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全部话题 - 话题: metastatic
1 2 3 4 5 下页 末页 (共5页)
m******g
发帖数: 69
1
Immunology: Pro-metastatic TReg cells get RANKed
http://www.nature.com/nrc/journal/v11/n4/full/nrc3049.html
please email to 5*******[email protected]
y******m
发帖数: 14
2
NEW YORK, Jan. 10 /PRNewswire-FirstCall/ -- ImClone Systems Incorporated (
Nasdaq: IMCL - News) and Bristol-Myers Squibb Company (NYSE: BMY - News)
today announced that a Phase III study of ERBITUX® (cetuximab) plus
FOLFIRI (an irinotecan- based chemotherapy) met the primary endpoint of
increasing median duration of progression-free survival over FOLFIRI alone
in patients with previously untreated metastatic colorectal cancer (mCRC).
More than 1,000 patients were recruited from around the wo
G***G
发帖数: 16778
3
来自主题: Fishing版 - clinical analysis
现在有如下这些胃癌数据参数。老板让挖掘。我不知道挖掘什么。
有经验的请指点一下,这些临床数据中可以挖掘些什么?
how to do clinical analysis based on clinical data?
maybe this is a big question.
let's give an example. suppose we have the 200 gastric patients' data like
the following. What kind of analysis should be done? what parameters should
be focused
and what parameters should be ignored?
Classification by age
hospital days
Postoperation hospital day
Family history
Biopsy before surgery
Operation duration(min)
Surgeon
Anesthesia
Volume of blood tr... 阅读全帖
G***G
发帖数: 16778
4
来自主题: Biology版 - clinical analysis
how to do clinical analysis based on clinical data?
maybe this is a big question.
let's give an example. suppose we have the 200 gastric patients' data like
the following. What kind of analysis should be done? what parameters should
be focused
and what parameters should be ignored?
Classification by age
hospital days
Postoperation hospital day
Family history
Biopsy before surgery
Operation duration(min)
Surgeon
Anesthesia
Volume of blood transfusion
Ascites
Peritoneal metastasis
Hepatic metastas... 阅读全帖
f**********g
发帖数: 2252
5
来自主题: _pennystock版 - vicl
SLOW COW.
Publication Highlights Allovectin-7(R) Phase 2 Safety and Efficacy Results
in Melanoma
6 hours 15 minutes ago - PMZ
GlobeNewswireVical Incorporated (Nasdaq:VICL) today announced a new
publication summarizing results from the company's completed trials of
Allovectin-7(R) including systemic responses and an excellent safety profile
in patients with metastatic melanoma. An article published in the January
issue of Immunotherapy1 noted that the U.S. incidence of melanoma is
increasing rapi... 阅读全帖
f**********g
发帖数: 2252
6
来自主题: _pennystock版 - vicl
SLOW COW.
Publication Highlights Allovectin-7(R) Phase 2 Safety and Efficacy Results
in Melanoma
6 hours 15 minutes ago - PMZ
GlobeNewswireVical Incorporated (Nasdaq:VICL) today announced a new
publication summarizing results from the company's completed trials of
Allovectin-7(R) including systemic responses and an excellent safety profile
in patients with metastatic melanoma. An article published in the January
issue of Immunotherapy1 noted that the U.S. incidence of melanoma is
increasing rapi... 阅读全帖
v**********m
发帖数: 5516
7
来自主题: _pennystock版 - dcth怎么看
http://seekingalpha.com/article/894061-delcath-systems-an-exclu
Delcath Systems: An Exclusive Interview With ROTH Capital Senior Analyst
September 28, 2012 | about: DCTH
Disclosure: I am long DCTH. (More...)
Today I have the pleasure of publishing an exclusive interview that took
place this week between me and one of the leading senior analysts for
medical technology, Mr. Matt Dolan of ROTH Capital Partners. Mr. Dolan has
followed the industry for nearly a decade and has been the senior analys... 阅读全帖
v**********m
发帖数: 5516
8
楼上文章的comments
Not yet but stay tuned. But a definite fact and you can review it in the FDA
's analysis in the briefing document is that there was no SS of astrocytomas
in male rats or female rats.
