u*********1
发帖数: 2518 | 1 sequencing: 更多的sequence 新方法，还有intron, promoter sequencing, levi
的TERT promoter是不是要引起一阵promoter and intron region sequencing的热潮
关于melanoma promotor mutation的文章，不知道大家有何评价？
70%的sporadic melanoma都有promotor区域的SNP，这也太surprising了
一般我们就是找coding region的SNP，或者noncoding区域的CNV/SV；没想到小小的
promotor的SNP竟然会成为背后杀手。
同样的，对于其他的神经疾病的genetics，会不会也是noncoding region的很多问题呢
？真是越来越难做了。从SNP到SV/CNV到complex region，从coding到noncoding
levi |
|
d*p
发帖数: 534 | 2 我说的将近50％反应率是pd-1/pd-l1，具体可以参考nejm上的三篇文章，两个pd-1 抗
体，一个pd-l1 抗体。 在melonoma, lung cancer, renal cancer 上效果都不错，秒
杀过去几十年搞的那些药，如果这都没什么意义，癌症治疗也没啥搞头了。目前看到的
肿瘤生长曲线已经非常的exciting了，有兴趣的可以去读读这三篇文章，看看肿瘤曲线
。从ctla4 到pd-1/pd-l1，不仅仅副作用下降了，疗效也有了大幅度的提高，再等3年
，让我们来看看pd-1/pd-l1 的长期存活率，那时候会更有意义。
anti-ctla-4, 具体可以参考nejm上hodi 的Ipilimumab文章。 在50％存活率这个点比
较，你会发现这个药的疗效也一般，但是重点不在这里，大家可以比较2年半以后，也
就是30个月以后，这个存活曲线的走向。 晚期黑色素瘤,长期存活率提高15%, 10个人
里，可以救活1.5个人，现在有那个药可以做到这点？我觉得这就是重大突破。
虽然pd-1/pd-l1的治疗和pd-l1的表达，以及t cell infiltration 有相关性... 阅读全帖 |
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s******y
发帖数: 28562 | 3
大致看了一下，数据很有意思啊。是否暗示了Kaposi's sarcoma, non-Hodgkin's
lymphomas, and nonmelanoma skin cancers是用免疫法治疗最有前途的几种癌症？
For most common tumors, e.g. colon, lung, prostate, stomach, esophagus,
pancreas, ovary and breast, cancer rates were roughly twofold higher after
kidney transplantation compared with the general population. Melanoma,
leukemia, hepatobiliary tumors, cervical and vulvovaginal tumors were each
approximately fivefold more common. Testicular and bladder cancers were
increased approximately t... 阅读全帖 |
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S*****s
发帖数: 242 | 4 你不读新文献，肯定悲观
-表达PD-L1的肿瘤细胞有多少种？
几乎所有的solid tumors都表达PD-L1，但比例有不同。Lung cancer~30%，melanoma~
45% 等等 （指晚期肿瘤，早期更高些）。有很多review可以看。血液肿瘤表达低。
Lieping Chen倡导用PD-L1作为biomarker，Genentech的lung cancer trial已经得益
-肿瘤快速产生的过程中为什么会产生大量的抗原？
晚期肿瘤，proof-reading enzyme缺失严重，DNA复制错误无法及时修复，突变，断裂
，translocation 等等大量出现，出现新的AA sequence。新的蛋白，就是抗原。Bert
Vogelstein有精彩描述。
-anti-PD-1治疗方案和大剂量IL2我看没什么两样。
什么是“治疗方案”，静脉注射？每天一针？who cares！那全天下的药都没有两样。
如果你说的是疗效比较，那就是睁眼说瞎话了：
举例，晚期melanoma治疗，
大剂量IL-2：有效（临床反应）率8%，高毒性，3年存活率〈10%；
Anti-PD-1：有效... 阅读全帖 |
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m******c
发帖数: 830 | 5 It's the opposite. Melanoma is the tumor type with the highest mutation load
among all tumor types. Therefore, most immuno-oncology trials start with
melanoma, including PD-1 and tumor vaccines, because high mutation load
means higher tumor immunogenecity. It is a 软柿子. Mutation load in lung
cancer is high, too, and is one of the FDA approved anti-PD-1 therapy
indications. |
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b*******g
发帖数: 1309 | 6 Carbohydrate-based vaccines are widely used to prevent infectious diseases,
but their use to fight cancer has so far proved problematic. To increase the
chance of success, researchers are pursuing a number of avenues that have a
common goal: enhance carbohydrates’ ability to induce the human immune
system to mount an effective fight against cancer.
