C**********r
发帖数: 8189 | 1
明显学化学的在测量dosage curve哪，都是进大药厂的好人选。凶手小心谨慎，从
小剂量投起，朱的体格太强，所以凶手到最后才“不得已而为之”下了狠手。这和黑客
黑来的email里体现的形象比较符合。 |
|
x****u
发帖数: 12955 | 2
She couldn't find evidence supporting single poisoning doesn't make her more
suspicious. Because all of the accusations and suspicions laid on her were
based on assumption that there were multiple instances of poisoning.
Now if someone find evidence that the poisoning was through continuous low
dosage poison instead of two instances of high dose poisoning, then it would
increase suspicion on her or someone in the dorm. Although that evidence
by itself still couldn't rule out that the poison w... 阅读全帖 |
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c***t
发帖数: 383 | 3 ☆─────────────────────────────────────☆
an (an) 于 (Sat May 4 02:37:12 2013, 美东) 提到:
我不是孙黑也不是孙粉。先说一下我的我的基本看法。
1。如果有任何一次投毒是在宿舍，那么凶手必是孙维。集体投毒我不大相信，没有这
么赶巧神经这么坚强的人都住一个宿舍。
2。如果两次投毒都不在宿舍，那么孙维的嫌疑也不比别人大，甚至可能更小一些。
下面来说说我知道的。我也没什么料要爆，我比朱令高一级，1991到1999我都在清华，
只是聊一下作为一个旁观者这19年来观测到的，算是一部分背景知识吧。我是理学院的
（数学，物理，化学，生物），对化学系接触的可能比非理学院的相对近一些，不过其
实深究的话也多不了太多。如果我下面聊的信息太少，那是我自己太孤陋寡闻。
我先说说什么时候知道孙维是投毒嫌疑人的吧。朱令她们二字班进校的时候，有什么美
女多多少少都会注意到。实话实说，朱令的长相也一般，远不到女神的程度。学校里的
美女在男生的卧谈会上那是如数家珍，尤其是同系或者相近系的美女。朱令还是挺默默
无闻的，至少我们临近几个宿舍... 阅读全帖 |
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t******n
发帖数: 2939 | 4 ☆─────────────────────────────────────☆
StarterYY (欣欣) 于 (Sat May 4 21:50:10 2013, 美东) 提到:
洗地党不要乱搅和，孙唯是凶手毋庸质疑
知道为什么是孙唯么－－就说朱令的隐形眼镜被投毒一例
－－导致朱令两次短暂视力模糊和失明，
就说明，坨溶液放到了隐形眼睛的清洗液里啦－－能准确地找到朱令的隐形眼睛的清洗
液，并放到里面－－－
（１）一定是她寝室的人，
(２）一定是化学坨盐，而不是老鼠药。。。
请大家注意---朱令两次短暂视力模糊和失明，
是发生在被发现在第一次全身反映--的正式大剂量 坨投毒之前大约一到两个月
http://www.mitbbs.com/article_t/WaterWorld/1942781.html
羊城晚报披露朱令案部分细节 - 至少4次下毒
--在众所周知的所谓第一次下毒之前（1994年11月)，
朱令的隐形眼镜消毒液曾经被2次下毒（ 1994年10月)，2次！
(3) 说明投毒的人一直可以有时间和空间很好的观察朱令的反应，
并且有很方便的物理空间 逐渐加大投毒剂量 而... 阅读全帖 |
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t******n
发帖数: 2939 | 5 ☆─────────────────────────────────────☆
timemachine2 (流光飞舞) 于 (Tue Jun 25 16:24:17 2013, 美东) 提到:
孙维的一个email中有这样一段话，大意是，“我们已经在互联网上表明了自己的态度
，正常人都会听进去，疯狗还是会继续叫，我们不必理他们。”
这一段，我看了以后也连连点头。确实，我们只能把自己的想法说出来，至于说出来之
后别人会怎么想，没人能控制，也根本不必挂在心上。
可是这个email中接下来的一段就不好理解了。
“我的家人会密切关注互联网。如果真有什么严重的问题，我再来请大家帮忙。否则，
你们就不必关注互联网了。”(大意)
首先，孙维的家人为什么要严密关注互联网？
如果说孙维关注互联网，无可厚非。年轻气盛，被人在网上定罪，换了我也会长期驻扎
，与暴民们一决雌雄。可是，为什么要全家关注互联网呢？她们家的人难道都饱食终日
无所事事？何况如果孙维是清白的，是被人诬陷的，那么互联网上只能存在毫无证据的
谩骂。这种谩骂有什么值得蹲守的呢？难道是为评选骂得最文明最有新意的选手收集资
料，做准备工... 阅读全帖 |
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k**********4
发帖数: 16092 | 6 I am curious why you didnt mention the conclusion
reached in the German study you cited :
Monotherapy with tea preparations from A. annua
can therefore not be recommended as a treatment option for
malaria also due to concerns about possible resistance development
against artemisinin.
