p*****c
发帖数: 20445 | 1 Christopher D. Lima, Ph.D.
Memorial Sloan-Kettering Cancer Center
Christopher Lima doesn’t pick easy problems. A structural biologist, he is
investigating how cells attach small proteins—like ubiquitin and the
related molecule SUMO—to other proteins to modify their function or fate.
Alongside those studies, he is exploring the molecular mechanisms that
underlie RNA processing and degradation—modifications to an RNA copy of a
gene that influence its stability and ability to be used as a template ... 阅读全帖 |
|
m******g
发帖数: 467 | 2 自己吐槽一下，虽然对于看过文献的研究系统／漂亮的图什么的记得比较清楚
但是作者什么的老是不太记得
有时候看到有的人可以一堆一堆地数出来，感觉好厉害啊！
觉得这期science比较有趣，虽然没有那种看得超感动的文章，但是还是有不少很值得
一看的paper的。
Science 13.11.22
推荐：
1. Organization of the Mitotic Chromosome
用5C和Hi-C, 发现分裂中期结构是与位点无关的均质，并用polymer模拟
“A simple, robust model explains higher-order organization of mammalian
chromosomes.”
（最近这类文章真多，好像周周都有？感觉个人不是那么感兴趣了～～～）
2. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction
in the Mouse
testis determinant factor Sry
spermatogonial proliferatio... 阅读全帖 |
|
m******g
发帖数: 467 | 3 自己吐槽一下，虽然对于看过文献的研究系统／漂亮的图什么的记得比较清楚
但是作者什么的老是不太记得
有时候看到有的人可以一堆一堆地数出来，感觉好厉害啊！
觉得这期science比较有趣，虽然没有那种看得超感动的文章，但是还是有不少很值得
一看的paper的。
Science 13.11.22
推荐：
1. Organization of the Mitotic Chromosome
用5C和Hi-C, 发现分裂中期结构是与位点无关的均质，并用polymer模拟
“A simple, robust model explains higher-order organization of mammalian
chromosomes.”
（最近这类文章真多，好像周周都有？感觉个人不是那么感兴趣了～～～）
2. Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction
in the Mouse
testis determinant factor Sry
spermatogonial proliferatio... 阅读全帖 |
|
m******g
发帖数: 467 | 4 Nature 14.04.24
推荐：
1. Guidelines for investigating causality of sequence variants in human
disease
some status quo and general guidelines
稍微了解一下：
Paper1. Mammalian Y chromosomes retain widely expressed dosage-sensitive
regulators
Paper2. Origins and functional evolution of Y chromosomes across mammals
sequencing by cloning into BAC
multi-species comparison
fast survey using genes expressed in males also only appear in male genomic
DNA
Y chromosome currently stable
evolutionary history and enri... 阅读全帖 |
|
m******g
发帖数: 467 | 5 PNAS 14.05.27
推荐：
1. Repair of DNA double-strand breaks by templated nucleotide sequence
insertions derived from distant regions of the genome
2. Genome-wide high-resolution mapping of chromosome fragile sites in
Saccharomyces cerevisiae
reduced level of DNA pol alpha
galactose-inducible GAL1 promoter to control level
map LOH after crossing two strains
稍微了解一下：
1. Interactions between chromosomal and nonchromosomal elements reveal
missing heritability
小知识：
1. Selection and constraint underlie ir... 阅读全帖 |
|
z****u
发帖数: 1007 | 6 这个问题问得好。专门对干细胞衰老的研究好像没有。因为干细胞的传统定义就是life
long maintenance.理想得被定义为永远具有更新能力。自然不具有衰老问题。
我也在琢磨这个问题，如果在病理状况下，比如我contituional activate某signal
pathway 来不停的激活qienscent stem cell,那他们会不会最终衰竭。再比如糖尿病的
创口不愈合是否就是由于干细胞的提早衰老导致？
不对称分裂的行为在干细胞里研究很多。如楼上所说，在低等生物里常见到
asymmetrical division. 以此来维持stem cell population的总数问题。但在
mammalian里，不对称和对称分裂都有。比如复层化前的上皮干细胞的不对称分裂就类
似与
drosophila的 germ cell。symmetrical也不少 好像satellite cell就是, 对称分裂在
群体水平上，有的give rise to two progenitor, 有的give rise to two stem cell.
