http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2472.htm
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by
folate receptor-a targeting: first in-human results
Abstract:
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-speci
fic intraoperative fluorescence imaging may improve staging and debulkin
g efforts in cytoreductive surgery and thereby improve prognosis. The ov
erexpression of folate receptor-a (FR-a) in 905% of epithelial ovarian
cancers prompted the investigation of intraoperative tumor-specific flu
orescence imaging in ovarian cancer surgery using an FR-a杢argeted fluor
escent agent. In patients with ovarian cancer, intraoperative tumor-spec
ific fluorescence imaging with an FR-a杢argeted fluorescent agent showca
sed the potential applications in patients with ovarian cancer for impro
ved intraoperative staging and more radical cytoreductive surgery.