Dr. Alavi had concerns about how Arena calculated the exposure margin for
Lorcaserin, that is why it appeared in the CRL. When Arena met directly with
the FDA on December 15th and 16th at the FDA, both Arena and the FDA agreed
on the CSF methodology and the number of participants that would be
acceptab... 阅读全帖
y*****l
发帖数: 5997
9
来自主题: _pennystock版 - 医保部讨论一下EXEL吧
1月有个会议,这个最近有什么炒点吗?
Exelixis reports encouraging data from Phase II MBC trial
4 days 2 hours 36 minutes ago - Datamonitor via Comtex
Exelixis, Inc., a biotechnology company, has reported positive preliminary
data from a cohort of 45 patients with metastatic breast cancer, or MBC,
participating in the ongoing cabozantinib Phase II randomized
discontinuation trial, or RDT.
As of the October 15, 2011 data cut-off, 45 patients with previously treated
estrogen receptor-positive, triple negative, or in... 阅读全帖
P********6
发帖数: 709
10
Dynavax Announces Acceptance of Two Data Abstracts for SD-101 in Combination
with KEYTRUDA® for Presentation at the 2018 Ameri
2018-03-15 10:30:02.354 GMT
Dynavax Announces Acceptance of Two Data Abstracts for SD-101 in Combination
with KEYTRUDA® for Presentation at the 2018 American Association for
Cancer Research (AACR) Annual Meeting
Data from Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
(HNSCC)
Durability Data in... 阅读全帖
m*****n
发帖数: 5245
11
来自主题: Biology版 - 找paper,伪币谢
我的邮箱: m*****[email protected]
Kim HL, Seligson D, Liu X et al (2005) Using tumor markers to predict the
survival of patients with metastatic renal cell carcinoma. J Urol 173:1496–
1501
Mancuso A, Sternberg CN (2005) New treatments for metastatic kidney cancer.
Can J Urol 12(Suppl 1):66–70
Motzer RJ, Mazumdar M, Bacik J et al (1999) Survival and prognostic
stratification of 670 patients with advanced renal cell carcinoma. J Clin
Oncol 17:2530–2540
Fyfe G, Fisher RI, Rosenberg SA et al (1995) Results of... 阅读全帖
d**********0
发帖数: 13081
12
来自主题: Medicalpractice版 - 刚看到首页盛年得癌症的帖子。
Metastatic adenocarcinoma is a cancer arising in glandular tissue that
spreads to other regions of the body. This type of cancer can be highly
aggressive in some cases, and there are a number of treatment options
available to manage it. Patients diagnosed with metastatic adenocarcinoma
typically work with an oncologist, a physician who focuses on cancer care,
and they may see nuclear medicine specialists, as well as other medical
specialists during the course of their treatment.
Adenocarcinomas ... 阅读全帖
l*h
发帖数: 4124
13
In principle, I agree with you on the use of pathway inhibitors. I think I
disagree with you on the practical issues.
1. her dad's oncologist doesn't seem to have a good knowledge of the
mutations of the tumor, the complexity of the pathways and the mechanisms of
these inhibitors.
2. his intracranial metastasis is a real big concern. if you think those
more conventional drugs are bad in getting into the brain (and the tumor),
currently available TKIs are worse. certain chemo drugs have been show... 阅读全帖
s*****g
发帖数: 7857
14
http://en.wikipedia.org/wiki/Bevacizumab
Bevacizumab (trade name Avastin, Genentech/Roche) is a drug that slows
angiogenesis, the growth of new blood vessels. It is licenced to treat
various cancers, including colorectal, lung, breast (outside the USA),
glioblastoma (USA only), kidney and ovarian.
Bevacizumab is a humanized monoclonal antibody that inhibits vascular
endothelial growth factor A (VEGF-A).[1] VEGF-A is a chemical signal that
stimulates angiogenesis in a variety of diseases, especia... 阅读全帖
b******a
发帖数: 704
15
来自主题: Medicalpractice版 - 贡献两个case, cancer related
Happy Chinese New Year!
Here is what I recently read online. Very interesting topic from MAYO CLINIC !
PUBLIC HEALTH RELEVANCE: Clear cell renal cell carcinoma (ccRCC) is the most
lethal form of kidney malignancy, killing nearly 13,000 patients annually.
