s*********1
发帖数: 316 | 1 要的品种如下，牛油果眼霜要2个，其他每样要一个。有的请带价联系，谢谢！
1、牛油果眼霜 原价$28
Creamy Eye Treatment with Avocado 0.5 fl. oz. Jar
2、黄瓜水 250ml 原价$16
Cucumber Herbal Alcohol-Free Toner 8.4 fl. oz. Bottle
3、特效保湿面霜 125ml 原价$46.5
Ultra Facial Cream 4.2 fl. oz. Jar
4、特效保湿乳液（不带SPF） 75ml $18.5
Ultra Facial Moisturizer 2.5 fl. oz. Bottle
5、特效保湿洁面乳 150ml 原价$19.5
Ultra Facial Cleanser 5.0 oz Tube
6、海洋精华面霜（蓝瓶） 50ml 原价$54
Cryste Marine Ultra Riche 1.7 fl. oz. Jar
7、紧肤唤醒保湿面霜（淡绿瓶）50ml 原价$60
Rosa Arctica 1.7 oz.
8、紧致精华 50... 阅读全帖 |
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t*********u
发帖数: 691 | 2 origins
1. High-Potency Night-A-Mins™
Mineral-enriched renewal cream 30ml 10刀each
2. 身体乳和磨砂膏75mleach 2刀each 3刀一套 |
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r********m
发帖数: 593 | 3 这楼包括MAC, Natura Bisse, Omorovicza , Origins, Peter Thomas Roth and
Philosophy
=== M A C === 图1
小样均为管装
Strobe cream hydratant lumineux
A76, B76
Size 6mL
Value 4.00
Qty 3
Price 3 for 1.00
False lashes extreme black
A35
Size 3mL
Value 12.00
Qty 1
Price 1.00 each
Natural radiance base lumiere
B36
Size 6mL
Value 5.00
Price 0.50
**********************************************************
=== Natura Bisse === 图1
小样均... 阅读全帖 |
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c**********8
发帖数: 835 | 5 http://www1.macys.com/catalog/product/index.ognc?ID=558659&Cate
这个三个，都很大瓶
# 3) Rénergie Lift Volumetry: Volumetric Lifting and Reshaping Cream – SPF
15 Sunscreen
# 4) High-Resolution Refill-3X™: Triple Action Renewal Anti-Wrinkle
Cream SPF 15 Sunscreen
# 5) Bienfait Multi Vital: High Potency Daily Moisturizing Cream - Vitamin
Enriched UVA/UVB SPF 30 |
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k****0
发帖数: 305 | 6 它家搞活动，50Free shipping,还送小样，找了下
正好发现这个是50刀。打算给妈妈用，不知道好用不？
姐妹们建议下。谢谢 |
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r*s
发帖数: 2555 | 7 Main points:
(1) 十三钗 is not as good as Lu Chuan's Nanjing Nanjing!
(2) If Warner Bros. had made a film with this plot back in 1942, it would
have made effective anti-Japanese propaganda and probably absorbing drama in
the bargain. 十三钗 just plays like hokum。
source: http://www.hollywoodreporter.com/review/flowers-of-war-film-review-christian-bale-272125
It's something you'd think only the crassest of Hollywood producers would
come up with — injecting sex appeal into an event as ghastly at the Nan... 阅读全帖 |
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a******n
发帖数: 257 | 8 哥们，那是我猜想你只是google了一下，看了wiki的介绍，然后告诉我这本书的内容。
也许我错了，也许你就是看了wiki. 因为你也辩解了一下为何不可以引用wiki，所以我
就想当然地认为你肯定是看了wiki，否则我不知道你为什么要辩解。
因为我实在想不出这个和EE有什么关系。你是不是要说你对iq真的很感兴趣。你是不是
说你还真的去图书馆借了这本书来看了。而且你还知道那些数据在哪一页了？这本书本
来就是controversial的，你用google scholar搜一下就知道针对这本书的很多评论。
难道你还拿这个当定论了？你丝毫不质疑？一个国家几亿的人口，全世界几十亿的人口
，你觉得有可操作性吗？
如果不是歧视，你想用这个例子在这个辩论中来证明一个什么观点？
是的，你说中国人平均身高比白人矮不是种族歧视，它跟说iq低不一样，这个例子不恰
当，不可类比。说人家的iq地就好比你去说一个男人impotent一样，这不能拿来公开说
，这关系一个男人的自尊。他也许可以不要命，但是他不能容忍人家指指点点他的
potence。
这种对iq的问题也是一样的，iq低让人联想什么啊？这明明是在说，你iq |
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s****g
发帖数: 1795 | 9 【 以下文字转载自 ebiz 讨论区 】
发信人: sdwang (网络包打听), 信区: ebiz
标 题: Re: 别抗日媚日了啦， 大家还是囤积点碘吧
发信站: BBS 未名空间站 (Wed Mar 16 11:11:31 2011, 美东)
面子翻译成reputation? 你懂得...
