M*****n
发帖数: 16729 | 1 Basically, inbreeding dramatically increases the frequency of homozygosity,
which is the cause of lots of recessive genetic disorders in human being.
eg. regarding allele a, the ratio of homozygotes (aa) among the progenies of a
random mating is only a*a, while from an inbreeding you mentioned is 1/64.
Usually the recesssively pathogenic alleles are rare, and thus a<<1/8.
Therefore the risk for your gf to get two a alleles, which results in a
recessive homozygote, is much higher than the others. |
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