S*******l
发帖数: 4637 | 1 传染性更高但是极轻症状。
赶紧开发下，可比疫苗经济高效多了。没准儿轻症无症的人是感染了这一株然后对致病
性更高的新冠免疫了。
Emerg Microbes Infect. 2020; 9(1): 837–842.
Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Siu-Ying Lau,a,* Pui Wang,a,* Bobo Wing-Yee Mok,a,* Anna Jinxia Zhang,a Hin
Chu,a Andrew Chak-Yiu Lee,a Shaofeng Deng,a Pin Chen,a Kwok-Hung Chan,a
Wenjun Song,a,b Zhiwei Chen,a Kelvin Kai-Wang To,a Jasper Fuk-Woo Chan,a
Kwok-Yung Yuen,a and Honglin Chena,
CONTACT
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ABSTRACT
The emergence of SARS-CoV-2 has led to the current global coronavirus
pandemic and more than one million infections since December 2019. The exact
origin of SARS-CoV-2 remains elusive, but the presence of a distinct motif
in the S1/S2 junction region suggests the possible acquisition of cleavage
site(s) in the spike protein that promoted cross-species transmission.
Through plaque purification of Vero-E6 cultured SARS-CoV-2, we found a
series of variants which contain 15-30-bp deletions (Del-mut) or point
mutations respectively at the S1/S2 junction. Examination of the original
clinical specimen from which the isolate was derived, and 26 additional SARS
-CoV-2 positive clinical specimens, failed to detect these variants.
Infection of hamsters shows that one of the variants (Del-mut-1) which
carries deletion of 10 amino acids (30bp) does not cause the body weight
loss or more severe pathological changes in the lungs that is associated
with wild type virus infection. We suggest that the unique cleavage motif
promoting SARS-CoV-2 infection in humans may be under strong selective
pressure, given that replication in permissive Vero-E6 cells leads to the
loss of this adaptive function. It would be important to screen the
prevalence of these variants in asymptomatic infected cases. The potential
of the Del-mut variants as an attenuated vaccine or laboratory tool should
be evaluated.
KEYWORDS: Coronavirus, COVID-19, SARS-CoV-2, Spike mutant, Spike S1/S2
mutant | O**W
发帖数: 58 | 2 这文章作者都哪儿的？既有大陆拼写的华人，也有非大陆拼写的，像是香港华人名 | y****i
发帖数: 2108 | 3 没用，抗体没有保护性
Hin
exact
motif
SARS
【在 S*******l 的大作中提到】
: 传染性更高但是极轻症状。
: 赶紧开发下，可比疫苗经济高效多了。没准儿轻症无症的人是感染了这一株然后对致病
: 性更高的新冠免疫了。
: Emerg Microbes Infect. 2020; 9(1): 837–842.
: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
: Siu-Ying Lau,a,* Pui Wang,a,* Bobo Wing-Yee Mok,a,* Anna Jinxia Zhang,a Hin
: Chu,a Andrew Chak-Yiu Lee,a Shaofeng Deng,a Pin Chen,a Kwok-Hung Chan,a
: Wenjun Song,a,b Zhiwei Chen,a Kelvin Kai-Wang To,a Jasper Fuk-Woo Chan,a
: Kwok-Yung Yuen,a and Honglin Chena,
: CONTACT
| m*****u
发帖数: 15526 | 4 疫苗有传染性的，闻所未闻。这玩意生物安全过不了。
Hin
【在 S*******l 的大作中提到】
: 传染性更高但是极轻症状。
: 赶紧开发下，可比疫苗经济高效多了。没准儿轻症无症的人是感染了这一株然后对致病
: 性更高的新冠免疫了。
: Emerg Microbes Infect. 2020; 9(1): 837–842.
: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
: Siu-Ying Lau,a,* Pui Wang,a,* Bobo Wing-Yee Mok,a,* Anna Jinxia Zhang,a Hin
: Chu,a Andrew Chak-Yiu Lee,a Shaofeng Deng,a Pin Chen,a Kwok-Hung Chan,a
: Wenjun Song,a,b Zhiwei Chen,a Kelvin Kai-Wang To,a Jasper Fuk-Woo Chan,a
: Kwok-Yung Yuen,a and Honglin Chena,
: CONTACT
| s********i
发帖数: 17328 | 5 差，流感疫苗就有啊。。。注射是灭活的，喷鼻子的是减活的。。。
【在 m*****u 的大作中提到】
: 疫苗有传染性的，闻所未闻。这玩意生物安全过不了。
:
: Hin
| m*x
发帖数: 1 | 6 万一又变异出了PRRA呢？
一个位点，变异嵌入PRRA不是难事喔。
可以算算概率。
【在 m*****u 的大作中提到】
: 疫苗有传染性的，闻所未闻。这玩意生物安全过不了。
:
: Hin
| m*****u
发帖数: 15526 | 7 减活的没有传染性。
【在 s********i 的大作中提到】
: 差，流感疫苗就有啊。。。注射是灭活的，喷鼻子的是减活的。。。
| m*x
发帖数: 1 | 8 这个干，还不如台巴子的电饭锅蒸的猪油口罩呢。
都是减活疫苗！ | l*******2
发帖数: 1 | 9 日，我要找他们收版权费。
Hin
【在 S*******l 的大作中提到】
: 传染性更高但是极轻症状。
: 赶紧开发下，可比疫苗经济高效多了。没准儿轻症无症的人是感染了这一株然后对致病
: 性更高的新冠免疫了。
: Emerg Microbes Infect. 2020; 9(1): 837–842.
: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
: Siu-Ying Lau,a,* Pui Wang,a,* Bobo Wing-Yee Mok,a,* Anna Jinxia Zhang,a Hin
: Chu,a Andrew Chak-Yiu Lee,a Shaofeng Deng,a Pin Chen,a Kwok-Hung Chan,a
: Wenjun Song,a,b Zhiwei Chen,a Kelvin Kai-Wang To,a Jasper Fuk-Woo Chan,a
: Kwok-Yung Yuen,a and Honglin Chena,
: CONTACT
| m*****n
发帖数: 1631 | 10 传染性更高，变异更快，放毒啊，哈哈
Hin
【在 S*******l 的大作中提到】
: 传染性更高但是极轻症状。
: 赶紧开发下，可比疫苗经济高效多了。没准儿轻症无症的人是感染了这一株然后对致病
: 性更高的新冠免疫了。
: Emerg Microbes Infect. 2020; 9(1): 837–842.
: Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
: Siu-Ying Lau,a,* Pui Wang,a,* Bobo Wing-Yee Mok,a,* Anna Jinxia Zhang,a Hin
: Chu,a Andrew Chak-Yiu Lee,a Shaofeng Deng,a Pin Chen,a Kwok-Hung Chan,a
: Wenjun Song,a,b Zhiwei Chen,a Kelvin Kai-Wang To,a Jasper Fuk-Woo Chan,a
: Kwok-Yung Yuen,a and Honglin Chena,
: CONTACT
|
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