这样来维持群体数目的稳定。Elaine F... 阅读全帖 |
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s********9
发帖数: 132 | 7 Since you are female and this duplicated region localize on X chromosome.
Chance,if you only have one allele that's duplicated, could be that you have
another allele that's normal. Problem with most X-linked genes are they are
silenced on one X chromosome, in your case it could be the duplicated one
got silenced.But for your kid (son? since you mentioned Y chromosome), it is
hard to say. So if you concerned, you still need to counsel specialist.
了X |
|
d********m
发帖数: 3662 | 8 If the chromosomes were extracted, how do you convince us that the
structures you have observed are not artificial ones that are not found in
physiological conditions.
Let alone EM has notoriety destroying generic chromosome structures and that
's why it has been long deserted for chromosome structure studies. |
|
D*****l
发帖数: 554 | 9 吾妻是妖（5-7-4-1）
FA 2010 P.410
Biceps = C5 nerve root
Tricepts=C7
Knee Jerk=L4
Ankle jerk=S1.
p53 related numbers. 17 (1x10 + 7) and 6 (7-1).
5+3 = 1+7.
p53 is located on chromosome 17.(we don't have chromosomes 71,25, 52, 34, 43).
p53 inactivates E6 protein.
7-1=6. (chromosome 17)
Rb inactivates E7 protein. |
|
D*****l
发帖数: 554 | 10 p53 related numbers. 17 (1x10 + 7) and 6 (7-1).
5+3 = 1+7.
p53 is located on chromosome 17.(we don't have chromosomes 71,25, 52, 34, 43
).
p53 inactivates E6 protein.
7-1=6. (chromosome 17)
Rb inactivates E7 protein. |
|
A**********9
发帖数: 151 | 11 请版上的朋友帮忙看看，我们小组讨论后，对这两题还有疑问。谢谢！
1. A 3-week-old newborn is brought to the physician because of recurrent
vomiting after feeding since birth. The mother says that her child is eager
to feed even after vomiting. There is no fever. Abdominal examination shows
a firm, 1-to 2-cm, mobile mass in the epigastrium to the right of the
midline. If this condition has a lower threshold of liability in males than
in females, which of the following relative of this patient is at greatest
risk of also develo... 阅读全帖 |
|
j***b
发帖数: 5901 | 12 "那么下一个自然的问题是： 这个新得到偶数染色体的新种是如何传代下去？根据种的生物学定义，它是不能与原种交配生出有生育能力的后代的，猴是不可能于人交配生出有生育能力半人半猴的。"
This is wrong. The 新得到偶数染色体的 individual may not be a 新种. It may still produce viable offspring with other individuals with different number of 染色体. The number of 染色体 isn't the whole story. The structure is also important.
For example, the first human who had 46 chromosome could produce offspring of 47 chromosome. For these first generation offspring, they had sperms or eggs of either 23 or 24 chromosome. De |
|
w*****1
发帖数: 473 | 13 【 以下文字转载自 DataSciences 讨论区 】
发信人: wz99331 (dotti), 信区: DataSciences
标 题: 如何把１个文件分成２２个以chromosone为单位的文件
发信站: BBS 未名空间站 (Mon Mar 31 18:19:51 2014, 美东)
我想用merlin做gwas,结果说内存不够，问了作者，建议把我的ped 文件分成２２个文
件，每个chromosome一个文件。请问plink里面有命令可以把包括２２个chromosome的
ped file和map file分成以每个chromosome为单位的２２个子文件吗？
另外分成２２个后，如何产生merlin 需要的.dat file呢？谢谢！ |
|
w*****1
发帖数: 473 | 14 我想用merlin做gwas,结果说内存不够，问了作者，建议把我的ped 文件分成２２个文
件，每个chromosome一个文件。请问plink里面有命令可以把包括２２个chromosome的
ped file和map file分成以每个chromosome为单位的２２个子文件吗？
另外分成２２个后，如何产生merlin 需要的.dat file呢？谢谢！ |
|
t******u
发帖数: 187 | 15 Hi, Slei
Thanks for your reply to my questions.