Carbohydrates are studded all over the surfaces of human cells, where they
help with essential functions ranging from protein transport and cell-cell... 阅读全帖 |
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a****y
发帖数: 1035 | 7 诸平
几十年来，不少人认为食用含有抗氧化剂的食物能够促进健康并预防癌症。而美国德克
萨斯大学西南医学研究中心（ UT Southwestern Medical Center）儿童研究所（
Children's Research Institute，CRI）的研究人员最近发现，癌细胞比正常细胞更容
易从抗氧化剂中获益,对于癌症患者，提高其膳食抗氧化剂的使用量，其效果使令人担
忧的，因为抗氧化剂会促使癌细胞扩散。无独有偶，2014年7月10日，两位美国科学家
也曾经有过类似的研究结果，发现对于抗氧化剂而言，事实可能并非像人们以前认识的
那样。他们称，抗氧化剂对癌症不但没有预防和治疗作用，甚至在某些特殊的情况下还
会增加癌症患病几率，加速肿瘤生长。相关论文发表在2014年第二期的《新英格兰医学
》（New England Journal of Medicine）杂志上——Elizabeth G. Phimister,
Navdeep S. Chandel, David A. Tuveson. The Promise and Perils of Antioxidants
for Cancer ... 阅读全帖 |
|
a****y
发帖数: 1035 | 8 诸平
几十年来，不少人认为食用含有抗氧化剂的食物能够促进健康并预防癌症。而美国德克
萨斯大学西南医学研究中心（ UT Southwestern Medical Center）儿童研究所（
Children's Research Institute，CRI）的研究人员最近发现，癌细胞比正常细胞更容
易从抗氧化剂中获益,对于癌症患者，提高其膳食抗氧化剂的使用量，其效果使令人担
忧的，因为抗氧化剂会促使癌细胞扩散。无独有偶，2014年7月10日，两位美国科学家
也曾经有过类似的研究结果，发现对于抗氧化剂而言，事实可能并非像人们以前认识的
那样。他们称，抗氧化剂对癌症不但没有预防和治疗作用，甚至在某些特殊的情况下还
会增加癌症患病几率，加速肿瘤生长。相关论文发表在2014年第二期的《新英格兰医学
》（New England Journal of Medicine）杂志上——Elizabeth G. Phimister,
Navdeep S. Chandel, David A. Tuveson. The Promise and Perils of Antioxidants
for Cancer ... 阅读全帖 |
|
c****l
发帖数: 1086 | 9 纠正一下，单纯的BRAF mutation不导致melanoma，只导致nevus，melanoma需要在BRAF
基础上进一步accumulate muations，譬如说CDKN2A... |
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z*******n
发帖数: 1034 | 10 BY Emily Price @emily 5 hours ago
You can already use your smartphone to do things like hail a pimp ride home
or order an artisan pizza, obviously the next step is cancer detection,
right? Researchers at the University of Houston think they've created a
smartphone app that can detect melanoma even better than your doctor. Called
DermoScan, the app works by taking a photo of your odd-shaped mole, and
then analyzing it to determine if it might be cancerous. Initial testing
found that DermoScan was... 阅读全帖 |
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p***o
发帖数: 714 | 11 Unlike U.S. Food and Drug Administration drug approvals, which are more
precisely timed, the release dates for data from clinical trials is bit
fuzzier, so the timelines here are culled from company guidance when
possible.
The working list of clinical trials expected to complete in 2009 is fairly
long, so expect more information on clinical trials to watch in the coming
weeks.
Company: GTx(GTXI)
Drug/indication: Acapodene for precancerous prostate lesions (high-grade PIN)
Clinical trial event: p... 阅读全帖 |
|
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y*****l
发帖数: 5997 | 13 This Small Biotech Firm's Shares Could Rocket in the Next 30 Days
By: Anthony Haddad
Staff Writer
StreetAuthority
Published: March 26, 2010
Every year, about a quarter million cases of liver cancer are diagnosed in
the United States; around the world the number is estimated to exceed two
million. According to the American Cancer Society, the five-year survival
rate of liver cancer is just 10.8%. This is one of the most fatal of all
cancers -- prostate (98.4%), breast (88.6%), and even lung can... 阅读全帖 |
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y*****l
发帖数: 5997 | 14 Date Company Name Ticker Drug Event Outcome Details
04/30/2011 GlaxoSmithKline PLC GSK, GSK.L Lamictal-XR (sNDA) FDA
decision on Lamictal-XR for conversion to monotherapy for treatment of
partial seizures FDA approved Lamictal XR for conversion to monotherapy
for treatment of partial seizures on Apr.25
-Drug Status
-Approved in Other Countries
04/29/2011 Spectrum Pharmaceuticals Inc SPPI Fusilev (sNDA) FDA
action on Fusilev for additional use in c... 阅读全帖 |
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y*****l
发帖数: 5997 | 15 http://www.thestreet.com/_yahoo/story/11215926/1/biotech-calend
Updated with corrected FDA approval decision date for Roche's melanoma drug
Zelboraf. It's Oct. 28, 2011, not Nov. 11, 2011, as previously reported.
