y*j
发帖数: 200 | 1 两片文章:
1.
FASEB J. 2014 May;28(5):2202-13. doi: 10.1096/fj.13-243105. Epub 2014 Jan 30.
Hypercholesterolemia-induced priming of hematopoietic stem and progenitor
cells aggravates atherosclerosis.
Seijkens T1, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M,
de Winther MP, Lutgens E.
http://www.fasebj.org/content/28/5/2202.long
2.
Current Opinion in Lipidology:
October 2013 - Volume 24 - Issue 5 - p 393-400
doi: 10.1097/MOL.0b013e32836484a4
Hypoxia in atherosclerosis and inflammation
... 阅读全帖 |
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z*t
发帖数: 863 | 2 最近nature有一篇文章用transposon+barcode说即使是transplant后体内绝大多数造血
过程也是由progenitor cell而非stem cell负责的，当然他们主要是用老鼠，我怀疑在
人里做时间长了之后会不会看到stem cell的克隆。这个strategy对其它系统也应该适
用。
PS:我觉得很多组织器官因为turnover慢其实很少涉及到tissue homeostasis的概念，
血液系统，肠道，皮肤这种turnover速度很快的系统才涉及到homeostasis，所以只有
在challenge这些homeostasis比较慢的组织器官时才能找到特定细胞的功能
.
homeostasis
contribute |
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t****w
发帖数: 130 | 3 这方法够牛B, 不过结论其实并不算太出奇啊。 跟我之前探讨的一样，homeostasis or
repair of mild damage 由progenitor负责，repair of catastrophic damage由stem
cell负责。 |
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s******r
发帖数: 2876 | 4 实际上我觉得Pax7细胞就不应该叫做stem cell，
叫个其他名字，比如progenitor cell。
大家都管自己的细胞叫干细胞，实际上只不过是炒作概念，
做development的都说自己是做的干细胞了。
TA cells是个stem cell 的动力学问题. 对于fast turnover tisue以及slow turnover
tissue,我认为其dynamic应该是不同的。fast turnover tissue 来说，quiescent
stem cell-->proliferating TA cells——》committed progenitors_-->terminal
differentiated cells 这样的过程有利于stem cell快速扩增。但对于很多slow
turnover tissue, 比如，肌肉，骨，这样的TA population在生理状况下是检测不到的
。当然对slow turnover tissue的 stem cell dynamic的研究本来就很少。
关于multipotential是否该是stem cell的定义，最好的... 阅读全帖 |
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z****u
发帖数: 1007 | 5 总觉得说一个pathway控制organ size 实在太简化了点。
换个角度看，发育的过程就是embryonic progenitor cell逐渐specify, restrict成为
lineage specific stem cell或者消失的过程。看看Hippo pathway是如何调控stem
cell的形成，特化应该会很有意思。 |
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Q**********r
发帖数: 214 | 6 谁能帮我找一个下面文章的pdf,发到[email protected]
/* */
Mol Cell Neurosci. 2006 Mar;31(3):560-73.
Differential properties of adult rat and mouse brain-derived neural stem/
progenitor cells.
Ray J1, Gage FH.
不胜感激！ |
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z****u
发帖数: 1007 | 7 这个问题问得好。专门对干细胞衰老的研究好像没有。因为干细胞的传统定义就是life
long maintenance.理想得被定义为永远具有更新能力。自然不具有衰老问题。
我也在琢磨这个问题，如果在病理状况下，比如我contituional activate某signal
pathway 来不停的激活qienscent stem cell,那他们会不会最终衰竭。再比如糖尿病的
创口不愈合是否就是由于干细胞的提早衰老导致？
不对称分裂的行为在干细胞里研究很多。如楼上所说，在低等生物里常见到
asymmetrical division. 以此来维持stem cell population的总数问题。但在
mammalian里，不对称和对称分裂都有。比如复层化前的上皮干细胞的不对称分裂就类
似与
drosophila的 germ cell。symmetrical也不少 好像satellite cell就是, 对称分裂在
群体水平上，有的give rise to two progenitor, 有的give rise to two stem cell.
这样来维持群体数目的稳定。Elaine F... 阅读全帖 |
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S******i
发帖数: 71 | 8 Distinct lineage-dependent structural and functional organization of the
hippocampus.
