n********k
发帖数: 2818 | 1 Are u a biochemistry/molecular biologist? I think some of the mechanistic
questions should not count on neurobiologists at all...I heard ys ago,
Schier's interests are more in behavior and circuitry...
embryo
of |
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t**m
发帖数: 158 | 2 A postdoc position is available in a newly established Lab at Stanford
University School of Medicine to study eukaryotic membrane protein structure
and function.
Research in the lab focuses on mechanistic understanding of ion channels,
transporters and membrane-embedded enzymes and their applications. The work
will involve protein production, biophysical characterization, functional
assay and structure determination by X-ray crystallography.
We are seeking highly motivated applicants with substa... 阅读全帖 |
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k******0
发帖数: 1073 | 3 Odds Against Winning the 2012 Nobel Prize in Chemistry
Nuclear Hormone Signaling, Chambon/Evans/Jensen, 6-1
Bioinorganic Chemistry, Gray/Lippard/Holm/–, 7-1
Spectroscopy & Application of Lasers, Zare/Moerner/+, 8-1
Techniques in DNA Synthesis, Caruthers/Hood/+, 13-1
The Field (everything not listed), 14-1
Electrochemistry/Electron Transfer, Bard/Hush/Gray/–, 19-1
Biological Membrane Vesicles, Rothman/Schekman/+, 19-1
Instrumentation/Techniques in Genomics, Venter/+, 24-1
Molecular Studies of Gen... 阅读全帖 |
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S**********e
发帖数: 1789 | 4 Vanderbilt University School of Medicine
Lopez, Carlos F , Ph.D. Assistant Professor of Cancer Biology
Publications
Giovambattista, N, Lopez, CF, Rossky, PJ, Debenedetti, PG. Hydrophobicity of
protein surfaces: Separating geometry from chemistry. Proc Natl Acad Sci U
S A, 105(7), 2274-9, 2008. PMCID:2268126
Lopez, CF, Darst, RK, Rossky, PJ. Mechanistic elements of protein cold
denaturation. J Phys Chem B, 112(19), 5961-7, 2008. PMCID:2268126
Lopez, CF, Nielsen, SO, Srinivas, G, Degrado, ... 阅读全帖 |
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h*******o
发帖数: 4884 | 5 俺以前投过J of neuroscience， 纯粹是折腾人， 什么都要mechanistic analyses
后来直接改投另外一个杂志，虽然影响因子低了2, reviewer和编辑的看法都nice多了
现在也好， j of neuroscience年年降， 另外哪个杂志每年小升， 两个估计过2年就
一样了 |
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j********r
发帖数: 156 | 6 so far,没几篇文章是直接肿瘤相关的(one from Lin He, one from Elledge)。如果
cancer cell / cancer discovery 上的文章投elife, 大家觉得会受吗？前面两个刊物
上的文章大部分太phenotypic, often with correlating mechanistic data
肿瘤研究真不是人干的，看看bt的NCI, 到bt的投稿。大牛说说投稿的经历吧！ |
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A******y
发帖数: 2041 | 7 You don't, unless you don't want to get funded. You can mention and cite
the published data, but the reviewers are looking for more i.e. what's the
progress after the paper published. Btw, I literally finished all the
things I purposed to do in my grant except I told them that I need more
money to improve my compound and resolve some mechanistic paradox. |
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g*********5
发帖数: 2533 | 8 Introduction:
Cells that simultaneously secrete and sense the same signaling molecule are
ubiquitous. Bacteria sense a quorum by secreting and sensing an autoinducer;
T cells induce a monoclonal
immune response by secreting and sensing a cytokine; and epithelial cells
can become cancerous through misregulated secreting and sensing of a growth
factor. Many of these cells use the same core signaling-circuit motif to
realize a diverse repertoire of biological functions. The full range of
functions ... 阅读全帖 |
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a*********n
发帖数: 2526 | 9 20分的子刊。投出去几天，editor回信说 interesting but mechanistically
premature, however we still decided to send it out for review.
