O******e
发帖数: 4845 | 1 CML Patients on Imatinib Have Similar Mortality Rates to General Population,
Study Shows
ScienceDaily (Mar. 22, 2011) Patients taking imatinib (Gleevec) for CML, or
chronic myelogenous leukemia, and in remission after two years of treatment,
have a mortality rate similar to that of the general population according to
a
study published online in the Journal of the National Cancer Institute.
全文参见：
http://www.sciencedaily.com/releases/2011/03/110322161522.htm?u |
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A******y
发帖数: 2041 | 2 Imatinib side effects are not that bad...it also have positive side effects
i.e. restoring nature hair color. Brian Druker is going to win Nobel price
soon... |
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t********4
发帖数: 2 | 3 家母前段时间查出胆囊瘤，活检结果是3a 间质瘤。（医生又说不排除6a）
国内医生开了甲磺酸伊马替尼片（Imatinib Mesylate Tablets)
不知道美国哪个医生是胆囊瘤方面比较厉害。
不知道这种药有效率是多少？在美国能否购买到。
另外国内的药不知道属于Generic 版本的还是Branded 版本的
如果已经开始吃药，能否换一个月后换美国或加拿大产的药？
加拿大有批准Generic version 的同类药，价格是Branded 的1/5；不知道有什么具体
区别。
十分感谢回复 |
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s*****g
发帖数: 7857 | 5 http://en.wikipedia.org/wiki/Imatinib
tyrosine-kinase inhibitor
is a tyrosine-kinase inhibitor used in the treatment of multiple cancers,
most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous
leukemia (CML).[1] Like all tyrosine-kinase inhibitors, imatinib works by
preventing a tyrosine kinase enzyme, in this case BCR-Abl, from
phosphorylating subsequent proteins and initiating the signaling cascade
necessary for cancer development, thus preventing the growth of cancer cells
an... 阅读全帖 |
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f****o
发帖数: 2770 | 6 A follow-up on patients using imatinib published in the New England Journal
of Medicine in 2006 showed an overall survival rate of 89% after five years.
[15] In 2011, an independent study performed in 832 CML patients worldwide
reported that the group of patients who achieve a stable cytogenetic
response with imatinib shows an overall survival rate of 95.2% after 8 years
, which is similar to the rate in the general population. Only 1% of
patients died because of leukemia progression.
因为药还算比较新，也... 阅读全帖 |
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W***M
发帖数: 50 | 7 CML is very treatable since the development of tyrosine kinase inhibitor (
Imatinib). 5 year overall survival increased from 10-20% to 60-70% with TKI.
It is totally worth the money. the key is to take the medicine as long as
it still works. Sometime, CML can be resistant to imatinib, they you can
switch to second generation inhibitor such as dasatinib. |
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h******y
发帖数: 1374 | 8 新浪科技讯 北京时间9月21日晚间消息，汤森路透9月21日公布了年度汤森路透引文桂
冠得主名单，以预测将于10月公布的诺贝尔奖科学和经济学类得主，名单上的科研人员
将有可能成为各项诺贝尔奖的有力争夺者。
每年，汤森路透都会利用其研究解决方案Web of Knowledge™中的数据，根
据诺贝尔奖的生理或医学、物理、化学与经济分类，使用定量数据来分析和预测最有影
响力的研究人员。根据其发表的研究成果的总被引频次，这些高影响力研究人员被授予
汤森路透引文桂冠得主(Citation Laureates)称号，预示着他们可能成为今年或不久将
来的诺贝尔奖得主。
汤森路透是唯一采用定量数据预测年度诺贝尔奖得主的机构，自2002年起，共有21
位引文桂冠奖得主赢得诺贝尔奖。
汤森路透研究服务引文分析师David Pendlebury说：“在科学社群里，若经过分析
和计算，引文可以作为另一种形式的同行评审。一位科学家发表研究成果的被引用次数
越多，这位学者在其同行之中、从学术角度的受敬重程度越高，而这可以作为如诺贝尔
奖这类奖项的预测指标。汤森路透引文桂冠奖是通过成熟完善的方法评估引用... 阅读全帖 |
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l***d