BOSTON (TheStreet) -- The 2011 FDA drug approval calendar has been updated
and extended through the first quarter of 2012.
For easier reference, this regulatory calendar is organized in chronological
order based on the drug approval decision date. Information on pending FDA
advisory pan... 阅读全帖 |
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y*****l
发帖数: 5997 | 16 11:55 Do you think there is > 50% chance someone buys HGSI in next 12 mos.?
Yes
( 68% )No
( 32% )
Thursday October 20, 2011 11:55
11:56 adam feuerstein: Hello! Welcome to the October edition of Biotech
Stock Live Chat.
Thursday October 20, 2011 11:56 adam feuerstein
12:02 adam feuerstein: hi everyone
Thursday October 20, 2011 12:02 adam feuerstein
12:02 adam feuerstein: I'll get started in a minute or so, let folks log in
.
Thursday October 20, 2011 12:02 adam feuerstein
12:02 adam feuers... 阅读全帖 |
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d******8
发帖数: 1972 | 17 http://www.thestreet.com/story/11351242/1/10-biotech-stock-pred
BOSTON (TheStreet) -- Ten biotech predictions for 2012:
1. The Amgen(AMGN_) strategy of returning cash to shareholders in form of
share buybacks, Dutch tender offers and dividends is abandoned in favor of
ramped up acquisitions i.e. Gilead Sciences(GILD_) buying Pharmasset(VRUS_).
Large-cap biotech firms start acting like Big Pharma -- choosing to buy
growth instead of seeking it from internal drug development.
2. After much wrangli... 阅读全帖 |
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w*********g
发帖数: 30882 | 18 平井宪夫揭示日本核电业惊天内幕——素人造核电，豆腐渣工程
作者：蜀中行 更新时间：2011-3-16
设施配管1级技士平井宪夫(1997年1月因癌症逝世)生前的最后吶喊。
/来自中华网社区 club.china.com/
/来自中华网社区 club.china.com/
关于平井宪夫：
1997年1月逝世。设施配管1级技士，核电事故调查国民会议顾问，核电劳工救济中
心代表，北陆电力志贺核电厂停止诉讼原告特别辅佐人，东北电力女川核电停止诉讼原
告特别辅佐人，福岛二号核电厂三号机运转停止诉讼原告证人。「核电劳工救济中心代
表」在他仙逝后，因后继无人关闭
"我不是反核运动家。这20年来，我一直在核电厂工作。社会上有听不完的拥核反
核理论，但我只想在这里告诉大家：「所谓的核电厂是这样一回事。」大部份的人都不
知道核电内部的实际情形。希望大家有耐心把这篇文章读完。所谓核电，跟各位所想的
或许有点出入。在那里，每天都有遭受放射线污染的工人，以及严重的岐视产生。
我的专长，是负责大型化学工场的内部配管施工与维修。快30岁时，日本掀起了一
阵核电建设的... 阅读全帖 |
|
x********i
发帖数: 905 | 19 Intel STS 2015 Finalists
Anandapadmanaban, Eswar
Dr. Ronald E. McNair Academic High School, Jersey City, NJ
The ThereNIM: A Touch-less Respiratory Monitor
Ashkin, Emily Lorin
Providence Day School, Charlotte, NC
A Novel Synergistic Approach for Enhancing Immunotherapy in the Treatment of
Melanoma
Chemparathy, Augustine George
Dougherty Valley High School, San Ramon, CA
Accumulation of the Biodiesel Precursor Triacylglycerol Offsets Oxidative
Stress in the Model Alga Chlamydomonas reinhardtii
Cui... 阅读全帖 |
|
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s******s
发帖数: 13035 | 21 【 以下文字转载自 Biology 讨论区 】