我和老板都很纳闷，看来编辑不大喜欢,但是为什么不直接锯掉，还要找review去申呢
？老板建议马上撤稿投他家，但我觉得NPG review cycle 蛮快的，不妨等了review的
意见再说。
大家有什么建议？
多谢了 |
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B******o
发帖数: 496 | 10 for mechanistic study of gene regulation network/signaling pathways/, siRNA
for sure.
For drug development, ASN is way better and more mature. |
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s********3
发帖数: 231 | 11 《科学》对STAP手稿的专家评审意见曝光
《科学》对传说中的STAP细胞论文的三名评审专家意见，过去一直被雪藏，今天终于
被曝光。专家对这一研究的评价不高，认为非常全面的描述性研究，如果结果确定，可
能导致发育生物学大厦的颠覆，其实是不相信这种研究结论。因为没有当时的投稿件，
所以没有办法对这些评价进行更深入分析。不过这些资料显然都在某个地方，只是拥有
的人不愿意拿出来。
Retraction Watch readers are of course familiarwith the STAP stem cell saga,
which was punctuated by tragedy last month whenone of the authors of the
two now-retracted papers in Nature committed suicide.
In June, Science‘s news section reported:
Sources in the scientific community confirm that early version... 阅读全帖 |
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v*******a
发帖数: 759 | 12 Science. 2015 Jan 2;347(6217):44-9. doi: 10.1126/science.1259859.
Structural biology. Mechanistic insight from the crystal structure of
mitochondrial complex I.
Zickermann V1, Wirth C2, Nasiri H3, Siegmund K4, Schwalbe H5, Hunte C6,
Brandt U7.
[email protected]
/* */
Thanks! |
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A**I
发帖数: 73 | 13 2012年回国现在就成了C9的院长，这速度和坐火箭差不多了啊。胖老师来八卦八卦呀，
科大生科院长江，杰青一大堆，怎么就齐心协力推了新人当院长啊？
薛天简历：（来自科大生科院官网）
薛 天 中国科学技术大学生命科学院教授、博士生导师，中组部“青年千人计划”入
选者。 2000年毕业于中国科学技术大学少年班系（强化班）获学士学位; 2005年获美
国约翰霍普金斯大学医学院生理学博士; 2006-2011年在美国约翰霍普金斯大学医学院
从事感受器官神经生物博士后研究工作; 2011-2012年任美国约翰霍普金斯大学医学院
助理研究员。
自2002年来，薛天博士主要从事感光细胞的光信号转导、神经和心脏电生理、干细胞和
再生医学等相关研究。首次较完整的阐述了非成像视觉中melanopsin的信号转导分子机
制；首次实现了对感光前体细胞移植-体内再生视杆细胞的单细胞光反应记录；使用基
因转导和干细胞再生等方法研究起搏细胞节律性活动及再生生物起搏器。研究成果发表
在Nature（3篇）、Nature Neuroscience、PNAS、Stem Cell、Circulation、
Circulati... 阅读全帖 |
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n**********u
发帖数: 77 | 15 施一公：“厕所里面纸巾用完了，不哭。。。，再过1年，我一公还是一条好汉。。。
呜呜，~~~~(>_<)~~~~” |
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y***n
发帖数: 109 | 17 Although this prize is ”for mechanistic studies of DNA repair“, it is in
fact only single－strand damage. There is another big field of double-
stranded DNA damage repair, including non-homologous end jointing and
homologous recombination. It is so unfair. |
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D*a
发帖数: 6830 | 18 Red meat
After thoroughly reviewing the accumulated scientific literature, a Working
Group of 22 experts from 10 countries convened by the IARC Monographs
Programme classified the consumption of red meat as probably carcinogenic to
humans (Group 2A), based on limited evidence that the consumption of red
meat causes cancer in humans and strong mechanistic evidence supporting a
carcinogenic effect.
