众说:“德州也出现了长时间的干旱,直到佩里州长签署了一项法案(即“
胎儿也会感到疼痛”法案)。就在该法案签署的当晚,德州就下雨了。现在,上帝正在
拿加州是问。”
当媒体要求格罗夫证实她是否在该演讲中作过该陈述时,她没有立刻做出回应,但她却
在一个脸谱评论上详细地讲述了她的看法。
她写道:“我认为,而且大多数的美国人也认为,上帝会干预人间事务,而且在这个国
家的形成中神肯定有过干预。这一干旱是上帝造成的吗?没有人知道。但圣经历史显示
人的行为会有后果。”
格... 阅读全帖
z*****a
发帖数: 3809
8
【 以下文字转载自 USANews 讨论区 】
发信人: gemini2012 (双子AB), 信区: USANews
标 题: 希拉里要被民主党抛弃了:加州初选舞弊案曝光
发信站: BBS 未名空间站 (Fri Jul 15 09:36:29 2016, 美东)
California Calls Fraud: Demands DNC Investigation
A month after the California primary, Hillary Clinton’s initial lead of 12
points has diminished to seven—still a substantial win, but not convincing
enough to halt state-wide investigations into voter fraud.
The controversy stems from California’s semi-open policy allowing voters
who aren’t registered Democrats to... 阅读全帖
t******f
发帖数: 2109
9
来自主题: Piebridge版 - 感恩节,讲个剩女的故事。
prolific, ...
m********8
发帖数: 7463
10
【 以下文字转载自 Military 讨论区 】
发信人: umutata (土著人), 信区: Military
标 题: 80-20规律:给琐男科普下自由婚恋市场的那些事
发信站: BBS 未名空间站 (Thu Feb 12 15:58:42 2015, 美东)
文章比较长,我给个尽量简短易懂的摘要。我只陈述客观现象,不作道德评判。
如果有1000个男的,1000的女的,放到一个孤岛上。理论上,他们很快会结成1000对伴
侣,但实际上比这复杂多了。
这1000个女的当中,有800个会去围着男的当中200个条件最好的转。这200个男的平均
每人有四个女的,于是就变得花心,在多个女的中间周旋,保持好几个炮友。而其他
800个男的就很难操上逼,心理容易出问题,有的会攻击那些Top 20%的男的,成为杀人
犯;有的会攻击那些80%的女的,成为强奸犯。
而女的当中,那80%的女的会逐渐厌倦跟众多其他女人的竞争,离开top 20%的男的,去
找80%的男的接盘。甚至还有女的跟top 20%男的生了孩子之后找人接盘,接盘男还要养
别人的孩子。
最后加上我的评论:
第一,所谓的“自由”婚恋市场,... 阅读全帖
w****r
发帖数: 17566
11
来自主题: Literature版 - Re: 申请文海拾贝版版副 (转载)
【 以下文字转载自 board 讨论区 】
发信人: Analyst (SemiparametricBulman Straub Credibility), 信区: board
标 题: Re: 申请文海拾贝版版副
发信站: BBS 未名空间站 (Thu Sep 24 17:04:09 2009, 美东)
只看了《献给>,《不堪回首》《青春》,文笔优美,内容真实,虽然目前搞不懂
playdate属于那一流派,师从何方 :但有一点是肯定的,我念得这几篇既不像<读者>
煽情,也不虚构离奇的情节。 不时有点睛之笔,充满对生活的思考,有内涵。 似乎是
有生活经历的作家。 (闭门造车的嘛 - 除非造得好。)
很久以前有个叫 什么nycHunter/nyHunter 帅哥(把自己照片做头像的),写的和
playdate似乎有一比,也是篇篇上十大 。就是内容有些空,念完了不知他要说什么。
回头把剩下没看完的,打下来睡觉前看 - (我躺着就特别有灵感,嘿)
补充一点, playdate is also a prolific/prolifilic author.
l*r
发帖数: 79569
12
来自主题: Literature版 - Re: 申请文海拾贝版版副 (转载)
害我去查啥叫prolific
我们不是学术版,板斧业务水平不重要,恩,给自己找个台阶
wh
发帖数: 141625
13
来自主题: Literature版 - Re: 申请文海拾贝版版副 (转载)
prolific我知道。prolifilic不知道。
v**e
发帖数: 8422
14
来自主题: Literature版 - 也谈Nobel和平奖
有本书是讲NED的.
