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发帖数: 18160 | 1 【 以下文字转载自 Biology 讨论区 】
发信人: Suave911 (911), 信区: Biology
标 题: Post-doc Position in Vascular Biology/Signal Transduction
发信站: BBS 未名空间站 (Fri Jun 21 10:22:51 2013, 美东)
Post-doc Position in Vascular Biology/Signal Transduction
Molecular Cell Biology, Leiden University Medical Center, The Netherlands
A Post-Doctoral position is available in a dynamic, international and
interdisciplinary research team to study the molecular basis of subverted
TGF- signal transduction in cardiovascular biology.
Focus of the research group: Our group is interested in unraveling
mechanisms by which TGF-β family members elicit their multifunctional
cellular effects and how perturbation in their signal transduction pathways
contribute to diseases. The present focus within our group is on 1) the
identification of novel critical (de)ubiquitin ligase regulators of TGF-β
family signaling pathways, 2) how TGF-β family receptor signaling
specificity is (dynamically) regulated and 3) interplay with Wnt and other
signaling pathways. We use mouse and zebrafish models. Our long term aim is
to translate our findings towards the development of novel treatments.
Project description Pulmonary arterial hypertension (PAH) is a fatally
progressive form of PH with characteristic changes in small lung arteries.
PH almost invariably leads to right heart failure and death. Mutations in
the BMP type II receptor are responsible for 80% of heritable PAH cases, yet
deregulation of BMP signaling also occurs in non-hereditary forms of PAH.
BMP is frequently antagonized by transforming growth factor-β (TGF-β). We
hypothesize that an imbalance in TGF-β and BMP signaling and a vicious
circle of alterations in pulmonary blood flow velocity and pressure are at
the basis of vascular remodeling in all types of PH. Our aim is to break the
vicious circle in a multidisciplinary approach in which patient and
preclinical material is used to characterize altered TGF-β/BMP signaling
and pulmonary vascular remodeling. Genetic approaches will be used to
identify key regulators and targets of BMP/TGF- receptor and Smad
signaling in vascular cells. Specific small molecule drugs will be
identified to normalize the TGF-β/BMP imbalance and tested in preclinical
models.
Requirements: We are searching for a highly motivated and experimentally
talented scientist with drive to answer important fundamental and
biomedical research questions. Applicants should hold a recent Ph.D. and
have a strong background in biochemistry and molecular cell biology and have
previous experience in signal transduction. Reporting and publishing the
results in high impact scientific journals and at international conferences
is expected. The employment will be for a period of 2 years with possibility
for extension. Start date: August, 2013 to January 2014.
Selected References: Zhang et al. (2012) Mol Cell, 46:650-61. Zhang et al.
(2012) Nat Cell Biology, 14:717-26.
Please send a cover letter with curriculum vitae, a description of research
accomplishments, and contact information of two references to:
Peter ten Dijke, Molecular Cell Biology, Leiden University Medical Center,
Postbus 9600, 2300 RC Leiden, The Netherlands; Email: p*********[email protected].
http://www.lumc.nl/con/1050/85468/812090135182537/8121001255725 |
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