Abstract
Artemisia annua L. (annual wormwood) contains the antimalarial artemisinin.
Aqueous preparations of the dried herb are included in the pharmacopoeia of
the People’s Republic of China for treatment of fever ... 阅读全帖 |
|
发帖数: 1 | 7 controlled dosage of six god florida water... |
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H********g
发帖数: 43926 | 8 【 以下文字转载自 Military 讨论区 】
发信人: cccpwx (暱稱太短), 信区: Military
标 题: 牛肉姐血泪控诉美帝医生和医疗 ZT
发信站: BBS 未名空间站 (Tue Jan 23 01:15:19 2018, 美东)
niernier11
注册@2017-08-17
字体大小: 发表于 2018-01-23 00:42 |只看楼主
甲状腺大潮， 说说我的二次甲亢， 第二次进行中。。。 美国医生就是shit
高中在国内， 有一天， 我妈觉得我的头颈特别粗。 她以为我缺碘， 拼命叫我吃海带
。 。我对海带觉得很不好吃，但还被逼着吃。
直到有一天， 我骑自行车， 骑到一半， 心跳太快， 骑不动了， 倒在路边， 我妈带
我去医院看病。 一查， 甲亢。 碘太多了。
然后吃药。 吃了什么药， 忘了。 吃了三年， 就好了。 其实， 吃了几个月， 就感
觉好了。 后面是maintain。 当时吃药一点副作用都没有。觉得这甲亢不是个big
deal
二十年后， 我自己vacation， 带着我狗儿子去了一次cabo mexico， 顺便在这里推荐
一下我住的... 阅读全帖 |
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m***y
发帖数: 14763 | 9 还是擅自4x dosage更牛逼，不过甲亢就是性子急。 |
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o********l
发帖数: 12430 | 10 这个是follow up, make sure the dosage of the drugs are okay for him.
刚刚Vet打电话来了，所有都正常，什么kidney, lever, red blood cell, white
blood cell, thyroids，blah blah都normal.可以继续吃同样的药了。不用换剂量了。
bless 豆豆。怎么还要查这么多，不是确诊了吗，折腾可怜的豆豆 |
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y*********u
发帖数: 14561 | 11 ALL ABOUT FLEAS
To treat a flea- infested cat, a 3-step approach is recommended:
1. Treat with Capstar, a pill which kills fleas within an hour (lasts
only 24 hr). We use dog size Capstar (>25 lb). The dose is ¼ pill for
adults, and 1/8 pill for kittens.
2. Wait 30-60 minutes, then bathe the cat using a mild shampoo (NOT a “
flea” shampoo) to remove dead fleas and larvae.
3. Wait 24 hrs, then treat with a topical flea treatment- Frontline or
Advantage (must wait after bathing for ... 阅读全帖 |
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y*********u
发帖数: 14561 | 12 ALL ABOUT FLEAS
To treat a flea- infested cat, a 3-step approach is recommended:
1. Treat with Capstar, a pill which kills fleas within an hour (lasts
only 24 hr). We use dog size Capstar (>25 lb). The dose is ¼ pill for
adults, and 1/8 pill for kittens.