At first sight nothing can be more irrational than to call that which is
shared with the whole human race a “characteristic” of the Chinese. But
the word “face” does not in China signify simply the front part of the
head, but is literally a compound noun of multitude, with more meanings than
we shall be able to describe, or perhaps to comprehend.
... 阅读全帖 |
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s****g
发帖数: 1795 | 10 "语言都是通的"？？
you are such a moron
read the following , you idiot!
At first sight nothing can be more irrational than to call that which is
shared with the whole human race a “characteristic” of the Chinese. But
the word “face” does not in China signify simply the front part of the
head, but is literally a compound noun of multitude, with more meanings than
we shall be able to describe, or perhaps to comprehend.
In order to understand, however imperfectly, what is meant by “face,” we
must take ac... 阅读全帖 |
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p********3
发帖数: 5750 | 11 再让你长长见识：大家看和文献3-6相关的那句话，专门提出了中药的肾脏毒性问题，表明实际上的肾脏毒性比原先预期想象的还要普遍。
大家没有忘记在对Herb Medicine管制更严格的欧盟对中药 Ban了吧。 我上篇文献里面说了欧盟对Herb的管理对美国严格， 谈得比较细，有兴趣的可以仔细阅读。
Author
Marc E De Broe, MD, PhD Section Editor
Gary C Curhan, MD, ScD Deputy Editor
John P Forman, MD, MSc
Last literature review version 19.2: May 2011 | This topic last updated:
June 15, 2010
INTRODUCTION — In 1991, physicians in Belgium noted an increasing number of
women who presented with acute, often near end-stage renal disease
following expo... 阅读全帖 |
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n***9
发帖数: 3 | 12 It's a tightrope the Chinese government would rather not walk, with the
sensitive 10th anniversary of Tiananmen Square just gone by. Falun Gong,
however, is pressing its own issues with communist leaders. The sect, a
popular quasi-religious movement gaining followers worldwide, desires
official recognition and respect. This has precipitated a power struggle
that has tensions rising.
After being caught off guard by the emerging movement's 25 April 1999 ten-
thousand-plus-member sit-in — a silent ... 阅读全帖 |
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s*****o
发帖数: 2490 | 13 为什么说尼古丁是特殊例子？尼古丁对人和大鼠小鼠的主要target都是nAChR，而且他
们的nAChR的pharmacological profile还很相似，这个例子完美的解释了我的理论啊--
虽然代谢速率差别很大，但是target site的potency相似导致了相似的LD50啊。
你的一般规律怎么解释尼古丁的毒性数据？或者你的一般规律能解释哪些毒性数据？
NMDA的？你确定？有人对不同动物对同一种物质的LD50做过线性分析么？比如人的和鼠
的，得到slope 95%CI在25-50？
我说过这个等效剂量适用于药理剂量范围不适用于毒性评估，没说完全不能成立啊。我
做老鼠急毒实验的时候怎么没人告诉我要用等效剂量推测，做预实验啊？ |
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y****i
发帖数: 12114 | 14 https://en.wikipedia.org/wiki/Nitrous_oxide#Health_hazards
Safety[edit]
The major safety hazards of nitrous oxide come from the fact that it is a
compressed liquefied gas, an asphyxiation risk, and a dissociative
anaesthetic.
Health hazards[edit]
While relatively non-toxic, nitrous oxide has a number of recognized ill
effects on human health, whether through breathing it in or by contact of
the liquid with skin or eyes.
