j*****d
发帖数: 787 | 1 =====>>>>>>> 为稀释版面灌点水......
NBT 二月份有两份报告显示可以通过 基因打靶 修饰 human 活体细胞，看得我心里痒
痒的。美国funding势必继续大批超这个方向转移，作为在mouse genetic领域的也看到
了威胁。
而且，我觉得我们距离科幻世界的确不远了，如果我们 定点 修饰人类细胞的技术 更
趋成熟，定向制造 更强壮 更聪明 更忠贞 human cell 是非常可能的。
http://www.nature.com/nbt/journal/v29/n2/pdf/nbt.1755.pdf
http://www.nature.com/nbt/journal/v29/n2/pdf/nbt.1775.pdf （这篇还是zhang feng哥的）
随后上个月，分别有三个组发现 TALEN 这项技术竟然在大鼠和小鱼里也得心应手！
Knockout rats generated by embryo microinjection of TALENs - pp695 - 696
Laurent Tesson, Claire Usal, Séverine Ménoret, Elo Leung, Brett J Niles, S
éverine Remy, Yolanda Santiago, Anna I Vincent, Xiangdong Meng, Lei Zhang,
Philip D Gregory, Ignacio Anegon & Gregory J Cost
doi:10.1038/nbt.1940
Full Text - Knockout rats generated by embryo microinjection of TALENs | PDF
(259 KB) - Knockout rats generated by embryo microinjection of TALENs |
Supplementary information
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Targeted gene disruption in somatic zebrafish cells using engineered TALENs
- pp697 - 698
Jeffry D Sander, Lindsay Cade, Cyd Khayter, Deepak Reyon, Randall T Peterson
, J Keith Joung & Jing-Ruey J Yeh
doi:10.1038/nbt.1934
Full Text - Targeted gene disruption in somatic zebrafish cells using
engineered TALENs | PDF (174 KB) - Targeted gene disruption in somatic
zebrafish cells using engineered TALENs | Supplementary information
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Heritable gene targeting in zebrafish using customized TALENs - pp699 - 700
Peng Huang, An Xiao, Mingguo Zhou, Zuoyan Zhu, Shuo Lin & Bo Zhang
doi:10.1038/nbt.1939
Full Text - Heritable gene targeting in zebrafish using customized TALENs |
PDF (281 KB) - Heritable gene targeting in zebrafish using customized TALENs
| Supplementary information |
