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发帖数: 9831 | 1 http://www.youtube.com/watch?v=kkVEGVHcxNQ
http://www.npr.org/blogs/health/2013/08/12/210487410/new-muscle
Research intended to help people with muscle-wasting diseases could be about
to launch a new era in performance-enhancing drugs.
The research has produced several muscle-building drugs now being tested in
people with medical problems, including muscular dystrophy, cancer and
kidney disease. The drugs all work by blocking a substance called that the
body normally produces to keep muscles from getting too big.
It's likely that at least one of the drugs will receive FDA approval in the
next few years, researchers say.
"When the myostatin inhibitors come along, they'll be abused," says , a
bodybuilder and a physician in Greenwich, Conn., who works with professional
athletes. "There's no question in my mind."
One reason is that athletes and bodybuilders have seen pictures of animals
like Belgian Blue bulls, which naturally lack myostatin and appear to be
made of muscle. "They're huge," Colker says. "I mean they're ridiculous
looking."
Athletes and bodybuilders have been fascinated by myostatin ever since it
was discovered in the 1990s by a researcher at Johns Hopkins named . If you
visit Lee's mouse lab, you can see why the discovery got so much attention.
The secured facility is filled with rows of plastic cages containing some
very muscular mice. "They look bulked up," he says, and they are. Lee
gestures toward the cages on one shelf. "Those mice," he says, "have about
twice the muscle mass of normal mice."
"So when you get rid of the myostatin gene entirely, you see more muscle
fibers, and then you get bigger muscle fibers," Lee says. | I***i
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