Trojan Horse:
The National Endowment for Democracy
excerpted from the book
Rogue State
A Guide to the World's Only Superpower
by William Blum
Common Courage Press, 2000
How many Americans could identify the National Endowment for Democracy? An
organization which often does exactly the opposite of what its name implies.
The NED was set up in the early 1980s under President Reagan in the wake of
all the negative revelations about the CIA in the second half of the 1970s.
The latter was a... 阅读全帖
s*******y
发帖数: 46535
15
来自主题: OperaHouse版 - PBS的Great Performance将播出Ring cycle
GP at the Met: Wagner’s Ring Cycle
About the Opera
Robert Lepage’s acclaimed new production of Wagner’s Der Ring des
Nibelungen, will air on Great Performances at the Met, September 11-14 in
primetime each night on PBS stations (check local listings), as a major
television event.
The operas – Das Rheingold, Die Walkre, Siegfried, and Gtterdmmerung —
will be preceded on Monday, September 10 at 9 p.m. (check local listings) by
the airing of award-winning filmmaker Susan Froemke’s documentary Wagne... 阅读全帖
t*******n
发帖数: 4445
16
来自主题: Translation版 - [ZZ] Pablo Neruda and his passions
URL: http://www.newyorker.com/critics/books/?030908crbo_books1
THE ECSTASIST, by MARK STRAND
The New Yorker, Issue of 2003-09-08
Pablo Neruda was easily the most prolific and popular of all twentieth-century
poets. His collected poems run in excess of thirty-five hundred pages, and his
books, which have been translated into dozens of languages, have sold in the
millions. His life as a diplomat, an exile, and sometimes a fugitive was not
an easy one. The solitude that most writers need in order
k********k
发帖数: 5617
17
http://www.nytimes.com/2012/11/07/nyregion/cecilia-chang-ex-dea
Ex-Dean of St. John’s Is Found Dead at Home
Ex-Dean of St. John’s, on Trial for Stealing Over $1 Million, Is Found Dead
at Home
By MOSI SECRET and WILLIAM K. RASHBAUM
Published: November 6, 2012
http://cn.nytimes.com/article/education/2012/11/08/c08dean/zh-h
美大學傳奇華裔院長受審後自殺
MOSI SECRET, WILLIAM K. RASHBAUM 聯合報道2012年11月08日
翻譯:陶夢縈、黃錚
Hers was the kind of rise through the academic ranks that could have
epitomized the American dream, if ... 阅读全帖
I****2
发帖数: 1091
18
那这个呢,哈哈,比个案,你比不了这些连环杀手,人家很多都是根红苗正的信耶稣的
,所以,这么比没有没意思没意义
Serial Killers:
The FBI gave the standard profile of a serial killer, He is a person with
few friends. He became much more religious just before he started murdering
people. After reading all the available studies I could find and studying
all the articles in the newspapers for over 30 years, I find what is most
outstanding is Serial killers were sexually inhibited by their strong
religious upbringing.
Nearly all serial killers are very devo... 阅读全帖
b********n
发帖数: 38600
19
来自主题: TrustInJesus版 - The Einstein letter about God just sold on Ebay
http://www.ebay.com/itm/Albert-Einstein-Historic-1954-God-Lette
This private letter expresses views never meant for public consumption by of
one of the most prolific minds of modern times on the subjects of God,
religion and tribalism.
