A***X
发帖数: 7 | 1 Hi All,
I am having difficulties on synthesizing the product below. I can only find
two methods reported in Literature. The first one is way too complicated.
Unless I really don't have any other choices, I would like to leave this
method as my last choice. The second one requires "autoclave", which I
couldn't do at all.
So, can anybody help me on this --- find other ways to synthesize the
product? The method can be just a speculation, as long as it is reasonable.
I can always to give a try to see it will work or not. Thanks in advance. | x********i
发帖数: 130 | | a********h
发帖数: 89 | 3 第一种靠谱。
Chem. Commun., 2011,47, 5181–5183
看这篇文献，条件一样，只需要变一下锌试剂。 | s***k
发帖数: 29 | 4 Try a new strategy:
Do the C-H activation at the benzylic position | A***X
发帖数: 7 | 5 Thanks. Actually I tried this one. The chemistry worked fine. But the
problem is that I can only get a mixture of isomers from the coupling
product on the different position of the alky chain. There is no way I can
purify the product from these isomers. They are so close on GC and TLC. So,
I gave up on this method. If anybody has any idea on how to control these
isomers, please let me know. Thanks.
【在 a********h 的大作中提到】
: 第一种靠谱。
: Chem. Commun., 2011,47, 5181–5183
: 看这篇文献，条件一样，只需要变一下锌试剂。
| A***X
发帖数: 7 | 6 Thanks. It might be a good approach. Do you have any reference on this? or,
if you have something in your mind, can you share with me. Reaction scheme
would be fine to me. Thanks.
【在 s***k 的大作中提到】
: Try a new strategy:
: Do the C-H activation at the benzylic position
|
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