d**e
发帖数: 1124 | 1 Tired of winning
ABSTRACT
Background
In a recent survey, most physicians worldwide considered that
hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
drugs among available molecules against COVID-19. Nevertheless, to date, one
preliminary clinical trial only has demonstrated its efficacy on the viral
load. Additionally, a clinical study including 80 patients was published,
and in vitro efficiency of this association was demonstrated.
Methods
The study was performed at IHU Méditerranée Infection, Marseille, France.
A cohort of 1061 COVID-19 patients, treated for at least 3 days with the HCQ
-AZ combination and a follow-up of at least 9 days was investigated.
Endpoints were death, worsening and viral shedding persistence.
Findings
From March 3rd to April 9th, 2020, 59,655 specimens from 38,617 patients
were tested for COVID-19 by PCR. Of the 3,165 positive patients placed in
the care of our institute, 1061 previously unpublished patients met our
inclusion criteria. Their mean age was 43.6 years old and 492 were male (46.
4%). No cardiac toxicity was observed. A good clinical outcome and
virological cure was obtained in 973 patients within 10 days (91.7%).
Prolonged viral carriage at completion of treatment was observed in 47
patients (4.4%) and was associated to a higher viral load at diagnosis (p <
10-2) but viral culture was negative at day 10 and all but one were PCR-
cleared at day 15. A poor outcome was observed for 46 patients (4.3%); 10
were transferred to intensive care units, 5 patients died (0.47%) (74-95
years old) and 31 required 10 days of hospitalization or more. Among this
group, 25 patients are now cured and 16 are
still hospitalized (98% of patients cured so far). Poor clinical outcome was
significantly associated to older age (OR 1.11), initial higher severity (
OR 10.05) and low 2 hydroxychloroquine serum concentration. In addition,
both poor clinical and virological outcomes were associated to the use of
selective beta-blocking agents and angiotensin II receptor blockers (P<0.05)
. Mortality was significantly lower in patients who had received > 3 days of
HCQ-AZ than in patients treated with other regimens both at IHU and in all
Marseille public hospitals (p< 10-2).
Interpretation
The HCQ-AZ combination, when started immediately after diagnosis, is a safe
and efficient treatment for COVID-19, with a mortality rate of 0.5%, in
elderly patients. It avoids worsening and clears virus persistence and
contagiosity in most cases. |
a*********n
发帖数: 390 | 2 这个又字从何而来？到现在为止川普就没对过啊
one
viral
【在 d**e 的大作中提到】
: Tired of winning
: ABSTRACT
: Background
: In a recent survey, most physicians worldwide considered that
: hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
: drugs among available molecules against COVID-19. Nevertheless, to date, one
: preliminary clinical trial only has demonstrated its efficacy on the viral
: load. Additionally, a clinical study including 80 patients was published,
: and in vitro efficiency of this association was demonstrated.
: Methods
|
Y*****k
发帖数: 1 | 3 他说CNN fake news基本还是对的。
【在 a*********n 的大作中提到】
: 这个又字从何而来？到现在为止川普就没对过啊
:
: one
: viral
|
s*****r
发帖数: 11545 | |
l*******1
发帖数: 1 | 5 Win again, endless wins, tired of wins
【在 a*********n 的大作中提到】
: 这个又字从何而来？到现在为止川普就没对过啊
:
: one
: viral
|
V*******n
发帖数: 1 | 6 hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
drugs among available molecules against COVID-19.
这他妈的是文盲写的或者是四月一号笑话。 |
d**e
发帖数: 1124 | 7 没学过有机化学吗？
大分子
hydroxychloroquine
Property Name Property Value Reference
Molecular Weight 335.9 g/mol Computed by PubChem 2.1 (PubChem release
2019.06.18)
Azithromycin, as the dihydrate, is a white crystalline powder with a
molecular formula of C38H72N2O12•2H2O and a molecular weight of 785.0.
【在 V*******n 的大作中提到】
: hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
: drugs among available molecules against COVID-19.
: 这他妈的是文盲写的或者是四月一号笑话。
|
z**********5
发帖数: 63 | 8 "5 patients died (0.47%)"
"Mortality was significantly lower in patients who had received > 3 days of
HCQ-AZ than in patients treated with other regimens both at IHU and in all
Marseille public hospitals (p< 10-2)."
很神奇的样子。一共就5个人死了，他们还能够得出用药组死亡率显著的低？ |
V*******n
发帖数: 1 | 9 这文盲居然没看懂这句话的毛病，智商啊。。。
release
0.