Few people have had access to the thoughts and uncensored opinions of this
brilliant mind as it relates to his personal views on God and religion. The
personal nature of the letter and the timing of it in Albert Einstein's life
adds to the implication of the certa... 阅读全帖
N*******8
发帖数: 1449
20
昨天刚出炉的. 老E看后能不能谈谈读后感?
Top 10 Everything of 2012
Top 10 Medical Breakthroughs
http://healthland.time.com/2012/12/04/top-10-health-lists/slide
1. Junk No More
After being ignored as useless genetic garbage, the vast 98% of the human
genome that does not code for genes finally has a purpose. It turns out that
these previously insignificant portions of DNA are the true genetic master-
minds, or metabolic switches that regulate how and when genes function, as
well as how prolifically these genes chur... 阅读全帖
E*****m
发帖数: 25615
21
来自主题: TrustInJesus版 - 最近研究宣稱宗教將在 2041年前消失
http://guardianlv.com/2013/07/religion-to-disappear-by-2041-cla
Religion to Disappear By 2041 Claims New Study
Added by Rebecca Savastio on July 23, 2013.
Saved under Rebecca Savastio, World
Religion to Disappear By 2038 Claims New Study
Author and noted biopsychologist Nigel Barber has completed a new study that
shows Atheism is most prevalent in developed countries, and, according to
his projections, religion will completely disappear by 2041. His findings
are discussed in his new book “Why At... 阅读全帖
T*******y
发帖数: 6523
22
Thich Nhat Nanh is my favorite. He is so prolific, fun, and impacting the
world actively.
I'd love to read the posts about him, too.
w*******w
发帖数: 2051
23
❖ DAYLONG RETREAT WITH AJAAN GEOFF IN LOS ANGELES ❖
A daylong retreat, “Investigating the Aggregates,” with Ajaan Geoff, will
be held on Saturday, February 27th at
Against the Stream Buddhist Meditation Society, 4300 Melrose Avenue, Los
Angeles, CA 90029, telephone
323-665-4300. The morning session begins at 9:00AM. There will be a two-hour
lunch break at 11:00AM.
Please bring a dish to share as this is the main meal for the monks. The
afternoon session concludes at 4:00PM.
For mor... 阅读全帖
w*******w
发帖数: 2051
24
eh, copy wiki的,那个信息太outdated啦。
Thanissaro Bhikkhu (Geoffrey DeGraff) is an American monk of the Thai forest
tradition. After graduating from Oberlin College in 1971 with a degree in
European Intellectual History, he studied meditation under Ajaan Fuang
Jotiko in Thailand and ordained in 1976. In 1991 he helped establish Metta
Forest Monastery in San Diego, CA where he is the abbot. He is a prolific
writer and translator. Many of his works can be found online at www.
accesstoinsight.org.
j****u
发帖数: 1413
25
来自主题: USTC版 - 崔景荣科普与癌生存
新闻与图片花絮请见:http://www.ustcif.org/default.php/content/1605/
加USTCIF为微信好友,即可订阅每日一期中国科大手机新闻报,科大要闻与校友动态尽
在掌握
扫一扫二维码,即可在微信添加好友,每天收到中国科大新闻:
2013年5月2日,肺癌新药发明人、辉瑞公司科学家崔景荣博士(803校友)在北京为中

科大校友带来精彩的科普报告《癌症的发生,演变与个体化治疗》。她还介绍她作为主
导发明人的抗癌药克唑替尼 (Crizotinib) 的研发历程,并阐述了她对癌症治疗的抗药
性及抗癌的新理念的看法。

崔景荣领衔的辉瑞公司团队,因发明治疗肺癌新药“克里唑替尼”(Xalkori),2011

荣获美国第38届年度国家发明奖,该药2011年在美国上市,之后在北京协和医院、解放
军307医院等地进行中国临床三期实验。2013年,中国食品药品监督管理局(SFDA)批

该药在中国上市。
崔景荣介绍癌症的相关基础知识,癌症是细胞生长失控的表现、长期基因突变累积的结
果。她简单列举了诱发癌症的原因,并指出“癌症的复杂性在于癌细胞与周边环境的相
辅... 阅读全帖
s*****o
发帖数: 22187
26
来自主题: Beijing版 - 喜欢喝红酒的小心了 (转载)
【 以下文字转载自 Military 讨论区 】
发信人: DSJS (DSJS), 信区: Military
标 题: 喜欢喝红酒的小心了
发信站: BBS 未名空间站 (Thu Jan 12 16:07:02 2012, 美东)
如果你就好那口儿,无所谓,接着喝。
如果你是因为信了所谓红酒对心血管有好处的说法才饮用的,恭喜你了,丑闻来了!