Xu HT, Han Z, Gao P, He S, Li Z, Shi W, Kodish O, Shao W, Brown KN, Huang K,
Shi SH.
Cell. 2014 Jun 19;157(7):1552-64. doi: 10.1016/j.cell.2014.03.067.
SDCCAG8 regulates pericentriolar material recruitment and neuronal migration
in the developing cortex.
Insolera R, Shao W, Airik R, Hildebrandt F, Shi SH.
Neuron. 2014 Aug 20;83(4):805-22. doi: 10.1016/j.neuron.2014.06.029. Epub
2014 Jul 31.
Cortical neurogenesi... 阅读全帖 |
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g*****n
发帖数: 250 | 10 抢了眼球，拿了经费。
zika---microcephaly? 大伙儿被哥伦比亚小大夫给忽悠了。 |
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g*****n
发帖数: 250 | 13 哥伦比亚一个儿科大夫觉得她的病人里多了两个小脑袋（microcephaly), 就问孩子他
妈，有没有被蚊子咬过，觉得不舒服。在那个鬼地方，谁不被蚊子咬。于是她就说这跟
zika有关。于是就上了报。美国人看到了吓坏了。不是害怕发烧呕吐，而是害怕小脑袋
。马上调查zika的分布。发现3/4的美国都有，北到Michigan。媒体用扩散（spread)这
个词，听上去像是蚊子几天就从南美飞到Michigan。
zika不仅美洲有，非洲和亚洲也有。跟小脑袋的关系只在南美局部发现。非洲和亚洲蚊
子一样多，一样厉害。但是，没有发现那个关系。
zika不是突然从天上掉下来的，它和人类的关系历史悠久。小脑袋突然增多，可zika年
年都那样。那个CDC文章引用的主要数据不是研究论文，而是巴西国家统计数字。作者
都没敢说microcephaly的增多跟zika outbreak有关，只是说recognition of Zika
virus transmission。（原文：An increase in the number of infants with
microcephaly in Brazil wa... 阅读全帖 |
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发帖数: 1 | 14 Foxg1 will label progenitors. hSynI is the best way to go. |
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T*****e
发帖数: 74 | 15 在下面回文里看见了这篇文章
"Generation of neural progenitor cells by chemical cocktails and hypoxia"
Lin Cheng, Wenxiang Hu, Binlong Qiu, Jian Zhao, Yongchun Yu, Wuqiang Guan,
Min Wang, Wuzhou Yang, Gang Pei, Cell Res (2014)
为了跟上小保方的风，直接低级作假。裴院长和仇英雄所见略同
开始 |
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b******k
发帖数: 2321 | 16 Faculty and Postdoctoral Positions at the Life Sciences Institute, Zhejiang
University
The Institute
The Life Sciences Institute of Zhejiang University (LSI-ZJU) was founded in
2009. Dr. Xin-Hua Feng was appointed as the founding director and Dr. Kun-
Liang Guan as the co-director. Located in the scenic city of Hangzhou, LSI
is now a world’s leading center of biological and biomedical research in
China.
As the first special academic zone of ZJU, LSI runs its own graduate program
and enjoys unpar... 阅读全帖 |
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发帖数: 1 | 17 本人想申绿，急求Review稿件！
在美有两年博后经历，主要研究方向：
1. Molecular/cellular biology.
2. Development of molecular/ cellular therapies for heart disease.
3. Stem and progenitor cell transplantation for cardiovascular regeneration.
4. Cardiovascular tissue engineering.
5. Development of novel methods of in vivo/ex vivo cell reprogram.
6. Novel approaches to therapeutic cell regeneration for coronary and
peripheral ischemic disease.
7. heart development.
8. Mechanisms of Congenital heart disease.
以上相关内容的稿件请都向我砸过来吧！谢谢... 阅读全帖 |
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g**********y
发帖数: 423 | 18 哪种细胞最容易变成癌细胞？
(1) Stem cell
(2) Progenitor cell
(3) Differentiated cell
为什么？ |
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g**********y
发帖数: 423 | 19 就上面三种来说，是不是
(2) Progenitor cell > (1) Stem cell > (3) Differentiated cell ?? |
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z*******x
发帖数: 103 | 20 又有几个浙大生科院的有作弊的可能。三篇文章里的图， 互相重复。
------
me Publications
Deletion of core-binding factor β (Cbfβ) in mesenchymal progenitor cells
provides new insights into Cbfβ/Runxs complex function in cartilage and
bone development.
