e**r
发帖数: 1144 | 1 感染不是会发烧么？
动物和人的反应是不一样的吗？ |
n***w
发帖数: 2405 | 2 Toxins may affect the brain temperature regulation function. |
r******g
发帖数: 600 | 3 Theoretically, LPS should induce cytokine storm, including TNF-a and IL-6,
through direct stimulation of PRRs. TFNa, IL-6 and other innate cytokines
lead to increased body temperature by directly stimulating hypothalamus temp
control system.
It seems to me that a septic shock happened in your model. It is pretty much
what happened to human during severe bacteria infection, especially
bacteremia.
High dose of LPS leads to septic shock, which lowers blood pressure and
blood temperature (can be very low), followed by multiple organ dysfunction
syndrome. You can take it as one of the death-approaching signs.
All my guess. |
z*******6
发帖数: 679 | 4 Raryyang is correct... Typical septic shock will lead to thermopenia... |
S*********s
发帖数: 304 | 5 http://www.nature.com/nature/journal/v506/n7489/full/nature1302
in recent Maters aring paper.
RIP3 KO can prevent LPS induced low body temperature.
temp
much
dysfunction
【在 r******g 的大作中提到】
: Theoretically, LPS should induce cytokine storm, including TNF-a and IL-6,
: through direct stimulation of PRRs. TFNa, IL-6 and other innate cytokines
: lead to increased body temperature by directly stimulating hypothalamus temp
: control system.
: It seems to me that a septic shock happened in your model. It is pretty much
: what happened to human during severe bacteria infection, especially
: bacteremia.
: High dose of LPS leads to septic shock, which lowers blood pressure and
: blood temperature (can be very low), followed by multiple organ dysfunction
: syndrome. You can take it as one of the death-approaching signs.
|
r******g
发帖数: 600 | 6 看不了，再发一遍～ 谢谢啊
【在 S*********s 的大作中提到】
: http://www.nature.com/nature/journal/v506/n7489/full/nature1302
: in recent Maters aring paper.
: RIP3 KO can prevent LPS induced low body temperature.
:
: temp
: much
: dysfunction
|
S*********s
发帖数: 304 | |
r******g
发帖数: 600 | 8 TNF other than LPS.
Check out the paper.
【在 S*********s 的大作中提到】
: http://www.nature.com/nature/journal/v506/n7489/full/nature1302
|
