v******l
发帖数: 235 | 1 求Paper, 请发到 j********[email protected]. 包子答谢!
PMID: 19546862
[PubMed - indexed for MEDLINE]
Nat Rev Nephrol. 2009 Aug;5(8):441-9. Epub 2009 Jun 23.
The role of transient receptor potential channels in kidney disease.
Woudenberg-Vrenken TE, Bindels RJ, Hoenderop JG.
Source
Department of Physiology, Radboud University Nijmegen Medical Centre,
Nijmegen, The Netherlands.
Abstract
The transient receptor potential (TRP) superfamily consists, in mammals, of
six protein subfamilies, TRPC, TRPM, TRPV, T... 阅读全帖 |
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a***y
发帖数: 19743 | 2 在英国的Xiangchao Gan牛啊。
Genetic differences between Arabidopsis thaliana accessions underlie the
plant’s extensive phenotypic variation, and until now these have been
interpreted largely in the context of the annotated reference accession Col-
0. Here we report the sequencing, assembly and annotation of the genomes of
18 natural A. thaliana accessions, and their transcriptomes. When assessed
on the basis of the reference annotation, one-third of protein-coding genes
are predicted to be disrupted i... 阅读全帖 |
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l**********1
发帖数: 5204 | 3
Patch Clamp founder: Erwin Neher and Bert Sakmann stood on the shoulders of
1963 Nobel Prize in Physiology or Medicine winners:
Hodgkin and Huxley
//www.nobelprize.org/nobel_prizes/medicine/laureates/1963/#
//en.wikipedia.org/wiki/Hodgkin-Huxley_model
details
cited from
//www.kenrico.com/media/bembook/04/04.htm
This chapter describes the voltage clamp device, the experiments of Hodgkin
and Huxley, the mathematical model into which their data were fitted, and
the resulting simula... 阅读全帖 |
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l**********1
发帖数: 5204 | 4 please go to
//evol.mcmaster.ca/cgi-bin/my_wrap/brian/evoldir/PostDocs/
then search web with key word:
Droso
match three
then click just one:
Postdoctoral Researcher in Drosophila Evolutionary Genomics
Potential start dates are between April 1 and July 1, 2012. Please
indicate the earliest start date you would consider.
Feel free to contact me with any questions (jpool (at) wisc.edu).
John Pool
Assistant Professor
Laboratory of Genetics
University of Wisconsin-Madison
jpool (at )wisc.edu
----
A... 阅读全帖 |
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p*****c
发帖数: 20445 | 5 Christopher D. Lima, Ph.D.
Memorial Sloan-Kettering Cancer Center
Christopher Lima doesn’t pick easy problems. A structural biologist, he is
investigating how cells attach small proteins—like ubiquitin and the
related molecule SUMO—to other proteins to modify their function or fate.
Alongside those studies, he is exploring the molecular mechanisms that
underlie RNA processing and degradation—modifications to an RNA copy of a
gene that influence its stability and ability to be used as a template ... 阅读全帖 |
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p*****c
发帖数: 20445 | 6 Michael Rape, Ph.D.
University of California, Berkeley
Michael Rape’s love of science began in the basement of his parent’s house
, where he used to conduct rudimentary biochemistry experiments. Today, he
uses far more sophisticated methods to understand a complex process critical
to nearly all organisms: ubiquitylation. The term describes the attachment
of a regulatory protein called ubiquitin—named for its ubiquity—onto other
proteins. Ubiquitin tags communicate a wealth of information to the ... 阅读全帖 |
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r*********e
发帖数: 27 | 7 Albert Lasker
Basic Medical Research Award
Award Description
Richard H. Scheller and Thomas C. Südhof
For discoveries concerning the molecular machinery and regulatory mechanism
that underlie the rapid release of neurotransmitters.
The 2013 Albert Lasker Basic Medical Research Award honors two scientists
for their discoveries concerning rapid neurotransmitter release, a process
that underlies all of the brain's activities. Richard H. Scheller (Genentech
) and Thomas C. Südhof (Stanford Universit... 阅读全帖 |
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n*********m
发帖数: 38 | 8 Another controversial story!!!!!
Albert Lasker
Basic Medical Research Award
Award Description
Richard H. Scheller and Thomas C. Südhof
For discoveries concerning the molecular machinery and regulatory mechanism
that underlie the rapid release of neurotransmitters. |
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m******g
发帖数: 467 | 9 Science 13.11.15 (包含Editor's Choice等推荐的其他杂志的文章，之后省略这句话)
推荐：
1. Dosage compensation via transposable element mediated rewiring of a
regulatory network
D. miranda在1 my前出现neo-X chromosome, TE-mediated rewiring of regulatory
network (domestication, amplification, and fine-tuning) followed by erosion
of nonfunctional parts of the transposon
idea挺有趣的.
