b*********y
发帖数: 93 | 1 就是fa神经系统一章的神经肌肉阻滞药物, 去极化药物succinylcholine: FA上写的是
在phase II, 可以用cholinesterase inhibitor解救. 可我理解的是,在phase II, N受
体都已经去敏感化了, 什么都不能激动它了, 即使给予再多的Ach也不能激动了. 我从
网上查到的也都是这个结论. 但FA 近几年都是这样写的, 好像没人指出它是错的. 哪
位大虾能帮俺解释一下捏? 先拜了 | s******n
发帖数: 2279 | 2 不是大虾啊，我蛮喜欢这种方式的讨论，能让我仔细看看自己也不是很清楚地东西
quote from "Basic and Clinical Pharmacology"
DEPOLARIZING RELAXANT DRUGS
Phase I Block (Depolarizing)
Succinylcholine is the only clinically useful depolarizing blocking drug.
Its neuromuscular effects are like those of acetylcholine except
that succinylcholine produces a longer effect at the myoneural junction.
Succinylcholine reacts with the nicotinic receptor to open the
channel and cause depolarization of the motor end plate, and this in turn
spreads to t | b*********y
发帖数: 93 | |
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