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发帖数: 18160 | 1 【 以下文字转载自 Chemistry 讨论区 】
发信人: plainer (又是一年), 信区: Chemistry
标 题: San Diego bioanalysis position
发信站: BBS 未名空间站 (Thu May 22 22:51:55 2014, 美东)
Research Associate/Associate Scientist (DMPK)
Location: La Jolla, California 92121
Position type: Full time
Job Code: WB-DMPK-03
Required education: BS/MS Degree
Area(s) of expertise desired: Bioanalysis, LC-MS/MS, ADME/PK
Description: Wellspring Biosciences is discovering and developing small
molecule drugs that target signal transduction networks for the treatment of
cancer and other diseases. Through partnerships with academic and industry
experts, we are translating chemical and biological insights into highly
targeted, novel drugs. Our team has a proven track record of drug discovery
and development, having played pivotal roles in the discovery of clinical-
stage compounds for the treatment of cancer and immune-mediated inflammatory
diseases at Intellikine.
We are currently seeking a Research Associate/Associate Scientist to join
our experienced drug discovery team in San Diego. This is a hands-on
position within our DMPK group with responsibility to perform various in
vitro and in vivo ADME/PK studies to support small molecule drug discovery
projects. The ideal candidate will have industrial experience in aspects of
LC-MS/MS based bioanalysis or ADME/PK. A strong team player who enjoys
scientific discovery and has the ability to communicate and collaborate in
an interdisciplinary and fast-paced environment is essential.
Responsibilities:
Prepare in vitro and in vivo bioanalytical samples and execute
routine bioanalysis tasks in a timely manner with minimal supervision.
Develop bioanalytical methods and analyze PK/PD biological samples
(various matrices) using quantitative LC-MS/MS assays.
Perform a variety of in vitro ADME experiments such as liver
microsomal incubation, solubility, plasma stability, metabolic stability,
CYP inhibition, etc.
Interact and communicate professionally with supervisors, peers,
and team members.
Maintain proper documentation, such as laboratory notebooks and
electronic report files.
Requirements
BS/MS in Analytical Chemistry or Biochemistry with 5+ years
industrial (pharmaceutical/biotech) experience in the bioanalysis scientific
discipline.
Hands-on experience on LC-MS/MS and automated liquid handlers.
Ability to set up, validate, and conduct new DMPK assays.
Strong knowledge of the principles of drug metabolism and
pharmacokinetics is a plus.
Wellspring Biosciences offers an attractive salary and benefits package,
including equity incentives. Applicants must be authorized to work in the U.
S.
To apply, please submit your resume to c*****[email protected]. |
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