Current treatment options for metastatic ccRCC are limited as evident in 2
year survival rates of 10-20%. Advancing ccRCC patient care centers around
several areas including better methods for identifying patients at high risk
for metastatic rel... 阅读全帖
E****e
发帖数: 315
16
来自主题: _eMoney版 - IMGN
from SeekingAlpha
The recent news announcing Genentech’s (DNA) receipt of a “Refuse to File
(RTF)” letter from the FDA for the accelerated approval of the Biologic
License Application (BLA) for trastuzumab-DM1 (T-DM1) has caused a sell-off
in Immunogen, the owner of the technology and partner on the drug with Roche
. According to the FDA letter, the refusal to give the early approval was
because “the trials had not yet exhausted all available drugs approved for
metastatic breast cancer, regardle... 阅读全帖
E****e
发帖数: 315
17
来自主题: _eMoney版 - IMGN
from SeekingAlpha
The recent news announcing Genentech’s (DNA) receipt of a “Refuse to File
(RTF)” letter from the FDA for the accelerated approval of the Biologic
License Application (BLA) for trastuzumab-DM1 (T-DM1) has caused a sell-off
in Immunogen, the owner of the technology and partner on the drug with Roche
. According to the FDA letter, the refusal to give the early approval was
because “the trials had not yet exhausted all available drugs approved for
metastatic breast cancer, regardle... 阅读全帖
t****r
发帖数: 702
18
http://phx.corporate-ir.net/phoenix.zhtml?c=148005&p=irol-newsA
9293&highlight=
没那么夸张,只是phase I study 有效果而已。。。
Alnylam and Collaborators Publish Results from Phase I Clinical Trial and Ex
tension Study with ALN-VSP, an RNAi Therapeutic for the Treatment of Liver C
ancer
- Results Published in Cancer Discovery Document Most Comprehensive Human Ex
perience To Date for RNAi Therapeutics Delivered with Lipid Nanoparticles (L
NPs) -
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jan. 30, 2013-- Alnylam Pharmaceu... 阅读全帖
l**x
发帖数: 110
19
下面这个患者希望能得到版上医生专家的指导意见,危险多大,如何治疗,预后如何?
患者44岁,男,6年前因为肝癌做了肝移植 (符合米兰标准),之后无灾无病好几年。
去年2016年初发现轻微贫血,血色素12,因为当时在服小剂量阿司匹林,于是停服,看
看有没好转。托托拉拉到了年底,还是贫血,血色素10.5。医生说做个内镜。于是在胃
内发现一个肿瘤,内镜医生直觉是GIST。随后CT,但CT却没有异常。4月初第二次胃镜
,GIST依然还在,取样活检表明可能肝癌转移或者是非常罕见的HAC。第二次CT 报告大
小46x35mm,说比较第一次32mm变大了。可能第一次看片医生那天喝多了?肿瘤位置在
Fundus,非常接近GOJ。
AFP好久没有查了,因为肝上的情况一直很好,肝移植前AFP 100多,移植后AFP一直小
于2。上一次至少是2,3年前。也是疏忽了。现在AFP 254. 显然胃上这个要么是转移,
要么是HAC。
下周二医生还要安排一次PETCT,周三见外科医生,估计排除转移外就安排切除了。 求
这里的专家教授指点,这个情况如何是好?下面我贴上最近几个报告。
个人感觉肝移植后5,6年转移到胃实在... 阅读全帖
T**********e
发帖数: 29576
20
下面这篇文章对Jobs的胰腺内分泌癌治疗总结的不错,看来死的有点冤。
1. 10-2003 确诊,07-2004终于手术切除,期间Jobs一直在试自己选的diet疗法。扫描发现癌变在扩大才动了手术,这段时间癌转移的多少不可知,但肯定越拖转移的越多。
2.手术后没化疗和放疗。Jobs 2005年演讲说这表明病情乐观,不知是哪个庸医给他灌输的。2004年手术是大面积切除,部分胰腺和胃和小肠,胆和胆管都切除,目的是要消除扩散,但不系统化疗和放疗怎么能最大程度减少扩散威胁?哪个外科大夫这么信自己的手艺?