Nitrous oxide is a significant occupational hazard for surgeons, dentists,
a... 阅读全帖 |
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x********u
发帖数: 15396 | 16 有没有狗吃这个心丝虫药的？
Virbac has issued a voluntary recall for six lots of their heartworm
prentive, Iverhart Plus Flavored Chewables, due to a failure to meet
stability specifications during the life of the product.
The following lots have been included in the recall:
Lot 120076 (Large 51-100 pounds)
Lot 120086 (Large 51-100 pounds)
Lot 120856 (Large 51-100 pounds)
Lot 120202 (Medium 26-50 pounds)
Lot 120196 (Small up to 25 pounds)
Lot 120844 (Small up to 25 pounds)
According to... 阅读全帖 |
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n********n
发帖数: 8336 | 17 http://hinduism.about.com/od/lordkrishna/a/christ_krishna.htm
Despite their differences, Hinduism and Christianity have great
similarities . And this is particularly prominent in the case of the life
and teachings of the two central figures of these world religions — Christ
and Krishna .
Similarities in just the names of Christ and Krishna have enough fuel
for the curious mind to prod into the proposition that they were indeed one
and the same person. Although there is little historical evid... 阅读全帖 |
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N****f
发帖数: 25759 | 18 Haha...sorry, the first one:
"Having strength or power. Power, Strength, Energy, Might,
Force, Potency, Ability, Excite." |
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C***r
发帖数: 759 | 19 On the Principles of Nature (De principiis naturae)
by Saint Thomas Aquinas, trans. by Jerry Campbell
Notice carefully that some thing can be although it is not,
whereas another thing truly is. That which can be is called
being in potency; that which already is, is called being in
act. But there are two kinds of being: namely essential
being or
the substantial being of the thing (as, for example, to be a
man) and this is to be absolutely. The other kind of being
is
accidental being (as, for exam |
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b*****l
发帖数: 3821 | 20 这个里面11楼有些评价：
http://forums.randi.org/showthread.php?t=88831
“The UV spectroscopy is just wrong. The spectrum he presents for ethanol
just is not the UV spectrum of ethanol, period. He then seems to be saying
that the potentised remedies are less absorbent than the solvent. I could
see no data supporting his contention that he could tell different potencies
or different remedies apart.
If in fact what he says is true (that ethanol has significant UV absorbance
at 320nm which is eliminated when th... 阅读全帖 |
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o****h
发帖数: 721 | 21 老兄，你的搜索功能太强大了。不过那些评价，说的很有道理。
potencies
absorbance
the
capable |
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Y**u
发帖数: 5466 | 22 I hope you can all hear me, can you? Is it quite audible? Right. This is the
last talk. During the last three times that we have met here we have been
talking about the chaos in the world, the misery, the suffering, and the
desire for entertainment and the avoidance of fear. We went into several
things concerning our daily life. During all these talks it must have been
very clear that we are concerned with the human transformation
psychologically, for that alone can bring about a change in the s... 阅读全帖 |
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e*******a
发帖数: 988 | 23 谁有可推荐的purity and potency比较有保证的牌子吗？我看了看觉得Osteo Bi-flex
（triple strength）的看着不错，谁有经验没？
多谢。 |
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e*******a
发帖数: 988 | 24 知不道。。。我买Nature Made 100mg，
给我爸查这个的时候读到过在几家大牌子
lab检验potency的时候，NM最好，我就信了 |
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d****n
发帖数: 12461 | 25 除非搞科学计算的，要不高档cpu配集成显卡是在太跛脚。当然也可以以后再升级显卡
，不过这样可以先搞块很便宜的显卡抵着，不一定非要集成显卡主板。
机箱和电源前两天推荐过了。Tuniq Potency 550W+Silverstone PS05机箱。内存都差
不多吧，挑ddr3速度快的买就可以了。硬盘也是差不多吧，反正在容量，静音，性能，
价格当中权衡。
主板和cpu，一般选i5 7xx+p55, i7 xxx或者amd x4, x6配amd 8xx主板。这个有熟悉的
人说一下？ |
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s*****3
发帖数: 41 | 26 I just read this article. It seems pretty good.
