w*****n
发帖数: 310 | 1 请问有人知道SLC2A1(Facilitated glucose transporter)的药吗？记得好像是个减肥
药． |
w*****n
发帖数: 310 | |
d**********r
发帖数: 36 | 3 CytochalasinB or phloretin? |
w*****n
发帖数: 310 | 4 谢谢!不过这两个都太不特异了.一包子答谢.
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d***3
发帖数: 181 | 5 Are you asking for Slc2a1 or Slc5a1?
【在 w*****n 的大作中提到】
: 请问有人知道SLC2A1(Facilitated glucose transporter)的药吗？记得好像是个减肥
: 药．
|
s*******e
发帖数: 1010 | 6 GLUT有特异性的抑制剂吗？那岂止减肥，简直可以做化疗药物了。 |
d***3
发帖数: 181 | 7 Slc2a1 is Glut1, mainly expressed in liver, brain, and red blood cells.
Slc5a1 is Sglt1, which is the major transporter responsible for intestinal
glucose absorption. I don't think there is any Glut1 inhibitor on the market
. CNS side effect can be a major concern for Glut1 inhibition. Sglt1
inhibitors or Sglt1/Sglt2 dual inhibitors are being developed for diabetes
and obesity. Sglt2 (mainly in kidney) inhibitors are more advanced in
development. The primary indication for Sglt2 inhibition is diabetes. It may
have some limited effects on obesity.
【在 d***3 的大作中提到】
: Are you asking for Slc2a1 or Slc5a1?
|
w*****n
发帖数: 310 | |
w*****n
发帖数: 310 | 9 一包子答谢.
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