2. Wait 30-60 minutes, then bathe the cat using a mild shampoo (NOT a “
flea” shampoo) to remove dead fleas and larvae.
3. Wait 24 hrs, then treat with a topical flea treatment- Frontline or
Advantage (must wait after bathing for ... 阅读全帖 |
|
G**********e
发帖数: 11693 | 13 你确定能这么来？
我上次问过tech，他说这个东西一份的dosage要是分开了浓度会不够，我听着觉得不太
make sense，但还是没去冒险 |
|
G**********e
发帖数: 11693 | 14 今天朋友来我们家玩，晚上出去吃饭时，我走在最前面，我问了一句，“把狗都关好了
吗”，我就先出门了。
一个多小时后我们回家，一开门小不点居然已经在门口greet我们，我的第一个反应就
是，完了，茶几上的巧克力一定被她吃得一点也不剩了！我很了解我家小不点儿，她平
时是一只很乖很规矩的小女孩狗，我们在她面前吃东西她从来都会装出一副很有风度的
样子，对吃的表现得很有克制力。但实际上她是一直惦记着食物的，一旦人前脚一走开
，她后脚立刻变成一只最猥琐的小狗，猛虎扑兔一样的飞奔着去偷吃东西（亲眼见过很
多次）。今天的情况应该就是这样，可能因为混乱，所有的人都以为狗已经被安顿好了
，我们就一行人出了门。回来茶几上一看果然如我所料，巧克力全部被吃得光光的。我
连她是以什么顺序吃掉的都知道，一定是先吃了reese peanut butter，然后吃了white
chocolate with hazelnut，最后可能还吃了蓝粉白色的marshmallow。
以前从来没有遇到过这种情况，只知道chocolate对狗来说是highly toxic的，甚至可
以造成死亡。所以马上在网上查找处理方法。网上说吃过之... 阅读全帖 |
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p***7
发帖数: 449 | 15 或者是不是 herpes 跟 calcivirus infections?
我抄来一大段，是一个人问的 http://www.vetinfo.com/cherpes.html#b：
Herpes virus (rhinotracheitis) and calcivirus infections
Question: Dr. Mike, Great site. I love the information. Our situation: We
had an older male cat, 12 years, who had been an only cat all that time.
Three weeks ago we adopted a six month old kitten from the Humane Society
here in NYC. We wanted a kitten and thought it would keep Fish, the older
cat, company. Unfortunately we did not take the time to... 阅读全帖 |
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c*****a
发帖数: 5428 | 16 bless PU!
every time Tango has diarrhea I give him Pepto bismol in children's dosage.
one teaspoon will get him back to normal |
|
d******g
发帖数: 5484 | 17 整晚喘个不停
浑身乱抓
到处都是大包
四肢爪子嘴边全都有
耳朵也肿了耳廓很厚 还有infection
局部掉毛 hotspot
昨晚给了benedryl 50mg dog safe dosage 1mg/lb
可以暂时缓解症状
只管了3个小时
今天去看医生
说比较严重的hives
看着像被什么咬了蜘蛛昆虫一类的
必须口服steroids和抗生素
周末我们在院子里多待了一会儿
不得不说东岸各种蚊虫确实是多
原来在中西部没这么厉害
跳蚤tick什么都来了
我自己都被咬了不知道多少次
医生提到秋天是lab过敏高发季节
上周五个这样的病例了
分享一下 |
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x*****b
发帖数: 271 | 18 I'm not sure if this would help you.
Once one of my kitties got eye infection, and I just mixed some 阿莫西林 in
his food, and it works like magic. I think the dosage is 5ml/lb. If you
decide to use them, make sure don't over dose. |
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f*******a
发帖数: 174 | 19 这个我就不清楚了，不好意思，breeder说如果需要吃就给她打电话咨询dosage.