In the last figure, they compare the neutralization potency and breadth of
the new antibody VRC01 with that of b12, a well-known broadly neutralizing
Ab against CD4 binding site of gp120. Under IC50 <50 ug/ml, VRC01 can
neutralize 91% of 190 Env pseudoviruses, whereas b12 can only neutralize 41%.
One question about the paper is that they design a molecule, RSC3, that
keeps the antigenicity of CD4 binding site of gp120 whereas remove the
antigenicit |
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s***o
发帖数: 58 | 27 Archives of Toxicology
Volume 83, Number 11, 1009-1019, DOI: 10.1007/s00204-009-0443-x
Title ;Brevetoxins 2, 3, 6, and 9 show variability in potency and cause
significant induction of DNA damage and apoptosis in Jurkat E6-1 cells |
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H*****e
发帖数: 120 | 28 Well, nothing need to be hidden. If some experimental discussion is needed,
we can communicate privately.
From academic view, there are several questions that need to be answered (
Sorry my chinese input is very slow):
1.Whether stem cell is cancer stem cell is an issue. I read so many
literature that people are using tissue stem cell marker for identify cancer
stem cells. Frankly, I reject all of them, manuscript or grant application.
2.Whether there is Lung stem cell is rather unclear (coul... 阅读全帖 |
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h********n
发帖数: 4079 | 29 I am so glad to read your thought. I would like to discuss a little more.
to 1: the term of CSC is controversy, but what if I say: "In lung adenocarcinoma, there is a population of tumor cells whose potency (in vivo) is much higher than other population in the same tumor. It is important to study this population of cells. How about we call it tumor initiating cell?"
what is your opinion to my above thought?
to 4: I don't agree with you on this point. Most lung cancer model use SPC or CCSP or C... 阅读全帖 |
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r***e
发帖数: 2539 | 30 Thank everyone for the discussion!
As pineseed pointed out, too many topics were discussed here.
But my personal interests are:
1. what is the cell origin of different type of lung cancers?
2. does cell origin or mutation decide tumor types?
3. how to model different type of lung cancer?
HGTPase, it seems you are working in this field (more lung development than
lung cancer?), and I hope you can give your opinions. We can also discuss in
private mails for technique details.
1. ... 阅读全帖 |
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h********n
发帖数: 4079 | 31 Why the concept of CSC is important in basic cancer research? To me, the
key question is: does a solid tumor (such as lung, liver, etc) arise from a
differentiated epithelial cell, or it arise from a tissue specific stem cell
/progenitor cell.
tissue specific stem cell/progenitor cell ---> differentiated epithelial
cell.
CSC--->differentiated cancer cells (with different potency).
Think of the comparison between these cells, especially the cancer vs normal
cells.
As to cancer cell lines, some o... 阅读全帖 |
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h********n
发帖数: 4079 | 32 Another key question I would like to ask, if you think there is not enough
evidence showing CSC existing, what is the level of enough data?
If I say I isolate a population of cancer cells from a solid tumor in a
patient, and I show that these cells:
1. can differentiate to other types of epithelial-cancer cells (found in the
same tumor), which has their normal counterparts in normal tissue.
2. can self-renew.
3. when implanted to the same organ of healthy mice, it form a solid tumor,
and the pot... 阅读全帖 |
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s******r
发帖数: 2876 | 33 不过自从iPS发明以后，我觉得solid tumor也可能起源于分化细胞。
Why the concept of CSC is important in basic cancer research? To me, the
key question is: does a solid tumor (such as lung, liver, etc) arise from a
differentiated epithelial cell, or it arise from a tissue specific stem cell
/progenitor cell.
tissue specific stem cell/progenitor cell ---> differentiated epithelial
cell.
CSC--->differentiated cancer cells (with different potency).
Think of the comparison between these cells, especially the cancer vs normal... 阅读全帖 |
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H*****e
发帖数: 120 | 34 Wow, on the top list!
Well, I never expect to be on the top list. This reason is that I am not
here very often. Also apologize to those are discussing about the topic and
expect me to give my opinion.