This association was observed mainly for colorectal cancer, but associations
were also seen for panc... 阅读全帖 |
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q******g
发帖数: 3858 | 19 A red meat-derived glycan promotes inflammation and
cancer progression
A well known, epidemiologically reproducible risk factor for human
carcinomas is the long-term consumption of “red meat” of mammalian
origin. Although multiple theories have attempted to explain
this human-specific association, none have been conclusively
proven. We used an improved method to survey common foods
for free and glycosidically bound forms of the nonhuman sialic acid
N-glycolylneuraminic acid (Neu5Gc), showing tha... 阅读全帖 |
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h*****b
发帖数: 492 | 20 我们组想找个做 polymerase modeling的，postdoc经验有最好，但不required. 如果
感兴趣的话，可以把简历发到[email protected]/* */
Here is the job description
Scientist, Structural Biology
Location: Headquarters - Menlo Park, CA USA
Job Code: 1562
# of openings: 1
Description
Pacific Biosciences is seeking a highly motivated macromolecular modeler.
The candidate will work within an interdisciplinary team to model
macromolecular complexes, enzyme variants and their interactions with
nucleotide analogs. The candidate ... 阅读全帖 |
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v********a
发帖数: 646 | 21 Associate Scientist, High Throughput Screening/Assay Development (Req#
8755170202):
http://bit.ly/2kNiyCI
Janssen Research and Development, L.L.C., a member of Johnson and Johnson's
Family of Companies, is recruiting for an Associate Scientist, High
Throughput Screening/Assay Development, to be located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters
most is helping people live full and healthy lives. We focus on treating,
curing and preventing some... 阅读全帖 |
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b*******0
发帖数: 125 | 22 NATURE | ARTICLE
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Yalin Zhang, Min Soo Kim, Baosen Jia, Jingqi Yan, Juan Pablo
Zuniga-Hertz, Cheng Han & Dongsheng Cai
Abstract
It has been proposed that the hypothalamus helps to control ageing, but the
mechanisms responsible remain unclear. Here we develop several mouse models
in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1
are ablated, as we observed that ageing in mice start... 阅读全帖 |
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x****6
发帖数: 4339 | 23 【 以下文字转载自 Military 讨论区 】
发信人: xiao86 (xiao86), 信区: Military
标 题: 哥来科普一下，一一公的剪接体还是有希望的
发信站: BBS 未名空间站 (Wed Oct 4 15:51:34 2017, 美东)
大分子照相相关的炸药奖加上这次的，已经发了14个了（见下表）。
之前主要是基于X衍射或者核磁共振的技术开发和应用，拍一些单分子的裸照。82，91
，02年颁给X衍射和核磁共振的技术开发，剩下11个的给了应用。
而冷冻电镜，这次算是第一个（可能是第二个），直接给了技术。用它可以看更加复杂
、分子量更大的大分子复合体。这些大个头的结构当然更有复杂也更有意思。
这个技术开启了一个新时代，细胞里重要的复合体实在太多。接下来可能拿奖的那就是
：真核细胞的细胞核通道复合体；一一公搞的剪接体（这个结构无论在生命进化和疾病
相关都非常的重要）；G蛋白偶联受体（跟N多疾病有关）等等。
彦宁的工作好像确实没有什么希望，葡萄糖转运蛋白跟上面这些不是一个量级的。
------------------------
2017: Chemistry cr... 阅读全帖 |
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i***l
发帖数: 9994 | 24 急求全文：
Electrooxidation of ortho-substituted aromatic amines mechanistic
investigation.
Korbi, B. H.; Tapsoba, I.; Benkhoud, M. L.; Boujlel, K.
Journal of Electroanalytical Chemistry (2004), 571, (2), 241-246. |
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c*****t
发帖数: 198 | 27 【 以下文字转载自 Biology 讨论区 】
发信人: compact (support), 信区: Biology
标 题: paper help - link included
发信站: BBS 未名空间站 (Mon May 2 19:51:50 2011, 美东)
Title: The Paradigm of G Protein Receptor Transactivation: A Mechanistic
Definition and Novel Example
Authors: Little, Peter J. ; Burch, Micah L; Al-aryahi, Sefaa ; Zheng,
Wenhua
Journal: TheScientificWorldJOURNAL
Year: 2011
Volume: 11
Page Range: 709-714
www.thescientificworld.com/TSW/toc/TSWJ_ArticleLanding.asp?