University Suspects Fraud by a Researcher Who Studied Red Wine
A charge of widespread scientific fraud, involving 26 articles published in
11 journals, was leveled by the University of Connecticut today against
Dipak K. Das, one of its researchers, whose work reported health benefits in
red wine.
Many of the articles reporte... 阅读全帖
c******n
发帖数: 4965
27
来自主题: CS版 - BULLs in MS
Knuth isn't so NIU bah
his records in ACM is "for prolific writing" or something like that.
j*****I
发帖数: 2626
28
我有说assembly无聊么? 不过你这里提到的移植性倒是有点意思。 对于machine dependent
language,这样已经够革新的了。看来我理解的有点死。
我就把我看得贴在这八。
The late 1940s and the late 1950s saw the introduction of the first
general-purpose electronic computers for defense purposes. These
machines could run code that addressed any problem, not just a single
predetermined task. The downside was that the code executed on those
computers was in a machine-specific "language" with the program coupled
to the hardware itself. Code developeed for one machine cou... 阅读全帖
t***s
发帖数: 15
29
Everything Old is New Again: A Fresh Look at Historical
Approaches in Machine Learning
Ryan Rifkin, PhD Thesis, 2002
Page 100:
Hans Suykens has also rederived the RLSC algorithm, under the
name of Least Squares Support Vector Machines. He has been
extremely prolific on the topic, publishing literally dozens of
papers; the papers most relevant to the topic discussed in this
thesis are [109,110,107,108,105,44,106]. However, these papers
do not seem to advance either the theory or practice of RLSC.... 阅读全帖
R*******e
发帖数: 36
u****s
发帖数: 2186
31
Will this adapter work for you?
http://www.prolific.com.tw/eng/products.asp?id=59
I use it to connect to an external modem,don't ask me why.

吗?
l********1
发帖数: 72
32
来自主题: Java版 - 请求帮助,关于Java VS Python
实验室最近有个Java和Python之争,几个中国人想使用Java重写一个网站,但是一个美
国人不愿意,他只懂Python,而且他搬了救兵,据说是硅谷的高手,发的邮件里把我们
提到的java的东西说的一无是处。
可能他说的也有道理,但是任何东西都可以说出优势和劣势。而我们的表达不行,反驳
也力不从心。
现把那个硅谷高手的邮件贴出来,纯属技术探讨。请大家出谋划策,或者看看他说的是
否有道理,或者看看如何来辩驳。非常感谢。
Hey folks,
Point by point, I guess,
The only thing the tiobe shootout shows is that there are more search result
s for Java than there are for other languages. This is mostly about prolifer
ation of usage as the language of choice in the late 90s and early 2000s tha
n anything else. Java... 阅读全帖
l********1
发帖数: 72
33
来自主题: Java版 - 请求帮助,关于Java VS Python
实验室最近有个Java和Python之争,几个中国人想使用Java重写一个网站,但是一个美
国人不愿意,他只懂Python,而且他搬了救兵,据说是硅谷的高手,发的邮件里把我们
提到的java的东西说的一无是处。
可能他说的也有道理,但是任何东西都可以说出优势和劣势。而我们的表达不行,反驳
也力不从心。
现把那个硅谷高手的邮件贴出来,纯属技术探讨。请大家出谋划策,或者看看他说的是
否有道理,或者看看如何来辩驳。非常感谢。
Hey folks,
Point by point, I guess,
The only thing the tiobe shootout shows is that there are more search result
s for Java than there are for other languages. This is mostly about prolifer
ation of usage as the language of choice in the late 90s and early 2000s tha
n anything else. Java... 阅读全帖
j*****I
发帖数: 2626
34
我就把我看得贴在这八。
The late 1940s and the late 1950s saw the introduction of the first
general-purpose electronic computers for defense purposes. These
machines could run code that addressed any problem, not just a single
predetermined task. The downside was that the code executed on those
computers was in a machine-specific "language" with the program coupled
to the hardware itself. Code developeed for one machine could not run on
another. Initially this was not a cause for concern since there were
on... 阅读全帖
n***w
发帖数: 2405
35
EPCs and pathological angiogenesis: when good cells go bad.