I believe that the previous title regarding to someone retract her paper is
misleading. So it is necessary to clear some issue and have an opportunity
to draw more discussion. Now back to the stem cell issue not the Amy or
Carla although name may be mentioned but please ignore my own personal
... 阅读全帖 |
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c**a
发帖数: 94 | 36 版上这么多大侠,谢谢各位的分析. 可能开始解释有误. 这个图每条curve都是
orthosteric agonist的dose-response curve, 完全相同的浓度梯度和条件. 但是3条
彩色的curve是叠加了compound的curve, 不同颜色表示不同浓度, 但是在同一个curve
下,compound的浓度是一样的. 回头查了一下以前的数据,似乎在这些浓度下,compound
自己有弱效果. 所以这个结果有可能是效果叠加的结果. 没法说明到底是不是
allosteric modulation. 是这样吧.
撇开这个图. 从头想想. 我有个compound, 与receptor的 binding affinity 是几十个
nM级. radiolabel的competition assay, 看上去几乎80-90% replace orthosteric
agonist. 问题是,测了compound自己所有的下游信号, 几乎都是negative,或者是uM级
的potency. 而且没有任何antagonism. 不懂这个东西到底在干什么. 简单的sticky吗?... 阅读全帖 |
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c**a
发帖数: 94 | 37 potency在 uM 级别, 低浓度基本没有效果,到10uM 差不多70%的效果, 所以图不是个S
型, 是个U型的右半边. |
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l**********1
发帖数: 5204 | 38 not 大侠 but 小虾米
>在不确定binding site的情况下,怎么区别antagonist 和 negative allosteric
modulator?
sometimes even antagonistic actions are biased.
pls refer pituitary gonadotropin follicle stimulating hormone (FSH) and its
receptor actions by ADX61623 compound as A negative allosteric modulator
References:
Dias JA et al. (2011)
A negative allosteric modulator demonstrates biased antagonism of the
follicle stimulating hormone receptor.
Mol Cell Endocrinol. 333: 143-50.
PubMed link:
http://www.ncbi.nlm.nih.go... 阅读全帖 |
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m******g
发帖数: 467 | 39 这期Nature好赞！
Nature 14.1.30
非常推荐：
1. Molecular biology: A second layer of information in RNA
1) In vivo genome-wide profiling of RNA secondary structure reveals novel
regulatory features
2) Genome-wide probing of RNA structure reveals active unfolding of mRNA
structures in vivo
3) Landscape and variation of RNA secondary structure across the human
transcriptome
2. Cell biology: Potency unchained
Mildly acidic conditions triggers potential for a new cell state with
diverse potentials
1) Bidirecti... 阅读全帖 |
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m******g
发帖数: 467 | 40 这期Nature好赞！
Nature 14.1.30
非常推荐：
1. Molecular biology: A second layer of information in RNA
1) In vivo genome-wide profiling of RNA secondary structure reveals novel
regulatory features
2) Genome-wide probing of RNA structure reveals active unfolding of mRNA
structures in vivo
3) Landscape and variation of RNA secondary structure across the human
transcriptome
2. Cell biology: Potency unchained
Mildly acidic conditions triggers potential for a new cell state with
diverse potentials
1) Bidirecti... 阅读全帖 |
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m*********D
发帖数: 1727 | 41 下班前被老板叫住，到他的办公室，他有重要事情告诉我：去年送出去的三个proposal
,一个去年就被拒了。今天另一个的消息来了--三年，60万左右的经费！又有三年不用
担心工作了，也离我55岁可以退休的日子不远了--Get the monkey off my back!