【在 d**e 的大作中提到】
: 没学过有机化学吗？
: 大分子
: hydroxychloroquine
: Property Name Property Value Reference
: Molecular Weight 335.9 g/mol Computed by PubChem 2.1 (PubChem release
: 2019.06.18)
: Azithromycin, as the dihydrate, is a white crystalline powder with a
: molecular formula of C38H72N2O12•2H2O and a molecular weight of 785.0.
|
d**e
发帖数: 1124 | 10 这个不是临床试验，没有placebo对比组,只能和统计数字比了
of
【在 z**********5 的大作中提到】
: "5 patients died (0.47%)"
: "Mortality was significantly lower in patients who had received > 3 days of
: HCQ-AZ than in patients treated with other regimens both at IHU and in all
: Marseille public hospitals (p< 10-2)."
: 很神奇的样子。一共就5个人死了，他们还能够得出用药组死亡率显著的低？
|
|
|
z**********5
发帖数: 63 | 11
你这个回答比原作者更加高深。
【在 d**e 的大作中提到】
: 这个不是临床试验，没有placebo对比组,只能和统计数字比了
:
: of
|
d**e
发帖数: 1124 | 12 你英文不好不要现眼
In a recent survey, most physicians worldwide considered that
hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
drugs among available molecules against COVID-19.
主语:most physicians worldwide
谓语：considered
宾语从句： that hydroxychloroquine (HCQ) and azithromycin (AZ) are the two
most effective drugs among available molecules against COVID-19.
宾语从句内 -
主语：hydroxychloroquine (HCQ) and azithromycin (AZ)
谓语：are
宾语：the two most effective drugs against COVID-19.
among available molecules是定语，定宾语的
【在 V*******n 的大作中提到】
: 这文盲居然没看懂这句话的毛病，智商啊。。。
:
: release
: 0.
|
d**e
发帖数: 1124 | 13 没啥啊，这个study就是主媒说的antidote evidence
【在 z**********5 的大作中提到】
:
: 你这个回答比原作者更加高深。
|
V*******n
发帖数: 1 | 14 真是智商不行没法说。。。提示问题不在语法。。。
【在 d**e 的大作中提到】
: 你英文不好不要现眼
: In a recent survey, most physicians worldwide considered that
: hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
: drugs among available molecules against COVID-19.
: 主语:most physicians worldwide
: 谓语：considered
: 宾语从句： that hydroxychloroquine (HCQ) and azithromycin (AZ) are the two
: most effective drugs among available molecules against COVID-19.
: 宾语从句内 -
: 主语：hydroxychloroquine (HCQ) and azithromycin (AZ)
|
V*******n
发帖数: 1 | 15 啥叫antidote evidence？文盲啊。 LOL
【在 d**e 的大作中提到】
: 没啥啊，这个study就是主媒说的antidote evidence
|
w*****s
发帖数: 2896 | 16 这篇文章是什么时候发表的？要真是这样，那HCQ和AZ确实有效啊，而且很有效。
川普也不是随便说说的，他也是听了那位纽约有名的临床医生介绍后认为有效，才推荐
的。而这位临床医生，也是看了法国研究机构的结论，照着做的，有点试验味道，死马
当活马医，试了几百人，结果疗效很好。
但据说川普有生产AZ的药厂的股份，所以成了利益攸关者了，这样又有故意做广告的嫌
疑。
事实到底怎样，应该马上就会有公论。 |
d**e
发帖数: 1124 | 17 和china virus一样的用法啊
名词可以替做形容词的
你学院大阴小刘的英语就不要现眼了
人家那句话没问题。
【在 V*******n 的大作中提到】
: 啥叫antidote evidence？文盲啊。 LOL
|
V*******n
发帖数: 1 | 18 笑死人了。。。。。哈哈哈哈哈。
【在 d**e 的大作中提到】
: 和china virus一样的用法啊
: 名词可以替做形容词的
: 你学院大阴小刘的英语就不要现眼了
: 人家那句话没问题。
|
d**e
发帖数: 1124 | 19 你说说那句话啥问题啊
【在 V*******n 的大作中提到】
: 笑死人了。。。。。哈哈哈哈哈。
|
g******y
发帖数: 1 | |
p********2
发帖数: 1 | 21 挺好啊，有人看见药有效要哭丧什么心态。
one
viral
【在 d**e 的大作中提到】
: Tired of winning
: ABSTRACT
: Background
: In a recent survey, most physicians worldwide considered that
: hydroxychloroquine (HCQ) and azithromycin (AZ) are the two most effective
: drugs among available molecules against COVID-19. Nevertheless, to date, one
: preliminary clinical trial only has demonstrated its efficacy on the viral
: load. Additionally, a clinical study including 80 patients was published,
: and in vitro efficiency of this association was demonstrated.
: Methods
|