PMID: 20188747
Proliferative retinopathies: Angiogenesis that blinds
PMID: 19836461
New insights into hyperglycemia-induced molecular changes in microvascular
cells.
PMID: 20042738
please send to n***[email protected]
Thank you.
m*p
发帖数: 226
36
来自主题: Biology版 - 心肌细胞BrDU染色FACs求助
They did not say how long they pulse label the heart with BrdU. But, since
their data indicates the percentage
of BrdU positive cells is almost equal to Ki67 percentage, that means the
BrdU labeling time will be more than
24 hours. When you label an E14.5 hearts with Brdu for 24 hours, more than
half of the cardiomyoctyes will be
positive if you know how fast the embryonic cells proliferate in vivo,
however they only found about 20% cells
were positive.
Their Ki67 staining is not the right sta... 阅读全帖
b*****l
发帖数: 9499
37
来自主题: Biology版 - 心肌细胞BrDU染色FACs求助
是啊是啊。建议 lz 做一个 in vivo positive control,也就是说,用一种一定能够
使心肌细胞 prolif 的方法处理一下,比如说人为造成心肌损伤,然后做 FACS 看看是
否能看到 brdu 信号。

cells
a********k
发帖数: 2273
38
花了一个小时,深深的鄙视一下自己的无聊行径!!
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖
s**********e
发帖数: 2888
39
来自主题: Biology版 - 说点对青蒿素的个人理解
天然产物的方法有很大的局限:bio-assay是否合理,经常分离的过程中活性就丢失了
,有些分子据说对硅胶很不稳定或者会bind在硅胶上面,虽然我还没有遇到,如果活性
来自于好几个分子的combination,那就几乎完蛋了。
很多时候,有活性的分子量很低,根本没有这么多的植物来源来分离。分离一般就是mg
级别的纯品,根本不够后面的animal/clinical,这个时候需要化学全合成,又是非常
的挑战,尤其是需要1-100g的化学纯品来做clinical,多步化学反应合成这么大量可能
会是超级艰巨的任务。
分离/合成的分子可能ADME不好,或者其他的原因,需要进一步化学修饰,很少有青蒿
素/紫杉醇这样的例子,一分离出来就不需要修饰就是药物的。选择性半合成也是非常
艰巨的任务,尤其对复杂的天然产物。
我看到一个报道,说是一个公司,花了上百个博士,好几年,合成出来60g的一个天然
产物做临床试验。大家可以想象这个过程的完整成本是多么的巨大。
最后,最近很多数据都表明,天然产物的活性,很多都是anti-proliferation, anti-
proliferative,等等这种杀死org... 阅读全帖
h*******o
发帖数: 4884
40
For primary neurons, we use neurobasal media +B 27. It is selective towards
neurons and glia usually cannot survive for long term in NBM+B27. With that
said, there is no pure neuronal culture. Anyway, cultured neurons do exhibit
some glial properties, such as glucose transporter expression, metabolic
activity, etc.