我家这个还没吃过。。。
我看药瓶上是按小孩的体重算的，对狗是不是也差不多？ |
|
|
e*****e
发帖数: 1275 | 21 网上抄的。
Apply vitamin E to the wart. Use a sterilized needle or knife to puncture a
standard vitamin E capsule. Apply the vitamin directly to the wart using
clean fingers or a cotton swab. Repeat this procedure three to four times a
day for two to three weeks until you see improvement.
2Rub castor oil over the wart. Standard castor oil, found in most drug
stores, can soften dog warts and greatly reduce irritation, which will help
prevent your dog from scratching the wart open. Use a clean finger o... 阅读全帖 |
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P******2
发帖数: 2312 | 22 You may give Dramamine to dogs to prevent motion sickness. Check out this
website for dosage. It also gives a list of over-the-counter human
medications that can be used on dogs/cats, and the list of the ones that can
not (toxic or non-effective).
http://www.walkervalleyvet.com/otc-meds.htm
To be sure, you might want to call your vet to confirm. |
|
x**c
发帖数: 1435 | 23 I used to be my own doctor cutting down the dosage the doctor had prescribed
me or stopped taking some medicine without consulting my doctor and I had
paid a big price because I had to suffer withdrawl side effect of medicine.
Since I have learned my lession I now listen to my doctors they are trained
and most of the time know more than us. |
|
l******e
发帖数: 41 | 24 如果我没有理解错的话，水疗实际上感统训练的一种，主要是针对自闭症，或者由有自
闭倾向的小孩的一种治疗。
楼主是有强迫症的症状，如果有过 extreme ups and downs 符合bipolar诊断的话，和
你的医生说说， probably you also need to be on anti-depressant on top of
mood stabilizers such as lithium or valproic acid.
One of the rationales is that relatively high dosage of antidepressant works
for OCD (obsessive and compulsive disorder) |
|
F*****e
发帖数: 270 | 25 This is my 2nd week of taking the medicine, still with the minimum dosage of
150mg for adult. I continue having benefit from it. Some side effect, such
as diarrhear in the first week was gone, just as the same you experienced.
I am glad to seek help from doctor in time, because my work load increased
like your case this week. You can not only rely on medicine to maintain your
health. Good nutrition and sleep can not be replaced by simply taking more
medicine and hope it can resolve all the troub... 阅读全帖 |
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w***e
发帖数: 1331 | 26 有兴趣的可以联系我帮忙递简历:
There is an R4/R5 job opening in Pfizer's global Materials Science
discipline which is focused on predictive drug-product design. We are
looking for an engineer/materials scientist/physical chemist to develop
predictive tools for solid dosage form design. It is envisaged that the
scientist will conduct both experimental and modeling studies directed at
using particle level properties (size, shape, mechanical properties, etc) to
predict bulk properties and manufacturing/processin |
|
B*******a
发帖数: 801 | 27 发信人: hellozero (hellozero), 信区: Biology
标 题: Re: 科普一下制药公司的相关职位和工作职能
发信站: BBS 未名空间站 (Tue Nov 3 23:44:15 2009, 美东)
我也来贡献一把吧
新药开发的几个关键步骤
1) hypothesis generation，包括： target identification and validation; assay
development; lead generation, 这一部分主要是basic science和translational
science
2)candidate development，包括lead optimization, non clinical/pre clinical
studies,IND， Phase IA, IB and phase II这部分主要是cell/animal model，以及早
期的clinical trial的safety和dosage/formulation
3) Commercialization，主要包括phase III, NDA, |
|
B*******a
发帖数: 801 | 28 发信人: hellozero (hellozero), 信区: Biology
标 题: Re: 科普一下制药公司的相关职位和工作职能
发信站: BBS 未名空间站 (Tue Nov 3 23:44:15 2009, 美东)
我也来贡献一把吧
新药开发的几个关键步骤
1) hypothesis generation，包括： target identification and validation; assay
development; lead generation, 这一部分主要是basic science和translational
science
2)candidate development，包括lead optimization, non clinical/pre clinical
studies,IND， Phase IA, IB and phase II这部分主要是cell/animal model，以及早
期的clinical trial的safety和dosage/formulation
3) Commercialization，主要包括phase III, NDA, |
|
b******z
发帖数: 387 | 29
jaudice
with
high dosage applied,
wonder if this is ACTH (ADRENOCORTICOTROPIC HORMONE), which has another name
corticotropin; or natural/synthetic corticosteroids, which might generally
used. sorry, cant recall more, just for information confirmation. go ahead to
make it sure. it shoudnt be hard.