发帖数: 1828 | 9 生理学或医学
Brian J. Druker 美国奥勒冈州波特兰市奥勒冈健康暨科学大学 (Oregon Health
Science University)医学教授、JELD-WEN血癌研究教授及奈特癌症研究所(OHSU
Knight Cancer Institute)主任、同时也是霍尔休斯医学研究所(Howard Hughes
Medical Institute)研究人员
Nicholas B. Lydon 美国怀俄明州杰克森洞(Jackson Hole, WY)Granite ***a, LLC
创办人；美国加州圣地牙哥AnaptysBio共同创办人兼总监；及美国麻州剑桥Blueprint
Medicines共同创办人兼总监
Charles L. Sawyers 美国纽约州纽约市Memorial Sloan-Kettering癌症中心人类肿
瘤学及病因Marie-Josee and Henry R. Kravis教授、同时也是霍尔休斯医学研究所(
Howard Hughes Medical Institute)研究人员
获奖成就：他们发展出***性慢性骨髓性白血病治疗药物im... 阅读全帖 |
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f******g
发帖数: 1003 | 10 首先，我还是要说，我不是做结构的。为了回答你的问题，我在google搜索两个关键词
protein structure, drug discovery,得到很多结果，我把维基的链接放在这里，你可
以看看
http://en.wikipedia.org/wiki/Drug_design
里面举例如下，
A particular example of rational drug design involves the use of three-
dimensional information about biomolecules obtained from such techniques as
X-ray crystallography and NMR spectroscopy. Computer-aided drug design in
particular becomes much more tractable when there is a high-resolution
structure of a target protein bound to a potent ligand. ... 阅读全帖 |
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c****e
发帖数: 32 | 11 【 以下文字转载自 Chemistry 讨论区 】
发信人: Chimie (止于至善), 信区: Chemistry
标 题: 请问这个印度公司的药（genexpharma）能买吗？ (转载)
发信站: BBS 未名空间站 (Fri Jan 9 08:50:13 2009)
发信人: Chimie (止于至善), 信区: Medicine
标 题: 请问这个印度公司的药（genexpharma）能买吗？
发信站: BBS 未名空间站 (Fri Jan 9 08:49:46 2009)
诺华制药的格列卫（glivec 0.1g imatinib NOVARTIS）国内200元一粒，它给2美刀一
粒，不过要批发。亲戚得了肠癌，一天就要800元吃药，本来就穷，医生就给开这药，
现在家里要卖房给吃药，估计也只有十几万元。看的实在可怜，在网上找到这家，要是
可靠的话，打算跟他买。谢谢各位先。
据说是Generic version，所以便宜。是不是像当年我们卖的干扰素啊？
药物信息:
http://en.wikipedia.org/wiki/Imatinib
公司信息:
http://w |
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c****e
发帖数: 32 | 12 【 以下文字转载自 Chemistry 讨论区 】
发信人: Chimie (止于至善), 信区: Chemistry
标 题: 请问这个印度公司的药（genexpharma）能买吗？ (转载)
发信站: BBS 未名空间站 (Fri Jan 9 08:50:13 2009)
发信人: Chimie (止于至善), 信区: Medicine
标 题: 请问这个印度公司的药（genexpharma）能买吗？
发信站: BBS 未名空间站 (Fri Jan 9 08:49:46 2009)
诺华制药的格列卫（glivec 0.1g imatinib NOVARTIS）国内200元一粒，它给2美刀一
粒，不过要批发。亲戚得了肠癌，一天就要800元吃药，本来就穷，医生就给开这药，
现在家里要卖房给吃药，估计也只有十几万元。看的实在可怜，在网上找到这家，要是
可靠的话，打算跟他买。谢谢各位先。
据说是Generic version，所以便宜。是不是像当年我们卖的干扰素啊？
药物信息:
http://en.wikipedia.org/wiki/Imatinib
公司信息:
http://w |
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s**i
发帖数: 4448 | 13 医学是基于现代生物，化学和各种技术的进展来发展的。哪里只单靠统计。
随便几个例子，
HIV protease inhibitor,ACE inhibitor都是成功的structure-based drug design的
例子。
Imatinib 作为 bcr-Abl tyrosine-kinase inhibitor, 可以治愈chronic myelogenous
leukemia (慢性粒细胞白血病）
这都是在对疾病机理在分子水平上的了解以后设计的针对性药物，挽救了成千上万人的
生命。
现代医学的成就不要太多（消灭传染病比如麻风之类的就不说了），甩古老神奇的中医
以光年计。
贬西医抬中医，纯粹是无知所致。 |
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o******f
发帖数: 46 | 14
很不喜欢扣帽子的做法
举个例子，Imatinib |
|
发帖数: 1 | 15 比如这个新出来的，药名就是为欧美市场定的 zanubrutinib，后缀tinib就直指欧美市
场，大家都默认为是酪氨酸激酶抑制剂，比如imatinib， erlotinib, 都是革命性的药
物，名字大家都接受了
都是上WTO基本药物清单上的
再看看AD假药 971， 甘露什么鸡巴玩意儿
麻痹的连个名字都取不好
也就糊弄厉害锅的傻逼们 |
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z******n
发帖数: 97 | 16 Genentech is the leading player, you may check their website for their
targeted therapy compounds, however, these approved agents usually can
extend patient life span for 3-5 month, like Trastuzumab emtansine, and the
cost in the US is about 9400 $ per month.