3.2009年换肝,这在扩散性癌治疗是有争议的,因为换肝后压制免疫反应有可能促进别处癌的生长。也有可能当时肝已经不行了没办法。
这种癌正常治疗大多数可活10年以上,Jobs真该到东岸Hopkins或Harvard找个靠谱的大夫。
Jobs’s Unorthodox Treatment
Some of Apple trailblazer Steve Jobs’s cancer treatment choices, from
alternative therapies to a liver tra... 阅读全帖
r********0
发帖数: 22
21
来自主题: MedicalCareer版 - 肝癌求助
She should be referred to an oncology specialist who could offer better
advice. If that means she has to go to Shanghai to find an oncologist then
by all means she should go.
It would be hard to answer your question without knowing more details about
her disease. The key piece missing is histo-pathology findings. Primary
cancers of skin, breast and liver and their histology subtypes have very
different prognosis and life expectancy.
Therefore before she leaves for Shanghai, she should take all... 阅读全帖
yf
发帖数: 272
22
http://jop.ascopubs.org/content/early/2013/03/26/JOP.2012.00081
Perspective
Practicing Western Oncology in Shanghai, China: One
Group’s Experience
By David H. Garfield, MD, Harold Brenner, MD, FRCR (Lond), and Lucy Lu, RN
ProMed Cancer Centers–Shanghai, Shanghai, People’s Republic of China
In October 2011, we—David H. Garfield, MD, medical oncologist,
United States; Harold Jacob Brenner, MD, FRCR,
radiation oncologist, Israel; and Lucy Lu, oncology nurse,
Shanghai, China—were part of a group tha... 阅读全帖
l**x
发帖数: 110
23
知道这个版的专业医生很多,所以占宝地求指点。恳请大家一点给点指导,下一步怎么
办合适?
患者44岁,男,6年前因为肝癌做了肝移植 (符合米兰标准),之后无灾无病好几年。
去年2016年初发现轻微贫血,血色素12,因为当时在服小剂量阿司匹林,于是停服,看
看有没好转。托托拉拉到了年底,还是贫血,血色素10.5。医生说做个内镜。于是在胃
内发现一个肿瘤,内镜医生直觉是GIST。随后CT,但CT却没有异常。4月初第二次胃镜
,GIST依然还在,取样活检表明可能肝癌转移或者是非常罕见的HAC。第二次CT 报告大
小46x35mm,说比较第一次32mm变大了。可能第一次看片医生那天喝多了?肿瘤位置在
Fundus,非常接近GOJ。
AFP好久没有查了,因为肝上的情况一直很好,肝移植前AFP 100多,移植后AFP一直小
于2。上一次至少是2,3年前。也是疏忽了。现在AFP 254. 显然胃上这个要么是转移,
要么是HAC。
下周二医生还要安排一次PETCT,周三见外科医生,估计排除转移外就安排切除了。 求
这里的专家教授指点,这个情况如何是好?下面我贴上最近几个报告。
个人感觉肝移植后5,6年转... 阅读全帖
s*****e
发帖数: 404
24
Based on the pathology and 15/23 positive lymph nodes, it is likely an
aggressive tumor. I agree with againstwind, your wife needs biopsy of the
enlarged lymph node. She can get a PET/CT before biopsy to see whether the
lymph nodes have FDG uptake. Should these tests confirm recurrent disease,
it suggests that the tumor is radio-I insensitive. If PET/CT only shows
localized disease in the neck, surgery need to be considered. If she has
metastatic disease, she needs to be referred to medical onco... 阅读全帖
s**r
发帖数: 669
25
查了一篇paper:Metastatic Behavior of Breast Cance
Results:
Median follow-up time among 3,726 eligible patients was 14.8 years. Median
durations of survival with distant metastasis were 2.2 (luminal A), 1.6 (
luminal B), 1.3 (luminal/HER2), 0.7 (HER2 enriched), and 0.5 years (basal-
like; P < .001).