ArticleId=3724&jid=
Thank you... 阅读全帖 |
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l****z
发帖数: 1754 | 28 目前审过的期刊主要有Macromolecules,Dalton Trans, Organometallics,polymer
chemistry, Inorganic Chemistry Communication,Polymer Bulletin
我的方向主要是金属有机化合物的合成,聚合反应及其机理的研究(Synthetic,
mechanistic, & catalytic organometallic and polymer chemistry),还有一个副方
向就是现在比较热门的renewable energy and sustainability,在JACS,Angew,
Chemistry-a European Journal,Macromolecules, Organometallics等发过文章
各位大侠如果已经拿到绿卡,可否将多余的review机会转让给我，请战内联系或给
l****[email protected]发信,我可以发个CV过去,非常感谢!!!! |
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g****y
发帖数: 26 | 29 【 以下文字转载自 Postdoc 讨论区 】
发信人: galupy (Galoppogos-horse), 信区: Postdoc
标 题: postdoc opening@Sloan-Kettering Institute
关键字: postdoc opening,sloan kettering
发信站: BBS 未名空间站 (Sun Aug 14 14:28:02 2011, 美东)
We are seeking highly motivated individuals for postdoctoral positions in
the Structural Biology Program of the Sloan-Kettering Institute, Memorial
Sloan-Kettering Cancer Center, NYC, USA.
The lab develops cutting-edge techniques (Nature,doi:10.1038/ nature09163 (
2010)) aimed at gaining a mechanisti... 阅读全帖 |
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q***l
发帖数: 177 | 30 Odds Against Winning the 2012 Nobel Prize in Chemistry
Nuclear Hormone Signaling, Chambon/Evans/Jensen, 6-1
Bioinorganic Chemistry, Gray/Lippard/Holm/–, 7-1
Spectroscopy & Application of Lasers, Zare/Moerner/+, 8-1
Techniques in DNA Synthesis, Caruthers/Hood/+, 13-1
The Field (everything not listed), 14-1
Electrochemistry/Electron Transfer, Bard/Hush/Gray/–, 19-1
Biological Membrane Vesicles, Rothman/Schekman/+, 19-1
Instrumentation/Techniques in Genomics, Venter/+, 24-1
Molecular Studies of Gen... 阅读全帖 |
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D***a
发帖数: 1616 | 31 麻烦大家帮我查些文献， 搞绿卡用的，这些文献不在google scholar里,谢谢，包子请
一次拿走
http://onlinelibrary.wiley.com/doi/10.1002/chem.201305021/full
或者点以上链接，再点citing literature
Number of times cited: 14
1Miriam M. Schwab, Daniel Himmel, Sylwia Kacprzak, Daniel Kratzert,
Valentin Radtke, Philippe Weis, Kallol Ray, Ernst-Wilhelm Scheidt, Wolfgang
Scherer, Bas de Bruin, Stefan Weber, Ingo Krossing, [Ni(cod)2][Al(ORF)4], a
Source for Naked Nickel(I) Chemistry, Angewandte Chemie International
Edition, 2015, n/aWiley Online Li... 阅读全帖 |
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b*****h
发帖数: 3386 | 32 In scientific research, data-driven approach and hypothesis-driven
approach are both ok, depending on your research project.
Also, correlation analysis alone is not very satisfactory. As a
scientist, not just a statistician, one is inherently bound to search
for mechanistic answer, not that vague philosophical ying-yang type
of blablabla. |
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c****n
发帖数: 21367 | 33 for simple systems, i agree with you.
however, for complex systems, you can only "guess" the low dimension
asymptotical model. because if the system is "complex" to us human being
micro-level knowledge cannot infer the macro-level behavior, and vice versa
the mechanistic answer is meaningful, the phenomenological one is
meaningful too. and for complex systems, these two cannot subsititute
each other unless the system become resolvable (not complex anymore). |
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m*****n
发帖数: 3575 | 34 As a
scientist, not just a statistician, one is inherently bound to search
for mechanistic answer, not that vague philosophical ying-yang type
of blablabla.
___________________
That scientist is mistaken to model human as a car, while in fact you are
not. The simplicity can be tolerated because of low ability but should not
be worshipped against a more realistic yet more complex model as yin and
yang. |
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b*****h
发帖数: 3386 | 35 not exactly, I also explained serveral other reasons
why understanding the mechanism is important, mainly
because you can have a better solution and better predictive
power. In this sense, mechanistic understandings and saving
lives are not exclusive to each other at all.
