d******g
发帖数: 258 | 1 How to manage step3 CCS?
It’s hard in the beginning, kind of clueless for me. But you will be able
to get the idea pretty quickly after 5-6 cases in computer. Here’s my
thoughts how to manage it quickly and try not to miss things.
1. Differential if need urgent care.
All Chest pain, SOB, AMS, post-trauma, little infant all need to be ordered
with ER order before physical exam.
ER order mnemonic will be POC IV, ( have to poke someone for IV line)
Pulse oxygen
Oxygen
Cardiac monitor and BP mon... 阅读全帖 |
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i*******e
发帖数: 127 | 2 Of course. That's why those reformulated drugs (such as TID to QD regimen)
have to pass phase III studies to prove they have efficacy before any filing
. Sometimes PK/PD relationship holds when you change the PK profile, but
sometimes not. So you need not only PK study to prove you get what your want
for the new PK profile, you also need PoC and later Phase III studies for
approval. On the other hand, if you target your new formulation to be BE
with the current registered formulation, the approv |
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t********o
发帖数: 228 | 3 Thanks in advance.
I got this on-site interview next week but still don't have a detailed
picture about the responsibility of this position.
Job description:
The main focus of this role will be to provide full development expertise
and to input into pre Proof of Concept (PoC) compounds. This will involve
developing close working relationships with colleagues in drug development
matrix (particularly discovery medicine), Global Product Strategy (GPS),
project management and clinical operations.
E |
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p*********7
发帖数: 54 | 4 This seems to be a quite critical and strategic position in the clinical
development.
The description of the function is quite general and can fit clinical
development director, or medical director. It seems to involve mostly early
development, as the focus is mainly PoC. It requires the capability to
connect discovery (pre-clinical research) and clinical, set strategies for
clinical development, design clinical study protocols, etc. Early
development safety is a major concern, althogh signals o |
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k******n
发帖数: 133 | 5 The ADC is a major part of so called mAb v.2.0. The POC is now very well
established. The ker players are Seattle gen and immunogen.
ADC is projected to outpace general mAbs in terms of revenue growth in the
next 5years. Howerver, it remains a very small part of the overall mAb
markets. Its prime time has yet to come. |
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k******n
发帖数: 133 | 6 The ADC is a major part of so called mAb v.2.0. The POC is now very well
established. The ker players are Seattle gen and immunogen.
ADC is projected to outpace general mAbs in terms of revenue growth in the
next 5years. Howerver, it remains a very small part of the overall mAb
markets. Its prime time has yet to come. |
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M******A
发帖数: 15 | 7 Title: Oncology Physician
Location: Shanghai, China
Company: A Pharma company R&D Center
We are looking for an Oncology Physician for a Pharma company R&D Center in
Shanghai, Below is the detail requirements for the qualified candidate:
POSITION SUMMARY:
The Project Physician is part of the Compound Development Team, providing
oversight and execution of early development program from clinical study
design, protocol development, safety and efficacy data analysis and
interpretation and clinical st... 阅读全帖 |
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x*********g
发帖数: 927 | 8 大家好， 小弟最近拿到两个有关formulation development 的position的offer。两个
都是需要Ph.D. 加 2-3 年工作经验。 但是工作的偏向和地点有不同。有点难以取舍。
想在这里请大家看看， 帮忙出出主意。先谢过啦！
1. Early research formulation 职位。做vaccine的。 site 和组规模很小，在波士