see the following link, or google Antibody-drug conjugate
http://en.wikipedia.org/wiki/Trastuzumab_emtansine
you may also check the kinase inhibitors for cancer, sometimes they also
work,like Imatinib (Gleevec)cost $92,000/year |
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a*******e
发帖数: 253 | 17 达人们，您们好。我爸的病经过北大医院的骨髓化验，他们结论是嗜酸粒细胞白血病。
我有一位生物学专家朋友告诉我，慢性粒细胞白血病(chronic myeloid leukemia)美国
已有药治疗，是Novartis公司生产的，叫作Gleevec(named "Glivec" in Europe)，主
要成分是imatinib。
请问哪位达人了解这种药？它对嗜酸粒细胞白血病有疗效吗？
即使这药有用，也要美国癌症医生开处方才可买到。
先叩谢了！！ |
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y***1
发帖数: 236 | 18 大家好，我大学时的好友前天跟我联系，说他母亲得了胃肠道间质瘤(
gastrointestinal stromal tumor, GIST)，他说这个病很急，比癌症还严重。他妈妈
现在在用一种印度产的药，名字叫做Imatinib Mesylate Capsules ，25000人民币才买
120粒，而且还只够吃一个月。我查了一下，美国这个药好像也差不多是这个价钱。他
现在非常的着急，他想让我帮他问问美国的朋友，看看有没有其他的药可以治疗。或者
有没有从印度直接购买的方法，据说印度制药很便宜。
多谢大家了，我这两天在线等，希望大家帮忙。 |
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t*******n
发帖数: 4445 | 19 Both versions have imatinib mesylate as the active ingredient. Norvatis'
Gleevec uses the beta-crystalline form while Natco's Veenat uses the
polymorphic form.
During the legaL fight in India, it turns out Gleevec may have 30% more
bioavailability (probably due to different solubility), but the patent
office ruled it as not a significant improvement in efficacy:
http://www.deolhonaspatentes.org.br/media/file/Casos/India/noticia_business_line.PDF
Anybody else has more clinical advice here? |
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l******s
发帖数: 1276 | 20 爷爷得了胃部间质瘤， 要吃一种甲磺酸伊马替尼片Imatinib mesylate tablets， 200
RMB一片， 每天要4片。
求问美国或者加拿大可以买到这种药吗？ 会不会便宜点？ |
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a****y
发帖数: 7 | 21 谢谢你。我朋友说她吃的是格列卫，查了一下，就是你说的imatinib。维基上说这个药
每年花费3万多到近10万美元。。。她单位有医保，但是这个药的报销很严格，得要申
请什么的，即使申请到了也只是报销一部分，剩下的部分每年自己还要负担十几万...
不过只要能有希望好好活着，花多少钱都是值得的...
Journal
years.
years |
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l*h
发帖数: 4124 | 22 most GISTs are benign on histology but almost all are malignant in
biological behavior. they have a high recurrence rate. on average, one in 5
or 6 recur in a year after complete surgical resection if not treated with
TKIs.
based on the size, this one should have a fairly high recurrence probability
. imatinib can be considered for recurrence reduction. |
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l*h
发帖数: 4124 | 23 请问你说的tki中文是什么？
TKIs are tyrosine kinase inhibitors. Imatinib is one of them.