Here is some inputs for the chromosome test. My husband did the chromosome
karyotype test before. That
is the test showing every chromosome's shape, number, length and abnormals.
Since my RE want to figure
out why my husband can not produce any sperms.
I just checked my blood test results. There is one test is for the cystic
fibrosis carrier screen. It is a genetic
test showing how many mutations I have. This test is recommended for the
women befor |
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c**i
发帖数: 6973 | 16 supports archaeology, that a single-origin domestication 8 to 9,000 years
years ago at Yangtze Valley (of China) and spread to India, rather than the
competing proposition that Ganges in India independently accomplished the
feat.
研究显示:中国是驯化水稻的原产地. VOA Chinese, May 3, 2011.
http://www.voanews.com/chinese/news
/international/20110503-RICE-ORIGIN-121155584.html
, which cites
Molina J et al, . Proceeding of National Academy Science (PNAS), published
online before print May 2, 2011, doi: 10.1073/pna... 阅读全帖 |
|
i*****s
发帖数: 4596 | 17 you've got a point. but most village in ancient china were like that. so
as long as the same y chromosome got passed, the modern villagers are still
the proud descendants of the same famous ancestor. isn't it fascinating?
chromosome. |
|
d*****u
发帖数: 17243 | 18 彝族这个民族还是比较独特的
早期数据显示他们的Y染色体里N占到了三成，我估计黑彝还要高些
另外还有F-M427，基本只在彝族和拉祜族里有
The F-M427 subclade (lineage) is defined by two mutations: M427 and M428.
This subclade has been detected with varying frequency in samples of Loloish
-speaking peoples, such as the Lahu and the Yi, minority groups who
primarily inhabit some mountainous areas in Southwest China.
F-M427是F-M89分化出来的，而F-M89主要分布在南亚
The Ailao Mountains of Yunnan Province in southwestern China appear to be th
e one of few regions where such lineages, ... 阅读全帖 |
|
m*********a
发帖数: 3299 | 19 汉族的历史，男人的Y染色体单一，北方和南方一致的，但是女性的DNA是非常复杂的。
Y-chromosome haplogroup O3 is a common DNA marker in Han Chinese, as it
appeared in China in prehistoric times. It is found in more than 50% of
Chinese males, and ranging up to over 80% in certain regional subgroups of
the Han ethnicity. However, the mitochondrial DNA of Han Chinese increases
in diversity as one looks from northern to southern China, which suggests
that male migrants from northern China married with women from local peoples
after arriving... 阅读全帖 |
|
K**********n
发帖数: 1197 | 20
跟这帮自称理科的文科生物wsn实在纠缠不清楚。给丫们上点洋大人自己的说法吧，而
且都是学术圈的，已有reference一堆，其中一份是著名的兰德公司的报告。
另外，美国和澳洲已立法限制使用脑波扫描仪，拿脑波扫描仪扫本国公民已是联邦法的
重罪。不过这个比较难的是你无法证实谁接收了你的脑信号。所以立了法跟没立一个样。
Remote Mind Control Technology
Reprinted from SECRET AND SUPPRESSED: BANNED IDEAS AND HIDDEN
HISTORY, edited by Jim Keith, $12.95, available from
1-800-680-INET.