她从被查出Metastatic到病逝有半年,也不算长。
n*******n
发帖数: 540
26
Postdoctoral Fellow in Cancer Metastasis, Nanotechnology and Biology
The Laboratory for Drug Delivery and Personalized-Medicine Technologies,
Faculty of Chemical Engineering, Technion - Israel Institute of Technology
, Haifa, Israel
Dr. Avi Schroeder, PhD
Metastasis, the spread of cancer to distant sites, is the leading cause of
cancer deaths. In this project we will construct nanotechnology tools for
detecting and treating metastatic cancer. This position requires previous
expertise with bio... 阅读全帖
f******I
发帖数: 769
27

some
on
big
spleen
can't tell much with very limited information you provided, the type of
liver cancer and whether is hepatic primary or metastatic would be helpful,
assume he had hepatocellular carcinoma from hep C, and maybe he had upper gi
bleed from either esophageal or gastric varices from portal hypertension
from cirrhosis from hep C, the outlook is not very good,
if it's metastatic disease with solitary hepatic mets sometimes they could
consider chemo embolization,
f******I
发帖数: 769
28

查,
if it's solitary lesion on liver, even if it's metastatic disease, you could
still have the liver tumor resected, bony metastatic disease is often
treated with radiation,
need to know what type of cancer and where is the primary, his age and other
co-morbidity factors also play a role in deciding whether to pursue chemo
or not had it been confirmed that it is malignant, chemotherapy in general
is very very toxic,
l*******n
发帖数: 68
29
It looks like that your friend's mother has metastatic renal carcinoma with
liver metastasis and biliary tract obstruction (primary kidney cancer and
spreaded to liver causing biliary tract obstruction). Unfortunately, the
prognosis in this situation is terminal. There is no cure. She is not a
candidate for surgery given metastatic situation. she is too ill to receive
chemotherapy. In addition, kidney cancer does not respond to chemotherapy
well. What the doctors in China have been doing are all
I****a
发帖数: 407
30
MRI and PET should give you the somewhat definite answer. If still in doubt and that is the only suspected area, it is not unreasonable to consider CT guided biopsy of lumbar spine.
Even it is metastatic breast cancer, it is not the end of the world, bone only disease carry the best prognosis among all metastatic breast cancer, you might expect 5 years and sometimes even longer. Treatment normally involves bisphosphonate and hormonal therapy. I assume your mother had ER/PR (+) disease. Once horm... 阅读全帖

发帖数: 1
31
来自主题: Stock版 - What about ZIOP @6.5
Anyone is interesting it @6.5 ?
it seems a good entry point.
target 14, but I don't know how long time to wait.
ZIOPHARM Oncology, Inc. is a biopharmaceutical company, which is seeking to
develop, acquire and commercialize, on its own or with partners, a portfolio
of cancer therapies that address unmet medical needs. The Company is
focused on developing products in immuno-oncology that employ gene
expression, control and cell technologies to deliver cell- and viral-based
therapies for the treatm... 阅读全帖
S*****s
发帖数: 242
32
病人在中国吗? 如果是,好吃好喝的伺候着,等死吧。
如果在美国,想办法进这个phase I trial。 可靠消息是有30-40%的效果。你可以去今
年的ASCO (American Society of Clinical Oncology)annual meeting,可能会有最
新的结果公布。这些结果短期内不会发表(听说是BMS要等到Phase III结果)。这个
trial只接受晚期垂死病人。
1 Recruiting: A Phase 1b Study of MDX-1106 in Subjects With Advanced or
Recurrent Malignancies Conditions: Metastatic Castration-resistant
Prostrate Cancer (mCRPC); Renal Cell Carcinoma (RCC); Metastatic
Melanoma (MEL); Non-small Cell Lung Cancer (NSCLC)
Intervention: Biological: BMS-9365... 阅读全帖
n*******n
发帖数: 540
33
【 以下文字转载自 Faculty 讨论区 】
发信人: nnnnnnnnn (hv), 信区: Faculty
标 题: Postdoctoral Fellow position in Cancer Metastasis, Nanotechnology and Biology
关键字: postdoc,postdoctoral fellow
发信站: BBS 未名空间站 (Fri Jun 15 10:42:34 2012, 美东)
Postdoctoral Fellow in Cancer Metastasis, Nanotechnology and Biology
The Laboratory for Drug Delivery and Personalized-Medicine Technologies,
Faculty of Chemical Engineering, Technion - Israel Institute of Technology
, Haifa, Israel
Dr. Avi Schroeder, PhD
Metastasis, the sprea... 阅读全帖
h********8
发帖数: 49
34
索性把我最近看的文献的摘要发出来。有谁看到有趣的做癌症诊断的公司,麻烦告诉我
一声哈。谢谢!