发信人: shakuras (doskey), 信区: Biology
标 题: 我早就看天天宣传抗氧化物包治百病的不爽了，终于。。。
发信站: BBS 未名空间站 (Sat Oct 24 11:30:36 2015, 美东)
抗氧化物促销就是一个骗局，某某水果／蔬菜某种抗氧化物比较多，就贵两美金，
甚至制成保健品糊弄人，请问这里面的抗氧化加起来，有两分钱成本的维生素C片
的十分之一多么？
我不是说抗氧化物没有生物学作用，相反，这玩意儿确实有用，不过有用不一定有
好处。最简单的说，这些玩意儿虽然对保护健康细胞可能有点好处，不过抗癌药物很多
依赖杀死癌细胞的作用可能被抗氧化物抵消，造成失去作用。
不过，我还是没想到这篇文章的出炉，说明抗氧化物可能促进癌细胞生长。 在Sci
Trans Med可是IF16的顶级杂志之一，不是那些发表反转基因的欧洲三流杂志。
Antioxidants can increase melanoma metastasis in mice。
http://stm.sciencemag.org/content/7/30... 阅读全帖 |
|
t*c
发帖数: 6929 | 22 Five-year Relative Survival Rates*(%) for Selected Cancers among Individuals
† Aged 15 and Older in Select Countries
United States England Demark Austria Poland Belgium Germany
Brain 26.1 17.6 18.1 20.8 19.8 22.7 22.6
Breast (female) 89.0 77.3 77.5 80.0 73.7 77.3 78.3
Colorectal 65.0 50.5 49.3 58.1 38.8 57.4 57.5
Esophagus 17.0 9.9 5.2 10.6 7.6 19.0 19.2
Hodgkin lymphoma 84.2 78.6 79.6 79.6 78.4 83.5 —
Kidney 68.4 45.6 45.1 68.1 53.8 58.8 64.9
Larynx 61.3 63.9 59.1 63.6 47.9 5... 阅读全帖 |
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d*b
发帖数: 21830 | 23 你究竟在美国呆过没有？
美国医院有selfpay不假，但你要claim selfpay的话，你治疗之前就得付钱。而且价格
也根本不是你说的，你要不信，前不久NY版有个老中来的小孩，Ocular Melanoma, NY
某医院看的，一次刷卡12万刀。 |
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k**********4
发帖数: 16092 | 24 risk of melanoma, but for Caucasians mostly,do u look like a white cow?
tell him you are asian. |
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m*****u
发帖数: 15526 | 25 如果有一天，你突然发现身上的一颗痣变得有些奇怪，你会怎么做？虽然这可能是一个
危险的信号，但很多人因为工作忙、去医院不便等种种原因，往往不会及时去检查。现
在，人工智能为这个问题提供了更好的解决方案：在未来，我们或许可以在手机上下载
一个APP，开个摄像头让机器医生帮我们看一看，这是不是皮肤癌的早期症状。
斯坦福大学一个联合研究团队开发出了一个皮肤癌诊断准确率媲美人类医生的人工智能
，相关成果刊发为了1月底《自然》杂志的封面论文，题为《达到皮肤科医生水平的皮
肤癌筛查深度神经网络》（Dermatologist-level classification of skin cancer
with deep neural networks）。他们通过深度学习的方法，用近13万张痣、皮疹和其
他皮肤病变的图像训练机器识别其中的皮肤癌症状，在与21位皮肤科医生的诊断结果进
行对比后，他们发现这个深度神经网络的诊断准确率与人类医生不相上下，在91%以上。
深度学习为医学添砖加瓦
在中国，皮肤癌并不是癌症家族中特别瞩目的成员，这是因为黄种人的皮肤癌发病率要
低于白种人。但在美国，皮肤癌却是最常见的癌症... 阅读全帖 |
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b****a
发帖数: 4465 | 26 While ocular melanoma is extremely rare, affecting just six in every one
million people every year, 36 graduates of Auburn University have reported
that they have been diagnosed with the cancer — including three women who
were close friends in their college days. Additionally, 18 patients, all in
Huntersville, North Carolina, also have the incurable cancer.
http://people.com/health/college-friend-group-rare-eye-cancer/ |
|
|
发帖数: 1 | 28 joe tippens 总结的成功的病例：
June 25, 2019
1. Ewing Sarcoma with Mets to the brain and spine (too many tumors to count
). Started the protocol after having to stop chemo due to blood clots.