There had been an ongoing controversy over health effects of electromagnetic
fields (EMF) for years (e.g., extremely low frequency radiation and the
Navy's Project Sea... 阅读全帖 |
|
b********n
发帖数: 38600 | 21 http://www.telegraph.co.uk/history/world-war-two/7961211/Hitler
By Heidi Blake
6:25AM BST 24 Aug 2010
Saliva samples taken from 39 relatives of the Nazi leader show he may have
had biological links to the “subhuman” races that he tried to exterminate
during the Holocaust.
Jean-Paul Mulders, a Belgian journalist, and Marc Vermeeren, a historian,
tracked down the Fuhrer’s relatives, including an Austrian farmer who was
his cousin, earlier this year.
A chromosome called Haplogroup E1b1b1 which show... 阅读全帖 |
|
D*********n
发帖数: 279 | 22 http://en.wikipedia.org/wiki/Native_Americans_in_the_United_Sta
Native Americans in the United States
From Wikipedia, the free encyclopedia
Jump to: navigation, search
"American Indian" redirects here. For other indigenous peoples, see
Indigenous peoples of the Americas and other geographic regions. For
Americans from South Asia, see Indian American.
This article may be too long to read and navigate comfortably. Please
consider splitting content into sub-articles and/or condensing it. (January
2... 阅读全帖 |
|
y**********g
发帖数: 2285 | 23 靠谱吗？
LONDON: Humans are actually hybrids, who emerged as an offspring of a male
pig and a female chimpanzee, according to one of the world's leading
geneticist.
Turning the theory of human ancestry on its head, Dr Eugene McCarthy — one
of the world's leading authorities on hybridization in animals from the
University of Georgia has suggested that humans didn't evolve from just apes
but was a backcross hybrid of a chimpanzee and pigs.
His hypothesis is based on the fact that though humans have ma... 阅读全帖 |
|
E*******F
发帖数: 2165 | 24 DNA evidence[edit]
Zerjal et al. (2003)[6] identified a Y-chromosomal lineage present in about
8% of the men in a large region of Asia (about 0.5% of the world total). The
paper suggests that the pattern of variation within the lineage is
consistent with a hypothesis that it originated in Mongolia about 1,000
years ago, and thus several generations prior to the birth of Genghis. Such
a spread would be too rapid to have occurred by genetic drift, and must
therefore be the result of selection. The... 阅读全帖 |
|
S*******l
发帖数: 4637 | 25 Zionist当然这么说。想论证巴勒斯坦人是外来户，所以拿走他们土地没问题。
但是遗传学研究表明巴人就是当地土著，阿拉伯化的土著。
Genetic analysis suggests that a majority of the Muslims of Palestine,
inclusive of Arab citizens of Israel, are descendants of Christians, Jews
and other earlier inhabitants of the southern Levant whose core may reach
back to prehistoric times. A study of high-resolution haplotypes
demonstrated that a substantial portion of Y chromosomes of Israeli Jews (70
%) and of Palestinian Muslim Arabs (82%) belonged to the same chromosome
... 阅读全帖 |
|
T**********e
发帖数: 29576 | 26 4w-8w年前泥人和人类大量混合交配，现代欧亚人保留了1%以上的泥人基因，以中国北京
汉族人保留了1.4%为世界最多，平均略高于中国南方汉人。最后泥人很可能融入现代人
种继而消失。
How Neanderthal DNA Changed Humans
------
The researchers analyzed genetic variants in 846 people of non-African
heritage, 176 people from sub-Saharan Africa and a 50,000-year-old
Neanderthal.
The clearest indicator that a gene variant came from a Neanderthal was if
the variant appeared in some non-Africans and the Neanderthal, but not in
the sub-Saharan Africans.
Levels of Neanderthal ancestry differ in E... 阅读全帖 |
|
w**********5
发帖数: 1741 | 27 Queen Elizabeth II may not be the rightful ruler, as scientists have made
some genetic discovery on King Richard III's body, which poses doubt on the
royal line of succession.