约翰斯•霍普金斯大学Kimmel癌症中心
(文献1, 2012年11月) 不依赖于已知癌症基因组成而检查肿瘤DNA的方法。研究人员
从取自10位结肠癌和乳腺癌患者的血液标本里分离出DNA。然后,他们使用下一代DNA测
序技术读取了血液DNA中的全部基因组。结果显示,癌症患者的血液DNA都出现了染色体
拷贝变化和重排,而10个健康对照组成员的DNA没有异常。
癌症患者血液中来自肿瘤的DNA所占比例从1.4%到47.9%,差异很大。这种新检测法还可
能需要从肿瘤DNA低于0.1%的血液样本中检查出小的、可治愈的肿瘤。只需要做更多的
测序就能克服这些困难。这项实验有望在未来5到10年内用于临床
(文献2,2013年1月)利用常规巴氏检测(Pap test)获得的宫颈分泌物来检测卵巢癌
及子宫内膜癌。在一项初步研究中,研究人员采用这种命名为“PapGene”的测试方法
,依靠全基因组测序癌症特异性突变,检测出了全部24个子宫内膜癌,以及22个卵巢癌
其中的9个,准确率分别为100%和41%... 阅读全帖
s*********y
发帖数: 292
35
看这个 http://www.sciencemag.org/content/339/6127/1546.full
PDF版的Fig1右边那段话。
One potential explanation invokes mutations
or epigenetic changes that are difficult to identify
with current technologies (see section on “dark
matter” below). Another explanation is that metastatic
lesions have not yet been studied in sufficient
detail to identify these genetic alterations,
particularly if the mutations are heterogeneous
in nature. But another possible explanation is
that there are no metastasis genes. A ... 阅读全帖
b*******1
发帖数: 16
36
岗位一:吴虹课题组博士后工作人员 (2名)
主要职责:
1)独立开展科研工作,动手进行体内外实验;
2)协助PI负责实验室研究课题的设计和开展;
3)参与科研基金撰写;
4)协助培养研究生。
招聘条件:
1)品学兼优,身体健康,年龄在40岁以下;
2)近年来在国内外获得分子生物学、细胞生物学、肿瘤遗传学、药理学等相关专业博
士学位;
3)至少具备一项以下领域内的工作经验和文献发表:
a. 独立运用细胞和动物模型进行肿瘤药物的机理研究
b. 在分子生物学和细胞生物学领域有深厚的知识背景;
c. 在蛋白质分析、核酸分析和细胞生长分析等相关技术方面有丰富的经验;
d. 对治疗癌症的药物疗效和安全性评价方面有强烈的兴趣和研究背景 ;
4)有较强的团队合作精神,沟通协调能力强,动手能力强,工作细心,积极主动,能
持之以恒;
聘用待遇:
本职位将为你提供在生物学领域极具竞争力和创造性的工作机会。博士后工作人员薪酬
标准按照北京大学生命科学院和北大-清华生命科学中心相应规定及个人工作经验及能
力确定。
联系方式:
有意者请将本人应聘材料电子文档发至以下联络方式(请在应聘材料及邮件主题上注明
:姓名 ... 阅读全帖
r*****m
发帖数: 3619
37
来自主题: Biology版 - Wang Jun这么狠了吗?
Results: 46
Select item 25597018
1.
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated
Genes in Seminomas.
Cutcutache I, Suzuki Y, Tan IB, Ramgopal S, Zhang S, Ramnarayanan K, Gan A,
Lee HH, Tay ST, Ooi A, Ong CK, Bolthouse JT, Lane BR, Anema JG, Kahnoski RJ,
Tan P, Teh BT, Rozen SG.
Eur Urol. 2015 Jan 14. pii: S0302-2838(14)01396-7. doi: 10.1016/j.eururo.