I don't agree with you at all about this point:
"human body is a complex system to our current capability,
therefore to induct macro level function from the micro level knowledge
is futile." The logic is confusing. The reason |
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c****n
发帖数: 21367 | 36 i agree that mechanistic understanding can improve the
predictive power. it is important in this sense, but
the key is to predict, not induct. this is the main point.
second, i completely agree that for some disease the micro
level mechanism can be pinned down or even fully understood.
kill the cause from micro level can eliminate the disease
behavior. cool!
however, when the system is complex and not fully resolvable,
kill the micro cause can result other unpredictable effects.
the treatment do |
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b*****h
发帖数: 3386 | 37
比如，你用现代仪器测各类激素，那是用的是现代医学的mechanistic
理解？还是基于中医的阴阳五行？ |
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c****n
发帖数: 21367 | 38 你说反了，应该是问用现代仪器测量各种激素水平以后
这个结论要用到医学上，是利用mechanistic的知识，还是
phenomenological的知识。
我认为主要还是表象性的。
说个最实在的，progesteron/progestin的测量，我们知道它
和怀孕的相关性。难道是通过progesteron在人体内的作用研究
出来的吗？当然是反之，先观察怀孕过程的显著特征，发现了
这个，再去找机理。
中医有了能测量的东西，当然模型维数更高，更准确，能做
更多更好的预测啊。就不用光靠指头，靠问孕妇是否停经了。 |
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c****n
发帖数: 21367 | 39
当然，中医预测一般人天天熬夜就会上火，上火吃萝卜可以降火
类似的中国人的常识也很多，没完善的mechanistic解释吧。纯粹的
phenomenological的东西，但是看病管用啊。 |
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c****n
发帖数: 21367 | 40 i have no reason / motivation to be cynic for biology
those views about biology are copied from biology researchers
people like Sydney or my boss are established, considering
the majority :) you can predict my sampling result.
for me, just be pathetic about current medical/pharma research
and feel funny when they attack TCM with urges on mechanistic
explanation.
... |
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y********4
发帖数: 1116 | 41 Two research assistant and one postdoc positions are immediately available
in the Micro/nanoscale Transport Lab at the University of South Carolina.
1. Flow boiling in microchannels: design & fabricate novel micro/nano-
structures in microchannels to regulate flow boiling regimes, characterize
flow boiling, and develop mechanistic thermo-hydraulic models to predict
heat transfer rate, pressure drop, and CHF.
2. Heat pipe experiment and modeling: design, fabricate, and characterize
novel hy... 阅读全帖 |
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l********u
发帖数: 823 | 42 我感觉所有engineering的都这个路子。我老公他们搞个方法，基于remote sensing的
，他们搞的方法是mechanistic model，就是尽量搞一个物理模型，同时实测验证。可
是他们的competitor就是大量实测数据，然后弄个统计模型。然后好像是两边互相看不
起的样子...
其实我看是都不大明白。 |
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w********h
发帖数: 12367 | 43 Date: Feb. 6, 2014
FOR IMMEDIATE RELEASE
National Academy of Engineering Elects 67 Members and 11 Foreign Associates
WASHINGTON — The National Academy of Engineering (NAE) has elected 67 new
members and 11 foreign associates, announced NAE President C.D. (Dan) Mote
Jr. today. This brings the total U.S. membership to 2,250 and the number of
foreign associates to 214.
Election to the National Academy of Engineering is among the highest
professional distinctions accorded to an engineer. Academy m... 阅读全帖 |
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w********h
发帖数: 12367 | 44 Date: Feb. 6, 2014
FOR IMMEDIATE RELEASE
National Academy of Engineering Elects 67 Members and 11 Foreign Associates
WASHINGTON — The National Academy of Engineering (NAE) has elected 67 new
members and 11 foreign associates, announced NAE President C.D. (Dan) Mote
Jr. today. This brings the total U.S. membership to 2,250 and the number of
foreign associates to 214.