2. Long-term dynamics of adaptation in asexual populations
Power law model fits/predicts the data better than Hyperbolic model with an
asymptote.
Fitne... 阅读全帖 |
|
m******g
发帖数: 467 | 10 祝大家新年快乐！
我果然坑了，呵呵，这个帖子好久没更新。
圣诞节期间在忙别的没用的事情去了
以后求不坑，呵呵……
PNAS 13.11.26
推荐：
1. Gene amplification and microsatellite polymorphism underlie a recent
insect host shift
Model: polyphagous aphid
Host shift to feed on tobacco
expression level of CYP6CY3
expansion of dinucleotide microsatellite in promoter and a recent gene
amplification
稍微了解一下：
1. Intrinsic karyotype stability and gene copy number variations may have
laid the foundation for tetraploid wheat formation
allopolyploidy of tetraploid whea... 阅读全帖 |
|
m******g
发帖数: 467 | 11 Science 13.11.15 (包含Editor's Choice等推荐的其他杂志的文章，之后省略这句话)
推荐：
1. Dosage compensation via transposable element mediated rewiring of a
regulatory network
D. miranda在1 my前出现neo-X chromosome, TE-mediated rewiring of regulatory
network (domestication, amplification, and fine-tuning) followed by erosion
of nonfunctional parts of the transposon
idea挺有趣的.
2. Long-term dynamics of adaptation in asexual populations
Power law model fits/predicts the data better than Hyperbolic model with an
asymptote.
Fitne... 阅读全帖 |
|
m******g
发帖数: 467 | 12 祝大家新年快乐！
我果然坑了，呵呵，这个帖子好久没更新。
圣诞节期间在忙别的没用的事情去了
以后求不坑，呵呵……
PNAS 13.11.26
推荐：
1. Gene amplification and microsatellite polymorphism underlie a recent
insect host shift
Model: polyphagous aphid
Host shift to feed on tobacco
expression level of CYP6CY3
expansion of dinucleotide microsatellite in promoter and a recent gene
amplification
稍微了解一下：
1. Intrinsic karyotype stability and gene copy number variations may have
laid the foundation for tetraploid wheat formation
allopolyploidy of tetraploid whea... 阅读全帖 |
|
m******g
发帖数: 467 | 13 Science 14.03.07
推荐：
1. The Secret Garden—Epigenetic Alleles Underlie Complex Traits
inherited across generations in plant genomes
QTL mapping for traits
future: environmentally induced transgenerationally stable epialleles
Actual paper: Mapping the Epigenetic Basis of Complex Traits
稍微了解一下：
1. A Genomic Road Map for Complex Human Disease
小知识：
1. Combating Evolution to Fight Disease
2. Review - Developments in X-ray Crystallographic Structure Determination
of Biological Macromolecules
3. A Sing... 阅读全帖 |
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m******g
发帖数: 467 | 14 PNAS 14.05.27
推荐：
1. Repair of DNA double-strand breaks by templated nucleotide sequence
insertions derived from distant regions of the genome
2. Genome-wide high-resolution mapping of chromosome fragile sites in
Saccharomyces cerevisiae
reduced level of DNA pol alpha
galactose-inducible GAL1 promoter to control level
map LOH after crossing two strains
稍微了解一下：
1. Interactions between chromosomal and nonchromosomal elements reveal
missing heritability
小知识：
1. Selection and constraint underlie ir... 阅读全帖 |
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o*****h
发帖数: 293 | 15 Scientist (Data Curation/Analytics)
Omicsoft - Cary, NC
Company Description:
Omicsoft Corporation is the leader in providing enterprise solutions for
next-generation sequencing and Omics data analysis, management, and
visualization. Our flagship product, Array Suite (Array Studio and Array
Server), provides full data management with server-client architecture.
Array Server stores and manages all of the large data for users, while Array
Studio provides the graphical user interface and full visual... 阅读全帖 |
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m******g
发帖数: 467 | 16 Science 15.01.16
小知识：
1. Expectations of brilliance underlie gender distributions across academic
disciplines
个人觉得这篇paper就是个噱头…… |
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w***r
发帖数: 709 | 17 表达某种受体蛋白在所有细胞表面，以增加得病时基因治疗的效率
endogenous crispr cas9,受体导入rna,癌突变随意切
Uptake of extracellular double-stranded RNA by SID-2.
McEwan DL1, Weisman AS, Hunter CP.
Author information
Abstract
Ingested dsRNAs trigger RNA interference (RNAi) in many invertebrates,
including the nematode Caenorhabditis elegans. Here we show that the C.
elegans apical intestinal membrane protein SID-2 is required in C. elegans
for the import of ingested dsRNA and that, when expressed in Drosophila S2
cells, SID-2 enables t... 阅读全帖 |
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V******t
发帖数: 444 | 18 他做博后期间发过cell？？
Publications
1.Jiang H, Guo W, Liang X, Rao Y (2005). Both the establishment and the
maintenance of neuronal polarity require active mechanisms: critical roles
of GSK-3beta and its upstream regulators. Cell 120:123-35. (Highlighted in
Science 307:646 (2005), and Nature Review Neuroscience 6:172-173(2005),
commented in Current Biology 15: R198-200)
2.Jiang H, Rao Y (2005). Axon formation: fate versus growth. Nat Neurosci.8:
544-6.
