R****y
发帖数: 1 | | B******n
发帖数: 1920 | | R****y
发帖数: 1 | 3 蝙蝠花了俩月从美国飞到武汉？
中间怎么加的油？
: 正好这俩月病毒找中间宿主然后开始人传人.
【在 B******n 的大作中提到】
: 正好这俩月病毒找中间宿主然后开始人传人.
| B******n
发帖数: 1920 | 4 美国P4早有病毒了,看下面这个课题,2014年就开始了
Award Number: R01AI110964
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
DESCRIPTION (provided by applicant): This project will examine the risk of
future coronavirus (CoV) emergence from wildlife using in-depth field
investigations across the human-wildlife interface in China, molecular
characterization of novel CoVs and host receptor binding domain genes,
mathematical models of transmission and evolution, and in vitro and in vivo
laboratory studies of host range. Zoonotic CoVs are a significant threat to
global health, as demonstrated with the emergence of pandemic severe acute
respiratory syndrome coronavirus (SARS-CoV) in China in 2002, and the recent
and ongoing emergence of Middle East Respiratory Syndrome (MERS-CoV). Bats
appear to be the natural reservoir of these viruses, and hundreds of novel
bat-CoVs have been discovered in the last two decades. Bats, and other
wildlife species, are hunted, traded, butchered and consumed across Asia,
creating a large scale human-wildlife interface, and high risk of future
emergence of novel CoVs. This project aims to understand what factors
increase the risk of the next CoV emerging in people by studying CoV
diversity in a critical zoonotic reservoir (bats), at sites of high risk for
emergence (wildlife markets) in an emerging disease hotspot (China). The
three specific aims of this project are to: 1. Assess CoV spillover
potential at high risk human-wildlife interfaces in China. This will include
quantifying he nature and frequency of contact people have with bats and
other wildlife; serological and molecular screening of people working in wet
markets and highly exposed to wildlife; screening wild-caught and market
sampled bats from 30+ species for CoVs using molecular assays; and genomic
characterization and isolation of novel CoVs. 2. Develop predictive models
of bat CoV emergence risk and host range. A combined modeling approach will
include phylogenetic analyses of host receptors and novel CoV genes (
including functional receptor binding domains); a fused ecological and
evolutionary model to predict host-range and viral sharing; and mathematical
matrix models to examine evolutionary and transmission dynamics. 3. Test
predictions of CoV inter-species transmission. Predictive models of host
range (i.e. emergence potential) will be tested experimentally using reverse
genetics, pseudovirus and receptor binding assays, and virus infection
experiments across a range of cell cultures from different species and
humanized mice. | n*****4
发帖数: 2 | 5 你是真听不懂吗？人家说的是第一变异可以传人的变异，从关闭到变异不需要时间？
【在 R****y 的大作中提到】
: 欢迎廊坊的同志们来洗地，哈哈。
| F*****d
发帖数: 2848 | 6 在军运会开幕钱2个月主动关闭，就是为了制造不在场的假象，掩盖军运会投毒的嫌疑
。 | p*a
发帖数: 3350 | 7 这智商太感人了
【在 R****y 的大作中提到】
: 蝙蝠花了俩月从美国飞到武汉？
: 中间怎么加的油？
:
:
: 正好这俩月病毒找中间宿主然后开始人传人.
:
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