Started with a jump start of 9 straight days, then pulsed 3 on and 4 off for
14 weeks. Recent scan was an all clear NED ("no evidence of disease").
2. Esophogeal with Mets to the Liver. Started with a double dose 7 days a
week for 3 weeks and then the recommended 222mg dose 7 days a week for 9
weeks, then all ... 阅读全帖 |
|
s******s
发帖数: 13035 | 29 【 以下文字转载自 Biology 讨论区 】
发信人: shakuras (doskey), 信区: Biology
标 题: 我早就看天天宣传抗氧化物包治百病的不爽了，终于。。。
发信站: BBS 未名空间站 (Sat Oct 24 11:30:36 2015, 美东)
抗氧化物促销就是一个骗局，某某水果／蔬菜某种抗氧化物比较多，就贵两美金，
甚至制成保健品糊弄人，请问这里面的抗氧化加起来，有两分钱成本的维生素C片
的十分之一多么？
我不是说抗氧化物没有生物学作用，相反，这玩意儿确实有用，不过有用不一定有
好处。最简单的说，这些玩意儿虽然对保护健康细胞可能有点好处，不过抗癌药物很多
依赖杀死癌细胞的作用可能被抗氧化物抵消，造成失去作用。
不过，我还是没想到这篇文章的出炉，说明抗氧化物可能促进癌细胞生长。 在Sci
Trans Med可是IF16的顶级杂志之一，不是那些发表反转基因的欧洲三流杂志。
Antioxidants can increase melanoma metastasis in mice。
http://stm.sciencemag.org/content/7/30... 阅读全帖 |
|
f******I
发帖数: 769 | 30
ABCD of melanoma are asymmetry of the shape, border being irregular, color
being uneven/non-homogenous, and diameter/size tend to increase,
if you worry too much, go see a dermatologist, good luck |
|
d********r
发帖数: 303 | 31 be sure to give good nutrition.
there is one therapy in nci. (check this: http://www.cancer.gov/newscenter/pressreleases/MelanomaGeneTherapy)
basically he used immune cells to attack melanoma and shows some progress.
his results have been published on science last year. however, it is
difficult to get this type of therapy in china. the only good news is, as i
mentioned, immune system does some time can control this type of cancer.
also, you may ask doctor for interferon or IL-2, they may also sh |
|
f******I
发帖数: 769 | 32
i don't think the location of the "mole" means a whole lot,
the size, color, and whether the border is regular/smooth are important, or
the so-called ABCDE of the melanoma,
generally speaking, if the size is greater than the size of a pencil eraser,
you know, the #2 pencil, you need to have it checked out, |
|
c********e
发帖数: 496 | 33 recent chance of size, border, color of the nevus are alarming signs of
melanoma, do get it removed, ask your PCP to refer. |
|
t*******n
发帖数: 4445 | 34
Yes, and make it an excisional biopsy. If heaven forbid it is melanoma,
much more than the mole itself needs to be cut out. |
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s********g
发帖数: 290 | 35 now that it's not yours, let me tell you: initially, I thought they were
very likely melanoma. |
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d****0
发帖数: 16 | 36 又给医生诊所打电话，强调可能是melanoma，改成本周四了 |
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j****d
发帖数: 123 | 37 is right for her. It should be available in China now. The other name is
ipilimumab. It can cure some melanoma |
|
f****o
发帖数: 2770 | 38 what stage is her melanoma now?
any metastasis? |
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L********r
发帖数: 58 | 41 Thanks.
早中期黑色素瘤用什么药? 我在MITBBS没有找到很多在这方面的 |
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n***a
发帖数: 1373 | 42 If it is very early stage, additional medication or other treatment may not
be needed. |
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L********r
发帖数: 58 | 45 恩 昨天手术切了。医生说接下来会用干扰素治疗一两个月。 |
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m****a
发帖数: 6567 | 46 你这个要担心的不是美观不美观，而是有没有可能是melanoma吧（虽然可能性非常非常
小，但是边缘不规则是症状之一）。从现在开始注意大小颜色和有没有突起，最好一个
月用同样的scale照个像以免记忆不准。出去活动的时候注意防晒。下次看儿医，跟他
讨论一下。 |
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c*******k
发帖数: 1308 | 47 据说人在儿童期一般不会得melanoma. 应该不是大事，但还是该找个dermatologist看
一看。 |
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c*******k
发帖数: 1308 | 48 yes yes yes. The most important skin care you can apply on your baby is
sunscreen. Go to American Melanoma Association website and educate your
husband and
yourself. |
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