顿大城市，整体biotech 机会多。这个formulation 组 规模很小，暂时还没有boss，
以后可能招一个新的boss。但感觉风险就是因为是很上游的POC类型的work。job
security不高。如果公司有什么风吹草动，整个cite 都危险。
2. 大的CMO公司的formulation职位，在RTP地区。好处是现在公司在成长期，有
expansion比较快。做的东西可能更偏向development和manufacture，job decurity可
能会更高。消费低一些。不好的是不像波士顿的大城市，而且老板已明确表明时间不会
总是8-5. 家里LD目前在波士顿做博后，LD需要relocate。
3. 第... 阅读全帖 |
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m**s
发帖数: 520 | 9 这两年foreign pharmacist可能难一点，主要还是不了解他们的运作方式。孤军作战，
自身条件也不够，通过TOEFL+NAPLEX只是个门槛，没有经过他们的系统训练。现在招人
什么MTM，POC，DM education, CPR,Immun。。。，各大连锁店的grad intern
checklist长长的一大摞
美国药学院毕业的，好像还没听说找不到的。都是毕业之前很久很久就有offer了。
本人所在州药师需求在全美倒数前10（根据下面这个不太靠谱的地图）
http://www.pharmacymanpower.com/usstatemap.jsp |
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m**s
发帖数: 520 | 10 这两年foreign pharmacist可能难一点，主要还是不了解他们的运作方式。孤军作战，
自身条件也不够，通过TOEFL+NAPLEX只是个门槛，没有经过他们的系统训练。现在招人
什么MTM，POC，DM education, CPR,Immun。。。，各大连锁店的grad intern
checklist长长的一大摞
美国药学院毕业的，好像还没听说找不到的。都是毕业之前很久很久就有offer了。
本人所在州药师需求在全美倒数前10（根据下面这个不太靠谱的地图）
http://www.pharmacymanpower.com/usstatemap.jsp |
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j****e
发帖数: 245 | 11 http://www.mentalhelp.net/poc/view_doc.php?type=doc&id=3831
Internet Addiction - Symptoms
Internet addiction is not recognized as a formal mental health disorder.
However, mental health professionals who have written about the subject note
symptoms or behaviors that, when present in sufficient numbers, may indicate
problematic use. These include:
Preoccupation with the Internet: User often thinks about the Internet while he
or she is offline.
Loss of control: Addicted users feel unable or unwill |
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j****e
发帖数: 245 | 12 The bottom line when dealing with Internet Addiction is to identify triggers
that lead to problematic use, to set realistic goals for reducing use, and to
then stick to and monitor conformance with those goals, sharing this
conformity data with someone else to encourage honesty and sticking to the
plan.
http://www.mentalhelp.net/poc/view_doc.php?type=doc&id=3832
Internet Addiction - Treatment
Internet Addiction is not an official disorder, and many mental health
professionals are not certain if |
|
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l****a
发帖数: 352 | 14 就是phase1, phase2a PoC, and biomarker/genetic marker exploratory research
三合一的statistician，做点pkpd modeling and simulation，做点bayesian
adpative design for clinical trial
三样全占的不多见，全都做得精的更加少，得看罗氏开多少钱了:)
小打击一下，fresh phd能符合要求的基本没有 |
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l******n
发帖数: 9344 | 15 基本知道你是哪个酒店了
去年给你们澳门公司做poc，不知道为什么最后你们找了另外一个vender
MATH
. |
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g**********l
发帖数: 214 | 16 for the one who uses sas with hadoop, does your company really have sas co-
located with hadoop? or just streaming data in and out via odbc?
the latter is useless. the former - are you guys paying for the big bucks?
sas connection to hadoop is not as simple and easy as some may think. it
costs an arm and an leg, hardware AND software. i was reading from here:
http://thomaswdinsmore.com/2013/10/21/sas-and-hadoop/
we are sas shop. we did POC with sas to hadoop access and gave up on it. too
clucky,... 阅读全帖 |
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j*******g
发帖数: 331 | 17 【 以下文字转载自 DataSciences 讨论区 】
发信人: jasonmeng (dueduedue), 信区: DataSciences
标 题: data scientist consultant类型的工作
发信站: BBS 未名空间站 (Thu Jul 2 12:56:27 2015, 美东)
最近拿了某个搞big data platform的公司里面一个professional consultant的工作
就是帮助客户设计一些data science的方案 有可能只做售前 poc之类 也可能要去客户
那里帮他们写代码 搭分析模型 请问版上各位前辈这种类型的工作对职业发展如何 |
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y*******d
发帖数: 1765 | 18 lol
That's no reason to argue it more.
Someone understand the mech already did more and more attacks on the site
all via POST channel.
So your GET theory is dead.
Let's see what gonna mitbbs.com do.