这个药物筛选的项目有十年了。记得十几年前来试验室的一个Ph.D./M.D.学生作腻了用
gel shift的方法来检测蛋白质和DNA结合，改用旋光方法来分析，方法发表在一个三流
杂志上。老板破天荒第一次从基因表达调控的理论研究转向药物筛选的应用研究，把一
个药物筛选的方法的proposal送进了NIH，拿到了三年的经费。他有些不舍，给我说：
大多数顶尖科学家还是冲诺贝儿奖，喜欢搞理论的，我们这个转向也许是对的。
三年时间，我把一个旋光检测蛋白质（transcription factor)和DNA结合的方法
develop成High Throughput Screening（HTS)。刚接手的时候，看到同类型的文章已经
出来--证明了in vitro筛选出来的compound在细胞水平是不起作用的。当时拿着人家文
章和老... 阅读全帖 |
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e****y
发帖数: 129 | 42 这个不一样，lilly那个三期fail之所以对业界打击那么大，是因为target被否定了。
做药的最怕的是这个。potency，efficacy不行都有办法，再花时间改，这个时候结构
信息确实很有用。但是target完蛋就是彻底完蛋，一夜回到解放前，100个1A的结构毛
用没有。所以老施这个忽悠有点大。 |
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s*****o
发帖数: 2490 | 43 那篇trypsin消化的实验用的pH是9啊，人的小肠pH是多少？不到8吧？bt protoxin在pH
低于9的情况下是不溶的晶体状态，能被正确切割么？
另外你提到的bt toxin和人的cadherin受体的结合。我相信你说的有可能结合。但是关
键是potency啊，得多大的剂量才会结合？得多大的剂量才会导致你说的炎症反应？人
体的肠道有多大的可能会expose到这个剂量的active bt toxin？你要知道现在市面
上的几乎所有杀虫剂在人体都有specific target，比bt受体明确得多。如果你觉得bt
这种级别的风险都是不能接受的，那其他的杀虫剂你就更没法接受了吧？呵呵。所以说
你和我看问题的角度不一样，你考虑的是到底有没有这种风险，而我考虑的是这个风险
到底有多大。
把0 |
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m*********D
发帖数: 1727 | 44 兄弟明显和pharm挺熟悉的。我们的是小分子的。我们target的是一种发病率很高的癌
症，市场上有药。我们是希望能对付对现有药物产生抗药性后的病人的。关键试验还没
有在老鼠上作。上次是拿常规爱细胞作的。你知道，学术界界就是钱紧张啦，当时看钱
不多了，又要发文章，就没作抗药行的癌细胞（也没有一个好的公认的细胞系）。现在
在准备作。
确实，要一筛就拿到能作drug的compound,确实是中lottery的概率。现在是potency在
老鼠上面够，toxicity在老鼠身上也问题不大。但从这里到人还有几步呢。所以，指望
这个发财是不现实的。
等明年抗性细胞的老鼠试验出来了，也许就有大的vc找上门来。 |
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w*********o
发帖数: 3030 | 45 I am not sure. It might still doable unless your current funding is through
this mechanism already. 14-279 covers:
"In vitro cellular and tissue activities (potency, selectivity, specificity,
etc.);
In vitro structural, physicochemical, and biochemical properties (solubility
, stability, membrane permeability, protein binding, microsome stability,
metabolite identification, CYP inhibition, etc.);
In vivo pharmacokinetics (PK) with absorption, distribution, metabolism,
excretion (ADME) and toxici... 阅读全帖 |
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w*********o
发帖数: 3030 | 46 Sometimes it is not about potency. The lead will need to be optimized unless
there is already a lot of SAR around current compound already. Did the
chemist want to sell the compound as it is, not to do further optimization
around it? |
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m*********D
发帖数: 1727 | 47 你说我们现在的compound?我们搞生物的没本事作合成，只能找市场上现存的可以买来
的strucuture-related compound来试试。从学术角度看（我们找的chemist也是学术界
的。他们导师有compound在临床二期了。），我们这样的potency很高了，再合成就没
有必要了。但你们industry不一样，连backbone都可能换的，好钻patent的空子，自然
比我们要强多了。
还在申请patent阶段，能不能拿到还不知道呢。所以，还没有大的VC有兴趣。另外，我
们的抗药性细胞的结果也是很关键的一步，不然，现存的药已经有了，我们不能进一步
，也不会有VC干兴趣的。当然，我们因为知道一些MOA,对抗药性癌细胞还是比较
confident。但总是希望看到实在的结果后才能说。所以，离卖还有很远的路要走。
optimization和可能看动物代谢试验后决定是不是有优化的必要。
unless |
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w*********o
发帖数: 3030 | 48 Your boss is the PI on current project? Might need the current chemist's
boss's help to sell the proposal then :). That's why I mentioned half of the
work would be chemistry. Your compound have high potency, how about
specificity? There might be a lot of more work before the compound goes from
small animal non-GLP to small Animal-GLP.
Even if it's not suitable for a drug, it can still be an "in vivo probe" and
sell it to sigma or something :) |
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