According to the researchers at the University of Leicester, they are now 99
.999 percent sure that the skeleton with a twisted spine found in a
Leicester car park in 2012 was the last Plantagenet king who had died in
battle in 1485. However, the skeleton's male Y chromosome, only passed from
father to son, and did not mat... 阅读全帖 |
|
D***r
发帖数: 7511 | 28 A lot of fathers are going to hate this, but genetic research has found guys
probably get a lot of their intelligence from their X gene, the feminine
one. Of 23 sets of matched chromosomes we all have, twenty-two line up
pretty similarly, but we differ on the sex chromosome—men get an X from
their mother and a Y from their father, and women get X’s from both mother
and father.
http://drkeithwitt.com/males-inherit-more-intelligence-from-mot |
|
l*******1
发帖数: 16217 | 29 CRISPR 这个绝对该得，我刚才查了一下 中国和美国FDA 今年已经批准肺癌试验了，前
面英国的报道过治愈过白血病，
The Chinese trial will enrol patients who have metastatic non-small cell
lung cancer and for whom chemotherapy, radiation therapy and other
treatments have failed. “Treatment options are very limited,” says Lu. “
This technique is of great promise in bringing benefits to patients,
especially the cancer patients whom we treat every day.”
Leukaemia success heralds wave of gene-editing therapies
Lu’s team will extract immune cells called T... 阅读全帖 |
|
发帖数: 1 | 30 【Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH D005368
[edit on Wikidata]
Filariasis is a parasitic disease caused by an infection with roundworms of
the Filarioidea type.[1] These are spread by blood-feeding black flies and
mosquitoes. This disease belongs to the group of d... 阅读全帖 |
|
发帖数: 1 | 31 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
|
发帖数: 1 | 32 12月27日 为什么我要替中国辩护
我要替中国辩护，并不是因为我是一个中国人，而是因为我知道中国就和这世界上绝大
数的国家一样，虽然有很多丑陋的现象，但是他们是受害者。就
象这个犯罪集团里很多的人一样，他们来自各种种族，他们可能充当了工具，但他们不
是制造这一切，谋划这一切的人。虽然经常会暴露中国产品出现问题。但要知道中国是
世界工厂，他们只是打工者，他们只是按照各种雇主提供的配方来生产，他们并不知道
他们会产生怎样的后果。或者这些工人知道后果，但他们只是奴隶，他们又如何去改变
这一切？ 所以，当我的调查不断往前推进的时候，不可避免地会涉及各国的企业，但
这并不表明是针对这个国家或这个国家的人民，而是针对一种社会现实和丑陋现象。就
拿菲律宾来说，菲律宾是一个犯罪猖獗的国家，有很多犯罪分子，但是菲律宾人民却是
这个集团的受害者，他们／她们被绑架，沦为了牺牲品，人体实验对象。一个日本人，
强奸上千名菲律宾女孩，却没有受到惩罚。以前我也提到过，有20个国家的名单，这20
个国家的人民其实都是受害者。现在他们把矛头对准中国，或许仅仅是因为我揭示了他
们图害世界人民的内幕，而我是一个中国人的缘... 阅读全帖 |
|
发帖数: 1 | 33 12月28日 仔细阅读以下文章
或许这些文章可以告诉你们孩子被伤害病毒的答案。
Astellas Pharma 应该和这些人体实验有莫大的关系！
Founded 2005; 11 years ago
Headquarters 2-5-1, Nihonbashi-Honcho, Chūō-ku, Tokyo 103-8411, Japan
Key people Yoshihiko Katakana
(President and CEO)
Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH ... 阅读全帖 |
|
发帖数: 1 | 34 12月28日，答案 2 （2011）
Filariasis
From Wikipedia, the free encyclopedia
Filariasis
Life cycle of Wuchereria bancrofti, a parasite that causes filariasis
Classification and external resources
Specialty Infectious disease
ICD-10 B74
ICD-9-CM 125.0-125.9
Patient UK Filariasis
MeSH D005368
[edit on Wikidata]