I'll send some poc to 3k or some other admins, but yeah, talking those shit
here is kinda opening da pandora box. |
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s**********8
发帖数: 25265 | 20 来自主题: MedicalDevice版 - 闲话GMP since all the poc, research protocol is from R&D and that's what DHF for.
DHF
owner? |
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l*****g
发帖数: 556 | 21
measure
On
dl
is
something
Totally agree. For blood, it is unnecessary.
Which company's meter and test stripe is already feasible at this range now?
For POC meters, many of them can do this range (passed 510k). |
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k*******y
发帖数: 219 | 22 关于移动医疗我们究竟应该有怎样的理解，目前业界投机取巧的办法就是，但凡能够跟
医疗沾边的互联网应用都算作移动医疗，不管它基础的医疗产品是何等品质；有人说电
子病历就是移动医疗。也有人认为提供在线挂号、预约就诊及专家咨询就算是移动医疗
了。以上种种都片面的理解了移动医疗。事实上移动医疗从产生到现在发展、完善历经
40年，它有专业的定义及操作模式，以互联网介入医疗服务只是其中很小的一部分。我
们且看移动医疗最发达的美国是如何定义、运作移动医疗的。
什么是移动医疗？
移动医疗是位于不同地域的用户通过数字通讯的方式来改善、提高患者的临床健康状态
。移动医疗方案包括各种不同的应用程序及服务手段，比如通过双向视频会话，电子邮
件，智能电话，无线设备或其他移动交互技术来解决医疗问题。美国移动医疗协会（
ATA）将移动医疗或移动健康两个名词认定为同等概念，广义来说移动医疗涵盖远程医
疗模式，但不能就此认为远程医疗就是移动医疗。患者可以通过视频会话咨询，传送静
止的图像及患者基础信息；远程生命体征监护；继续医学教育；以消费者为中心的无线
应用程序；护士呼叫中心，所有这些内容均包括在移动医疗或移动健康概念... 阅读全帖 |
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m******r
发帖数: 9604 | 23 http://ironman.com/events/ironman/worldchampionship/the-annual-
Bikes
Cervelo: 483
Trek: 211
Specialized: 170
Felt: 115
Cannondale: 86
Scott: 85
QR: 78
Argon18: 71
Giant: 64
Kestrel: 46
Orbea: 43
Kuota: 42
Ceepo: 37
BMC: 33
Look: 31
Guru: 28
Blue: 27
Fuji: 21
Ridley: 17
Cube: 17
PlanetX: 16
Litespeed: 11
Willier: 11
Storck: 10
Serotta: 9
Pinarello: 8
Parlee: 8
Canyon: 6
Colnago: 6
Stevens: 6
Elite: 6
Griffin: 5
BH: 5
Seven: 5
Teschner: 5
Beyond 4
Isaac: 3
Calfee: 3
Louis Garneau: 3
Jamis: 2
Chee... 阅读全帖 |
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l******n
发帖数: 9344 | 24 看板上的人大都是技术流派，关心的主要是技术，特别是编程，我来说点不一样的吧.
那就是怎么sell big data solution，因为无论你技术多牛，编程多厉害，你做出来的
东西最后是要卖出去的，如果你sell不出去，什么都是白搭。你说你是programmer，这
不关你的事,那只能说你很短时，因为你看不到你的将来，你可能从一个失败的公司跳
到另一个失败的公司，眼睁睁看着别人暴富。而且现在很多应用供需时脱节，供方面是
product，product都是程序员每天坐在电脑前想了半天弄出来的，都是能解决他们知道
的test problem；但是现实的需求比程序员脑袋里便的scenario复杂100倍.
这基本上就是solution architect/product manager的职业定位。这种职位一般要直接
面对客户，和客户做PoC,产品的demo，也要参与marketing的活动，比如一些
conference, 业界活动。要把东西sell给别人，我自己的感觉是
1.自己一定要有信心，要有belief，无论你的产品有多烂,你都要相信这是同类产品里
边最好的。说话一定要有激情和信心... 阅读全帖 |
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j*******g
发帖数: 331 | 26 最近拿了某个搞big data platform的公司里面一个professional consultant的工作
就是帮助客户设计一些data science的方案 有可能只做售前 poc之类 也可能要去客户
那里帮他们写代码 搭分析模型 请问版上各位前辈这种类型的工作对职业发展如何 |
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f**********t
发帖数: 11 | 27 Please send resume to [email protected]
/* */ and note which position
you are interested. Thanks
1. Cloud and Big Data Lead Engineer
• Bachelor degree in engineering in computer science or related;
Masters
preferable.
