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MedicalCareer版 - Step1 NBME#11 一题求教~
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话题: pertussis话题: barking话题: ac话题: activity话题: adenylyl
进入MedicalCareer版参与讨论
1 (共1页)
s********o
发帖数: 21
1
29. A previously health 6 month old boy develops fever and severe paroxysmal
barking coughing. He has not had any immunizations. His leukocyte count is
30,000/mm3 (70% lymphocytes). Neutrophil chemotaxis and oxidative metabolism
are defective due to increased activity of which of the following enzymes?
A. adenylyl cyclase
B. MPO
C. NADPH oxidase
D. Phospholipase C
E. Protein Kinase C
论坛上不少人选A,并且说是B. Pertussis 感染,请问大家什么看法啊?
我自己觉得:
1. 如果确定是Pertussis感染,adenylyl cyclase (AC)的activity就会up-
regulated. 但是,AC activity 会影响oxidative metabolism吗?
2. Pertussis感染典型症状应该是Whooping cough~ barking cough貌似是
parainfluenza infection的典型症状~ 真的确定这题是Pertussis吗?
3. 这题能选择C吗?
谢谢各位啦~
h**********a
发帖数: 74
2
百日咳的特点是淋巴细胞增加和低血糖,FA上没有写。小孩半岁发病,这个时间点考虑
百日咳。
这道题是容易出错,难点一在于诊断室百日咳,难点二在于要联想到百日咳上调cAMP,
FA2014,126面。
s********o
发帖数: 21
3
谢谢啦~ 感觉挺有道理的~
我主要是有点儿被 Barking Cough 给misled
谢谢~ 以后多讨论!

【在 h**********a 的大作中提到】
: 百日咳的特点是淋巴细胞增加和低血糖,FA上没有写。小孩半岁发病,这个时间点考虑
: 百日咳。
: 这道题是容易出错,难点一在于诊断室百日咳,难点二在于要联想到百日咳上调cAMP,
: FA2014,126面。

1 (共1页)
进入MedicalCareer版参与讨论
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帮忙分析一下CBC test resultKawaski disease? Pediatricans please come in to discuss this case.
相关话题的讨论汇总
话题: pertussis话题: barking话题: ac话题: activity话题: adenylyl