Bone (2014) - 11 Comments
doi: 10.1016/j.bone.2014.04.031 pubmed: 24798493 pmc: PMC4644668
Mengrui Wu, Chenguan Li, Guochun Zhu, Yong-Jun Wang, Joel Jules, Yun Lu,
Matthew McConnell, Yong-Jun Wang, Jian-Zhong Shao, Yi-Ping Li, Wei Chen
https://pubpeer.com/publications/4D291CC... 阅读全帖 |
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发帖数: 1 | 21 High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Ting Zhou11, Lei Tan11, Gustav Y. Cederquist11, Yujie Fan, Brigham J.
Hartley, Suranjit Mukherjee, Mark Tomishima, Kristen J. Brennand, Qisheng
Zhang, Robert E. Schwartz, Todd Evans, Lorenz Studer'Correspondence
information about the author Lorenz StuderEmail the author Lorenz Studer,
Shuibing Chen12,'Correspondence information about the author S... 阅读全帖 |
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发帖数: 1 | 22 High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.
Ting Zhou11, Lei Tan11, Gustav Y. Cederquist11, Yujie Fan, Brigham J.
Hartley, Suranjit Mukherjee, Mark Tomishima, Kristen J. Brennand, Qisheng
Zhang, Robert E. Schwartz, Todd Evans, Lorenz Studer'Correspondence
information about the author Lorenz StuderEmail the author Lorenz Studer,
Shuibing Chen12,'Correspondence information about the author S... 阅读全帖 |
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发帖数: 1 | 23 预测生物医学的奖项应该是这个实验室. 他们已经发现了能够治疗寨卡病毒的药物.
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates
that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain
Ting Zhou11, Lei Tan11, Gustav Y. Cederquist11, Yujie Fan, Brigham J.
Hartley, Suranjit Mukherjee, Mark Tomishima, Kristen J. Brennand, Qisheng
Zhang, Robert E. Schwartz, Todd Evans, Lorenz Studer'Correspondence
information about the author Lorenz StuderEmail the author Lorenz Studer,
Shuibing Chen12,'Corresp... 阅读全帖 |
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r*********w
发帖数: 119 | 24 请好心人帮忙！我们学校没有购买这个杂志的access。
多谢！
我的邮箱是：i**********[email protected]
文献见下面（九篇）。多谢啦！
Peptide-Based Therapeutic Approaches for Treatment of the Polyglutamine
Diseases.
Takeuchi T, Popiel HA, Futaki S, Wada K, Nagai Y.
Curr Med Chem. 2014 Feb 17. [Epub ahead of print]
A Translational View of Peptide Treatment of Neurological Disorders.
Brinker T.
Curr Med Chem. 2014 Feb 17. [Epub ahead of print]
Davunetide: Peptide Therapeutic in Neurological Disorders.
Magen I, Gozes I.
Curr Med Chem. 2014 Feb 17. [Epub a... 阅读全帖 |
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w******e
发帖数: 953 | 25 Tissue Engineering - Part A
Volume 16, Issue 2, 1 February 2010, Pages 605-615
Stem/Progenitor cell-mediated de novo regeneration of dental pulp with newly
deposited continuous layer of dentin in an in vivo model |
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w******e
发帖数: 953 | 26 Tissue Engineering - Part A
Volume 16, Issue 2, 1 February 2010, Pages 605-615
Stem/Progenitor cell-mediated de novo regeneration of dental pulp with newly
deposited continuous layer of dentin in an in vivo model |
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e****0
发帖数: 678 | 27 • leukemia
ALL AML CLL
child adult elderly
BM lymphoblasts 25%myeloblasts
lab Lymphocyte 5000, mature-appearing cells
• Osgood-schlatters disease
Adolescent male athletes
Traction apophysitis—quadriceps tendon put the traction on the
apophysis of the tibial tubercle where patellar tendon inserts.
A firm mass =heterotopic bone formation
Pain can be reproduced by extending the kne... 阅读全帖 |
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c*******3
发帖数: 48 | 28 Yamamoto T, Uenishi T, Ogawa M, et al.