药是格格列位吗？
yes.
请问如果复发还可以再切除吗？
these patients have close followup after the initial surgery. recurrence
would be caught when it's still small and amenable to removal.
癌变和转移的机率大吗？
GISTs are 癌 by behavior. metastasis is mainly short range ones.
谢谢 |
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l*h
发帖数: 4124 | 24 Ponatinib is a new drug approved for patients with Ph+ ALL. Preliminary
results show it is superior to other tyrosine kinase inhibitors in Ph+ ALL.
It should not be available in China now.
Imatinib, dasatinib etc should be easier to obtain.
Dose scaling in pediatric patients of tyrosine kinase inhibitors: should be
based on body surface area, not on body weight.
L |
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l*h
发帖数: 4124 | 25 4. 格列卫是否就是伊马替尼？深圳儿童医院现还没有用这个药的经验，得等到
预约香港医院医生去询问用药的相关事宜。
imatinib has been in use as an approved drug for more than 10 years, if you
also count the years it was in large scale clinical trials it is close to 20
years. it is also routinely used in pediatric patients. it is unbelievable
no one there can understand medical literature to figure out how to use it.
L |
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l*h
发帖数: 4124 | 26 Ponatinib is a new drug approved for patients with Ph+ ALL. Preliminary
results show it is superior to other tyrosine kinase inhibitors in Ph+ ALL.
It should not be available in China now.
Imatinib, dasatinib etc should be easier to obtain.
Dose scaling in pediatric patients of tyrosine kinase inhibitors: should be
based on body surface area, not on body weight.
L |
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l*h
发帖数: 4124 | 27 4. 格列卫是否就是伊马替尼？深圳儿童医院现还没有用这个药的经验，得等到
预约香港医院医生去询问用药的相关事宜。
imatinib has been in use as an approved drug for more than 10 years, if you
also count the years it was in large scale clinical trials it is close to 20
years. it is also routinely used in pediatric patients. it is unbelievable
no one there can understand medical literature to figure out how to use it.
L |
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W********r
发帖数: 158 | 28 Ph+ ALL used to have very poor prognosis and bone marrow transplant is
indicated. 5y overall survival is 20% even with bone marrow transplant.
However, the tyrosine kinase inhibitor such as gleevac (imatinib) completely
changed the disease. In Children's oncology group study, daily gleevac +
chemotherapy, 3 year overall survial is 80%, bone marrow transplant is no
longer recommended in Ph+ ALL patient. Slow reduction of WBC or residual
lymph nodes are very typical for Ph+ ALL that didn't receive... 阅读全帖 |
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h*******3
发帖数: 254 | 29 找到英文名了，求美国哪里可以买到？谢了先
---------------------------
通用名称：甲磺酸伊马替尼片
商品名称：格列卫(Glivec)
英文名称：Imatinib Mesylate Capsules |
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y****h
发帖数: 166 | 30 请问有没有人有知道可靠的途径从印度购买generic gleevic/glivec （Imatinib）？
谢谢！ |
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b*****a
发帖数: 2 | 31 我哥去年诊断为甲状腺上皮样横纹肌肉瘤（epithelioid rhabdomyosarcoma），做了切
除和放疗。但最近又查出转移到肺部，现在开始做化疗，但医生说化疗对这种横纹肌肉
瘤效果不好，而且他们的治疗方案只是借助于美国十几年前的案例。
故想求助美国的专业人士，可有什么特别的针对这种case的方案和药物？本人试图搜索
，无奈天书一般的英文术语。
另外，家人听朋友说起口服药：伊马替尼（Imatinib）和舒尼替尼（Sunitinib)。也想
请问它们是否能用于治疗横纹肌肉瘤？
恳请医生专业的或认识医生的网友帮忙！ |
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b*****a
发帖数: 2 | 33 谢谢你的帮助。通过搜索Tyrosine Kinase Inhibitor，找到了几篇专业paper，但还没
有明确的答案Imatinib 和 Sunitinib是否适用于我哥的情况。
再次感谢。 |
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M*****e
发帖数: 279 | 36 血压计: manometer （大名是：sphygmomanometer）
胃炎: gastritis
肠炎: enteritis
肺气肿: Emphysema
胆囊炎: Cholecystitis
suffix: -itis = Inflammation = 炎
Emphysema is included in a group of diseases called chronic obstructive
pulmonary disease or COPD (pulmonary refers to the lungs).