immune system suppression
better know the exact effective composition of the medicine, otherwise, dont
make sense.
|
|
p**********r
发帖数: 3581 | 30 八成也是中国人，老美医生真是没用。可惜没早发现。
http://www.app.com/article/20110209/NJNEWS10/110209088/Nurse-cr
recognizing-fatal-poisoning-symptoms?
odyssey=mod|newswell|text|Frontpage|p
NEW BRUNSWICK — Authorities are hailing a nurse at the University
Medical Center of Princeton for her assistance in a Monroe murder case.
First Deputy Assistant Middlesex County Prosecutor Nicholas Sewitch did
not reveal the nurse's identity, but said the Princeton staff member
recognized 39-year-old Xiaoye Wang's abnormal symptoms, ... 阅读全帖 |
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h*******o
发帖数: 4884 | 31 我也来贡献一把吧
新药开发的几个关键步骤
1) hypothesis generation，包括： target identification and validation; assay
development; lead generation, 这一部分主要是basic science和translational
science
2)candidate development，包括lead optimization, non clinical/pre clinical
studies,IND， Phase IA, IB and phase II这部分主要是cell/animal model，以及早
期的clinical trial的safety和dosage/formulation
3) Commercialization，主要包括phase III, NDA,以及marketlaunch和postmarket
surveillence 或者phase IV
这部分主要是clinical trial 部分
至于RA（regulatory affairs) 贯穿始终，CRO ，CRA |
|
h*******o
发帖数: 4884 | 32 我也来贡献一把吧
新药开发的几个关键步骤
1) hypothesis generation，包括： target identification and validation; assay
development; lead generation, 这一部分主要是basic science和translational
science
2)candidate development，包括lead optimization, non clinical/pre clinical
studies,IND， Phase IA, IB and phase II这部分主要是cell/animal model，以及早
期的clinical trial的safety和dosage/formulation
3) Commercialization，主要包括phase III, NDA,以及marketlaunch和postmarket
surveillence 或者phase IV
这部分主要是clinical trial 部分
至于RA（regulatory affairs) 贯穿始终，CRO ，CRA... 阅读全帖 |
|
a*****s
发帖数: 838 | 33 Can anybody help to get these two papers today, many thanks! contact z*****[email protected], thanks!
===first one===
pubmed link: http://www.ncbi.nlm.nih.gov/pubmed/19729489
Pkd2 dosage influences cellular repair responses following ischemia-
reperfusion injury.
Prasad S, McDaid JP, Tam FW, Haylor JL, Ong AC.
Am J Pathol. 2009 Oct;175(4):1493-503. Epub 2009 Sep 3.PMID: 19729489 [
PubMed - indexed for MEDLINE]
===another one===
Aberrant regulation of planar cell polarity in polycystic kidney disease. |
|
s******h
发帖数: 47 | 34 Can you guys tell me how to stimuate Rac1, Cdc42, and RhoA activation in
vivo in mice?
inject something? what is the dosage? how soon mice can be killed for
collecting sample?
I am assessing the peritoneal macrophage reponse to those activators.
Thanks very much for your help. |
|
s***o
发帖数: 1189 | 35
up
I second this and would highly suggest you find another lab.