Immunohistologic attempt to find carcinogenesis from hepatic progenitor cell
in hepatocellular carcinoma
DIGESTIVE SURGERY 22 (5): 364-370 2005
N***********[email protected] |
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p*******g
发帖数: 2976 | 29 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
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w******y
发帖数: 4871 | 30 NOVEL THERAPIES
Gene therapy — The identification of the gene responsible for the
dystrophinopathies led to initial excitement that transfer of a functioning
dystrophin protein (whether by transplanted myoblast or direct genetic
manipulation) may provide substantial benefit to or even "cure" affected
patients. Although myoblast transfer has been attempted in humans, the
results have thus far not been encouraging [47]. However, in one patient who
received a bone marrow transplant for severe combi... 阅读全帖 |
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l*w
发帖数: 567 | 31 坛子里，有没有波斯顿附近的哪位大侠手头上有mouse neuronal cell line的？能否给
我一点？
具有progenitor or precursor的性质最好。俺最近有个实验需要。
俺的邮箱h******[email protected]
或回本贴。
先谢了！ |
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V***b
发帖数: 3419 | 33 Part 1: A Fierce Family Feud
Volkswagen looks set to acquire Porsche, the troubled German sports car
manufacturer. At the core of the companies' tightly intertwined histories is
a deeply divided family engaged in a power struggle worth billions -- and
which could determine the fate of two of Germany's most famous carmakers.
In the end, the two men shook hands after all. When Ferdinand Pi?ch
encountered his rival Wendelin Wiedeking last Thursday evening at an event
to celebrate the 100-year anniv... 阅读全帖 |
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f**********g
发帖数: 2252 | 34 Anyone familiar with NBS?
http://finviz.com/screener.ashx?v=341&t=NBS
NeoStem to Present at Two Investor Conferences in San Francisco on Wednesday
, January 12, 2011
1 hours 20 minutes ago - PRN
PR NewswireNeoStem, Inc. (NYSE Amex: NBS) ("NeoStem" or the "Company"), an
international biopharmaceutical company with operations in the U.S. and
China, today announced that Dr. Robin Smith, the Company's Chairman and CEO,
will present on Wednesday, January 12, 2011 at the OneMedForum 2011 at 9:15
AM PS... 阅读全帖 |
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f**********g
发帖数: 2252 | 35 Anyone familiar with NBS?
http://finviz.com/screener.ashx?v=341&t=NBS
NeoStem to Present at Two Investor Conferences in San Francisco on Wednesday
, January 12, 2011
1 hours 20 minutes ago - PRN
PR NewswireNeoStem, Inc. (NYSE Amex: NBS) ("NeoStem" or the "Company"), an
international biopharmaceutical company with operations in the U.S. and
China, today announced that Dr. Robin Smith, the Company's Chairman and CEO,
will present on Wednesday, January 12, 2011 at the OneMedForum 2011 at 9:15
AM PS... 阅读全帖 |
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m****g
发帖数: 530 | 36 美国塔夫茨大学医学院的研究人员通过对老鼠研究发现两种与乳腺细胞分化有关的前体
细胞中，其中一种或许是导致管腔
型的乳腺癌的前体细胞。这项研究发表在1月19日的《Cancer Cell》杂志上，或将对治
疗乳腺癌提供一种新的治疗靶标。
乳腺癌一般分为两类：一类是管腔型(Luminal-like)乳腺癌，这种乳腺癌对激素十分敏
感，生长缓慢，是乳腺癌中最常见的
一种；另一种是具有侵润性的基底细胞样型(Basal-like)乳腺癌,这种乳腺癌对激素不
敏感，一般预后较差。之前有研究人员
认为这两种癌症可能是由不同的前提细胞分化而来。
最近，塔夫茨大学Charlotte Kuperwasser主持的课题组对老鼠研究，发现了不同类型
的乳腺前体细胞，而管腔型乳腺癌
细胞来自于小叶前体细胞(lobule progenitors)的分化。研究人员还发现，这类前体细
胞与一种参与细胞自我更新和分化的
蛋白质cyclin D1的活性有关。研究人员使模式老鼠中cyclin D1蛋白失活，与对照组小
鼠相比，cyclin D1蛋白失活组老鼠
小叶祖细胞的数量很少，且不出现管腔型乳腺肿瘤。
研究人员解释，导管 |
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