2014.12.040. [Epub ahead of print]
PMID: 25597018 [PubMed - as supplied by publisher] Free Article
Related citations... 阅读全帖

发帖数: 1
38
Two Postdoctoral Fellow positions are available for highly motivated and
productive applicants in the laboratory of Dr. Subhamoy Dasgupta at the
Department of Cell Stress Biology, Roswell Park Cancer Institute, NY- a
National Cancer Institute (NCI) designated comprehensive cancer center. The
Dasgupta lab will be moving to Roswell Park during the summer of 2017 and
the laboratory will be fully functional by July 2017. The laboratory focuses
on discovering novel metabolic adaptations that promote ... 阅读全帖
b*******g
发帖数: 1309
39
来自主题: Chemistry版 - 哪个把这个C&EN的 news 贴一下吧。
Carbohydrate-based vaccines are widely used to prevent infectious diseases,
but their use to fight cancer has so far proved problematic. To increase the
chance of success, researchers are pursuing a number of avenues that have a
common goal: enhance carbohydrates’ ability to induce the human immune
system to mount an effective fight against cancer.
Carbohydrates are studded all over the surfaces of human cells, where they
help with essential functions ranging from protein transport and cell-cell... 阅读全帖
V**y
发帖数: 788
40
来自主题: MedicalCareer版 - 癌症检测求翻译
病理诊断 :
贲门小弯侧:溃疡型低分化腺癌,局部为印戒细胞癌,侵及全层达浆膜外脂肪,侵犯神
经,累及食管下段。
瓶装上下切缘(-);网膜(-)。“第2,4,5组”示脂肪。
第3组(1/3);第1组(1/2)淋巴结见转移癌。
第7组(0/1);8A(0/2)淋巴结未见转移癌。
Pathology diagnosis:
Cardiac stomach,lesser curvature: ulcerative poorly differentiated
adenocarcinoma with focal signet ring cells, invades full thickness of
stomach wall to periseroal adipose tisse, perineural invasion identified,
lower segment of esophagus involved.
Negative resection margins;negative omentum.
"groups #2, 4, 5" show adipose tissue.
Group #3... 阅读全帖
p***o
发帖数: 714
41
Unlike U.S. Food and Drug Administration drug approvals, which are more
precisely timed, the release dates for data from clinical trials is bit
fuzzier, so the timelines here are culled from company guidance when
possible.
The working list of clinical trials expected to complete in 2009 is fairly
long, so expect more information on clinical trials to watch in the coming
weeks.
Company: GTx(GTXI)
Drug/indication: Acapodene for precancerous prostate lesions (high-grade PIN)
Clinical trial event: p... 阅读全帖
y*****l
发帖数: 5997
42
来自主题: _pennystock版 - Delcath Systems (Nasdaq: DCTH)
This Small Biotech Firm's Shares Could Rocket in the Next 30 Days
By: Anthony Haddad
Staff Writer
StreetAuthority

Published: March 26, 2010
Every year, about a quarter million cases of liver cancer are diagnosed in
the United States; around the world the number is estimated to exceed two
million. According to the American Cancer Society, the five-year survival
rate of liver cancer is just 10.8%. This is one of the most fatal of all
cancers -- prostate (98.4%), breast (88.6%), and even lung can... 阅读全帖
y*****l
发帖数: 5997
43
来自主题: _pennystock版 - 想喊sppi,可惜mittbbs坏了
sppi 最近要炒FDA吗?
Spectrum Pharmaceuticals Responds to FDA's Complete Response Letter for
Fusilev
Sunday 11/07/2010 1:04 AM ET - Close-up Media
Spectrum Pharmaceuticals, a biotechnology company with fully integrated
commercial and drug development operations with a primary focus in oncology,
announced that on Friday, October 29, it submitted a complete response to
the "Complete Response" letter issued by the U.S. Food and Drug
Administration (FDA), regarding its supplemental New Drug Application (s... 阅读全帖
y*****l
发帖数: 5997
44
Pre market up.