For embryonic glial culture, we use DMEM/F12 (1:1) +10% FBS. Because glial
cells are mitotic whereas neurons are post-mitotic, neurons will be easily
outnumbered by proliferative glia... 阅读全帖
l**********1
发帖数: 5204
41
奇了 怪了 没啥人曝这条吗 快一周了 哈
09/05/2012
Glasgow’s Beatson Institute investigating circumstances of Cell retraction
for inappropriate images
with 6 comments
The Beatson Institute for Cancer Research in Glasgow, Scotland is looking
into how inappropriate images ended up in a Cell paper that has just been
retracted.
Here’s the notice for the paper by Lynne Marshall, Niall S. Kenneth, and
Robert J. White:
This article has been retracted: please see Elsevier Policy on Article
Withdrawal http://www.elsevi... 阅读全帖
S**********e
发帖数: 1789
42
来自主题: Biology版 - 【想海归求建议】
给你看看我们系刚进来的助理教授
Vanderbilt University School of Medicine
Fingleton, Barbara Mary , Ph.D. Assistant Professor of Cancer Biology
Publications

Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK
, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required
for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Cancer Res, 71(4), 1302-12, 2011.
Koon, HB, Fingleton, B, Lee, JY, Geyer, JT, Cesarman, E, Parise, RA, Egorin,
MJ, Dezube, BJ... 阅读全帖
l**********1
发帖数: 5204
43
来自主题: Biology版 - 想学习使用oncomine, 怎么入门?
RE LZ
pls refer
Oncomine data analysis
The relative expression of individual PR target genes in
human breast tumor samples was determined by searching
the Oncomine database (version 4.4, October 2011 data
release, [36]). Individual PR target genes (for example,
RGS2) were queried in The Cancer Genome Atlas
(TCGA) Breast 2 dataset. Oncomine output data was
sorted to isolate ‘cancer versus normal’ associations and
reported (Figure 2A) as the copy number unit expression
values for blood, normal bre... 阅读全帖
m******5
发帖数: 1383
44
另外,这个也要看你做的是什么基因.
除了常见的比如clonal effect外 ,你所说的Stable Clone中上调,你的Control是什
么,是WT cell么?还是用empty vector从WT cell做出来的clone?
有一种可能是你所发现的基因上调和你的目的基因根本没关系,只是你clonal
selection过程中compensatary 的上调, Such like p53, ATF等protein都有可能这样
(还有无数别的可能)
所以主要看你做的pathway
最后,你做的是什么cell line?
如果是mES cell或者别的highly proliferative and self renewing 的cell line,
clonal effect要相对小.
如果是个Cancer cell line, 那么我觉得genome translocation导致的side effect可
能性非常大
s********3
发帖数: 231
45
《科学》对STAP手稿的专家评审意见曝光
《科学》对传说中的STAP细胞论文的三名评审专家意见,过去一直被雪藏,今天终于
被曝光。专家对这一研究的评价不高,认为非常全面的描述性研究,如果结果确定,可
能导致发育生物学大厦的颠覆,其实是不相信这种研究结论。因为没有当时的投稿件,
所以没有办法对这些评价进行更深入分析。不过这些资料显然都在某个地方,只是拥有
的人不愿意拿出来。
Retraction Watch readers are of course familiarwith the STAP stem cell saga,
which was punctuated by tragedy last month whenone of the authors of the
two now-retracted papers in Nature committed suicide.
In June, Science‘s news section reported:
Sources in the scientific community confirm that early version... 阅读全帖
A*****s
发帖数: 34
46
Neuralstem, Inc., a biopharmaceutical company headquartered in Germantown,
Maryland, is seeking
qualified candidates for the position of Manufacturing Associate. The
company focuses on the
development and commercialization of stem cell-based treatments for central
nervous system disease.
Human neural stem cell products in development include NSI-566 which is
currently in clinical trials for
the treatment of amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s
disease), chronic spinal cord injury,... 阅读全帖
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