• Minimum of 3-4 years of hands-on experience of designing and
developing comprehensive big data solutions on the cloud.
• Cloud certified; preferably in - AWS Certified Solutions Architect -
Associate or Professional
• Fluency in English (oral and wri... 阅读全帖 |
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f**********t
发帖数: 11 | 28 Please send resume to [email protected]
/* */ and note which position
you are interested. Thanks
1. Cloud and Big Data Lead Engineer
• Bachelor degree in engineering in computer science or related;
Masters
preferable.
• Minimum of 3-4 years of hands-on experience of designing and
developing comprehensive big data solutions on the cloud.
• Cloud certified; preferably in - AWS Certified Solutions Architect -
Associate or Professional
• Fluency in English (oral and wri... 阅读全帖 |
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b********1
发帖数: 291 | 29 你举个具体的项目说说，怎么tableau就适合poc了， 怎么就能越过it support了？
我举个excel能干，tableau干不了的例子。
简单的生存分析。告诉业务部门，什么产品赚钱了，什么赔钱了。
大量用到公式的地方。 随便翻开什么书，什么公式，只要你算，excel都能派上用场。
tableau就悬了，不是说不能算，而是很weird. 好比你用sql去处理统计计算问题，不
是不能做， 而是感觉很奇怪。
我再举个tableau能做，excel不能做的例子。
地图。 excel没这东西。 tableua有。你做个报告，显示地图当然比显示table好。
tableau的最大长处其实就是一个字：
卖相好。 教练包就真比地摊包好嘛？ 不一定。 但人家卖相好。再说的明白一点，大
老板为了显示自己的档次，用tableau, 底下的人，就是做business的，为了迎合 也用
tableau
至于说excel有大小限制。高度一个million,宽度几千列吧？ 我觉得这么说也很weird.
这年头raw data 都在数据库里呢 ，我不明白为什么要excel来处理原始数据？
tableau
... 阅读全帖 |
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w*******y
发帖数: 60932 | 31 CAVEAT: The only reason I'm posting this is because of the price. I
purchased one in March for over $20 and tried to use it today and the POC
somehow has the spray power of a gnat! Was looking to return it when found
this 'great price'. My 'regular' hose works well. Wondering if internal
valves or mechanism is defective. Hopefully others have better luck with it!
Link:
http://www.homedepot.com/webapp/wcs/stores/servlet/ProductDispl
Ideal for daily watering, Ames Water Genie All-In-One 40 ft. Hos... 阅读全帖 |
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w*******y
发帖数: 60932 | 32 Tweet your way to savings with American Express
1) Sync your eligible American ExpressCard with Twitter
2) Tweet the special offer #hashtags to load exclusive Cardmember offers
directly to your Card
3) Save with an automatic statement credit when you make a qualified
purchase in store or online with your synced Card
Sign up link:
https://sync.americanexpress.com/twitter/
Whole Foods Market ? @WholeFoods
Tweet #AmexWholefoods get 1-$20 credit w/single purchase in store of $75+ on
synced AmexCard ... 阅读全帖 |
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a****o
发帖数: 1786 | 33 【 以下文字转载自 Biology 讨论区 】
发信人: synbio79 (jingzhuo), 信区: Biology
标 题: Job posting: Research Scientist Molecular Microbiologist in Genomatica
发信站: BBS 未名空间站 (Thu Mar 4 13:27:04 2010, 美东)
FYI
Genomatica is seeking a Research Scientist, Molecular Microbiologist to join
our growing Proof of Concept (POC) team. This team is responsible for the
identification and improvement of enzymes, including cloning, isolation and
characterization, for the cost-advantaged production of chemicals using
microorgan |
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