The atmosphere in this group is not healthy. And problem like this generally
seeds from lacking proper managerial skills of the top, meaning: you can do
nothing and may only take heat. As a rotation student you have a long way
to go to get to the PhD level and during this process you need lots of
SINCERE help from your colleagues, which i just don't see it happen in this
group.
You are blaming yourself too much. If you are certain... 阅读全帖 |
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m*p
发帖数: 226 | 36 The gene dosage effect can contribute to the differentiation process and
cell identity. The DNA sequence of
cells from different organs will not be much difference, if not considering
somatic mutation. Maybe some
moving elements in different organs insert to different place and partially
contributes to the difference.
same
mutations which
formation
not
some |
|
M*****n
发帖数: 16729 | 37 i re-read your previous post, i think in your case the Z' will be low.
normalizing the control to 1 is OK, but it is not a clean way to do it. I
think you need an independent ELISA as a standard curve. do you always do a
dosage curve? |
|
w******e
发帖数: 1187 | 38 I only did one dosage curve -- it has the right trend, but I don't intend
to include the data anyway. the point of my project is, here I generated
a new aptamer pair for sensor ppl to play with (just google thrombin
sensor you'll know how those ppl are lol~), for assurance I demonstrated
they can give higher signal with target than w/o, and the signal is
specific to the target. I'll leave claims about sensitivity & stuff to
sensor ppl. end of story (hopefully).
anyway, thx for your time~
a |
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e**s
发帖数: 513 | 39 令我最puzzled是，为什么在所有的eukaryotes，pcna都是low copy number.如果是
random的，那总要有高有低吧。pcna也不是dosage sensitive，难道有一个什么原因都
是low copy number么？我查过pcna在chromosome上的位置，也不是固定的。 |
|
|
n***w
发帖数: 2405 | 41 directly use mice and give long-term radiation and see.
I am wondering how to mimic the exact or even close dosage of radiation
emitted by cell phone. I bet the
normal radiation from cell phone is very small especially when it is fully
charged and has perfect signal.
At least I am not worry about this. lol
mimic
some
data |
|
z****u
发帖数: 1007 | 42 ERT2 。。据说比ER 好。更强效，更特异。
tamoxifen induce的问题在于不会彻底，比如K14-Cre ERT2 在身体不同部位皮肤的诱导效
率就不一样。从30%到 60不等。所以这个诱导后更像是生成一个mosaic.当然了，有人要的就是这种mosaic KO效果。反正KO效果是dosage dependant的。另外
tamoxifen有毒性。剂量需要optimize。我目前做的一个Cre-ERT2 就遇到这个麻烦，在E18
.5打标准剂量Tamoxifen后所有embryo都会在出生后一天内死掉。 |
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D***y
发帖数: 693 | 43 我用过两种inducible KO
1. CreERT2 (就是第二代的CreER). Cre driven by tissue specific promoter.
我研究骨头。打了tamoxifen （我用oral gavage)10天后就有phenotype。但是
tamoxifen有些副作用，比如增加bone mass.所以需要optimize dosage.另外我用打了
tamoxifende wt mice 作为control,这样可以排除tamoxifen effect.
2. 我用过Tet-Off system. 需要三只老鼠：tissue specific-tTA; TetO-cre,加上你
的conditional 老鼠。喂老鼠doxycyline-containing water or food 直到你想要表达
基因的时候。
3. Teto-ON system:tissue specific-rtTA; TetO-cre,加上你的conditional 老鼠。
喂老鼠doxycyline-containing water or food to induce gen... 阅读全帖 |
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s******y
发帖数: 28562 | 44 是的，tamoxifen 的一个很讨厌的地方就是本身毒性很强，放少了状态不明显
让你没法做统计，放多了就统统都死了让你也没法做统计。
诱导效
人要的就是这种mosaic KO效果。反正KO效果是dosage dependant的。另外
在E18 |
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m*********n
发帖数: 215 | 45 refer to literature for the dosage you use. Match up with the tissue and age. |
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