Filariasis is a parasitic disease caused by an infection with roundworms of
the Filarioidea type.[1] These are spread by blood-feeding black flies and
mosquitoes. This disease belongs... 阅读全帖 |
|
D**s
发帖数: 6361 | 35 粗大！美国与法国DNA权威检测：汉人基因是世上最纯正的基因
[cp]【美国与法国DNA权威检测：汉人基因是世上最纯正的基因，同时证实客家人确为
中原汉人】2007年5月，美国权威学术杂志《human genetic》一文：《Y chromosomes
of prehistoric people along Yangtze River》（Hum Genet. 2007 Nov;122(3-4):
383-8. Epub 2007 Jul 27.）指出：
通过对陶寺文化（距今4500年）古人骨DNA的研究，可以肯定龙山文化的居民，其Y染色
体SNP单倍型是O3—M122，并且只含有O3和子类型O3e，无其他类型，和现代汉族的主体
完全一致，也就是说：现在汉族其父系远祖完全是古代中原人，也就是龙山人。
单独看O3，各地汉族中至少60%-70%来自龙山文化，对比2004年的文献 《evolution
and migration history of chinese population inferred from chinese Y-
chromosome evidence》（J Hum Ge... 阅读全帖 |
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s*****n
发帖数: 1998 | 36 【美国与法国DNA权威检测：汉人基因是世上最纯正的基因，同时证实客家人确为中原汉
人】2007年5月，美国权威学术杂志《human genetic》一文：《Y chromosomes of pre
historic people along Yangtze River》（Hum Genet. 2007 Nov;122(3-4):383-8. E
pub 2007 Jul 27.）指出：
通过对陶寺文化（距今4500年）古人骨DNA的研究，可以肯定龙山文化的居民，其Y染色
体SNP单倍型是O3—M122，并且只含有O3和子类型O3e，无其他类型，和现代汉族的主体
完全一致，也就是说：现在汉族其父系远祖完全是古代中原人，也就是龙山人。
单独看O3，各地汉族中至少60%-70%来自龙山文化，对比2004年的文献 《evolution an
d migration history of chinese population inferred from chinese Y-chromosome
evidence》（J Hum Genet. 2004;49(7):339-48. Epub 2004... 阅读全帖 |
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m******1
发帖数: 19713 | 37 Researchers Discover Sex-Change Gene
By Diane Anderson-Minshall
Dmrt1 XX XY CHROMOSOMES X390 (FAIR UNCREDITED) | ADVOCATE.COM
Researchers at the University of Minnesota Medical School and College of
Biological Sciences have discovered a gene that is required to maintain male
sex throughout life.
The research team, led by David Zarkower and Vivian Bardwell of the
University of Minnesota’s department of genetics, cell biology, and
development, found that removing an important male development gene... 阅读全帖 |
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L*******e
发帖数: 2202 | 38 http://www.huffingtonpost.com/2012/06/12/why-are-there-gay-men_
While female sexuality appears to be more fluid, research suggests that male
gayness is an inborn, unalterable, strongly genetically influenced trait.
But considering that the trait discourages the type of sex that leads to
procreation — that is, sex with women — and would therefore seem to thwart
its own chances of being genetically passed on to the next generation, why
are there gay men at all?
Put differently, why haven't gay man... 阅读全帖 |
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x******n
发帖数: 8550 | 39 再补充一点：男人的Y染色体已经萎缩了（呵呵，ws一下），看wiki的解释：
Shrinking
The human Y chromosome has lost 1,393 of its 1,438 original genes over the
course of its existence. With a
rate of genetic loss of 4.6 genes per million years, the Y chromosome may
potentially lose complete function
within the next 10 million years [11].