3.Ward ME, Jiang H, Rao Y (2005). Regulated formati... 阅读全帖 |
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a*****g
发帖数: 19398 | 20 幼教数学 What is Early Math and Why Should We Care?
[Posted by Ben Braun]
By Jennifer S. McCray, Assistant Research Scientist and Director of the
Early Math Collaborative at Erikson Institute [SEE http://www.erikson.edu/early-math-collaborative/ -- See this site]
Effective early childhood math teaching is much more challenging than most
people anticipate. Because the math is foundational, many people assume it
takes little understanding to teach it, and unfortunately this is distinctly
not the case... 阅读全帖 |
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d*******n
发帖数: 524 | 21 Not sure what you meant by "to control the portfolio risk by minimize the
implied volatility".
But in general, to estimate/understand/manage risk it's better to use
historical volatility, which is real-world vol, rather than implied
volatility, which is vol in risk-neutral prob space.
There is no such thing as one vol is more accurate than the other among hist
and implied vols. Implied vol is the collective opinion/guess of the option
traders on the volatility of the underlier. Whereas historica |
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d*******n
发帖数: 524 | 22 问一下，这篇文章讨论了interest rate，但似乎完全没有把interest rate当作term
structure来考虑？
对于n year into m year options, Table 3.1和Table 3.2给出了对于不同的n和m的nu
和rho。那么就是说，在篇文章里面，是把所有不同的forward rate f(t,T)当作独立的
underlier来calibrate的，对吧？
SABR |
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V******t
发帖数: 35 | 23 This one should have a closed form solution. You can think this is a knock-
out option pricing for random walk underlier (instead of GBM). |
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f**********r
发帖数: 53 | 24 找工作的时候看到的。 这几个职位有什么区别呢？ 那一个更有发展前景？
4 》 3 》 2 》 1？
1) Operations Strategies (this is a business and not a technology team)
The Operations Strategies team builds reporting tools and quantitative
models around back-office risks such as unconfirmed trades, settlement fails
, and collateral disputes. The team integrates data from all product
categories (securities, derivatives, loans) in order to build a gestalt view
of the firm's risks.
Requirements:
•Interest in developing a deep understandin... 阅读全帖 |
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x***i
发帖数: 106 | 25 我的假设是，the underlier是上涨的，但是怎么涨也没有涨到strike price，所以最
后Call全没了，我也没有办法依靠short delta来弥补（short只会亏更多，所以在这种
情况下delta接近0）。
所以delta hedging好像失效了。真奇怪。 |
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jl
发帖数: 398 | 26 It is different notation with PCA .
Independent component analysis (ICA) :
is a statistical and computational technique for revealing hidden facto
rs that underlie sets of random variables, measurements, or signals.
ICA defines a generative model for the observed multivariate data, which
is typically given as a large database of samples. In the model, the da
ta variables are assumed to be linear mixtures of some unknown latent va
riables, and the mixing system is also unknown. The latent variabl |
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b******a
发帖数: 704 | 27 Here are some links about this topic. Thanks for sharing such an interesting case!
1. World J Gastroenterol. 2011 November 21; 17(43): 4747–4756.
Pancreatic metastases from renal cell carcinoma: The state of the art
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229623/
"Tumor cells apparently have a high affinity for the parenchyma of the pancreas and only there do they find the conditions they need to mature to manifest metastases. The high affinity of some renal cancer cells for the parenchyma... 阅读全帖 |
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f**d
发帖数: 768 | 28 ScienceDaily (May 2, 2011) — In 2005, researchers from the University
of North Carolina at Chapel Hill found that 2-year-old children with
autism have brains up to 10 percent larger than children of the same age
without autism.
Now a follow-up study by UNC researchers has found that the children who
had enlarged brains at age 2 continued to have enlarged brains at
ages 4 and 5, but the amount of the enlargement was to the same degree
found at age 2. This increased brain growth did not continue b... 阅读全帖 |
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v**********m
发帖数: 5516 | 29 楼上文章的comments
Not yet but stay tuned. But a definite fact and you can review it in the FDA
's analysis in the briefing document is that there was no SS of astrocytomas
in male rats or female rats.
Dr. Alavi had concerns about how Arena calculated the exposure margin for
Lorcaserin, that is why it appeared in the CRL. When Arena met directly with
the FDA on December 15th and 16th at the FDA, both Arena and the FDA agreed
on the CSF methodology and the number of participants that would be
acceptab... 阅读全帖 |
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