Spectrum Pharmaceuticals Announces Record Revenue and Record Profit in First
Quarter 2011
28 minutes ago - BIZ via Comtex
BusinessWire--Anticipate Reporting a Record Quarterly Profit in the First
Quarter 2011 Second Consecutive Profitable Quarter
--FUSILEV(R) sNDA For Use In Advanced Metastatic Colorectal Cancer is
Currently Under Review by the FDA PDUFA Action Date -- This Week -- April 29
, 2011
--ZEVALIN(R) Prior Approval Supplement for the Removal of the Bioscan
Requirement Cu... 阅读全帖
v**********m
发帖数: 5516
45
来自主题: _pennystock版 - sppi
http://www.businesswire.com/news/home/20110421006626/en/Spectru
April 21, 2011 02:42 PM Eastern Daylight Time
Spectrum Pharmaceuticals Announces FDA Approval of FUSILEV®’s Ready-to
-Use Formulation (RTU)
* Until Now FUSILEV® Has Been Available Only As A Lyophilized
Product
* FUSILEV® sNDA For Use In Advanced Metastatic Colorectal Cancer is
Currently Under Review By The FDA
o PDUFA Action Date – April 29, 2011
* FUSILEV® Is Currently FDA Approved and Mark... 阅读全帖
y*****l
发帖数: 5997
46
大盘大跌 + debt ceiling + DNDN大跌.
How Dendreon Can Fix Its Broken Relationship With Wall Street
By David Miller Aug 04, 2011 20:00 pm
http://www.minyanville.com/businessmarkets/articles/health-care
Dendreon (DNDN) is down hugely this morning on last night's earnings miss
and guidance rescission. The NASDAQ Biotech Index (^NBI) and associated ETF
(IBB) are down also. This is not a good day for the biotech sector, as the
reimbursement issues faced by Dendreon seem, at the 10,000-foot level, to
fit wit... 阅读全帖
b**********k
发帖数: 1262
47
来自主题: _pennystock版 - After THLD, some other Cancer related stocks
AEZS 1.6 Phase 3 03/31/2012 metastatic colorectal cancer
GTXI 5.8 Phase 2b 03/31/2012 advanced prostate cancer
IMGN 14.10 Phase 2 03/31/2012 small-cell lung cancer
Kerx 3.19 Phase 3 03/31/2012 Complete Phase 3 Perifosine for
metastatic colorectal cancer 1Q 2012
SNTA 5.46 Phase 1b/2 03/31/2012 Initiate Phase 1b/2 rectal cancer
trial 1Q 2012
EXEL 5.78 Phase 3 06/30/2012 Phase 3 initiation of
Castration-Resistant Prostate Cancer - 2nd Phase 3 307 trial, 1H 2012
EXEL 5.78 NDA ... 阅读全帖
v**********m
发帖数: 5516
48
来自主题: _pennystock版 - DCTH 狂跌
NEW YORK, Aug. 15, 2012 /PRNewswire/ — Delcath Systems, Inc. (NASDAQ:DCTH)
announced today that it has submitted a New Drug Application (NDA) to the U.
S. Food and Drug Administration seeking approval for the Company’s
proprietary chemosaturation system for use with melphalan hydrochloride in
the treatment of patients with unresectable metastatic melanoma in the liver
. The Company included its Generation 2 filter in its NDA submission as a
technical change to the Chemistry, Manufacturing, and C... 阅读全帖
p********3
发帖数: 5750
49
INTRODUCTION — The word "acupuncture" is derived from the Latin words "acus
" (needle) and "punctura" (penetration). Acupuncture originated in China
approximately 2000 years ago and is one of the oldest medical procedures in
the world.
Over its long history and dissemination, acupuncture has diversified and
encompasses a large array of styles and techniques. Common styles include
Traditional Chinese, Japanese, Korean, Vietnamese, and French acupuncture,
as well as specialized forms such as hand,... 阅读全帖
w*****2
发帖数: 1584
50
这么严重的医疗事故,背后可能还有西方药业公司拿中国廉价病人做实验小白鼠的可能
性,太他妈的黑暗了,
avastin只是被FDA批准用作扩散性转移的癌症的治疗,而且存在疗效争议,
avastin的改装产品是Ranibizumab, 被FDA批准用于治疗部分眼疾。
有的人认为avastin和Ranibizumab有相同疗效,但是两者价格悬殊,(一个$42,一个$
1593)而且在眼疾的使用上,前者没有得到FDA的批准!
也就是说,avastin对眼疾的临床试验,是没有做或者结果不理想,
但是中国医生居然敢乱扎针用avastin,导致病人失明。
一下英文资料均来自wiki,
http://en.wikipedia.org/wiki/Bevacizumab
Bevacizumab (trade name Avastin, Genentech/Roche)
Bevacizumab is currently approved by the U.S. Food and Drug Administration (
FDA) for cancers that are metastatic (have s
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