会不会以后宇宙里没有男人存在了？ |
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x******n
发帖数: 8550 | 40 看wiki对 Y 染色体的注释：
http://en.wikipedia.org/wiki/Y_chromosome
Shrinking
The human Y chromosome has lost 1,393 of its 1,438 original genes over the
course of its existence. With a
rate of genetic loss of 4.6 genes per million years, the Y chromosome may
potentially lose complete function
within the next 10 million years [11].
还是不要吵架了，再等10 million years，妇女就解放了。呵呵。 |
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k*******g
发帖数: 629 | 41 【 以下文字转载自 Medicine 讨论区 】
发信人: keaneding (浮出海面), 信区: Medicine
标 题: 800多的账单，保险公司不管，怎么办？
发信站: BBS 未名空间站 (Wed Sep 8 13:48:07 2010, 美东)
今年3月份，lp经历了连续第二次自然流产，我们很着急，决定去医院好好查查原因。
医生给我们做了很多检查，包括给我和lp都抽血做了chromosome，之前医药版的xdjm也
有建议我们查一下这个，医生也建议查，我们当然做了。
可问题来了，上个月我收到一份账单，是查我的chromosome的费用，$833，保险一分钱
都不cover，（lp同样的检查费原价也是这个，但因为有保险，实际只交了几十块钱吧
）我想会不会是弄错了，就跟labcorp的人联系，他们帮我file了一个claim给保险公司
，结果是deny，他们的理由是这种检查有可能是作为research的用途，他们让我自己联
系保险公司。
我把情况详细汇报给了保险公司，期间他们还要了下医嘱的医生的姓名等信息，昨天收
到信，居然还是deny，原因是说it is unclea |
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S***w
发帖数: 1014 | 42 前面30分钟抓着问了我过去的经历，
做了一个小题目。
然后扔出这个大题 要求O(n)
且输出排序
我先用suffix array, 说不好
然后用hashmap, o(n), 但是输出不排行
恶心的地方，
输入不是string,是流
输出要排序
O(N)
最可气的是 找不到他想要的算法 不让写代码，
最后5分钟,找到他想要的答案，来不及了
好苦啊 为啥大家店面就那几道题，给我这么难的一个
This problem pertains to the field of bioinformatics, but it does not
require any specialized biological knowledge. All DNA is composed of
sequences of four "letters" of nucleotides, whose abbreviations are A, C, G,
and T, strung together, for example: "AAGATCCGTC". A typical chromosome (a
very long ... 阅读全帖 |
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S***w
发帖数: 1014 | 43 前面30分钟抓着问了我过去的经历，
做了一个小题目。
然后扔出这个大题 要求O(n)
且输出排序
我先用suffix array, 说不好
然后用hashmap, o(n), 但是输出不排行
恶心的地方，
输入不是string,是流
输出要排序
O(N)
最可气的是 找不到他想要的算法 不让写代码，
最后5分钟,找到他想要的答案，来不及了
好苦啊 为啥大家店面就那几道题，给我这么难的一个
This problem pertains to the field of bioinformatics, but it does not
require any specialized biological knowledge. All DNA is composed of
sequences of four "letters" of nucleotides, whose abbreviations are A, C, G,
and T, strung together, for example: "AAGATCCGTC". A typical chromosome (a
very long ... 阅读全帖 |
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w******h
发帖数: 2 | 44 Temporal Research Technician position is available at Michigan Center for
Translational Pathology http://www.med.umich.edu/mctp/. Responsibilities include tissue culture, chromosome preparation from cultured cell lines, banding and karyotype analysis of human chromosomes, DNA preparation from bacterial culture, and preparation of direct and indirect labeled probes for multi color fluorescence in situ hybridization (FISH). The applicants will be working part time or full time with flexible sche |
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f******I
发帖数: 769 | 45
if it's chronic myelogenous leukemia you are talking about, i don't think
there is any vaccine for it,
it is one of the myeloproliferative disorder due to translocation of
chromosome 9 and 22, the so called philadelphia chromosome, it is often
diagnosed incidently with leukocytosis and thrombocytosis, in chronic phase,
which often in 4 to 5 years might accelerate into blast phase, by that time
the life expectancy is about 6 months, people normally die from bleeding or
infection,
bone marrow tra |
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g*****j
发帖数: 1211 | 46 Gleevec only works in Chronic myeloid leukemia (CML) with Philadelphia
chromosome, which is a specific chromosomal abnormality that causes most
cases of CML. I don't think that is what your father has though according
to your description. Hematologic cancer is very sophisticated medicine.