胆囊: gallbladder = cholecyst = gall bladder = biliary vesicle
你举的这些例子，母语是英语的很多成年人还是知道的。
要知道：英语中词语有很多外来语。来源很杂。西医很多名词、术语，传统上从
LATIN来的。新的名词术语也尽量从LATIN中找词根，然后衍生。
英语中真正麻烦的是：药物名称，尤其新药。它的化学名称可能就是“字母+电话号码
”，比如，LY294002 (只是一个例子，它不是FDA批准的药）。它的商标名... 阅读全帖 |
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a***c
发帖数: 960 | 37 不是说吃Novatis的药imatinib mesilate立马见效就像好人一样吗？ |
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c***p
发帖数: 28 | 38 听说过Gleevec (imatinib, STI571)吗？自己google去。这是近代医药史里最著名的根
据结构设计阻扼药物的实例。Shi到底不是凡夫俗子，可惜在演讲里没有提及Gleevec来
佐证自己的观点。
人呐，任何时候还是收敛一些的好，呵呵。 |
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d***y
发帖数: 195 | 39 Imatinib或许可以,
毕竟引领了制药行业的一时潮流 |
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a****d
发帖数: 1919 | 40 the best protein-tyrosine kinase inhibitor so far being developed to treat
CML and GIST |
|
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g*********d
发帖数: 233 | 42 very effective!
worth couple Nobel prizes |
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y***i
发帖数: 11639 | 43 这种癌症太独特。单一变异引起。一旦找到弱点就一下被治好。我觉得历史证明绝大
部分单一起因的疾病都迟早能找到治疗方法。包括所有病毒和细菌引起的疾病。甚至艾
滋病毒都能被扛住。多起因或者损耗性的疾病是现在的主要难点。
Population,
or
treatment,
to |
|
A******y
发帖数: 2041 | 44 I think AIDS is under control...Magic Johnson still alive and well...that's
like 20 years. |
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T**********t
发帖数: 1604 | 45 That's probably because he have access to and could afford the expensive
treatment... About two thirds of people who need HIV therapy are not
receiving any treatment.
I do agree that AIDS is under control compared to 10 years ago. But that is
largely because of the effort of preventing new infections. After 26 years
of anti-HIV drug discovery, there are only six current FDA-approved drug
combinations, which consist of nine drugs all together. And there's no
effective vaccine. Under control it mi... 阅读全帖 |
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s*********y
发帖数: 1189 | 46 那imatinib，erlotinib和gefitinib的效果如何解释呢？这两种药治疗对症的癌症基本是百分之百的治愈。我认为至少有一部分癌症是有主导癌变基因的，知道这个基因和它的对症药就可以了。至于你说的红的绿的，基本属于effect，应该不是cause。 |
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c*2
发帖数: 24 | 47 Just a follow-up on this. In case some of you are interested. I emailed the
author and here is his response.
==
Thanks for your interest and your question. We made the same observation as
you did. Trp53 is represented by multiple probe sets (1438808_at, 1438542_at
, 1459780_at, 1457623_x_at, 1427739_a_at, 1426538_a_at) and only one of them
shows indeed upregulation in Imatinib-treated BCL6-/- leukemia cells (i.e.
the one you can see in Figure S6). Figure S6 shows examples of microarray
probe set... 阅读全帖 |
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J********n
发帖数: 534 | 48 Two most famous drugs benefited greatly from protein structures are:
dorzolamide, target carbonic anhydrase
imatinib, aka Gleevec, target Abl
They are many more in the clinic.
Read the story behind them, very inspiring. |
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j****x
发帖数: 1704 | 49 真正拿得出手的（unequivocally），据我所知目前仅此一家（Dorzolamide，1995）。
勉强可以拿出来凑数的撑场面的，还有其他不多几个Nelfinavir（1997），Zanamivir
（1999）
经常被拿来忽悠但是其实不能算数的，Imatinib（2001）。 |
|
