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发帖数: 435 | 1 【 以下文字转载自 Military 讨论区 】
发信人: envivas (envivas), 信区: Military
标 题: 重镑：新冠在2019年9月就已经在意大利流行
发信站: BBS 未名空间站 (Sun Nov 15 11:32:00 2020, 美东)
http://journals.sagepub.com/doi/10.1177/0300891620974755
Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in
Italy
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Giovanni Apolone*, Emanuele Montomoli*, Alessandro Manenti, ...
First Published November 11, 2020 Research Article
https://doi.org/10.1177/0300891620974755
Article information
No Access
Abstract
There are no robust data on the real onset of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection and spread in the prepandemic
period worldwide. We investigated the presence of SARS-CoV-2 receptor-
binding domain (RBD)–specific antibodies in blood samples of 959
asymptomatic individuals enrolled in a prospective lung cancer screening
trial between September 2019 and March 2020 to track the date of onset,
frequency, and temporal and geographic variations across the Italian regions
. SARS-CoV-2 RBD-specific antibodies were detected in 111 of 959 (11.6%)
individuals, starting from September 2019 (14%), with a cluster of positive
cases (>30%) in the second week of February 2020 and the highest number (53.
2%) in Lombardy. This study shows an unexpected very early circulation of
SARS-CoV-2 among asymptomatic individuals in Italy several months before the
first patient was identified, and clarifies the onset and spread of the
coronavirus disease 2019 (COVID-19) pandemic. Finding SARS-CoV-2 antibodies
in asymptomatic people before the COVID-19 outbreak in Italy may reshape the
history of pandemic. |
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