Accurate diagnosis based on molecular medicine is crucial, because we have
very effective ways to treat some disease, but little treatment for others.
BTW, I am glad that you are not only trying Hantang :) T |
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k*******g
发帖数: 629 | 47 今年3月份，lp经历了连续第二次自然流产，我们很着急，决定去医院好好查查原因。
医生给我们做了很多检查，包括给我和lp都抽血做了chromosome，之前医药版的xdjm也
有建议我们查一下这个，医生也建议查，我们当然做了。
可问题来了，上个月我收到一份账单，是查我的chromosome的费用，$833，保险一分钱
都不cover，（lp同样的检查费原价也是这个，但因为有保险，实际只交了几十块钱吧
）我想会不会是弄错了，就跟labcorp的人联系，他们帮我file了一个claim给保险公司
，结果是deny，他们的理由是这种检查有可能是作为research的用途，他们让我自己联
系保险公司。
我把情况详细汇报给了保险公司，期间他们还要了下医嘱的医生的姓名等信息，昨天收
到信，居然还是deny，原因是说it is unclear how the result of test will
directly impact the treatment being delivered to the member。
从字面意思理解，他们还是觉得我做这个检查和治疗没有什么关系。可是我做这个检查
不是为 |
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c********e
发帖数: 496 | 48 it depends, which chromosome, which segments on that chromosome,
there should be studies about it, and you may want to check it online.
i think 5-10% is big, while it totally up to you, how old you are, how many
children you have, family situation, etc. |
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C******r
发帖数: 790 | 49 http://www.plus-size-pregnancy.org/Prenatal%20Testing/prenataltest-amnios.htm#Accuracy of Amniocentesis
Accuracy of Amniocentesis
So how accurate is amniocentesis anyhow? What conditions does it test for?
What conditions does it not detect? Do "normal" results guarantee a
healthy baby?
What Conditions Amniocentesis Can Detect Accurately
Amniocentesis is very good at picking up most chromosomal birth defects,
such as Trisomies (3 chromosomes instead of a pair, such as Down Syndrome [
trisomy 21 |
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w****m
发帖数: 1245 | 50 染色体病是由于染色体数目或结构异常而发生的疾病。染色体数目异常比结构异常更为
常见。
遗传病类型：染色体病
1.数目性染色体畸变 染色体的数目异常可表现为非整倍体(aneuploid)，即其数目
并非单倍体(haploid)的整倍数，在数目上出现多或少于整倍体，如45或47条染色体。
还可表现为多倍体(polyploid)，即染色体数目整倍多于单倍体，如三倍体(triploid)
69条，四倍体 (tetraploid)92条。常见的非整倍体患者是某对染色体不是2条而出现3
条，称为三体综合征(trisomic syndrome)。如果某对染色体缺少1条，则称为单体综合
征(monosomic syndrome)。多倍体患者很少见，可见于肿瘤细胞和流产胎儿。
染色体数目异常几乎全是减数分裂不分离(non disjunction)或分裂后期迟延(
anaphase lag)的结果。在第一或第二次减数分裂时期，由于两条同源染色体未能分开
，而造成子代细胞染色体数目或多或少。
2.结构性染色体畸变 这种畸变是在细胞分裂过程中曾有染色体断裂所致。常见的
结构异常有缺失、环状染色体、易位、重复、... 阅读全帖 |
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