Election to the National Academy of Engineering is among the highest
professional distinctions accorded to an engineer. Academy m... 阅读全帖 |
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y********4
发帖数: 1116 | 45 Two research assistant and one postdoc positions are immediately available
in the Micro/nanoscale Transport Lab at the University of South Carolina.
1. Flow boiling in microchannels: design & fabricate novel micro/nano-
structures in microchannels to regulate flow boiling regimes, characterize
flow boiling, and develop mechanistic thermo-hydraulic models to predict
heat transfer rate, pressure drop, and CHF.
2. Heat pipe experiment and modeling: design, fabricate, and characterize
novel hy... 阅读全帖 |
|
n********y
发帖数: 187 | 46 http://blog.sciencenet.cn/blog-43772-648640.html
承认错误更需要底气
最近很少写博文，尤其是长博文。今天是元旦，我谨代表我自己以及小小（还没有征求
她的意见呢）祝大家新年快乐、万事如意。不过我还是要吐槽一下。刚看到编辑部也专
门发帖祝福大家，但看到“科学网祝广大网友元旦快乐！”之后我还是被刺了一下，如
鲠在喉，不吐不快。科学网是科学网博主的科学网，在科学网博主面前，编辑部何德何
能代表科学网啊？当然，这又确实是中国现实的某种折射。
下面转入正题，今天我要讲的题目是“承认错误更需要底气”。承认错误需要勇气几乎
是一句口头禅。但是我们要知道，勇气其实来自于底气。下面讲两个例子（学习一下反
面教材的风格）。一个是高中学习期间的一个观察，一个是化学界的一件公案。
1、高中两位老师截然不同的做法
我高中的时候有两位老师，一位是化学老师，脑子似乎不太灵光，所以平时难免有些错
误出现，但是他的习惯处理就是哧溜一下过去，从来不见他大方承认错误。另外一个是
数学老师，脑子很得转，但偶尔也有卡壳的时候，这个时候他会大方承认自己的错误或
不行，然后在下一节课给... 阅读全帖 |
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w******a
发帖数: 76 | 47 A job opening is available in a pharma in Cambridge, Massachusetts, please
sent your resume to t********[email protected] for consideration.
If you are Ph.D, please do not apply, thank you.
The candidate will carry out the following activities: enzymatic assay
development, medium throughput screening and IC50 determination, data
processing and management, protein characterization and mechanistic studies.
The job will predominantly focus on early discovery processes and will
involve frequent collaborat |
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g*******7
发帖数: 21 | 48 同意楼上说法。综合来看，quantitative skills很重要，只接触分子实验的职位一般
都不需要phd。但就pk
/pd来讲，你相比biostatistitian和computational biologist具备的优势就在于你懂
生化、生理、分子药理这些东西，所以能够建立有生理学意义的model，并且具有
interpret data的能力。传统的compartmental analysis其实就是curve fitting，以
后这类工作八成也会被biostatistitian取代。大分子pbpk以及所谓的mechanistic pk/
pd model都需要对生理药理的理解，所以应该是pk/pd modeling的一大发展方向。当然
，machine learning迟早要融入pk/pd的。所以在pk/pd领域成功也不容易，要懂很多领
域的东
西。 |
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s***h
发帖数: 592 | 49 that is the joint of metallurgy and mechanics
however, mechanists are not familiar with microstructures,
metallurgists are not familiar with stress strain either. |
|
c*****t
发帖数: 198 | 50 【 以下文字转载自 Biology 讨论区 】
发信人: compact (support), 信区: Biology
标 题: paper help - link included
发信站: BBS 未名空间站 (Mon May 2 19:51:50 2011, 美东)
Title: The Paradigm of G Protein Receptor Transactivation: A Mechanistic
Definition and Novel Example
Authors: Little, Peter J. ; Burch, Micah L; Al-aryahi, Sefaa ; Zheng,
Wenhua
Journal: TheScientificWorldJOURNAL
Year: 2011
Volume: 11
Page Range: 709-714
www.thescientificworld.com/TSW/toc/TSWJ_ArticleLanding.asp?
ArticleId=3724&jid=
Thank you... 阅读全帖 |
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